Life Sciences & Medicine

  • AB25 2ZD

Research Output 1970 2020

136 Citations (Scopus)

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., Fleming, I. N., Green, S. R., McNae, I., Wu, S-Y., McInnes, C., Zheleva, D., Walkinshaw, M. D. & Fischer, P. M., 25 Mar 2004, In : Journal of Medicinal Chemistry. 47, 7, p. 1662-1675 14 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
X Ray Crystallography
Structure-Activity Relationship
pyrimidine
Adenosine Triphosphate
60 Citations (Scopus)

2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism

Jung, K-M., Clapper, J. R., Fu, J., D'Agostino, G., Guijarro, A., Thongkham, D., Avanesian, A., Astarita, G., DiPatrizio, N. V., Frontini, A., Cinti, S., Diano, S. & Piomelli, D., 7 Mar 2012, In : Cell Metabolism. 15, 3, p. 299-310 12 p.

Research output: Contribution to journalArticle

Endocannabinoids
Prosencephalon
Energy Metabolism
Monoacylglycerol Lipases
Cannabinoid Receptors
22 Citations (Scopus)
4 Downloads (Pure)

2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting

Bouwman, F. G., De Roos, B., Rubio-Aliaga, I., Crosley, L. K., Duthie, S. J., Mayer, C., Horgan, G., Polley, A. C., Heim, C., Coort, S. LM., Evelo, C. T., Mulholland, F., Johnson, I. T., Elliott, R. M., Daniel, H. & Mariman, E. CM., 25 Mar 2011, In : BMC Medical Genomics. 4, 12 p., 24.

Research output: Contribution to journalArticle

Open Access
File
Body Fluids
Immunoassay
Proteomics
Electrophoresis
Fasting
2 Citations (Scopus)

2-Deoxy-D-[1-3H]glucose uptake by MCF7 and T47D breast tumour cells under conditions of active proliferation and serum deprivation

Smith, T. A. D., Titley, J., eccles, S. A. & McReady, R., 1998, In : Anticancer Research. 18, 3A, p. 1865-1870 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Glucose
Serum
S Phase
Intercellular Signaling Peptides and Proteins
13 Citations (Scopus)

2-Hydroxyacetophenone arylhydrazones. Supramolecular arrangements based on C–H · · · O(H), CH · · · O(NO), N–H · · · O(H), N–H · · · O(NO), C–H · · · π or π · · · π interactions

Baddeley, T. C., Franca, L. D. S., Howie, R. A., de Lima, G. M., Skakle, J., de Souza, J. D., Wardell, J. L. & Wardell, S. M. S. V., Sep 2009, In : Zeitschrift für Kristallographie. 224, 4, p. 213-224 12 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

2nd ESMO consensus conference on lung cancer: Early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up

Vansteenkiste, J., Crinò, L., Dooms, C., Douillard, J. Y., Faivre-Finn, C., Lim, E., Rocco, G., Senan, S., van Schil, P., Veronesi, G., Stahel, R., Peters, S., Felip, E., Kerr, K., Besse, B., Eberhardt, W., Edelman, M., Mok, T., O'Byrne, K., Novello, S. & 15 others, Bubendorf, L., Marchetti, A., Baas, P., Reck, M., Syrigos, K., Paz-Ares, L., Smit, E. F., Meldgaard, P., Adjei, A., Nicolson, M., Weder, W., de Ruysscher, D., Le Pechoux, C., de Leyn, P. & Westeel, V., 1 Aug 2014, In : Annals of Oncology. 25, 8, p. 1462-1474 13 p., mdu089.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Molecular Pathology
Neoplasms
Biomarkers
136 Citations (Scopus)

2nd ESMO Consensus Conference on Lung Cancer: Non-small-cell lung cancer first-line/second and further lines in advanced disease

Besse, B., Adjei, A., Baas, P., Meldgaard, P., Nicolson, M., Paz-Ares, L., Reck, M., Smit, E. F., Syrigos, K., Stahel, R., Felip, E., Peters, S., Stahel, R., Felip, E., Peters, S., Kerr, K., Besse, B., Vansteenkiste, J., Eberhardt, W., Edelman, M. & 27 others, Mok, T., O'Byrne, K., Novello, S., Bubendorf, L., Marchetti, A., Baas, P., Reck, M., Syrigos, K., Paz-Ares, L., Smit, E. F., Meldgaard, P., Adjei, A., Nicolson, M., Crinò, L., Van Schil, P., Senan, S., Faivre-Finn, C., Rocco, G., Veronesi, G., Douillard, J. Y., Lim, E., Dooms, C., Weder, W., De Ruysscher, D., Le Pechoux, C., De Leyn, P. & Westeel, V., 1 Aug 2014, In : Annals of Oncology. 25, 8, p. 1475-1484 10 p., mdu123.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Molecular Pathology
Neoplasms
Biomarkers

2-normed algebras-II

Srivastava, N., Bhattacharya, S. & Lal, S. N., 2011, In : Publications de l institut mathematique-Beograd. 90, 104, p. 135-143 9 p.

Research output: Contribution to journalArticle

2 pages for Foundation Years Journal

Vickers, M., 2010

Research output: Other contribution

Patents and inventions
Salts
Pharmaceutical Preparations
xanthylium
6 Downloads (Pure)
File
Salt
Drugs
Alzheimer's Disease
Invention
32 Citations (Scopus)

31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: Experiences at 3 T

Shivu, G. N., Abozguia, K., Phan, T. T., Ahmed, I., Henning, A. & Frenneaux, M., Feb 2010, In : European Journal of Radiology. 73, 2, p. 255-259 5 p.

Research output: Contribution to journalArticle

3D attenuation correction in PET

Campbell, C., Welch, A., Mikecz, P., Evans, N., Chaloner, F., Chilcott, F. & Sharp, P., 1998, 1997 IEEE NUCLEAR SCIENCE SYMPOSIUM - CONFERENCE RECORD, VOLS 1. NEW YORK: IEEE Press, p. 1542-1545 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)
3 Downloads (Pure)

3D-Geomorphometrics tooth shape analysis in hypodontia

Al-Shahrani, I., Dirks, W., Jepson, N. & Khalaf, K., 2014, In : Frontiers in Physiology. 5, 154.

Research output: Contribution to journalArticle

Open Access
File
Anodontia
Tooth
Tooth Crown
Discriminant Analysis
Principal Component Analysis
20 Citations (Scopus)

3D human cell culture: a novel system for testing drug toxicity

Li, J., Blease, N., Saunders, F. & Wallace, H. M., 30 Dec 2010, In : Toxicology. 278, 3, p. 374-375 2 p.

Research output: Contribution to journalAbstract

3-DIMENSIONAL GRAVITY ANALYSIS OF THE KIGLAPAIT LAYERED INTRUSION, LABRADOR

Stephenson, R., Thomas, M. D. & Stephenson, R., 1979, In : Canadian Journal of Earth Sciences. 16, 1, p. 24-37 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
4 Downloads (Pure)

3D MRI analysis of the lower legs of treated idiopathic congenital talipes equinovarus (clubfoot)

Duce, S. L., D'Alessandro, M., Du, Y., Jagpal, B., Gilbert, F. J., Crichton, L., Barker, S., Collinson, J. M. & Miedzybrodzka, Z., 30 Jan 2013, In : PloS ONE. 8, 1, 10 p., e54100.

Research output: Contribution to journalArticle

Open Access
File
Clubfoot
Magnetic resonance
magnetic resonance imaging
Muscle
Leg
12 Downloads (Pure)

3D-Printed Patient-Specific ACL Femoral Tunnel Guide from MRI

Rankin, I., Rehman, H. & Frame, M., 2018, In : The Open Orthopaedics Journal . 12, p. 59-68 10 p.

Research output: Contribution to journalArticle

Open Access
File
Thigh
Knee
Computer-Aided Design
Stainless Steel
Articular Cartilage

3D Stereoscopic Tutorials to Bolster Anatomical Teaching

Wohlgemut, J., Denison, A. R., Hamilton, N. M. & Hutchison, J., 8 Apr 2012.

Research output: Contribution to conferencePaper

2 Citations (Scopus)

3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Booth, M. E., Nash, C. E., Roberts, N. P., Magee, D. R., Treanor, D., Hanby, A. M. & Speirs, V., 1 Dec 2015, In : ATLA Alternatives to Laboratory Animals. 43, 6, p. 377-383 7 p.

Research output: Contribution to journalArticle

Mammography
Carcinoma, Intraductal, Noninfiltrating
Pathology
Screening
Animals
18 Citations (Scopus)

3 IN-FRAME N-TERMINALLY DIFFERENT PROTEINS ARE PRODUCED FROM THE REPRESSOR LOCUS OF THE STREPTOMYCES BACTERIOPHAGE-PHI-C31

Smith, M. C. M. & OWEN, C. E., Nov 1991, In : Molecular Microbiology. 5, 11, p. 2833-2844 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

4-Cyano-5-(2-Thiophenyl)-Pyrazoles are High Affinity CB1 Receptor Ligands

Altomonte, S., Baillie, G. L., Ross, R. & Zanda, M., 2015, In : RSC Advances. 5, 18, p. 13692-13701 10 p.

Research output: Contribution to journalArticle

Pyrazoles
Cannabinoid Receptor CB1
Bearings (structural)
Ligands
Cannabinoid Receptor CB2
7 Citations (Scopus)

4-Hydroxybenzoyl derivative from the aqueous extract of the hydroid Campanularia sp

Houssen, W. E. & Jaspars, M., 2005, In : Journal of Natural Products. 68, 3, p. 453-455 3 p.

Research output: Contribution to journalArticle

5.6 Emissions and uptake of CO2 by soil from land use change and management: Chapter 5. Land use change and forestry

Paustian, K., Mosier, A., Janzen, H., Tiessen, H., van Noordwijk, M., Andren, O., Davidson, E., Eswaran, H., Fernandes, E., Grace, P., Houghton, R., Kimble, J., Kolchingna, T., Lal, R., Scoles, M., Smith, P., Tian, G., Woomer, P. & Zhong, L., 1997, Revised 1996 IPCC Guidelines for National Greenhouse gas inventories: Volume 2: Workbook. Bracknell, Berks, United Kingdom: WMO, p. 23-38

Research output: Chapter in Book/Report/Conference proceedingChapter

43 Citations (Scopus)

5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.

Chatterjee, P. K., Chatterjee, B. E., Pedersen, H., Sivarajah, A., McDonald, M. C., Mota-Filipe, H., Brown, P. A. J., Stewart, K. N., Cuzzocrea, S., Threadgill, M. D. & Thiemermann, C., 2004, In : Kidney International. 65, 2, p. 499-509 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

5-Fluorouracil pharmacokinetics following intraperitoneal and intravenous administration using in-vivo 19-F magnetic resonance spectroscopy

Glaholm, J., Leach, M., Collins, D., Al Jehazi, B., Sharp, D., Smith, T. A. D., Adach, J., McReady, R. & White, H., 1990, In : British Journal of Radiology. 63, 751, p. 547-553 7 p.

Research output: Contribution to journalArticle

5-HT2Aand 5-HT2Creceptors as hypothalamic targets of developmental programming in male rats

Martin-Gronert, M. S., Stocker, C. J., Wargent, E. T., Cripps, R. L., Garfield, A. S., Jovanovic, Z., D'Agostino, G., Yeo, G. S. H., Cawthorne, M. A., Arch, J. R. S., Heisler, L. K. & Ozanne, S. E., 15 Apr 2016, In : Development. 143, 8, p. 401-412 12 p.

Research output: Contribution to journalArticle

Open Access
File
Serotonin
Appetite
Obesity
AIDS-Related Complex
Pro-Opiomelanocortin
10 Citations (Scopus)
3 Downloads (Pure)

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

Martin-Gronert, M. S., Stocker, C. J., Wargent, E. T., Cripps, R. L., Garfield, A. S., Jovanovic, Z., D'Agostino, G., Yeo, G. S. H., Cawthorne, M. A., Arch, J. R. S., Heisler, L. K. & Ozanne, S. E., 1 Apr 2016, In : Disease Models & Mechanisms. 9, 4, p. 401-412 12 p.

Research output: Contribution to journalArticle

Open Access
File
Receptor, Serotonin, 5-HT2C
Rats
Serotonin
Appetite
Nutrition
26 Citations (Scopus)

5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated

Doslikova, B., Garfield, A. S., Shaw, J., Evans, M. L., Burdakov, D., Billups, B. & Heisler, L. K., 5 Jun 2013, In : Journal of Neuroscience. 33, 23, p. 9800-9804 5 p.

Research output: Contribution to journalArticle

Open Access
182 Citations (Scopus)
5 Downloads (Pure)

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis

Xu, Y., Jones, J. E., Kohno, D., Williams, K. W., Lee, C. E., Choi, M. J., Anderson, J. G., Heisler, L. K., Zigman, J. M., Lowell, B. B. & Elmquist, J. K., 25 Nov 2008, In : Neuron. 60, 4, p. 582-589 8 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
4 Downloads (Pure)

5-HT obesity medication efficacy via POMC activation is maintained during aging

Burke, L. K., Doslikova, B., D'Agostino, G., Garfield, A. S., Farooq, G., Burdakov, D., Low, M., Rubinstein, M., Evans, M. L., Billups, B. & Heisler, L., 22 Jul 2014, In : Endocrinology. 155, 10, p. 3732–3738 7 p.

Research output: Contribution to journalArticle

Open Access
File
Pro-Opiomelanocortin
AIDS-Related Complex
Serotonin
Obesity
sibutramine
30 Citations (Scopus)

5-Hydroxytryptamine Medications for the Treatment of Obesity

Burke, L. K. & Heisler, L., Jun 2015, In : Journal of Neuroendocrinology. 27, 6, p. 389-398 10 p.

Research output: Contribution to journalLiterature review

5-year review of the medical management of miscarriage at the Aberdeen Maternity Hospital (AMH)

Woolner, A. & Crichton, L., Nov 2013, In : Journal of Obstetrics and Gynaecology. 33, 8, p. 918 1 p.

Research output: Contribution to journalAbstract

Maternity Hospitals
Spontaneous Abortion
Fetal Death
Misoprostol
Databases
3 Citations (Scopus)
5'-nucleotidase
5'-Nucleotidase
Macrophages
rainbow
Oncorhynchus mykiss
373 Citations (Scopus)

64-slice computed tomography angiography in the diagnosis and assessment of coronary artery disease: systematic review and meta-analysis

Mowatt, G., Cook, J. A., Hillis, G. S., Walker, S. M., Fraser, C. M., Jia, X. & Waugh, N. R., Nov 2008, In : Heart. 94, 11, p. 1386-1393 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

8OHdG as a marker for Huntington disease progression

Long, J. D., Matson, W. R., Juhl, A. R., Leavitt, B. R., Paulsen, J. S., PREDICT-HD Investigators And Coordinators Of The Huntington Study Group & Miedzybrodzka, Z., Jun 2012, In : Neurobiology of Disease. 46, 3, p. 625-634 10 p.

Research output: Contribution to journalArticle

Huntington Disease
Disease Progression
Liquid Chromatography
Leukocytes
Parietal Lobe
8 Citations (Scopus)

99mTc-labelled human serum transferrin for tumour imaging: an in vitro and in vivo study of the complex.

Smith, T. A. D., Walton, P. H. & Perkins, A., 2004, In : Nuclear Medicine Communications. 25, p. 387-391 4 p.

Research output: Contribution to journalArticle

407 Citations (Scopus)

A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients.

Bjordal, K., de Graeff, A., Fayers, P., Hammerlid, E., van Pottelsberghe, C., Curran, D., Ahlner-Elmqvist, M., Maher, E. J., Meyza, J. W., Brédart, A., Söderholm, A. L., Arraras, J. J., Feine, J. S., Abendstein, H., Morton, R. P., Pignon, T., Huguenin, P., Bottomly, A., Kaasa, S. & EORTC Quality of Life Group, Sep 2000, In : European Journal of Cancer. 36, 14, p. 1796-1807 12 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Neck
Head
Research
Neoplasms
42 Citations (Scopus)

A 14-3-3γ dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation

Valente, C., Turacchio, G., Mariggiò, S., Pagliuso, A., Gaibisso, R., Di Tullio, G., Santoro, M., Formiggini, F., Spanò, S., Piccini, D., Polishchuk, R. S., Colanzi, A., Luini, A. & Corda, D., Apr 2012, In : Nature Cell Biology. 14, 4, p. 343-354 12 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Proteins
1-Phosphatidylinositol 4-Kinase
GTP Phosphohydrolases
Golgi Apparatus
1 Citation (Scopus)
3 Downloads (Pure)

A1-adenosine acute withdrawal response and cholecystokinin-8 induced contractures are regulated by Ca2+- and ATP-activated K+ channels

Cascio, M. G., Valeri, D., Tucker, S. J. & Marini, P., May 2015, In : Pharmacological Research. 95-96, p. 82-91 10 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Contracture
Adenosine
Adenosine Triphosphate
Ileum
16 Citations (Scopus)

A2A adenosine receptors are located on presynaptic motor nerve terminals in the mouse

Baxter, R. L., Vega-Riveroll, L. J., Deuchars, J. & Parson, S. H., 15 Sep 2005, In : Synapse. 57, 4, p. 229-34 6 p.

Research output: Contribution to journalArticle

Adenosine A2A Receptors
Neuromuscular Junction
Adenosine
Acetylcholine
Purinergic P1 Receptors
24 Citations (Scopus)

A 5 '-3 ' exonuclease activity involved in forming the 3 ' products of histone pre-mRNA processing in vitro

Walther, T. N., Koning, T. H. W., Schumperli, D. & Muller, B. M., Sep 1998, In : RNA . 4, 9, p. 1034-1046 13 p.

Research output: Contribution to journalArticle

A55 A rCBF study of hallucinations in dementia.

Staff, R. T., Benjamin, K. D., Murray, A. D., Gemmell, H. . G. & Wischik, C. M., 2006, In : Nuclear Medicine Communications. 27, 3

Research output: Contribution to journalArticle

22 Citations (Scopus)

A 5cm colonic J pouch colo-anal reconstruction following anterior resection for low rectal cancer results in acceptable evacuation and continence in the long term

Amin, A. I., Hallböök, O., Lee, A. J., Sexton, R., Moran, B. J. & Heald, R. J., 1 Jan 2003, In : Colorectal Disease. 5, 1, p. 33-7 5 p.

Research output: Contribution to journalArticle

Colonic Pouches
Rectal Neoplasms
Colon
Incontinence Pads
Anal Canal
14 Citations (Scopus)
Operating Rooms
Ambulatory Surgical Procedures
Observational Studies
District Hospitals
General Hospitals
24 Citations (Scopus)

A 5′ UTR-mediated Translational Efficiency Mechanism Inhibits the Candida albicans Morphological Transition

Childers, D. S., Mundodi, V., Banerjee, M. & Kadosh, D., May 2014, In : Molecular Microbiology. 92, 3, p. 570-585 16 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Candida albicans
Virulence
Biological Phenomena
Polyribosomes
20 Citations (Scopus)

A 60-66 kDa protein with gonadotrophin surge attenuating factor bioactivity is produced by human ovarian granulosa cells

Fowler, P. A. F., Sorsa-Leslie, T. K., Cash, P., Dunbar, B., Melvin, W. T., Wilson, Y., Mason, H. D. & Harris, W. J., 2002, In : Molecular Human Reproduction. 8, 9, p. 823-832 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
7 Downloads (Pure)

A 6-Point TACS Score Predicts In-Hospital Mortality Following Total Anterior Circulation Stroke

Wood, A. D., Gollop, N. D., Bettencourt-Silva, J. H., Clark, A. B., Metcalf, A. K., Bowles, K. M., Flather, M., Potter, J. F. & Myint, P. K., Oct 2016, In : Journal of Clinical Neurology. 12, 4, p. 407-413 7 p.

Research output: Contribution to journalArticle

Open Access
File
Hospital Mortality
Stroke
Odds Ratio
Mortality
Heart Failure
7 Citations (Scopus)
23 Downloads (Pure)

AAPT Diagnostic Criteria for Fibromyalgia

Arnold, L. M., Bennett, R. M., Crofford, L. J., Dean, L. E., Clauw, D. J., Goldenberg, D. L., Fitzcharles, M-A., Paiva, E. S., Staud, R., Sarzi-Puttini, P., Buskila, D. & Macfarlane, G. J., Jun 2019, In : Journal of Pain. 20, 6, p. 611-628 18 p.

Research output: Contribution to journalReview article

Open Access
File
Fibromyalgia
Pain
Somatoform Disorders
Clinical Trials
Chronic Pain