Life Sciences & Medicine

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Research Output 1970 2019

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2019
2 Citations (Scopus)

27 years of prenatal diagnosis for Huntington disease in the United Kingdom

Piña-Aguilar, R. E., Simpson, S. A., Alshatti, A., Clarke, A., Craufurd, D., Dorkins, H., Doye, K., Lahiri, N., Lashwood, A., Lynch, C., Miller, C., Morton, S., O’Driscoll, M., Quarrell, O. W., Rae, D., Strong, M., Tomlinson, C., Turnpenny, P., Miedzybrodzka, Z. & UK HD Predictive Testing Consortium, Jul 2019, In : Genetics in Medicine. 21, p. 1639–1643 5 p.

Research output: Contribution to journalArticle

Preimplantation Diagnosis
Huntington Disease
Prenatal Diagnosis
United Kingdom
Neurodegenerative Diseases

ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris: a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

Wasi, M., Khandelwal, N. K., Moorhouse, A. J., Nair, R., Vishwakarma, P., Ruiz, G. B., Ross, Z. K., Lorenz, A., Rudramurthy, S. M., Chakrabarti, A., Lynn, A. M., Mondal, A. K., Gow, N. A. R. & Prasad, R., Jul 2019, In : Frontiers in Microbiology. 10, 16 p., 1445.

Research output: Contribution to journalArticle

Open Access
File
ATP-Binding Cassette Transporters
Candida
Genome
Pharmaceutical Preparations
Genes

A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor

Khatib, T., Whiting, A., Chisholm, D. R., Redfern, C., Muller, B. & McCaffery, P., 10 Apr 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Open Access
Retinoic Acid Receptors
AMPA Receptors
Glutamate Receptors
Tretinoin
Ligands
5 Downloads (Pure)

A Bright Future for Fluorescence Imaging of Fungi in Living Hosts

Chapuis, A. F., Ballou, E. R. & MacCallum, D. M., 1 Jun 2019, In : Journal of Fungi. 5, 2, 9 p., 29.

Research output: Contribution to journalArticle

Open Access
File
Luminescent Proteins
Optical Imaging
Fungi
Fungal Proteins
Mycoses

A case-note review of continued pregnancies found to be at a high risk of Huntington’s disease: considerations for clinical practice

Wadrup, F., Holden, S., MacLeod, R., Miedzybrodzka, Z., Németh, A. H., Owens, S., Pasalodos, S., Quarrell, O., Clarke, A. J. & on behalf of the UK Huntington’s Disease Predictive Testing Consortium, 19 Mar 2019, In : European Journal of Human Genetics. 27, p. 1215-1224 10 p.

Research output: Contribution to journalArticle

Huntington Disease
Prenatal Diagnosis
Pregnancy
High-Risk Pregnancy
Prenatal Care
2 Citations (Scopus)

Accumulation of nitrate and dissolved organic nitrogen at depth in a red soil Critical Zone

Wu, H., Song, X., Zhao, X., Peng, X., Zhou, H., Hallett, P. D., Hodson, M. E. & Zhang, G. L., 1 Mar 2019, In : Geoderma. 337, p. 1175-1185 11 p.

Research output: Contribution to journalArticle

dissolved organic nitrogen
red soil
regolith
nitrates
nitrate

Accuracy of gonadosomatic index in maturity classification and estimation of maturity ogive

Flores, A., Wiff, R., Ganias, K. & Marshall, C. T., 28 Feb 2019, In : Fisheries Research. 210, p. 50-62 13 p.

Research output: Contribution to journalArticle

1 Downloads (Pure)
Open Access
File
Aftercare
Melanoma
Self-Examination
Neoplasms
Skin

A comparison of professional and private time preferences of General Practitioners

Irvine, A., Van der Pol, M. & Phimister, E., 1 Feb 2019, In : Social Science & Medicine. 222, p. 256-264 9 p.

Research output: Contribution to journalArticle

general practitioner
General Practitioners
Patient Preference
Health
Likelihood Functions

A conceptual framework for patient-directed knowledge tools to support patient-centred care: Results from an evidence-informed consensus meeting

Dreesens, D., Stiggelbout, A., Agoritsas, T., Elwyn, G., Flottorp, S., Grimshaw, J., Kremer, L., Santesso, N., Stacey, D., Treweek, S., Armstrong, M., Gagliardi, A., Hill, S., Légaré, F., Ryan, R., Vandvik, P. & van der Weijden, T., 4 May 2019, In : Patient Education and Counseling.

Research output: Contribution to journalArticle

Patient-Centered Care
Consensus
Self Care
Decision Making

Acoustic characterization of sensors used for marine environmental monitoring

Cotter, E., Murphy, P., Bassett, C., Williamson, B. & Polagye, B., 1 Jul 2019, In : Marine Pollution Bulletin. 144, p. 205-215 11 p.

Research output: Contribution to journalArticle

Mammals
environmental monitoring
marine mammal
marine mammals
acoustics

A critical review of the impacts of cover crops on nitrogen leaching, net greenhouse gas balance and crop productivity

Abdalla, M., Hastings, A., Cheng, K., Yue, Q., Chadwick, D., Espenberg, M., Truu, J., Rees, R. M. & Smith, P., 13 May 2019, In : Global Change Biology. 25, 8, p. 2530-2543 14 p.

Research output: Contribution to journalArticle

Open Access
File
cover crop
Greenhouse gases
Leaching
Crops
greenhouse gas
1 Citation (Scopus)

Activity energy expenditure is an independent predictor of energy intake in humans

Hopkins, M., Duarte, C., Beaulieu, K., Finlayson, G., Gibbons, C., Johnstone, A., Whybrow, S., Horgan, G. W., Blundell, J. E. & Stubbs, R. J., 1 Jul 2019, In : International Journal of Obesity. 43, 7, p. 1466–1474 9 p.

Research output: Contribution to journalArticle

Open Access
File
Energy Intake
Energy Metabolism
Basal Metabolism
Body Composition
Diet Records

Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia/reperfusion injury through depletion of glutathione

Skene, K., Walsh, S. K., Okafor, O., Godsman, N., Barrows, C., Meier, P., Gordon, M. J., Beattie, J. H. & Wainwright, C. L., 14 May 2019, In : British Journal of Nutrition. 121, 9, p. 961-973 13 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Glutathione
Zinc

Addressing medication errors in an adult oncology department in Saudi Arabia: A qualitative study

Alharbi, W., Cleland, J. & Morrison, Z., Jul 2019, In : Saudi Pharmaceutical Journal. 27, 5, p. 650-654 5 p.

Research output: Contribution to journalArticle

Open Access
File
Medication Errors
Saudi Arabia
Communication
Delivery of Health Care
Education
Dental Schools
Crowns
Tongue
Tooth
Students

Adiponectin: An indicator for metabolic syndrome

Yosaee, S., Khodadost, M., Esteghamati, A., Speakman, J. R., Djafarian, K., Bitarafan, V. & Shidfar, F., 2 Jun 2019, In : Iranian Journal of Public Health. 48, 6, p. 1106-1115 10 p.

Research output: Contribution to journalArticle

Open Access
File
Adiponectin
Leptin
Healthy Volunteers
Obesity
Fats

Advancing human health risk assessment

Lanzoni, A., Castoldi, A. F., Kass, G. E. N., Terron, A., De Seze, G., Bal-Price, A., Bois, F. Y., Delclos, K. B., Doerge, D. R., Fritsche, E., Halldorsson, T., Kolossa-Gehring, M., Hougaard Bennekou, S., Koning, F., Lampen, A., Leist, M., Mantus, E., Rousselle, C., Siegrist, M., Steinberg, P. & 7 othersTritscher, A., Van de Water, B., Vineis, P., Walker, N., Wallace, H., Whelan, M. & Younes, M., Jul 2019, In : EFSA Journal. 17, S1, 21 p., e170712.

Research output: Contribution to journalArticle

Open Access
File
risk assessment
human health
Health
risk assessors
risk managers
1 Citation (Scopus)
7 Downloads (Pure)

Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age

Ireland, A., Saunders, F. R., Muthuri, S. G., Pavlova, A., Hardy, R., Martin, K., Barr, R., Kuh, D., Aspden, R. M., Gregory, J. & Cooper, R., Mar 2019, In : Journal of Bone and Mineral Research. 34, 3, p. 455-463 9 p.

Research output: Contribution to journalArticle

Open Access
File
Age of Onset
Walking
Hip
Walkers
Femur Neck

Age-length relationships in UK harbour seals during a period of population decline

Hall, A. J., Mackey, B., Kershaw, J. L. & Thompson, P., 24 Feb 2019, (Accepted/In press) In : Aquatic Conservation: Marine and Freshwater Ecosystems.

Research output: Contribution to journalArticle

Phoca vitulina
population decline
harbor
coast
Scotland
5 Downloads (Pure)

A global, empirical, harmonised dataset of soil organic carbon changes under perennial crops

Ledo, A., Hillier, J., Smith, P., Aguilera, E., Blagodatskiy, S., Brearley, F. Q., Datta, A., Diaz-Pines, E., Don, A., Dondini, M., Dunn, J., Feliciano, D., Lang, R., Liebig, M. A., Llorente, M., Zinn, Y. L., McNamara, N., Ogle, S. M., Qin, Z., Rovira, P. & 5 othersRowe, R., Vicente-Vicente, J. L., Whitaker, J., Yue, Q. & Zerihun, A., 13 May 2019, In : Scientific Data. 6, 57.

Research output: Contribution to journalArticle

Open Access
File
Organic carbon
Crops
Soil
Carbon
bioenergy
4 Downloads (Pure)

A high-fat diet induces rapid changes in the mouse hypothalamic proteome

McLean, F. H., Campbell, F. M., Langston, R. F., Sergi, D., Resch, C., Grant, C., Morris, A., Mayer, C-D. & Williams, L. M., 29 Apr 2019, In : Nutrition and Metabolism. 16, 26.

Research output: Contribution to journalArticle

Open Access
File
High Fat Diet
Proteome
Palmitic Acid
Oleic Acid
Neuronal Plasticity
4 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Muller, B. & Connolly, B., 5 Apr 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spliced Leader RNA
Trans-Splicing
Gene Targeting
Anthelmintics
Gene Expression

A literature review of the predictive validity of European dental school selection methods

Cunningham, C., Patterson, F. & Cleland, J., May 2019, In : European Journal of Dental Education. 23, 2, p. 73-87 15 p.

Research output: Contribution to journalArticle

Dental Schools
Aptitude
school
Dentistry
Research
2 Citations (Scopus)

Allometry of fine roots in forest ecosystems

Chen, G., Hobbie, S. E., Reich, P. B., Yang, Y. & Robinson, D., Feb 2019, In : Ecology Letters. 22, 2, p. 322-331 10 p.

Research output: Contribution to journalArticle

allometry
fine root
forest ecosystems
forest ecosystem
biomass
3 Citations (Scopus)
7 Downloads (Pure)

Alternative (backdoor) androgen production and masculinization in the human fetus

O'Shaughnessy, P. J., Antignac, J-P., Le Bizec, B., Morvan, M-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., Bellingham, M., Hough, D., Walker, N., Filis, P. & Fowler, P., 14 Feb 2019, In : PLoS Biology. 17, 2, e3000002.

Research output: Contribution to journalArticle

Open Access
File
androsterone
Androsterone
masculinization
androgens
Androgens

AMEE guide no. 123 - How to read studies of educational costs

Maloney, S., Cook, D. A., Golub, R., Foo, J., Cleland, J., Rivers, G., Tolsgaard, M. G., Evans, D., Abdalla, M. E. & Walsh, K., 2019, In : Medical Teacher. 41, 5, p. 497-504 8 p.

Research output: Contribution to journalArticle

decision making
costs
opportunity costs
economics
decision maker

A model for spatio-temporal injury surveillance: implications for the evolution of a trauma system

Jansen, J. O., Emerson, P., Morrison, J. J. & Cornulier, T., Feb 2019, In : The journal of trauma and acute care surgery. 86, 2, p. 289-298 10 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Scotland
Hebrides
Health Policy
Islands

An advantage for horizontal motion direction discrimination

Pilz, K. S. & Papadaki, D., May 2019, In : Vision Research. 158, p. 164-172 9 p.

Research output: Contribution to journalArticle

Direction compound
Individuality

An Anatomical Evaluation of a conventional Pectoralis II and a Sub-serratus Block for Breast Surgery

Robinson, H., Mishra, S., Davies, L., Craigen, F., Shahana, S. & Parson, S. H., 2019, (Submitted) In : Anesthesia and Analgesia.

Research output: Contribution to journalArticle

1 Citation (Scopus)
5 Downloads (Pure)
Open Access
File
Antigen Receptors
Transgenic Mice
Autoimmune Diseases
Arthritis
Tumor Necrosis Factor-alpha
6 Downloads (Pure)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O. K. L., Zhang, Q., McRae, A. F., Walker, R. M., Morris, S. W., Redmond, P., Campbell, A., Murray, A. D., Porteous, D. J., Evans, K. L., McIntosh, A. M., Deary, I. J. & Marioni, R. E., 6 Mar 2019, In : International Journal of Obesity.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Body Mass Index
Parturition
Health

A New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Hwang, D-J., He, Y., Ponnusamy, S., Mohler, M. L., Thiyagarajan, T., McEwan, I. J., Narayanan, R. & Miller, D. D., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 491-511 20 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Androgen Receptor Antagonists
Castration
Cyclization

An ex-vivo human skin model to study superficial fungal infections

Corzo-Leon, D. E., Munro, C. A. & MacCallum, D. M., 5 Jun 2019, In : Frontiers in Microbiology. 10, 17 p., 1172.

Research output: Contribution to journalArticle

Open Access
File
Mycoses
Skin
Infection
Microscopy
Animal Models
1 Downloads (Pure)

An integrated approach to processing WHO-2016 verbal autopsy data: the InterVA-5 model

Byass, P., Hussain-Alkhateeb, L., D'Ambruoso, L., Clark, S., Davies, J., Fottrell, E., Bird, J., Kabudula, C., Tollman, S., Kahn, K., Schiöler, L. & Petzold, M., 30 May 2019, In : BMC medicine . 17, 12 p., 102.

Research output: Contribution to journalArticle

Open Access
File
Autopsy
Mortality
Afghanistan
Cause of Death
Interviews
2 Citations (Scopus)

Annual ring growth of a widespread high arctic shrub reflects past fluctuations in community-level plant biomass

Le Moullec, M., Buchwal, A., Wal, R., Sandal, L. & Hansen, B. B., Jan 2019, In : Journal of Ecology. 107, 1, p. 436-451 16 p.

Research output: Contribution to journalArticle

growth rings
Arctic region
shrub
shrubs
aboveground biomass
5 Downloads (Pure)

Anti-cholinergic burden and patient related clinical outcomes in an emergency general surgical setting

Ablett, A. D., Browning, A., Quan, V., Tay, H. S., McCormack, C., Carter, B., Hewitt, J., Myint, P. K. & Older Persons Surgical Outcomes Collaboration (OPSOC), Apr 2019, In : Asian Journal of Surgery. 42, 4, p. 527-534 8 p.

Research output: Contribution to journalArticle

Open Access
File
Cholinergic Antagonists
Emergencies
Patients' Rooms
Odds Ratio
Length of Stay

Antioxidant capacity is repeatable across years but does not consistently correlate with a marker of peroxidation in a free-living passerine bird

Récapet, C., Arrive, M., Doligez, B. & Bize, P., Apr 2019, In : Journal of Comparative Physiology B. 189, 2, p. 283-298 16 p.

Research output: Contribution to journalArticle

peroxidation
Birds
passerine
repeatability
antioxidant

An update on Staphylococcus aureus infective endocarditis from the International Society of Antimicrobial Chemotherapy (ISAC)

Saeed, K., Bal, A., Gould, I., David, M. Z., Dryden, M., Giannitsioti, E., Hijazi, K., Meisner, J. A., Esposito, S., Scaglione, F., Tattevin, P. & Voss, A., Jan 2019, In : International Journal of Antimicrobial Agents. 53, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

Endocarditis
Staphylococcus aureus
Drug Therapy
Tricuspid Valve
Coagulase
4 Downloads (Pure)

Aortic stiffness in aortic stenosis assessed by cardiovascular MRI: a comparison between bicuspid and tricuspid valves

Singh, A., Horsfield, M. A., Bekele, S., Greenwood, J. P., Dawson, D. K., Berry, C., Hogrefe, K., Kelly, D. J., Houston, J. G., Guntur Ramkumar, P., Uddin, A., Suzuki, T. & McCann, G. P., May 2019, In : European Radiology. 29, 5, p. 2340-2349 10 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Stiffness
Tricuspid Valve
Aortic Valve Stenosis
Mitral Valve
Pulse Wave Analysis

AP-2-dependent endocytic recycling of the chitin synthase Chs3 regulates polarized growth in Candida albicans

Knafler, H. C., Smaczynska-de Rooij, I. I., Walker, L. A., Lee, K. K., Gow, N. A. R. & Ayscougha, K. R., 19 Mar 2019, In : mBio. 10, 2, e02421-18.

Research output: Contribution to journalArticle

Open Access
Chitin Synthase
Candida albicans
Cell Wall
Growth
Hyphae

A pilot study to improve sugar and water consumption in Maltese school children

Copperstone, C., McNeill, G., Aucott, L. & Jackson, D. M., 15 Feb 2019, In : International Journal of Adolescent Medicine and Health.

Research output: Contribution to journalArticle

Drinking
Pediatric Obesity
Energy Intake
Health Promotion
Drinking Water
Opiate Substitution Treatment
Hepatitis C
Primary Health Care
Motivation
Patient Acceptance of Health Care

A qualitative study exploring the key determinants of information gathering to inform the management of over‐the‐counter (OTC) consultations in community pharmacies

Cassie, H., Duncan, E., Gibb, E., Power, A., Young, L., Newlands, R. & Watson, M. C. M., 16 Jul 2019, (Accepted/In press) In : BMJ Open.

Research output: Contribution to journalArticle

Pharmacies
Pharmacists
Referral and Consultation
Medicine
Professional Role
1 Citation (Scopus)
5 Downloads (Pure)

A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Warren, A. Y., Massie, C. E., Watt, K., Luko, K., Orafidiya, F., Selth, L. A., Mohammed, H., Chohan, B. S., Menon, S., Baridi, A., Zhao, W., Escriu, C., D'Santos, C., Taylor, C., Qureshi, A., Zecchini, V. R., Shaw, G. L., Dehm, S. M., Mills, I. G., Carroll, J. S. & 5 othersTilley, W. D., McEwan, I. J., Baniahmad, A., Neal, D. E. & Asim, M., 2019, In : Oncogene. 38, 7, p. 1136-1150 15 p.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Prostatic Neoplasms
PDZ-binding kinase
Systems Biology
Proteome
5 Downloads (Pure)

A retino-retinal projection guided by Unc5c emerged in species with retinal waves

Murcia-Belmonte, V., Coca, Y., Vegar, C., Negueruela, S., de Juan, C., Valiño, A. J., Sala, S., DaSilva, R., Kania, A., Borrell, V., Martinez, L. M., Erskine, L. & Herrera, E., Apr 2019, In : Current Biology. 29, 7, p. 1149-1160 12 p.

Research output: Contribution to journalArticle

Open Access
File
axons
Axons
retina
Retina
Retinal Ganglion Cells
4 Downloads (Pure)
Open Access
File
diversification
Crops
Sustainable development
poverty
sustainable development
Open Access
File
Dietetics
Prostatic Neoplasms
Randomized Controlled Trials
Exercise
Diet

A simple approach to modelling the soil water budget in Scottish mineral soils

Brand, A. M., Lilly, A. & Smith, J. U., 2019, (In preparation) In : Environmental Modelling and Software.

Research output: Contribution to journalArticle