Research Output 1979 2020

2020

Ablation of Bscl2/Seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Mcilroy, G. D., Mitchell, S. E., Han, W., Delibegović, M. & Rochford, J. J., 17 Jan 2020, In : Disease Models & Mechanisms. 13, 1, dmm042655.

Research output: Contribution to journalArticle

Open Access
File
Congenital Generalized Lipodystrophy
Ablation
Hepatocytes
Liver
Lipids

A cell-based assay system for activators of the environmental cell stress response

Harbottle, J. A., Petrie, L., Ruhe, M., Houssen, W. E., Jaspars, M. & Kolb, A. F., 13 Jan 2020, In : Analytical Biochemistry. 592, 113583.

Research output: Contribution to journalArticle

Assays
Cells
Health
Vegetables
Hep G2 Cells

Anaemia and incidence of post stroke dementia

Myint, P. K., Macleod, M. J., Clark, A. B., Smith, T. O., Bettencourt-Silva, J. H., Metcalf, A. K. & Potter, J. F., 19 Jan 2020, (Accepted/In press) In : Clinical Neurology and Neurosurgery.

Research output: Contribution to journalArticle

Dementia
Anemia
Stroke
Incidence
International Classification of Diseases
Aspirin
Brain
Aging of materials
Cognition
Processing

Association of Inflammation With Pronociceptive Brain Connections in Rheumatoid Arthritis Patients With Concomitant Fibromyalgia

Kaplan, C. M., Schrepf, A., Ichesco, E., Larkin, T., Harte, S. E., Harris, R. E., Murray, A. D., Waiter, G. D., Clauw, D. J. & Basu, N., Jan 2020, In : Arthritis & Rheumatology. 72, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Fibromyalgia
Rheumatoid Arthritis
Inflammation
Brain
Parietal Lobe
Single-Payer System
Scotland
Length of Stay
Emergencies
Delivery of Health Care
1 Downloads (Pure)

Delirium screening in the intensive care unit using emerging QEEG techniques: A pilot study

Hunter, A., Crouch, B., Webster, N. & Platt, B., 13 Jan 2020, In : AIMS Neuroscience. 7, 1, p. 1-16 16 p.

Research output: Contribution to journalArticle

Open Access
File
Delirium
Intensive Care Units
Electroencephalography
Electrodes
Scalp

Determinants of Exercise Capacity and Myocardial Perfusion Reserve in Asymptomatic Patients With Aortic Stenosis

Singh, A., Jerosch-Herold, M., Bekele, S., Marsh, A-M., McAdam, J., Greenwood, J. P., Dawson, D. K., Lang, C. C., Berry, C., Zhang, R., Pakkal, M. & McCann, G. P., Jan 2020, In : JACC. Cardiovascular Imaging. 13, 1 Part 1, p. 178-180 3 p.

Research output: Contribution to journalLetter

Aortic Valve Stenosis
Perfusion
Open Access
File
Cannabinoids
Pharmacogenetics
Genes
Conserved Sequence
Nucleic Acid Regulatory Sequences

Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans

Ntessalen, M., Procter, N. E., Schwarz, K., Loudon, B. L., Minnion, M., Fernandez, B. O., Vassiliou, V. S., Vauzour, D., Madhani, M., Constantin-Teodosiu, D., Horowitz, J. D., Feelisch, M., Dawson, D., Crichton, P. G. & Frenneaux, M. P., Jan 2020, In : The American Journal of Clinical Nutrition. 111, 1, p. 79-89 11 p.

Research output: Contribution to journalArticle

Open Access
File
Nitrites
Nitrates
Sodium Nitrite
Skeletal Muscle
Pyruvic Acid

Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia

Hull, C., Dekeryte, R., Koss, D. J., Crouch, B., Buchanan, H., Delibegovic, M. & Platt, B., Jan 2020, In : Molecular Neurobiology. 57, 1, p. 539-550 12 p.

Research output: Contribution to journalArticle

Open Access
File
Frontotemporal Dementia
Insulin Resistance
Inflammation
Tauopathies
Phenotype

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

Kania, K., Colella, F., Riemen, A. H. K., Wang, H., Howard, K. A., Aigner, T., Dell'Accio, F., Capellini, T. D., Roelofs, A. J. & de Bari, C., 13 Jan 2020, In : Scientific Reports. 10, 157.

Research output: Contribution to journalArticle

Open Access
File
Osteoarthritis
Cartilage
Joints
Tibial Meniscus
Synovial Membrane

Statistical shape modelling provides a responsive measure of morphological change in knee osteoarthritis over 12 months

Gregory, J. S., Barr, R. J., Yoshida, K., Alesci, S., Reid, D. M. & Aspden, R. M., 14 Jan 2020, In : Rheumatology.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Osteoarthritis
Knee
Joints
Replacement Arthroplasties
Open Access
Candida
Bedding and Linens
Laundering
Delivery of Health Care
Infectious Disease Transmission
1 Downloads (Pure)

The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels

McFarland, M. R., Keller, C. D., Childers, B. M., Adeniyi, S. A., Corrigall, H., Raguin, A., Romano, M. C. & Stansfield, I., 16 Jan 2020, (Accepted/In press) In : Nucleic Acids Research.

Research output: Contribution to journalArticle

File
RNA, Transfer, Gln
Amino Acyl-tRNA Synthetases
Starvation
Transfer RNA
Maintenance

Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models

Viguié, C., Chaillou, E., Gayrard, V., Picard-Hagen, N. & Fowler, P. A., 16 Jan 2020, In : Molecular and Cellular Endocrinology. 110711.

Research output: Contribution to journalArticle

Endocrine Disruptors
Sheep
Health
Thyroid Gland
Biological Phenomena
2019
3 Citations (Scopus)

27 years of prenatal diagnosis for Huntington disease in the United Kingdom

Piña-Aguilar, R. E., Simpson, S. A., Alshatti, A., Clarke, A., Craufurd, D., Dorkins, H., Doye, K., Lahiri, N., Lashwood, A., Lynch, C., Miller, C., Morton, S., O’Driscoll, M., Quarrell, O. W., Rae, D., Strong, M., Tomlinson, C., Turnpenny, P., Miedzybrodzka, Z. & UK HD Predictive Testing Consortium, Jul 2019, In : Genetics in Medicine. 21, p. 1639–1643 5 p.

Research output: Contribution to journalArticle

Preimplantation Diagnosis
Huntington Disease
Prenatal Diagnosis
United Kingdom
Neurodegenerative Diseases
Open Access
Inguinal Hernia
Herniorrhaphy
Reoperation
Scotland
Cohort Studies

ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris: a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

Wasi, M., Khandelwal, N. K., Moorhouse, A. J., Nair, R., Vishwakarma, P., Ruiz, G. B., Ross, Z. K., Lorenz, A., Rudramurthy, S. M., Chakrabarti, A., Lynn, A. M., Mondal, A. K., Gow, N. A. R. & Prasad, R., 16 Jul 2019, In : Frontiers in Microbiology. 10, 16 p., 1445.

Research output: Contribution to journalArticle

Open Access
File
ATP-Binding Cassette Transporters
Candida
Genome
Pharmaceutical Preparations
Genes
2 Downloads (Pure)

A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor

Khatib, T., Whiting, A., Chisholm, D. R., Redfern, C., Muller, B. & McCaffery, P., Oct 2019, In : Molecular Neurobiology. 56, 10, p. 7074-7084 11 p.

Research output: Contribution to journalArticle

Open Access
File
Retinoic Acid Receptors
AMPA Receptors
Glutamate Receptors
Tretinoin
Ligands
6 Downloads (Pure)

A Bright Future for Fluorescence Imaging of Fungi in Living Hosts

Chapuis, A. F., Ballou, E. R. & MacCallum, D. M., 1 Jun 2019, In : Journal of Fungi. 5, 2, 9 p., 29.

Research output: Contribution to journalArticle

Open Access
File
Luminescent Proteins
Optical Imaging
Fungi
Fungal Proteins
Mycoses

A case-note review of continued pregnancies found to be at a high risk of Huntington’s disease: considerations for clinical practice

Wadrup, F., Holden, S., MacLeod, R., Miedzybrodzka, Z., Németh, A. H., Owens, S., Pasalodos, S., Quarrell, O., Clarke, A. J. & on behalf of the UK Huntington’s Disease Predictive Testing Consortium, 19 Mar 2019, In : European Journal of Human Genetics. 27, p. 1215-1224 10 p.

Research output: Contribution to journalArticle

Huntington Disease
Prenatal Diagnosis
Pregnancy
High-Risk Pregnancy
Prenatal Care
6 Downloads (Pure)

Adoptive T Cell Therapy Strategies for Viral Infections in Patients Receiving Haematopoietic Stem Cell Transplantation

Ottaviano, G., Chiesa, R., Feuchtinger, T., Vickers, M. A., Dickinson, A., Gennery, A. R., Veys, P. & Todryk, S., 14 Jan 2019, In : Cells. 8, 1, 47.

Research output: Contribution to journalReview article

Open Access
File
Hematopoietic Stem Cell Transplantation
Virus Diseases
Cell- and Tissue-Based Therapy
Viruses
T-Lymphocytes
4 Citations (Scopus)

Advancing human health risk assessment

Lanzoni, A., Castoldi, A. F., Kass, G. E. N., Terron, A., De Seze, G., Bal-Price, A., Bois, F. Y., Delclos, K. B., Doerge, D. R., Fritsche, E., Halldorsson, T., Kolossa-Gehring, M., Hougaard Bennekou, S., Koning, F., Lampen, A., Leist, M., Mantus, E., Rousselle, C., Siegrist, M., Steinberg, P. & 7 others, Tritscher, A., Van de Water, B., Vineis, P., Walker, N., Wallace, H., Whelan, M. & Younes, M., Jul 2019, In : EFSA Journal. 17, S1, 21 p., e170712.

Research output: Contribution to journalArticle

Open Access
File
risk assessment
human health
Health
risk assessors
risk managers
3 Citations (Scopus)
9 Downloads (Pure)

Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age

Ireland, A., Saunders, F. R., Muthuri, S. G., Pavlova, A., Hardy, R., Martin, K., Barr, R., Kuh, D., Aspden, R. M., Gregory, J. & Cooper, R., Mar 2019, In : Journal of Bone and Mineral Research. 34, 3, p. 455-463 9 p.

Research output: Contribution to journalArticle

Open Access
File
Age of Onset
Walking
Hip
Walkers
Femur Neck
5 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Muller, B. & Connolly, B., Aug 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spliced Leader RNA
Trans-Splicing
Gene Targeting
Anthelmintics
Gene Expression
9 Citations (Scopus)
11 Downloads (Pure)

Alternative (backdoor) androgen production and masculinization in the human fetus

O'Shaughnessy, P. J., Antignac, J-P., Le Bizec, B., Morvan, M-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., Bellingham, M., Hough, D., Walker, N., Filis, P. & Fowler, P., 14 Feb 2019, In : PLoS Biology. 17, 2, e3000002.

Research output: Contribution to journalArticle

Open Access
File
androsterone
Androsterone
masculinization
androgens
Androgens

A meta-analysis of genome-wide association studies of epigenetic age acceleration

Gibson, J., Russ, T. C., Clarke, T-K., Howard, D. M., Hillary, R. F., Evans, K. L., Walker, R. M., Bermingham, M. L., Morris, S. W., Campbell, A., Hayward, C., Murray, A. D., Porteous, D. J., Horvath, S., Lu, A. T., McIntosh, A. M., Whalley, H. C. & Marioni, R. E., Nov 2019, In : PLoS Genetics. 15, 11, e1008104.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
meta-analysis
Epigenomics
epigenetics
Meta-Analysis

An actionable KCNH2 Long QT Syndrome variant detected by sequence and haplotype analysis in a population research cohort

Kerr, S. M., Klaric, L., Halachev, M., Hayward, C., Boutin, T. S., Meynert, A. M., Semple, C. A., Tuiskula, A. M., Swan, H., Santoyo-Lopez, J., Vitart, V., Haley, C., Dean, J., Miedzybrodzka, Z., Aitman, T. J. & Wilson, J. F., 29 Jul 2019, In : Scientific Reports. 9, 11 p., 10964.

Research output: Contribution to journalArticle

Open Access
File
Long QT Syndrome
Haplotypes
Sequence Analysis
Research
Population
2 Citations (Scopus)
5 Downloads (Pure)
Open Access
File
Antigen Receptors
Transgenic Mice
Autoimmune Diseases
Arthritis
Tumor Necrosis Factor-alpha
6 Downloads (Pure)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O. K. L., Zhang, Q., McRae, A. F., Walker, R. M., Morris, S. W., Redmond, P., Campbell, A., Murray, A. D., Porteous, D. J., Evans, K. L., McIntosh, A. M., Deary, I. J. & Marioni, R. E., 6 Mar 2019, In : International Journal of Obesity. 43, p. 1795-1802 8 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Body Mass Index
Parturition
Health

An epigenome-wide association study of sex-specific chronological ageing

McCartney, D. L., Zhang, F., Hillary, R. F., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Evans, K. L., Chandra, T., Deary, I. J., McIntosh, A. M., Yang, J., Visscher, P. M., McRae, A. F. & Marioni, R. E., 31 Dec 2019, In : Genome Medicine. 12, 1.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Linear Models
Genome
X-Linked Genes
Quantitative Trait Loci
3 Citations (Scopus)
1 Downloads (Pure)

A New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Hwang, D-J., He, Y., Ponnusamy, S., Mohler, M. L., Thiyagarajan, T., McEwan, I. J., Narayanan, R. & Miller, D. D., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 491-511 20 p.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Prostatic Neoplasms
Androgen Receptor Antagonists
Castration
Cyclization

A new Publisher for Toxicology Research

Wallace, H., 3 Dec 2019, In : Toxicology Research. 1 p.

Research output: Contribution to journalEditorial

Toxicology
Research
1 Citation (Scopus)

An ex-vivo human skin model to study superficial fungal infections

Corzo-Leon, D. E., Munro, C. A. & MacCallum, D. M., 5 Jun 2019, In : Frontiers in Microbiology. 10, 17 p., 1172.

Research output: Contribution to journalArticle

Open Access
File
Mycoses
Skin
Infection
Microscopy
Animal Models
1 Citation (Scopus)
Streptomyces griseus
Lactalbumin
Pronase
lactalbumin
enzymatic treatment
6 Downloads (Pure)

Aortic stiffness in aortic stenosis assessed by cardiovascular MRI: a comparison between bicuspid and tricuspid valves

Singh, A., Horsfield, M. A., Bekele, S., Greenwood, J. P., Dawson, D. K., Berry, C., Hogrefe, K., Kelly, D. J., Houston, J. G., Guntur Ramkumar, P., Uddin, A., Suzuki, T. & McCann, G. P., May 2019, In : European Radiology. 29, 5, p. 2340-2349 10 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Stiffness
Tricuspid Valve
Aortic Valve Stenosis
Mitral Valve
Pulse Wave Analysis
2 Citations (Scopus)
5 Downloads (Pure)

A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Warren, A. Y., Massie, C. E., Watt, K., Luko, K., Orafidiya, F., Selth, L. A., Mohammed, H., Chohan, B. S., Menon, S., Baridi, A., Zhao, W., Escriu, C., D'Santos, C., Taylor, C., Qureshi, A., Zecchini, V. R., Shaw, G. L., Dehm, S. M., Mills, I. G., Carroll, J. S. & 5 others, Tilley, W. D., McEwan, I. J., Baniahmad, A., Neal, D. E. & Asim, M., 2019, In : Oncogene. 38, 7, p. 1136-1150 15 p.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Prostatic Neoplasms
PDZ-binding kinase
Systems Biology
Proteome
4 Citations (Scopus)
6 Downloads (Pure)

A retino-retinal projection guided by Unc5c emerged in species with retinal waves

Murcia-Belmonte, V., Coca, Y., Vegar, C., Negueruela, S., de Juan, C., Valiño, A. J., Sala, S., DaSilva, R., Kania, A., Borrell, V., Martinez, L. M., Erskine, L. & Herrera, E., Apr 2019, In : Current Biology. 29, 7, p. 1149-1160 12 p.

Research output: Contribution to journalArticle

Open Access
File
axons
Axons
retina
Retina
Retinal Ganglion Cells
2 Downloads (Pure)

A role for spinal cord hypoxia in neurodegeneration

Hernandez Gerez, E., Fleming, I. N. & Parson, S. H., 13 Nov 2019, In : Cell Death & Disease. 10, 8 p., 861.

Research output: Contribution to journalReview article

Open Access
File
Blood Vessels
Spinal Cord
Sclerosis
Pathology
Spinal Muscular Atrophy
Open Access
File
Dietetics
Prostatic Neoplasms
Randomized Controlled Trials
Exercise
Diet
2 Citations (Scopus)

Aspergillus colonisation and antifungal immunity in cystic fibrosis patients

Warris, A., Bercusson, A. & Armstrong-James, D., 1 Apr 2019, In : Medical Mycology. 57, Suppl. 2, p. S118-S126 9 p.

Research output: Contribution to journalReview article

Aspergillus
Cystic Fibrosis
Immunity
Aspergillus fumigatus
Lung

Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: a Propensity Score Matched Analysis from the SITS-ISTR registry

Tsivgoulis, G., Katsanos, A., Mavridis, D., Lambadiari, V., Roffe, C., Macleod, M. J., Sevcik, P., Cappellari, M., Nevšímalová, M., Toni, D. & Ahmed, N., Sep 2019, In : Diabetes. 68, 9, p. 1861-1869 9 p.

Research output: Contribution to journalArticle

Open Access
File
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid
Propensity Score
Hyperglycemia
Registries
Stroke

Associations of autozygosity with a broad range of human phenotypes

Murray, A. D., Clark, D. W., Yukinori, O., Kristjan H S, M., Mason, D., Pirastu, N. N. & consortium, ROH., 31 Oct 2019, In : Nature Communications. 10, 4957.

Research output: Contribution to journalArticle

Open Access
File
phenotype
Phenotype
Inbreeding
social factors
fertility

Author response to: Reducing postoperative mortality rates in England

Kumar, M. & Ramsay, G., Jul 2019, In : British Journal of Surgery. 106, 8, p. 1100 1 p.

Research output: Contribution to journalLetter

Open Access
England
Mortality
1 Citation (Scopus)
3 Downloads (Pure)
Open Access
File
scanners
biomarkers
cycles
micrometers
edema

Bilateral Breast coil for Fast Field-Cycling Relaxometric MRI

Davies, G. R., Broche, L., Gagliardi, T., Lurie, D. J. & Ross, P. J., May 2019.

Research output: Contribution to conferenceAbstract

Open Access
1 Citation (Scopus)

Biological Concepts for the Control of Aquatic Zoosporic Diseases

Frenken, T., Agha, R., Schmeller, D. S., van West, P. & Wolinska, J., 1 Jul 2019, In : Trends in Parasitology. 35, 7, p. 571-582 12 p.

Research output: Contribution to journalArticle

Plankton
Aquaculture
Biodiversity
Amphibians
Ecology
4 Citations (Scopus)

Candida albicans: Microbe of the month

Wilson, D., Feb 2019, In : Trends in Microbiology. 27, 2, p. 188-189 2 p.

Research output: Contribution to journalArticle

Open Access
File

Can Haematology Blood Tests at Time of Diagnosis Predict Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer?

Ramsay, G., Ritchie, D. T., MacKay, C., Parnaby, C., Murray, G. & Samuel, L., Oct 2019, In : Digestive Surgery. 36, 6, p. 495–501 7 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Hematologic Tests
Hematology
Rectal Neoplasms
Area Under Curve