Life Sciences & Medicine

Research Output

Research Output per year

1970 2021

• 1865539 Citations
• 25440 Article
• 1303 Abstract
• 1038 Chapter
• 669 Editorial
• 3806 More
  • 632 Literature review
  • 583 Letter
  • 483 Review article
  • 374 Poster
  • 372 Conference contribution
  • 280 Comment/debate
  • 193 Paper
  • 185 Commissioned Report
  • 160 Book
  • 76 Other
  • 75 Other contribution
  • 74 Other Report
  • 70 Patent
  • 59 Book/Film/Article review
  • 42 Chapter (peer-reviewed)
  • 29 Working paper
  • 29 Special issue
  • 16 Short survey
  • 16 Discussion paper
  • 13 Entry for encyclopedia/dictionary
  • 13 Conference article
  • 11 Featured article
  • 6 Website, Blog, Social Media
  • 4 Foreword/postscript
  • 3 Database
  • 3 Software
  • 2 Anthology
  • 2 Digital or Visual Products
  • 1 Book, Article, Film Review

Research Output per year

Research Output per year

Search results

• 2019

  Synthetic Retinoids for Use in RAR Mediated Conditions

  Whiting, A., Chisholm, D., Valentine, R., Greig, I. R., McCaffery, P. J. A. & Alkhatib, T., 18 Apr 2019, IPC No. C07C 63/66, A61K 31/192, A61K 31/203, A61P 25/28, C07D 209/82, C07D 215/06, European Patent Office, Patent No. WO2017174999, Priority date 6 Apr 2017, Priority No. 2017050977

  Research output: Patent

  • Retinoids
• 2017

  Synthetic retinoids for use in RAR mediated conditions

  Greig, I. R., McCaffery, P. J. A., Whiting, A., Valentine, R., Chisholm, D. & Khatib, T., 12 Oct 2017, Patent No. WO2017174999

  Research output: Patent

  • Retinoids
• 2016

  PATENT: Antibody molecules and uses thereof.

  Gow, N. A. R., Rudkin, F. M., Erwig, L-P. & Jensen, A., 15 Sep 2016, IPC No. C07K 16/14 , G01N 33/53, World Intellectual Property Organization, Patent No. WO 2016/142660 Al, 4 Mar 2016, Priority date 6 Mar 2015, Priority No. GB 1503812.8

  Research output: Patent

  • Antibodies
  • Candida
  • Fungal Antigens
  • Gene Targeting
  • Cell Extracts

• Enhanced RNAI Mediated Gene Regulation

  Bowman, A. S., Campbell, E. M. & Lewendon, A., 14 Jul 2016, IPC No. A61K31/7088; C12N15/113, Patent No. WO2016110691 (A1) , Priority date 6 Jan 2015, Priority No. GB20150000107 20150106

  Research output: Patent

  Open Access

  File

  • Nucleic Acids
  • Host-Parasite Interactions
  • Disclosure
  • Parasites
  • Genes
  14 Downloads (Pure)

• N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

  Smith, S., Patel, L. & Greig, I. R., 23 Jun 2016, Patent No. WO2016/097001, Priority date 17 Dec 2014

  Research output: Patent
• 2015

  Phenothiazine compounds for treating mild cognitive impairment

  Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D. & Staff, R. T., 15 Dec 2015, Patent No. US9211294, 17 Jun 2008, Priority date 19 Jun 2007, Priority No. 60/945006

  Research output: Patent

  • phenothiazine
  • Patents and inventions

• Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides

  D'Agostino, G., 13 Jun 2015, Patent No. CA2836069 A1, Priority date 13 Dec 2012

  Research output: Patent
• 2014

  Fish Vaccine

  Wawra, S., Van West, P. & Secombes, C. J., 4 Dec 2014, IPC No. A61K38/16; C07K14/37; C12N15/62, Patent No. WO2014191759, Priority date 30 May 2013, Priority No. GB20130009664 20130530

  Research output: Patent

  • Fishes
  • Vaccines
  • Eukaryotic Cells
  • Nucleic Acids
  • Cell Membrane
  1 Downloads (Pure)

• Fluoro-perhexiline compounds and their therapeutic use

  Greig, I. R., Tseng, C-C. & Zanda, M., 30 Oct 2014, Patent No. WO2014184561

  Research output: Patent

• ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL

  Barelle, C., Finlay, J. J. W. & Darmanin-Sheehan, A., 30 Oct 2014, IPC No. C07K16/00; C07K16/18; C12N15/13, Priority date 23 Apr 2013, Priority No. US201361815043P 20130423

  Research output: Patent

  • Antigen Receptors
  • Patents and inventions
  • Ligands
  • Molecules
  • Medicine

• N-(4-Hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and N-(4-Hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzene sulfonamides and their therapeutic use

  Patel, L., Smith, S., Greig, I. R. & Williams, S., 2014, Patent No. WO2014207445

  Research output: Patent
• 2013

  SINGLE DOMAIN BINDING MOLECULE

  Barelle, C., Muller, M., Calabro, V., Bikker, J., Steven, J., Tchistiakova, L., Kovalenko, O. V. & Olland, A., 14 Nov 2013, IPC No. C07K16/46, Priority No. US201313889134 20130507 ; US201261643407P 20120507

  Research output: Patent

  Open Access

  File

  • Complementarity Determining Regions
  • Human Serum Albumin
  • Patents and inventions
  • Molecules
  • Amino Acids
  16 Downloads (Pure)

• Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use

  Greig, I. R., Sheridan, R. M., Fisher, R., Tozer, M. J., Clase, J. A., Smith, A., Tufnell, A. R. & van 't Hof, R. J., 19 Sep 2013, Patent No. US2013245018

  Research output: Patent

  • Bone and Bones
  • Anistreplase
  • Rheumatoid Arthritis
  • Bone Neoplasms
  • Psoriatic Arthritis

• USE OF PLATELET GLYCOPEPTIDE IIIA EPITOPES IN THE TREATMENT OF IMMUNE THROMBOCYTOPENIC PURPURA

  Urbaniak, S., Barker, R. N. & Sukati, H. M., 27 Mar 2013, IPC No. A61K38/10; A61P7/00, Patent No. EP2120992, Priority date 18 Jan 2007, Priority No. GB0701048

  Research output: Patent

  Open Access

  • Glycopeptides
  • Idiopathic Thrombocytopenic Purpura
  • Epitopes
  • Blood Platelets
  • Autoantibodies
  2 Downloads (Pure)

• 18f-labelled barbiturate compounds for use as positron emission imaging agents

  Greig, I. R., Zanda, M., Platt, B. & Calamai, E., 21 Mar 2013, Patent No. WO2013038153

  Research output: Patent
• 2012

  New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

  Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M. & Wood, B. A., 16 Aug 2012, Patent No. WO2012107706-A1, Priority date 11 Feb 2011

  Research output: Patent

  • Pick Disease of the Brain
  • phenothiazine
  • Frontotemporal Lobar Degeneration
  • Progressive Supranuclear Palsy
  • tau Proteins
• 2011

  Bone Graft System

  Gibson, I. R., Skakle, J., Annaz, B. & Conway, J., 29 Dec 2011, IPC No. A61L27/46, Patent No. WO2011GB00939

  Research output: Patent

  • bones
  • silicon
  • healing
  • delivery
  • ions

• Methods and Feed Compositions for Masking of Fish Semiochemicals

  Wadsworth, S., Vecino, J. L. G., Pino, J. & Mordue, A. J., 9 Jun 2011, IPC No. A23K1/16; A23K1/18 (2006.1), Priority date 2 Dec 2009, Priority No. NO20090003460 20091202

  Research output: Patent

  Open Access

  File

  • feed composition
  • semiochemicals
  • parasites
  • fish
  • fish feeds
  26 Downloads (Pure)

• TRANSFER VEHICLE FOR PRODUCING PROTEINS IN TRANSGENIC ANIMALS

  Kolb, A. F., 13 Apr 2011, IPC No. C12N15/85; C12N15/90, Priority date 15 Jun 2009, Priority No. WO2009GB50677 20090615 ; GB20080010924 20080614

  Research output: Patent

  File

  • transgenic animals
  • gene transfer
  • Retroviridae
  • Adenoviridae
  • transgenes
  5 Downloads (Pure)

• N-(ARYLALKYL)-1H-INDOLE-2-SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

  Greig, I. R., Ross, R. A., Trembleau, L. A. C., Pertwee, R. G. & Abdelrahman, M. H., 28 Feb 2011, IPC No. WO2012117216, Patent No. WO2012117216

  Research output: Patent

  • Sulfonic Acids
  • indole
  • Cannabinoid Receptors
  • Amides
  • Cannabinoids

• 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

  Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P. & Baddeley, T., 15 Feb 2011, Patent No. US7,888,350

  Research output: Patent

  File

  • phenothiazine
  • Salts
  • Tauopathies
  • Prodrugs
  • Chlorides
  10 Downloads (Pure)

• Synthesis of Bioceramic Compositions

  Gibson, I. R. & Skakle, J., 27 Jan 2011, IPC No. A61L27/12, Patent No. US20110021338

  Research output: Patent

  • Bioceramics
  • Calcium
  • Chemical analysis
  • Alkalies
  • Silicon
• 2010

  Biomedical materials

  Gibson, I. R., Skakle, J., Smith, N. & Buckland, T., 23 Dec 2010, IPC No. A61K49/06, Patent No. US20100322867

  Research output: Patent

  • calcium phosphates
  • gadolinium

• Antibodies specifically directed to a soluble form of CTLA-4

  Ward, F. J., Barker, R. N. & Dahal, L. N., 2 Sep 2010, Patent No. US8697845 B2, Priority date 15 Apr 2014

  Research output: Patent

  Open Access

  File

  • HLA-D Antigens
  • Antibodies
  42 Downloads (Pure)

• A method of remediating contaminated water and apparatus for the same

  Killham, K. S., Paton, G. I. & Cassidy, L., 21 Jul 2010, Patent No. EP2207633

  Research output: Patent

• Silicate-substituted hydroxyapatite

  Gibson, I. R. & Skakle, J., 8 Jul 2010, IPC No. A61L27/12, Patent No. US20100173009

  Research output: Patent

  • Silicates
  • Molar ratio
  • Durapatite
  • Carbonates
  • Silicon

• 3,6-Disubstituted xanthylium salts

  Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R. & Wischik, C. M., 17 Jun 2010, IPC No. WO2010/067078

  Research output: Patent

  • drug
  • salt
  • material
  • method

• Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

  Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C. & Sinclair, J. P., 15 Jun 2010, Patent No. US7,737,138

  Research output: Patent

  • Methylene Blue
  • Purification
  • Thiosulfonic Acids
  • Patents and inventions
  • Chlorides

• Vision Exercising Apparatus

  Sahraie, A., 10 Jun 2010, IPC No. A61H 5/00; A61B 3/024, Priority date 17 Apr 2008, Priority No. 0513603.1

  Research output: Patent

  Open Access

  File
  28 Downloads (Pure)

• Ligands for aggregated tau molecules: WO2010034982

  Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S. & Heinrich, T., 1 Apr 2010, Patent No. WO2010/034982

  Research output: Patent

  File

  • imidazopyridine
  • benzothiazole
  • tau Proteins
  • Salts
  • Ligands
  14 Downloads (Pure)

• Aryl-phenyl-sulfonamide-cycloalkyl compounds and their use

  Greig, I. R., Clase, J. A., Fisher, R., Sheridan, R. M., Smith, A., Tozer, M. J. & Tufnell, A. R., 25 Mar 2010, IPC No. WO2010/032009 , Patent No. WO2010/032009

  Research output: Patent

• Aryl-phenyl-sulfonamide-phenylene compounds and their use

  Greig, I. R., Clase, J. A., Fisher, R., Sheridan, R. M., Smith, A., Tozer, M. J., Tufnell, A. R. & van 't Hof, R. J., 25 Mar 2010, IPC No. WO2010/032010, Patent No. WO2010/032010

  Research output: Patent

  File

  • Sulfonamides
  • Bone and Bones
  • Rheumatoid Arthritis
  • Bone Neoplasms
  • Psoriatic Arthritis
  4 Downloads (Pure)

• Antigen Binding Domains from Fish

  Dooley, H., Porter, A. J. R. & Flajnik, M. F., 3 Mar 2010, IPC No. C07K 16/00; 16/18; 15/63, Patent No. 1419179, Priority date 10 Aug 2001, Priority No. GB0119553; GB0210508

  Research output: Patent

  Open Access

  File

  • Antigens
  • Immunoglobulin Isotypes
  • Fishes
  27 Downloads (Pure)

• 1,5-Diaryl-pyrazoles and their use as cannabinoid receptor neutral antagonists

  Greig, I. R. & Ross, R. A., 25 Feb 2010, IPC No. WO2010020762, Patent No. WO2010020762

  Research output: Patent

  • Pyrazoles
  • Cannabinoid Receptor Antagonists
  • Cannabinoid Receptors
  • Breast Neoplasms
  • Smoking

• Materials and methods for medical imaging

  Smith, T. A. D., Trembleau, L. A. C., McLaughlin, A. & Simpson, M., 2010, IPC No. WO2009056837, Patent No. GB2467494 (A)

  Research output: Patent

  • positrons
  • inventions
  • marking
  • platforms
  • emitters
• 2009

  Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives

  Greig, I. R., Teismann, P., Hanisch, U-K. & Bruck, W., 16 Sep 2009, IPC No. GB2458259, Patent No. GB2458259

  Research output: Patent

  • Hydrogen
  • Neurodegenerative Diseases
  • Huntington Disease
  • Amyotrophic Lateral Sclerosis
  • Multiple Sclerosis

• Therapeutic Use of Diaminophenothiazines: WO2009044127

  Wischik, C. M., Damon J., W., Storey, J. M. D. & Harrington, C. R., 9 Apr 2009, IPC No. WO2009/044127

  Research output: Patent

  File

  • cognitive disorders
  • pharmacokinetics
  • disease control
  • therapeutics
  • dosage
  5 Downloads (Pure)

• US20120107320 - Antibodies specifically directed to the soluble form of CTLA-4

  Ward, F. J., Barker, R. N. & Dahal, L. N., 28 Feb 2009, IPC No. US20120107320

  Research output: Patent

  • HLA-D Antigens
  • Antibodies

• New pharmaceutical formulation comprising cannabidiol and tetrahydrocannabivarin

  Pertwee, R. G., Guy, G. W. & Whittle, B., 15 Jan 2009, IPC No. A61K31/05; A61K31/352; A61K36/185; A61P19/08;, Patent No. WO2009007697

  Research output: Patent

  • Cannabidiol
  • Cannabinoid Receptor CB2
  • Cannabinoid Receptor CB1
  • Drug Compounding
  • Cannabinoids

• Use of tetrahydrocannabinol and/or cannabidiol for the treatment of inflammatory bowel disease

  Pertwee, R. G., Guy, G. W., Jamontt, J. & Robson, P., 8 Jan 2009, IPC No. A61K31/05; A61K31/352; A61K36/185; A61P19/08; , Patent No. WO2009004302

  Research output: Patent

  • Cannabidiol
  • Dronabinol
  • Inflammatory Bowel Diseases
  • Cannabinoids
  • Therapeutics

• Apparatus for Variable Cycling the Water Depth in a Tank

  Fraser, P. & Smith, L., 2009

  Research output: Patent

• Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions

  Greig, I. R., Ralston, S., Idris, A. I. & Van't Hof, R. J., 2009, Patent No. US7598289

  Research output: Patent

• Methods of synthesis and/or purification of diaminophenothiazinium compounds

  Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P. & Baddeley, T., 2009, Patent No. EP2057136

  Research output: Patent

• Treatment and Diagnosis of Behavioural Disorders

  Miedzybrodzka, Z. H., St Clair, D. M., Muller, B. M., Neves-Pereira, M. D. L. & Massie, D., 2009, IPC No. C12Q 1/68 (2006.01), Patent No. WO/2009/144480

  Research output: Patent

  • Pharmaceutical Preparations
• 2008

  Therapeutic uses of cannabigerol

  Pertwee, R. G., 31 Dec 2008, IPC No. A61K31/352; A61K36/185; A61P25/28; (+3), Patent No. WO2009001081

  Research output: Patent

  • cannabigerol
  • Therapeutic Uses
  • Brain Injuries
  • Cannabinoid Receptor CB2
  • Cannabinoid Receptor CB1

• Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions

  Greig, I. R., Ralston, S., Van T Hof, R. J. & Mohamed, A. I. I., 18 Dec 2008, IPC No. US7598289, Patent No. US7598289

  Research output: Patent

• New use for cannabinoid

  Pertwee, R. G. & Guy, G. W., 21 Oct 2008, IPC No. A61K31/00; A61K31/33; A61K31/454; , Patent No. BRPI0518011

  Research output: Patent

  • Cannabinoid Receptor CB1
  • Cannabinoids
  • Cannabinoid Receptor Antagonists
  • Obesity
  • Appetite Depressants

• 2',4'-Dichloro-biphenyl-4-yl-hydroxyketones and related compounds and their use as therapeutic agents

  Greig, I. R., Van T Hof, R. J. & Ralston, S., 11 Sep 2008, IPC No. US20080221220, Patent No. US20080221220

  Research output: Patent

• Chimeric binding peptide library screening method

  McGregor, D., 11 Sep 2008, Priority date 13 Nov 2007, Priority No. 9718455.0

  Research output: Patent

  File

  • Peptide Library
  • Peptides
  • DNA-Binding Proteins
  • Gene Library
  • DNA
  2 Downloads (Pure)

• 1,5-diaryl-pyrazoles as cannabinoid receptor neutral antagonists useful as therapeutic agents

  Greig, I. R., Ross, R. A. & Pertwee, R. G., 21 Aug 2008, IPC No. A61K31/415; A61P29/00; C07D231/12; , Patent No. WO2008/099139

  Research output: Patent

  • Pyrazoles
  • Cannabinoid Receptor Antagonists
  • Cognition
  • Smoking
  • pyrazole