Life Sciences & Medicine

  • AB25 2ZD

Research Output 1970 2020

Filter
Article
2019
3 Citations (Scopus)

27 years of prenatal diagnosis for Huntington disease in the United Kingdom

Piña-Aguilar, R. E., Simpson, S. A., Alshatti, A., Clarke, A., Craufurd, D., Dorkins, H., Doye, K., Lahiri, N., Lashwood, A., Lynch, C., Miller, C., Morton, S., O’Driscoll, M., Quarrell, O. W., Rae, D., Strong, M., Tomlinson, C., Turnpenny, P., Miedzybrodzka, Z. & UK HD Predictive Testing Consortium, Jul 2019, In : Genetics in Medicine. 21, p. 1639–1643 5 p.

Research output: Contribution to journalArticle

Preimplantation Diagnosis
Huntington Disease
Prenatal Diagnosis
United Kingdom
Neurodegenerative Diseases

ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris: a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

Wasi, M., Khandelwal, N. K., Moorhouse, A. J., Nair, R., Vishwakarma, P., Ruiz, G. B., Ross, Z. K., Lorenz, A., Rudramurthy, S. M., Chakrabarti, A., Lynn, A. M., Mondal, A. K., Gow, N. A. R. & Prasad, R., 16 Jul 2019, In : Frontiers in Microbiology. 10, 16 p., 1445.

Research output: Contribution to journalArticle

Open Access
File
ATP-Binding Cassette Transporters
Candida
Genome
Pharmaceutical Preparations
Genes
1 Downloads (Pure)

A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor

Khatib, T., Whiting, A., Chisholm, D. R., Redfern, C., Muller, B. & McCaffery, P., Oct 2019, In : Molecular Neurobiology. 56, 10, p. 7074-7084 11 p.

Research output: Contribution to journalArticle

Open Access
File
Retinoic Acid Receptors
AMPA Receptors
Glutamate Receptors
Tretinoin
Ligands
1 Citation (Scopus)

Abnormal fatty acid metabolism is a core component of spinal muscular atrophy

Deguise, MO., Baranello, G., Mastella, C., Beauvais, A., Michaud, J., Leone, A., De Amicis, R., Battezzati, A., Dunham, C., Selby, K., Chardon, J. W., McMillan, H. J., Huang, YT., Courtney, N. L., Mole, A. J., Kubinski, S., Claus, P., Murray, L. M., Bowerman, M., Gillingwater, T. H. & 3 others, Bertoli, S., Parson, S. H. & Kothary, R., Aug 2019, In : Annals of Clinical and Translational Neurology. 6, 8, p. 1519-1532 14 p.

Research output: Contribution to journalArticle

Open Access
File
Spinal Muscular Atrophy
Fatty Acids
Dyslipidemias
Motor Neuron Disease
Muscular Atrophy
5 Downloads (Pure)

A Bright Future for Fluorescence Imaging of Fungi in Living Hosts

Chapuis, A. F., Ballou, E. R. & MacCallum, D. M., 1 Jun 2019, In : Journal of Fungi. 5, 2, 9 p., 29.

Research output: Contribution to journalArticle

Open Access
File
Luminescent Proteins
Optical Imaging
Fungi
Fungal Proteins
Mycoses

A case-note review of continued pregnancies found to be at a high risk of Huntington’s disease: considerations for clinical practice

Wadrup, F., Holden, S., MacLeod, R., Miedzybrodzka, Z., Németh, A. H., Owens, S., Pasalodos, S., Quarrell, O., Clarke, A. J. & on behalf of the UK Huntington’s Disease Predictive Testing Consortium, 19 Mar 2019, In : European Journal of Human Genetics. 27, p. 1215-1224 10 p.

Research output: Contribution to journalArticle

Huntington Disease
Prenatal Diagnosis
Pregnancy
High-Risk Pregnancy
Prenatal Care
4 Citations (Scopus)

Accumulation of nitrate and dissolved organic nitrogen at depth in a red soil Critical Zone

Wu, H., Song, X., Zhao, X., Peng, X., Zhou, H., Hallett, P. D., Hodson, M. E. & Zhang, G. L., 1 Mar 2019, In : Geoderma. 337, p. 1175-1185 11 p.

Research output: Contribution to journalArticle

dissolved organic nitrogen
red soil
regolith
nitrates
nitrate
1 Citation (Scopus)

Accuracy of gonadosomatic index in maturity classification and estimation of maturity ogive

Flores, A., Wiff, R., Ganias, K. & Marshall, C. T., 28 Feb 2019, In : Fisheries Research. 210, p. 50-62 13 p.

Research output: Contribution to journalArticle

Accuracy of the short-form Montreal Cognitive Assessment: Systematic review and validation

McDicken, J. A., Elliott, E., Blayney, G., Makin, S., Ali, M., Larner, A. J., Quinn, T. J. & Collaborators, VISTA-C., Oct 2019, In : The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 34, 10, p. 1515-1525 11 p.

Research output: Contribution to journalArticle

Stroke
Dementia
Sensitivity and Specificity
Research Personnel
Databases
2 Downloads (Pure)
Open Access
File
Aftercare
Melanoma
Self-Examination
Neoplasms
Skin
1 Citation (Scopus)

A comparison of professional and private time preferences of General Practitioners

Irvine, A., Van der Pol, M. & Phimister, E., 1 Feb 2019, In : Social Science & Medicine. 222, p. 256-264 9 p.

Research output: Contribution to journalArticle

general practitioner
General Practitioners
Patient Preference
Health
Likelihood Functions

A conceptual framework for patient-directed knowledge tools to support patient-centred care: Results from an evidence-informed consensus meeting

Dreesens, D., Stiggelbout, A., Agoritsas, T., Elwyn, G., Flottorp, S., Grimshaw, J., Kremer, L., Santesso, N., Stacey, D., Treweek, S., Armstrong, M., Gagliardi, A., Hill, S., Légaré, F., Ryan, R., Vandvik, P. & van der Weijden, T., Oct 2019, In : Patient Education and Counseling. 102, 10, p. 1898-1904 7 p.

Research output: Contribution to journalArticle

Patient-Centered Care
Consensus
Self Care
Decision Making
1 Downloads (Pure)

A concise guide to developing and using quantitative models in conservation management

García-Díaz, P., Prowse, T. A. A., Anderson, D. P., Lurgi, M., Binny, R. N. & Cassey, P., 2019, In : Conservation Science and Practice. 1, 2, e11.

Research output: Contribution to journalArticle

Open Access
File
conservation management
modeling
decision making
recommendation

Acoustic characterization of sensors used for marine environmental monitoring

Cotter, E., Murphy, P., Bassett, C., Williamson, B. & Polagye, B., 1 Jul 2019, In : Marine Pollution Bulletin. 144, p. 205-215 11 p.

Research output: Contribution to journalArticle

Mammals
environmental monitoring
marine mammal
marine mammals
acoustics
3 Citations (Scopus)

A critical review of the impacts of cover crops on nitrogen leaching, net greenhouse gas balance and crop productivity

Abdalla, M., Hastings, A., Cheng, K., Yue, Q., Chadwick, D., Espenberg, M., Truu, J., Rees, R. M. & Smith, P., 1 Aug 2019, In : Global Change Biology. 25, 8, p. 2530-2543 14 p.

Research output: Contribution to journalArticle

Open Access
File
cover crop
Greenhouse gases
Leaching
Crops
greenhouse gas
1 Citation (Scopus)

Activation of dendritic cells by crosslinked collagen hydrogels (artificial corneas) varies with their composition

Moelzer, C., Shankar, S. P., Griffith, M., Islam, M. M., Forrester, J. & Kuffova, L., Sep 2019, In : Journal of Tissue Engineering and Regenerative Medicine. 13, 9, p. 1528-1543 16 p.

Research output: Contribution to journalArticle

Hydrogels
Cornea
Dendritic Cells
Collagen
Gels
2 Citations (Scopus)

Activity energy expenditure is an independent predictor of energy intake in humans

Hopkins, M., Duarte, C., Beaulieu, K., Finlayson, G., Gibbons, C., Johnstone, A., Whybrow, S., Horgan, G. W., Blundell, J. E. & Stubbs, R. J., 1 Jul 2019, In : International Journal of Obesity. 43, 7, p. 1466–1474 9 p.

Research output: Contribution to journalArticle

Open Access
File
Energy Intake
Energy Metabolism
Basal Metabolism
Body Composition
Diet Records

Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia/reperfusion injury through depletion of glutathione

Skene, K., Walsh, S. K., Okafor, O., Godsman, N., Barrows, C., Meier, P., Gordon, M. J., Beattie, J. H. & Wainwright, C. L., 14 May 2019, In : British Journal of Nutrition. 121, 9, p. 961-973 13 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Glutathione
Zinc

Addressing medication errors in an adult oncology department in Saudi Arabia: A qualitative study

Alharbi, W., Cleland, J. & Morrison, Z., Jul 2019, In : Saudi Pharmaceutical Journal. 27, 5, p. 650-654 5 p.

Research output: Contribution to journalArticle

Open Access
File
Medication Errors
Saudi Arabia
Communication
Delivery of Health Care
Education
1 Citation (Scopus)
Dental Schools
Crowns
Tongue
Tooth
Students
1 Citation (Scopus)
2 Downloads (Pure)

Adiponectin: An indicator for metabolic syndrome

Yosaee, S., Khodadost, M., Esteghamati, A., Speakman, J. R., Djafarian, K., Bitarafan, V. & Shidfar, F., 2 Jun 2019, In : Iranian Journal of Public Health. 48, 6, p. 1106-1115 10 p.

Research output: Contribution to journalArticle

Open Access
File
Adiponectin
Leptin
Healthy Volunteers
Obesity
Fats
4 Citations (Scopus)

Advancing human health risk assessment

Lanzoni, A., Castoldi, A. F., Kass, G. E. N., Terron, A., De Seze, G., Bal-Price, A., Bois, F. Y., Delclos, K. B., Doerge, D. R., Fritsche, E., Halldorsson, T., Kolossa-Gehring, M., Hougaard Bennekou, S., Koning, F., Lampen, A., Leist, M., Mantus, E., Rousselle, C., Siegrist, M., Steinberg, P. & 7 others, Tritscher, A., Van de Water, B., Vineis, P., Walker, N., Wallace, H., Whelan, M. & Younes, M., Jul 2019, In : EFSA Journal. 17, S1, 21 p., e170712.

Research output: Contribution to journalArticle

Open Access
File
risk assessment
human health
Health
risk assessors
risk managers
1 Citation (Scopus)
7 Downloads (Pure)

Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age

Ireland, A., Saunders, F. R., Muthuri, S. G., Pavlova, A., Hardy, R., Martin, K., Barr, R., Kuh, D., Aspden, R. M., Gregory, J. & Cooper, R., Mar 2019, In : Journal of Bone and Mineral Research. 34, 3, p. 455-463 9 p.

Research output: Contribution to journalArticle

Open Access
File
Age of Onset
Walking
Hip
Walkers
Femur Neck

Age-length relationships in UK harbour seals during a period of population decline

Hall, A. J., Mackey, B., Kershaw, J. L. & Thompson, P., Sep 2019, In : Aquatic Conservation: Marine and Freshwater Ecosystems. 29, S1, p. 61-70 10 p.

Research output: Contribution to journalArticle

Open Access
Phoca vitulina
population decline
harbor
coast
Scotland

Age-related differences in the ability to decode intentions from non-literal language

Pomareda, C., Simkute, A. & Phillips, L. H., Jul 2019, In : Acta Psychologica. 198, 9 p., 102865.

Research output: Contribution to journalArticle

Aptitude
Language
Young Adult
Interpersonal Relations
Nonliteral Language
6 Downloads (Pure)

A global, empirical, harmonised dataset of soil organic carbon changes under perennial crops

Ledo, A., Hillier, J., Smith, P., Aguilera, E., Blagodatskiy, S., Brearley, F. Q., Datta, A., Diaz-Pines, E., Don, A., Dondini, M., Dunn, J., Feliciano, D., Lang, R., Liebig, M. A., Llorente, M., Zinn, Y. L., McNamara, N., Ogle, S. M., Qin, Z., Rovira, P. & 5 others, Rowe, R., Vicente-Vicente, J. L., Whitaker, J., Yue, Q. & Zerihun, A., 13 May 2019, In : Scientific Data. 6, 57.

Research output: Contribution to journalArticle

Open Access
File
Organic carbon
Crops
Soil
Carbon
bioenergy
1 Citation (Scopus)
5 Downloads (Pure)

A high-fat diet induces rapid changes in the mouse hypothalamic proteome

McLean, F. H., Campbell, F. M., Langston, R. F., Sergi, D., Resch, C., Grant, C., Morris, A., Mayer, C-D. & Williams, L. M., 29 Apr 2019, In : Nutrition and Metabolism. 16, 26.

Research output: Contribution to journalArticle

Open Access
File
High Fat Diet
Proteome
Palmitic Acid
Oleic Acid
Neuronal Plasticity
4 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Muller, B. & Connolly, B., Aug 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spliced Leader RNA
Trans-Splicing
Gene Targeting
Anthelmintics
Gene Expression

A literature review of the predictive validity of European dental school selection methods

Cunningham, C., Patterson, F. & Cleland, J., May 2019, In : European Journal of Dental Education. 23, 2, p. 73-87 15 p.

Research output: Contribution to journalArticle

Dental Schools
Aptitude
school
Dentistry
Research
3 Citations (Scopus)

Allometry of fine roots in forest ecosystems

Chen, G., Hobbie, S. E., Reich, P. B., Yang, Y. & Robinson, D., Feb 2019, In : Ecology Letters. 22, 2, p. 322-331 10 p.

Research output: Contribution to journalArticle

allometry
fine root
forest ecosystems
forest ecosystem
biomass
7 Citations (Scopus)
10 Downloads (Pure)

Alternative (backdoor) androgen production and masculinization in the human fetus

O'Shaughnessy, P. J., Antignac, J-P., Le Bizec, B., Morvan, M-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., Bellingham, M., Hough, D., Walker, N., Filis, P. & Fowler, P., 14 Feb 2019, In : PLoS Biology. 17, 2, e3000002.

Research output: Contribution to journalArticle

Open Access
File
androsterone
Androsterone
masculinization
androgens
Androgens
2 Citations (Scopus)

AMEE guide no. 123 - How to read studies of educational costs

Maloney, S., Cook, D. A., Golub, R., Foo, J., Cleland, J., Rivers, G., Tolsgaard, M. G., Evans, D., Abdalla, M. E. & Walsh, K., 2019, In : Medical Teacher. 41, 5, p. 497-504 8 p.

Research output: Contribution to journalArticle

decision making
costs
opportunity costs
economics
decision maker

A meta-analysis of genome-wide association studies of epigenetic age acceleration

McCartney, D. L., Zhang, F., Hillary, R. F., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Boutin, T. S., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Hayward, C., Evans, K. L., Chandra, T., Deary, I. J., McIntosh, A. M., Yang, J., Visscher, P. M. & 2 others, McRae, A. F. & Marioni, R. E., 6 Nov 2019, (Accepted/In press) In : PLoS Genetics.

Research output: Contribution to journalArticle

A method development randomised clinical study investigating efficacy of an experimental oral rinse in providing long-term relief from dentinal hypersensitivity

Milleman, K. R., Milleman, J. L., Young, S., Butler, A., Araga, M. & Atassi, M., Nov 2019, In : Journal of Dentistry: X. 2, 7 p., 100008.

Research output: Contribution to journalArticle

Open Access
File

A model for spatio-temporal injury surveillance: implications for the evolution of a trauma system

Jansen, J. O., Emerson, P., Morrison, J. J. & Cornulier, T., Feb 2019, In : The journal of trauma and acute care surgery. 86, 2, p. 289-298 10 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Scotland
Hebrides
Health Policy
Islands

Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

Martínez, K. A., Lauritano, C., Druka, D., Romano, G., Grohmann, T., Jaspars, M., Martín, J., Díaz, C., Cautain, B., de la Cruz, M., Ianora, A. & Reyes, F., 27 Jun 2019, In : Marine Drugs. 17, 7, 385.

Research output: Contribution to journalArticle

Open Access
File
Dinoflagellida
Cell Line
Aspergillus fumigatus
Biodiversity
Klebsiella pneumoniae

An actionable KCNH2 Long QT Syndrome variant detected by sequence and haplotype analysis in a population research cohort

Kerr, S. M., Klaric, L., Halachev, M., Hayward, C., Boutin, T. S., Meynert, A. M., Semple, C. A., Tuiskula, A. M., Swan, H., Santoyo-Lopez, J., Vitart, V., Haley, C., Dean, J., Miedzybrodzka, Z., Aitman, T. J. & Wilson, J. F., 29 Jul 2019, In : Scientific Reports. 9, 11 p., 10964.

Research output: Contribution to journalArticle

Open Access
File
Long QT Syndrome
Haplotypes
Sequence Analysis
Research
Population

An advantage for horizontal motion direction discrimination

Pilz, K. S. & Papadaki, D., May 2019, In : Vision Research. 158, p. 164-172 9 p.

Research output: Contribution to journalArticle

Direction compound
Individuality
2 Citations (Scopus)

Anaesthesia care team improves outcomes in surgical patients compared with solo anaesthesiologist: An observational study

Dony, P., Seidel, L., Pirson, M. & Forget, P., Jan 2019, In : European journal of anaesthesiology. 36, 1, p. 64-69 6 p.

Research output: Contribution to journalArticle

Observational Studies
Anesthesia
Length of Stay
Nurses
Mortality

An Anatomical Evaluation of a conventional Pectoralis II and a Sub-serratus Block for Breast Surgery

Robinson, H., Mishra, S., Davies, L., Craigen, F., Shahana, S. & Parson, S. H., 2019, (Submitted) In : Anesthesia and Analgesia.

Research output: Contribution to journalArticle

2 Citations (Scopus)
5 Downloads (Pure)
Open Access
File
Antigen Receptors
Transgenic Mice
Autoimmune Diseases
Arthritis
Tumor Necrosis Factor-alpha
6 Downloads (Pure)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O. K. L., Zhang, Q., McRae, A. F., Walker, R. M., Morris, S. W., Redmond, P., Campbell, A., Murray, A. D., Porteous, D. J., Evans, K. L., McIntosh, A. M., Deary, I. J. & Marioni, R. E., 6 Mar 2019, In : International Journal of Obesity. 43, p. 1795-1802 8 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Body Mass Index
Parturition
Health

A New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Hwang, D-J., He, Y., Ponnusamy, S., Mohler, M. L., Thiyagarajan, T., McEwan, I. J., Narayanan, R. & Miller, D. D., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 491-511 20 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Androgen Receptor Antagonists
Castration
Cyclization

An ex-vivo human skin model to study superficial fungal infections

Corzo-Leon, D. E., Munro, C. A. & MacCallum, D. M., 5 Jun 2019, In : Frontiers in Microbiology. 10, 17 p., 1172.

Research output: Contribution to journalArticle

Open Access
File
Mycoses
Skin
Infection
Microscopy
Animal Models
1 Citation (Scopus)
Streptomyces griseus
Lactalbumin
Pronase
lactalbumin
enzymatic treatment

An insight into piscidins: The discovery, modulation and bioactivity of greater amberjack, Seriola dumerili, piscidin

Milne, D. J., Fernández-Montero, Á., Gundappa, M. K., Wang, T., Acosta, F., Torrecillas, S., Montero, D., Zou, J., Sweetman, J. & Secombes, C. J., Oct 2019, In : Molecular Immunology. 114, p. 378-388 11 p.

Research output: Contribution to journalArticle

Head Kidney
Flagellin
Poly I-C
Diet
Spleen
2 Citations (Scopus)
1 Downloads (Pure)

An integrated approach to processing WHO-2016 verbal autopsy data: the InterVA-5 model

Byass, P., Hussain-Alkhateeb, L., D'Ambruoso, L., Clark, S., Davies, J., Fottrell, E., Bird, J., Kabudula, C., Tollman, S., Kahn, K., Schiöler, L. & Petzold, M., 30 May 2019, In : BMC medicine . 17, 12 p., 102.

Research output: Contribution to journalArticle

Open Access
File
Autopsy
Mortality
Afghanistan
Cause of Death
Interviews
1 Citation (Scopus)

An international study of the quality of life of adult patients treated with home parenteral nutrition

Baxter, J. P., Fayers, P. M., Bozzetti, F., Kelly, D., Joly, F., Wanten, G., Jonkers, C., Cuerda, C., Van Gossum, A., Klek, S., Boudreault, M-F., Gilbert, A., Jobin, M., Staun, M., Gillanders, L., Forbes, A., O'Callaghan, M., Martinez Faedo, C., Brunelli, C., Mariani, L. & 1 others, Pironi, L., Aug 2019, In : Clinical Nutrition. 38, 4, p. 1788-1796 9 p.

Research output: Contribution to journalArticle

Open Access
File
Home Parenteral Nutrition
Quality of Life
Linear Models
Psychometrics
Crohn Disease
4 Citations (Scopus)

Annual ring growth of a widespread high arctic shrub reflects past fluctuations in community-level plant biomass

Le Moullec, M., Buchwal, A., Wal, R., Sandal, L. & Hansen, B. B., Jan 2019, In : Journal of Ecology. 107, 1, p. 436-451 16 p.

Research output: Contribution to journalArticle

Open Access
File
growth rings
Arctic region
shrub
shrubs
aboveground biomass