Research Output 1995 2019

2019
3 Citations (Scopus)

27 years of prenatal diagnosis for Huntington disease in the United Kingdom

Piña-Aguilar, R. E., Simpson, S. A., Alshatti, A., Clarke, A., Craufurd, D., Dorkins, H., Doye, K., Lahiri, N., Lashwood, A., Lynch, C., Miller, C., Morton, S., O’Driscoll, M., Quarrell, O. W., Rae, D., Strong, M., Tomlinson, C., Turnpenny, P., Miedzybrodzka, Z. & UK HD Predictive Testing Consortium, Jul 2019, In : Genetics in Medicine. 21, p. 1639–1643 5 p.

Research output: Contribution to journalArticle

Preimplantation Diagnosis
Huntington Disease
Prenatal Diagnosis
United Kingdom
Neurodegenerative Diseases

A case-note review of continued pregnancies found to be at a high risk of Huntington’s disease: considerations for clinical practice

Wadrup, F., Holden, S., MacLeod, R., Miedzybrodzka, Z., Németh, A. H., Owens, S., Pasalodos, S., Quarrell, O., Clarke, A. J. & on behalf of the UK Huntington’s Disease Predictive Testing Consortium, 19 Mar 2019, In : European Journal of Human Genetics. 27, p. 1215-1224 10 p.

Research output: Contribution to journalArticle

Huntington Disease
Prenatal Diagnosis
Pregnancy
High-Risk Pregnancy
Prenatal Care
2 Downloads (Pure)
Open Access
File
Aftercare
Melanoma
Self-Examination
Neoplasms
Skin
1 Citation (Scopus)

A comparison of professional and private time preferences of General Practitioners

Irvine, A., Van der Pol, M. & Phimister, E., 1 Feb 2019, In : Social Science & Medicine. 222, p. 256-264 9 p.

Research output: Contribution to journalArticle

general practitioner
General Practitioners
Patient Preference
Health
Likelihood Functions

A comparison of the beta-geometric model with landmarking for dynamic prediction of time to pregnancy

van Eekelen, R., Putter, H., McLernon, D. J., Eijkemans, M. J. & van Geloven, N., 18 Nov 2019, In : Biometrical Journal.

Research output: Contribution to journalArticle

Open Access
Geometric Model
Pregnancy
Prediction
Mean Squared Error
Discrete-time

A meta-analysis of genome-wide association studies of epigenetic age acceleration

Gibson, J., Russ, T. C., Clarke, T-K., Howard, D. M., Hillary, R. F., Evans, K. L., Walker, R. M., Bermingham, M. L., Morris, S. W., Campbell, A., Hayward, C., Murray, A. D., Porteous, D. J., Horvath, S., Lu, A. T., McIntosh, A. M., Whalley, H. C. & Marioni, R. E., 18 Nov 2019, In : PLoS Genetics. 15, 11, e1008104.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
meta-analysis
Epigenomics
epigenetics
Meta-Analysis

An actionable KCNH2 Long QT Syndrome variant detected by sequence and haplotype analysis in a population research cohort

Kerr, S. M., Klaric, L., Halachev, M., Hayward, C., Boutin, T. S., Meynert, A. M., Semple, C. A., Tuiskula, A. M., Swan, H., Santoyo-Lopez, J., Vitart, V., Haley, C., Dean, J., Miedzybrodzka, Z., Aitman, T. J. & Wilson, J. F., 29 Jul 2019, In : Scientific Reports. 9, 11 p., 10964.

Research output: Contribution to journalArticle

Open Access
File
Long QT Syndrome
Haplotypes
Sequence Analysis
Research
Population
6 Downloads (Pure)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O. K. L., Zhang, Q., McRae, A. F., Walker, R. M., Morris, S. W., Redmond, P., Campbell, A., Murray, A. D., Porteous, D. J., Evans, K. L., McIntosh, A. M., Deary, I. J. & Marioni, R. E., 6 Mar 2019, In : International Journal of Obesity. 43, p. 1795-1802 8 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Body Mass Index
Parturition
Health

An epigenome-wide association study of sex-specific chronological ageing

McCartney, D. L., Zhang, F., Hillary, R. F., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Evans, K. L., Chandra, T., Deary, I. J., McIntosh, A. M., Yang, J., Visscher, P. M., McRae, A. F. & Marioni, R. E., 15 Nov 2019, (Accepted/In press) In : Genome Medicine.

Research output: Contribution to journalArticle

DNA Methylation
Linear Models
Genome
X-Linked Genes
Quantitative Trait Loci
Opiate Substitution Treatment
Hepatitis C
Primary Health Care
Motivation
Patient Acceptance of Health Care
Open Access
File
Medical Schools
Information Storage and Retrieval
Internship and Residency
Medical Education
Medical Students
Open Access
File
Dietetics
Prostatic Neoplasms
Randomized Controlled Trials
Exercise
Diet

Associations of autozygosity with a broad range of human phenotypes

Murray, A. D., Clark, D. W., Yukinori, O., Kristjan H S, M., Mason, D., Pirastu, N. N. & consortium, ROH., 31 Oct 2019, In : Nature Communications. 10, 4957.

Research output: Contribution to journalArticle

Open Access
File
phenotype
Phenotype
Inbreeding
social factors
fertility

A systematic review of associations between maternal exposures during pregnancy other than smoking and antenatal fetal measurements

Huang, I., Mak, D., Cheung, P., Abraham, M., Clemens, T. & Turner, S., Jun 2019, In : Environmental Research. 173, p. 528-538 11 p.

Research output: Contribution to journalArticle

Maternal Exposure
smoking
pregnancy
Nitrogen Dioxide
Smoking

Can we understand and improve poorer cancer survival in rural-dwellers?

Murchie, P., Adam, R., Wood, R. & Fielding, S., Jul 2019, In : BJGP Open. 3, 2, 4 p., bjgpopen19X101646.

Research output: Contribution to journalArticle

Open Access
File
Neoplasms
Rural Population
Research
Survival
Information Systems
26 Citations (Scopus)
1 Downloads (Pure)

Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies

Coresh, J., Heerspink, H. J. L., Sang, Y., Matsushita, K., Arnlov, J., Astor, B. C., Black, C., Brunskill, N. J., Carrero, J-J., Feldman, H. I., Fox, C. S., Inker, L. A., Ishani, A., Ito, S., Jassal, S., Konta, T., Polkinghorne, K., Romundstad, S., Solbu, M. D., Stempniewicz, N. & 12 others, Stengel, B., Tonelli, M., Umesawa, M., Waikar, S. S., Wen, C-P., Wetzels, J. F. M., Woodward, M., Grams, M. E., Kovesdy, C. P., Levey, A. S., Gansevoort, R. T. & Chronic Kidney Disease Prognosis Consortium and Chronic Kidney Disease Epidemiology Collaboration, Feb 2019, In : The lancet. Diabetes & endocrinology. 7, 2, p. 115-127 13 p.

Research output: Contribution to journalArticle

Open Access
File
Albuminuria
Chronic Kidney Failure
Observational Studies
Meta-Analysis
Creatinine
6 Citations (Scopus)
1 Downloads (Pure)

Change in FEV1 and FeNO measurements as predictors of future asthma outcomes in children

Fielding, S., Pijnenburg, M., de Jongste, J. C., Pike, K. C., Roberts, G., Petsky, H., Chang, A. B., Fritsch, M., Frischer, T., Szefler, S., Gergen, P., Vermeulen, F., Vael, R. & Turner, S., Feb 2019, In : Chest. 155, 2, p. 331-341 11 p.

Research output: Contribution to journalArticle

Open Access
File
Nitric Oxide
Asthma
Spirometry
Meta-Analysis
Reference Values

Clinical utility of fractional exhaled nitric oxide in the management of asthma and COPD

Turner, S., Chang, A. B. & Yang, I. A., 19 Sep 2019, (Accepted/In press) In : Breathe.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Nitric Oxide
Asthma
Eosinophilia
Guidelines

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

Habota, T., Sandu, A-L., Waiter, G. D., McNeil, C. J., Steele, J. D., Macfarlane, J. A., Whalley, H. C., Valentine, R., Younie, D., Crouch, N., Hawkins, E. L., Hirose, Y., Romaniuk, L., Milburn, K., Buchan, G., Coupar, T., Stirling, M., Baljit, J., MacLennan, B., Priba, L. & 20 others, Harris, M. A., Hafferty, J. D., Adams, M. J., Campbell, A. I., MacIntyre, D. J., Pattie, A., Murphy, L., Reynolds, R. M., Elliot, R., Penton-Voak, I. S., Munafò, M. R., Evans, K. L., Seckl, J. R., Wardlaw, J. M., Lawrie, S. M., Haley, C. S., Porteous, D. J., Deary, I. J., Murray, A. D. & McIntosh, A. M., 13 Nov 2019, (Accepted/In press) In : Wellcome open research.

Research output: Contribution to journalArticle

Open Access
Neuroimaging
Scotland
Health
Depression
Brain

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 26 Nov 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 931-946 16 p.

Research output: Contribution to journalArticle

Open Access
File
Atrophy
Alzheimer Disease
Brain
Therapeutics
Pharmaceutical Preparations
2 Citations (Scopus)

Consequences of being overweight or obese during pregnancy on diabetes in the offspring: a record linkage study in Aberdeen, Scotland

Lahti-Pulkkinen, M., Bhattacharya, S., Wild, S. H., Lindsay, R. S., Räikkönen, K., Norman, J. E., Bhattacharya, S. & Reynolds, R. M., Aug 2019, In : Diabetologia. 62, 8, p. 1412-1419 8 p.

Research output: Contribution to journalArticle

Open Access
File
Pregnancy in Diabetics
Scotland
Mothers
Obesity
Type 2 Diabetes Mellitus
1 Downloads (Pure)
Open Access
File
Primary Health Care
General Practice
Referral and Consultation
Secondary Care
Neoplasms
1 Citation (Scopus)
8 Downloads (Pure)
Open Access
File
Aging of materials
Brain
Neurodegenerative diseases
Complex networks
Magnetic resonance
15 Citations (Scopus)
6 Downloads (Pure)

Defining and measuring multimorbidity: a systematic review of systematic reviews

Johnston, M. C., Crilly, M., Black, C., Prescott, G. J. & Mercer, S. W., 1 Feb 2019, In : European Journal of Public Health. 29, 1, p. 182-189 8 p.

Research output: Contribution to journalArticle

Open Access
File
Comorbidity
PubMed
Public Health
Research Personnel
Outcome Assessment (Health Care)

Differences in brain functional connectivity networks between cognitive decliners and sustainers

Sandu-Giuraniuc, A-L., Waiter, G. D., Habota, T., Younie, D. A., McNeil, C. J., McIntosh, A. M. & Murray, A. D., 21 Jun 2019.

Research output: Contribution to conferenceAbstract

3 Citations (Scopus)

Distinguishing wheezing phenotypes from infancy to adolescence: A pooled analysis of five birth cohorts

Oksel, C., Granell, R., Haider, S., Fontanella, S., Simpson, A., Turner, S., Devereux, G., Arshad, S. H., Murray, C. S., Roberts, G., Holloway, J. W., Cullinan, P., Henderson, J. & Custovic, A., 1 Jul 2019, In : Annals of the American Thoracic Society. 16, 7, p. 868-876 9 p.

Research output: Contribution to journalArticle

Open Access
File
Respiratory Sounds
Parturition
Phenotype
Asthma
Forced Expiratory Volume
5 Downloads (Pure)

Does service heterogeneity have an impact on acute hospital length of stay in stroke? A UK-based multi-centre prospective cohort study

Tørnes, M., McLernon, D., Bachmann, M., Musgrave, S. D., Warburton, E. A., Potter, J. F., Myint, P. K. & On behalf of the Anglia Stroke Clinical Network Evaluation Study (ASCNES) Group, 3 Apr 2019, In : BMJ Open. 9, 4, e024506.

Research output: Contribution to journalArticle

Open Access
File
Length of Stay
Cohort Studies
Stroke
Prospective Studies
Stroke Volume
Open Access
File
Pharmacists
Medicine
Pharmacies
Neoplasms
Early Detection of Cancer
2 Downloads (Pure)

Engaging high-risk groups in early lung cancer diagnosis: a qualitative study of symptom presentation and intervention preferences amongst the UK’s most deprived communities

McCutchan, G. M., Hiscock, J., Hood, K., Murchie, P., Neal, R. D., Newton, G., Thomas, S., Thomas, A-M. & Brain, K., 2019, In : BMJ Open. 9, 5, e025902.

Research output: Contribution to journalArticle

Open Access
File
Early Detection of Cancer
Lung Neoplasms
Interviews
Focus Groups
Lung
6 Downloads (Pure)

Falling admissions to hospital with febrile seizures in the UK

Mccrorie, K., Thorburn, J., Symonds, J. & Turner, S. W., Aug 2019, In : Archives of Disease in Childhood. 104, 8, p. 750-754 5 p.

Research output: Contribution to journalArticle

Open Access
File
Accidental Falls
Febrile Seizures
Seizures
Scotland
England

Functional and structural magnetic resonance imaging correlates of fatigue in patients with rheumatoid arthritis

Basu, N., Kaplan, C. M., Ichesco, E., Larkin, T., Schrepf, A., Murray, A. D., Clauw, D. J., Waiter, G. D. & Harris, R. E., 1 Oct 2019, In : Rheumatology. 58, 10, p. 1822-1830 9 p.

Research output: Contribution to journalArticle

Fatigue
Rheumatoid Arthritis
Magnetic Resonance Imaging
Brain
Putamen
Communication
Disclosure
Parents
Health
Uncertainty

Gestational age at delivery of twins and perinatal outcomes: a cohort study in Aberdeen, Scotland

Murray, S. R., Bhattacharya, S., Stock, S. J., Pell, J. P. & Norman, J. E., 22 Jul 2019, In : Wellcome open research. 4, 65.

Research output: Contribution to journalArticle

Open Access
Scotland
Gestational Age
Cohort Studies
Hazards
Reproduction

Gestational age at delivery of twins and the risk of perinatal death: population cohort study

Murray, S. R., Mackay, D., Bhattacharya, S., Stock, S. J., Pell, J. & Norman, J. E., Jan 2019, In : American Journal of Obstetrics and Gynecology. 220, 1 Suppl. , p. S480-S481 2 p.

Research output: Contribution to journalAbstract

2 Citations (Scopus)
4 Downloads (Pure)

Glutathione S-Transferase Genotype Protects against In Utero Tobacco–linked Lung Function Deficits

Owens, L., Laing, I. A., Murdzosk, J., Zhang, G., Turner, S. W. & le Souëf, P. N., 15 Aug 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 4, p. 462-470 9 p.

Research output: Contribution to journalArticle

Open Access
File
Glutathione Transferase
Genotype
Tobacco
Lung
Mothers

Hospital-level Variations in Rates of Inpatient Urinary Tract Infections in Stroke

Tornes, M., McLernon, D. J., Bachmann, M. O., Musgrave, S. D., Warburton, E. A., Potter, J. F., Myint, P. K. & On behalf of the Anglia Stroke Clinical Network Evaluation Study (ASCNES) Group, 6 Aug 2019, In : Frontiers in Neurology. 10, 827.

Research output: Contribution to journalArticle

Open Access
File
Urinary Tract Infections
Inpatients
Stroke
Logistic Models
Odds Ratio

How European primary care practitioners think the timeliness of cancer diagnosis can be improved: a thematic analysis

Harris, M., Thulesius, H., Neves, A. L., Harker, S., Koskela, T., Petek, D., Hoffman, R., Brekke, M., Buczkowski, K., Buono, N., Costiug, E., Dinant, G-J., Foreva, G., Jakob, E., Marzo, M., Murchie, P., Sawicka-Powierza, J., Schneider, A., Smyrnakis, E., Streit, S. & 4 others, Taylor, G., Vedsted, P., Weltermann, B. & Esteva, M., 2019, In : BMJ Open. 9, 9, 9 p., e030169.

Research output: Contribution to journalArticle

Open Access
File
Primary Health Care
Neoplasms
Technology
Secondary Care
Continuing Medical Education
4 Downloads (Pure)
Open Access
File
Cardiovascular Diseases
Guidelines
Pregnancy
Urinalysis
Expert Testimony
7 Downloads (Pure)
Open Access
File
Social Class
Comorbidity
Cohort Studies
Parturition
Birth Certificates
6 Downloads (Pure)

Imprinting methylation in SNRPN and MEST1 in adult blood predicts cognitive ability

Lorgen-Ritchie, M., Murray, A. D., Ferguson-Smith, A. C., Richards, M., Horgan, G. W., Phillips, L. H., Hoad, G., Gall, I., Harrison, K., McNeill, G., Ito, M. & Haggarty, P., 1 Feb 2019, In : PloS ONE. 14, 2, 15 p., e0211799.

Research output: Contribution to journalArticle

Open Access
File
snRNP Core Proteins
Aptitude
Methylation
genomic imprinting
methylation
1 Citation (Scopus)
1 Downloads (Pure)

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., He, J., Fan, D., Fowdar, J., Kennedy, M., Pitcher, T., Pearson, J., Halliday, G., Kwok, J. B., Hickie, I., Lewis, S., Anderson, T., Silburn, P. A., Mellick, G. D., Harris, S. E. & 13 others, Redmond, P., Murray, A. D., Porteous, D. J., Haley, C. S., Evans, K. L., McIntosh, A. M., Yang, J., Gratten, J., Marioni, R. E., Wray, N. R., Deary, I. J., McRae, A. F. & Visscher, P. M., 23 Aug 2019, In : Genome Research. 11, 54.

Research output: Contribution to journalArticle

Open Access
File
Epigenomics
Sample Size
DNA Methylation
Mortality
Parturition

Individual and Combined Impact of Heart Failure and Atrial Fibrillation on Ischemic Stroke Outcomes: A Prospective Hospital Register Cohort Study

Pana, T. A., McLernon, D. J., Mamas, M. A., Bettencourt-Silva, J. H., Metcalf, A. K., Potter, J. F. & Myint, P. K., Jul 2019, In : Stroke. 50, 7, p. 1838-1845 8 p.

Research output: Contribution to journalArticle

Open Access
File
Atrial Fibrillation
Cohort Studies
Heart Failure
Stroke
Recurrence

Inflammation is associated with pro-nociceptive brain connections in rheumatoid arthritis patients with concomitant fibromyalgia

Kaplan, C. M., Schrepf, A., Ichesco, E., Larkin, T., Harte, S. E., Harris, R. E., Murray, A. D., Waiter, G. D., Clauw, D. J. & Basu, N., 5 Aug 2019, In : Arthritis & Rheumatology.

Research output: Contribution to journalArticle

Fibromyalgia
Rheumatoid Arthritis
Inflammation
Brain
Parietal Lobe
2 Citations (Scopus)
Stillbirth
Odds Ratio
Pregnancy
Spontaneous Abortion
Pre-Eclampsia
Spontaneous Abortion
Case-Control Studies
Nuclear Family
Mothers
Odds Ratio
3 Downloads (Pure)

Insulin resistance: Genetic associations with depression and cognition in population based cohorts

Frangou, S., Shirali, M., Adams, M. J., Howard, D. M., Gibson, J., Hall, L. S., Smith, B. H., Padmanabhan, S., Murray, A. D., Porteous, D. J., Haley, C. S., Deary, I. J., Clarke, T-K. & McIntosh, A. M., Jun 2019, In : Experimental Neurology. 316, p. 20-26 7 p.

Research output: Contribution to journalArticle

Open Access
File
Cognition
Insulin Resistance
Depression
Population
Intelligence
1 Citation (Scopus)

Is IUI with ovarian stimulation effective in couples with unexplained subfertility?

van Eekelen, R., van Geloven, N., van Wely, M., McLernon, D. J., Mol, F., Custers, I. M., Steures, P., Bhattacharya, S., Mol, B. W., van der Veen, F. & Eijkemans, M. J., 1 Jan 2019, In : Human Reproduction. 34, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Open Access
File
Ovulation Induction
Infertility
Fertility
Pregnancy Rate
Pregnancy

IVF for unexplained subfertility: whom should we treat?

van Eekelen, R., van Geloven, N., van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J. & McLernon, D. J., Jul 2019, In : Human Reproduction. 34, 7, p. 1249-1259 11 p.

Research output: Contribution to journalArticle

Infertility
Organized Financing
Scotland
Pregnancy
Anovulation
1 Citation (Scopus)

Letter in Response to Tibben et al., Risk Assessment for Huntington's Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners

Quarrell, O. W., Delatycki, M. B., Clarke, A. J., Lahiri, N., Craufurd, D., Miedzybrodzka, Z., MacLeod, R., Renwick, P. & Tomlinson, C., 27 Aug 2019, In : Journal of Huntington's disease. 8, 3, p. 357-359 3 p.

Research output: Contribution to journalLetter

Huntington Disease
Alleles
Penetrance
1 Downloads (Pure)

Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT

Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., Soyza, A. D., Gompertz, S., Haughney, J., Innes, K., Kaniewska, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A. & 1 others, Price, D., Jul 2019, In : Health technology assessment (Winchester, England). 23, 37, p. 1-146 146 p.

Research output: Contribution to journalArticle

Open Access
File
Theophylline
Chronic Obstructive Pulmonary Disease
Adrenal Cortex Hormones
Placebos
Forced Expiratory Volume