Research Output 1979 2019

2019
2 Citations (Scopus)

27 years of prenatal diagnosis for Huntington disease in the United Kingdom

Piña-Aguilar, R. E., Simpson, S. A., Alshatti, A., Clarke, A., Craufurd, D., Dorkins, H., Doye, K., Lahiri, N., Lashwood, A., Lynch, C., Miller, C., Morton, S., O’Driscoll, M., Quarrell, O. W., Rae, D., Strong, M., Tomlinson, C., Turnpenny, P., Miedzybrodzka, Z. & UK HD Predictive Testing Consortium, Jul 2019, In : Genetics in Medicine. 21, p. 1639–1643 5 p.

Research output: Contribution to journalArticle

Preimplantation Diagnosis
Huntington Disease
Prenatal Diagnosis
United Kingdom
Neurodegenerative Diseases

ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris: a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

Wasi, M., Khandelwal, N. K., Moorhouse, A. J., Nair, R., Vishwakarma, P., Ruiz, G. B., Ross, Z. K., Lorenz, A., Rudramurthy, S. M., Chakrabarti, A., Lynn, A. M., Mondal, A. K., Gow, N. A. R. & Prasad, R., 16 Jul 2019, In : Frontiers in Microbiology. 10, 16 p., 1445.

Research output: Contribution to journalArticle

Open Access
File
ATP-Binding Cassette Transporters
Candida
Genome
Pharmaceutical Preparations
Genes

A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor

Khatib, T., Whiting, A., Chisholm, D. R., Redfern, C., Muller, B. & McCaffery, P., Oct 2019, In : Molecular Neurobiology. 56, 10, p. 7074-7084 11 p.

Research output: Contribution to journalArticle

Open Access
File
Retinoic Acid Receptors
AMPA Receptors
Glutamate Receptors
Tretinoin
Ligands
5 Downloads (Pure)

A Bright Future for Fluorescence Imaging of Fungi in Living Hosts

Chapuis, A. F., Ballou, E. R. & MacCallum, D. M., 1 Jun 2019, In : Journal of Fungi. 5, 2, 9 p., 29.

Research output: Contribution to journalArticle

Open Access
File
Luminescent Proteins
Optical Imaging
Fungi
Fungal Proteins
Mycoses

A case-note review of continued pregnancies found to be at a high risk of Huntington's disease: considerations for clinical practice

UK Huntington's Dis Predictive Tes, Aug 2019, In : European Journal of Human Genetics. 27, p. 1215-1224 10 p.

Research output: Contribution to journalReview article

A case-note review of continued pregnancies found to be at a high risk of Huntington’s disease: considerations for clinical practice

Wadrup, F., Holden, S., MacLeod, R., Miedzybrodzka, Z., Németh, A. H., Owens, S., Pasalodos, S., Quarrell, O., Clarke, A. J. & on behalf of the UK Huntington’s Disease Predictive Testing Consortium, 19 Mar 2019, In : European Journal of Human Genetics. 27, p. 1215-1224 10 p.

Research output: Contribution to journalArticle

Huntington Disease
Prenatal Diagnosis
Pregnancy
High-Risk Pregnancy
Prenatal Care
6 Downloads (Pure)

Adoptive T Cell Therapy Strategies for Viral Infections in Patients Receiving Haematopoietic Stem Cell Transplantation

Ottaviano, G., Chiesa, R., Feuchtinger, T., Vickers, M. A., Dickinson, A., Gennery, A. R., Veys, P. & Todryk, S., 14 Jan 2019, In : Cells. 8, 1, 47.

Research output: Contribution to journalReview article

Open Access
File
Hematopoietic Stem Cell Transplantation
Virus Diseases
Cell- and Tissue-Based Therapy
Viruses
T-Lymphocytes
4 Citations (Scopus)

Advancing human health risk assessment

Lanzoni, A., Castoldi, A. F., Kass, G. E. N., Terron, A., De Seze, G., Bal-Price, A., Bois, F. Y., Delclos, K. B., Doerge, D. R., Fritsche, E., Halldorsson, T., Kolossa-Gehring, M., Hougaard Bennekou, S., Koning, F., Lampen, A., Leist, M., Mantus, E., Rousselle, C., Siegrist, M., Steinberg, P. & 7 others, Tritscher, A., Van de Water, B., Vineis, P., Walker, N., Wallace, H., Whelan, M. & Younes, M., Jul 2019, In : EFSA Journal. 17, S1, 21 p., e170712.

Research output: Contribution to journalArticle

Open Access
File
risk assessment
human health
Health
risk assessors
risk managers
1 Citation (Scopus)
7 Downloads (Pure)

Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age

Ireland, A., Saunders, F. R., Muthuri, S. G., Pavlova, A., Hardy, R., Martin, K., Barr, R., Kuh, D., Aspden, R. M., Gregory, J. & Cooper, R., Mar 2019, In : Journal of Bone and Mineral Research. 34, 3, p. 455-463 9 p.

Research output: Contribution to journalArticle

Open Access
File
Age of Onset
Walking
Hip
Walkers
Femur Neck
4 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Muller, B. & Connolly, B., Aug 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spliced Leader RNA
Trans-Splicing
Gene Targeting
Anthelmintics
Gene Expression
5 Citations (Scopus)
9 Downloads (Pure)

Alternative (backdoor) androgen production and masculinization in the human fetus

O'Shaughnessy, P. J., Antignac, J-P., Le Bizec, B., Morvan, M-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., Bellingham, M., Hough, D., Walker, N., Filis, P. & Fowler, P., 14 Feb 2019, In : PLoS Biology. 17, 2, e3000002.

Research output: Contribution to journalArticle

Open Access
File
androsterone
Androsterone
masculinization
androgens
Androgens

An actionable KCNH2 Long QT Syndrome variant detected by sequence and haplotype analysis in a population research cohort

Kerr, S. M., Klaric, L., Halachev, M., Hayward, C., Boutin, T. S., Meynert, A. M., Semple, C. A., Tuiskula, A. M., Swan, H., Santoyo-Lopez, J., Vitart, V., Haley, C., Dean, J., Miedzybrodzka, Z., Aitman, T. J. & Wilson, J. F., 29 Jul 2019, In : Scientific Reports. 9, 11 p., 10964.

Research output: Contribution to journalArticle

Open Access
File
Long QT Syndrome
Haplotypes
Sequence Analysis
Research
Population
1 Citation (Scopus)
5 Downloads (Pure)
Open Access
File
Antigen Receptors
Transgenic Mice
Autoimmune Diseases
Arthritis
Tumor Necrosis Factor-alpha
6 Downloads (Pure)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O. K. L., Zhang, Q., McRae, A. F., Walker, R. M., Morris, S. W., Redmond, P., Campbell, A., Murray, A. D., Porteous, D. J., Evans, K. L., McIntosh, A. M., Deary, I. J. & Marioni, R. E., 6 Mar 2019, In : International Journal of Obesity. 43, p. 1795-1802 8 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Body Mass Index
Parturition
Health

A New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Hwang, D-J., He, Y., Ponnusamy, S., Mohler, M. L., Thiyagarajan, T., McEwan, I. J., Narayanan, R. & Miller, D. D., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 491-511 20 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Androgen Receptor Antagonists
Castration
Cyclization

An ex-vivo human skin model to study superficial fungal infections

Corzo-Leon, D. E., Munro, C. A. & MacCallum, D. M., 5 Jun 2019, In : Frontiers in Microbiology. 10, 17 p., 1172.

Research output: Contribution to journalArticle

Open Access
File
Mycoses
Skin
Infection
Microscopy
Animal Models
Streptomyces griseus
Lactalbumin
Pronase
lactalbumin
enzymatic treatment
5 Downloads (Pure)

Aortic stiffness in aortic stenosis assessed by cardiovascular MRI: a comparison between bicuspid and tricuspid valves

Singh, A., Horsfield, M. A., Bekele, S., Greenwood, J. P., Dawson, D. K., Berry, C., Hogrefe, K., Kelly, D. J., Houston, J. G., Guntur Ramkumar, P., Uddin, A., Suzuki, T. & McCann, G. P., May 2019, In : European Radiology. 29, 5, p. 2340-2349 10 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Stiffness
Tricuspid Valve
Aortic Valve Stenosis
Mitral Valve
Pulse Wave Analysis
1 Citation (Scopus)
5 Downloads (Pure)

A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Warren, A. Y., Massie, C. E., Watt, K., Luko, K., Orafidiya, F., Selth, L. A., Mohammed, H., Chohan, B. S., Menon, S., Baridi, A., Zhao, W., Escriu, C., D'Santos, C., Taylor, C., Qureshi, A., Zecchini, V. R., Shaw, G. L., Dehm, S. M., Mills, I. G., Carroll, J. S. & 5 others, Tilley, W. D., McEwan, I. J., Baniahmad, A., Neal, D. E. & Asim, M., 2019, In : Oncogene. 38, 7, p. 1136-1150 15 p.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Prostatic Neoplasms
PDZ-binding kinase
Systems Biology
Proteome
1 Citation (Scopus)
6 Downloads (Pure)

A retino-retinal projection guided by Unc5c emerged in species with retinal waves

Murcia-Belmonte, V., Coca, Y., Vegar, C., Negueruela, S., de Juan, C., Valiño, A. J., Sala, S., DaSilva, R., Kania, A., Borrell, V., Martinez, L. M., Erskine, L. & Herrera, E., Apr 2019, In : Current Biology. 29, 7, p. 1149-1160 12 p.

Research output: Contribution to journalArticle

Open Access
File
axons
Axons
retina
Retina
Retinal Ganglion Cells
Open Access
File
Dietetics
Prostatic Neoplasms
Randomized Controlled Trials
Exercise
Diet
1 Citation (Scopus)

Aspergillus colonisation and antifungal immunity in cystic fibrosis patients

Warris, A., Bercusson, A. & Armstrong-James, D., 1 Apr 2019, In : Medical Mycology. 57, Suppl. 2, p. S118-S126 9 p.

Research output: Contribution to journalReview article

Aspergillus
Cystic Fibrosis
Immunity
Aspergillus fumigatus
Lung

Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: a Propensity Score Matched Analysis from the SITS-ISTR registry

Tsivgoulis, G., Katsanos, A., Mavridis, D., Lambadiari, V., Roffe, C., Macleod, M. J., Sevcik, P., Cappellari, M., Nevšímalová, M., Toni, D. & Ahmed, N., Sep 2019, In : Diabetes. 68, 9, p. 1861-1869 9 p.

Research output: Contribution to journalArticle

Open Access
File
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid
Propensity Score
Hyperglycemia
Registries
Stroke

Author response to: Reducing postoperative mortality rates in England

Kumar, M. & Ramsay, G., Jul 2019, In : British Journal of Surgery. 106, 8, p. 1100 1 p.

Research output: Contribution to journalLetter

Open Access
England
Mortality
1 Downloads (Pure)
Open Access
File
scanners
biomarkers
cycles
micrometers
edema

Biological Concepts for the Control of Aquatic Zoosporic Diseases

Frenken, T., Agha, R., Schmeller, D. S., van West, P. & Wolinska, J., 1 Jul 2019, In : Trends in Parasitology. 35, 7, p. 571-582 12 p.

Research output: Contribution to journalArticle

Plankton
Aquaculture
Biodiversity
Amphibians
Ecology
2 Citations (Scopus)

Candida albicans: Microbe of the month

Wilson, D., Feb 2019, In : Trends in Microbiology. 27, 2, p. 188-189 2 p.

Research output: Contribution to journalArticle

Can Haematology Blood Tests at Time of Diagnosis Predict Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer?

Ramsay, G., Ritchie, D. T., MacKay, C., Parnaby, C., Murray, G. & Samuel, L., Oct 2019, In : Digestive Surgery. 36, 6, p. 495–501 7 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Hematologic Tests
Hematology
Rectal Neoplasms
Area Under Curve
6 Citations (Scopus)

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M. & Lionakis, M. S., May 2019, In : Nature Immunology. 20, p. 559-570 12 p.

Research output: Contribution to journalArticle

Open Access
File
Neutrophil Infiltration
Microglia
Interleukin-1
Immunity
Central Nervous System
6 Downloads (Pure)

CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor

Phyu, S. M., Tseng, C-C. & Smith, T. A. D., Apr 2019, In : Magnetic Resonance Materials in Physics, Biology and Medicine. 32, 2, p. 227-235 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cytidine Diphosphate Choline
Glycogen Synthase Kinase 3
Colorectal Neoplasms
Breast Neoplasms
Lipids

Challenges of biofilm control and utilization: lessons from mathematical modelling

Dzianach, P. A., Dykes, G. A., Strachan, N. J. C., Forbes, K. J. & Pérez-Reche, F. J., Jun 2019, In : Journal of the Royal Society Interface. 16, 155, 16 p., 20190042.

Research output: Contribution to journalArticle

Open Access
File
Biofilms
Theoretical Models
Mathematical models
Food Industry
Waste Water
1 Citation (Scopus)
4 Downloads (Pure)

Climate, human behaviour or environment: individual-based modelling of Campylobacter seasonality and strategies to reduce disease burden

Rushton, S. P., Sanderson, R. A., Diggle, P. J., Shirley, M. D. F., Blain, A. P., Lake, I., Maas, J. A., Reid, W. D. K., Hardstaff, J., Williams, N., Jones, N. R., Rigby, D., Strachan, N. J. C., Forbes, K. J., Hunter, P. R., Humphrey, T. J. & O'Brien, S. J., 21 Jan 2019, In : Journal of translational medicine. 17, 1, 13 p., 34.

Research output: Contribution to journalArticle

Open Access
File
Campylobacter
Risk-Taking
Climate
Weather
Immunology
4 Downloads (Pure)

Combination peptide immunotherapy suppresses antibody and helper T cell responses to the major human platelet autoantigen GPIIb/IIIa in HLA-transgenic mice

Hall, L. S., Lennon, C. S., Hall, A. M., Urbaniak, S. J., Vickers, M. A. & Barker, R. N., May 2019, In : Haematologica. 104, 5, p. 1074-1082 9 p.

Research output: Contribution to journalArticle

Open Access
File
Integrin beta3
Autoantigens
Helper-Inducer T-Lymphocytes
Immunotherapy
Transgenic Mice
1 Citation (Scopus)
1 Downloads (Pure)
Open Access
File
Choline
Cell Cycle
Pharmaceutical Preparations
Neoplasms
Flow Cytometry
1 Citation (Scopus)
7 Downloads (Pure)

Comparison of fast field-cycling magnetic resonance imaging methods and future perspectives

Bödenler, M., de Rochefort, L., Ross, P. J., Chanet, N., Guillot, G., Davies, G. R., Gösweiner, C., Scharfetter, H., Lurie, D. J. & Broche, L. M., 2019, In : Molecular Physics. 117, 7-8, p. 832-848 17 p.

Research output: Contribution to journalArticle

Open Access
File
Magnetic resonance
magnetic resonance
Molecular Dynamics Simulation
Magnetic Resonance Imaging
Molecular dynamics
7 Downloads (Pure)
Open Access
File
Aging of materials
Brain
Neurodegenerative diseases
Complex networks
Magnetic resonance
1 Downloads (Pure)

Cryptococcal meningitis after ART: Need for proper baseline evaluation in the era of ‘Test & Treat’

Akase, I. E., Olowoyo, O., Oladele, R. O., Obiako, R. O., Warris, A. & Akanmu, S. A., Jun 2019, In : Medical mycology case reports. 24, p. 58-60 3 p.

Research output: Contribution to journalArticle

Open Access
File
Cryptococcal Meningitis
HIV
Therapeutics
Mortality
Lost to Follow-Up

C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease

Tone, K., Stappers, M. H. T., Willment, J. A. & Brown, G. D., 27 Sep 2019, (Accepted/In press) In : European Journal of Immunology.

Research output: Contribution to journalArticle

C-Type Lectins
Transplantation Tolerance
Autoimmune Diseases
Arthritis
Embryonic Development

Cu@Au self-assembled nanoparticles as SERS-active substrates for (bio)molecular sensing

Cabello, G., Nwoko, K. C., Marco, J. F., Sánchez-Arenillas, M., Méndez-Torres, A. M., Feldmann, J., Yáñez, C. & Smith, T. A. D., 30 Jun 2019, In : Journal of Alloys and Compounds. 791, p. 184-192 9 p.

Research output: Contribution to journalArticle

Raman scattering
Nanoparticles
Substrates
Electromagnetic coupling
Biomolecules

Deep anaesthesia and poor outcomes: the jury is still out

Galley, H. F. & Webster, N. R., 20 Oct 2019, In : The Lancet. 2 p.

Research output: Contribution to journalComment/debate

Anesthesia
Anesthetics
Heart Rate
Blood Pressure
Pharmaceutical Preparations

Definition Of The Minimal Contents For The Molecular Simulation Of The Yeast Cytoplasm

Kompella, V. P. S., Stansfield, I., Romano, M. C. & Mancera, R. L., Oct 2019, In : Frontiers in Molecular Biosciences. 6, 9 p., 97.

Research output: Contribution to journalArticle

Open Access
File
Yeast
Proteins
Chemical analysis
Cell growth
Biomolecules

Deletion of caveolin scaffolding domain alters cancer cell migration

Okada, S., Raja, S. A., Okerblom, J., Boddu, A., Horikawa, Y., Ray, S., Okada, H., Kawamura, I., Murofushi, Y., Murray, F. & Patel, H. H., 2019, In : Cell Cycle. 18, 11, p. 1268-1280 13 p.

Research output: Contribution to journalArticle

Caveolins
Caveolin 1
Cell Movement
Neoplasms
HeLa Cells

Dependence on Dectin-1 Varies With Multiple Candida Species

Thompson, A., Griffiths, J. S., Walker, L., da Fonseca, D. M., Lee, K. K., Taylor, P. R., Gow, N. A. R. & Orr, S. J., 6 Aug 2019, In : Frontiers in Microbiology. 10, 12 p., 1800.

Research output: Contribution to journalArticle

Open Access
File
Candida
C-Type Lectins
Infection
dectin 1
Immunity
1 Downloads (Pure)

Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

Gorgoni, B., Zhao, Y-B., Krishnan, J. & Stansfield, I., Aug 2019, In : Cells. 8, 8, 25 p., 800.

Research output: Contribution to journalArticle

Open Access
File
Nonsense Mediated mRNA Decay
Terminator Codon
Eukaryota
Ribosomes
Messenger RNA
3 Downloads (Pure)

Diastolic Ventricular Interaction in Heart Failure With Preserved Ejection Fraction

Parasuraman, S. K., Loudon, B. L., Lowery, C., Cameron, D., Singh, S., Schwarz, K., Gollop, N. D., Rudd, A., McKiddie, F., Phillips, J. J., Prasad, S. K., Wilson, A. M., Sen-Chowdhry, S., Clark, A., Vassiliou, V. S., Dawson, D. K. & Frenneaux, M. P., 2 Apr 2019, In : Journal of the American Heart Association. 8, 7, e010114.

Research output: Contribution to journalArticle

Open Access
File
Heart Failure
Exercise
Pulmonary Hypertension
Starlings
Diastole

Differences in brain functional connectivity networks between cognitive decliners and sustainers

Sandu-Giuraniuc, A-L., Waiter, G. D., Habota, T., Younie, D. A., McNeil, C. J., McIntosh, A. M. & Murray, A. D., 21 Jun 2019.

Research output: Contribution to conferenceAbstract

Cannabinoids
Pharmacogenetics
Genes
Conserved Sequence
Nucleic Acid Regulatory Sequences
2 Downloads (Pure)
Open Access
File
Addictive Behavior
Cannabinoid Receptors
Cannabinoids
Clustered Regularly Interspaced Short Palindromic Repeats
Anxiety
5 Downloads (Pure)

DNA sequence differences are determinants of meiotic recombination outcome

Brown, S. D., Mpaulo, S. J., Asogwa, M. N., Jézéquel, M., Audoynaud, C., Whitby, M. C. & Lorenz, A., 5 Mar 2019, (Accepted/In press) In : bioRxiv. 16 p., 568543.

Research output: Contribution to journalArticle

Open Access
File
Genetic Recombination
Chromosomes
DNA Helicases
Gene Conversion
Chromosome Segregation

Domestication of Campylobacter jejuni NCTC 11168

Pascoe, B., Williams, L. K., Calland, J. K., Meric, G., Hitchings, M. D., Dyer, M., Ryder, J., Shaw, S., Lopes, B. S., Chintoan-Uta, C., Allan, E., Vidal, A., Fearnley, C., Everest, P., Pachebat, J. A., Cogan, T. A., Stevens, M. P., Humphrey, T. J., Wilkinson, T. S., Cody, A. J. & 12 others, Colles, F. M., Jolley, K. A., Maiden, M. C. J., Strachan, N., Pearson, B. M., Linton, D., Wren, B. W., Parkhill, J., Kelly, D. J., van Vliet, A. H. M., Forbes, K. J. & Sheppard, S. K., 2019, In : Microbial Genomics. 5, 7, 279.

Research output: Contribution to journalArticle

Open Access
File
Campylobacter jejuni
Phenotype
Genome
Campylobacter
Ampicillin