Life Sciences & Medicine – Research Output

2017

Synthetic retinoids for use in RAR mediated conditions

Greig, I. R., McCaffery, P. J. A., Whiting, A., Valentine, R., Chisholm, D. & Khatib, T., 12 Oct 2017, Patent No. WO2017174999

Research output: Patent

Retinoids

2016

3 Downloads (Pure)

Enhanced RNAI Mediated Gene Regulation

Bowman, A. S., Campbell, E. M. & Lewendon, A., 14 Jul 2016, IPC No. A61K31/7088; C12N15/113, Patent No. WO2016110691 (A1) , Priority date 6 Jan 2015, Priority No. GB20150000107 20150106

Research output: Patent

Open Access

File

Nucleic Acids

Host-Parasite Interactions

Disclosure

Genes

Parasites

N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

Smith, S., Patel, L. & Greig, I. R., 23 Jun 2016, Patent No. WO2016/097001, Priority date 17 Dec 2014

Research output: Patent

PATENT: Antibody molecules and uses thereof.

Gow, N. A. R., Rudkin, F. M., Erwig, L-P. & Jensen, A., 15 Sep 2016, IPC No. C07K 16/14 , G01N 33/53, World Intellectual Property Organization, Patent No. WO 2016/142660 Al, 4 Mar 2016, Priority date 6 Mar 2015, Priority No. GB 1503812.8

Research output: Patent

Antibodies

Candida

Fungal Antigens

Gene Targeting

Cell Extracts

2015

Phenothiazine compounds for treating mild cognitive impairment

Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D. & Staff, R. T., 15 Dec 2015, Patent No. US9211294, 17 Jun 2008, Priority date 19 Jun 2007, Priority No. 60/945006

Research output: Patent

Cognitive Dysfunction

phenothiazine

Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides

D'Agostino, G., 13 Jun 2015, Patent No. CA2836069 A1, Priority date 13 Dec 2012

Research output: Patent

2014

1 Downloads (Pure)

Fish Vaccine

Wawra, S., Van West, P. & Secombes, C. J., 4 Dec 2014, IPC No. A61K38/16; C07K14/37; C12N15/62, Patent No. WO2014191759, Priority date 30 May 2013, Priority No. GB20130009664 20130530

Research output: Patent

vaccines

fish

nucleic acids

eukaryotic cells

plasma membrane

Fluoro-perhexiline compounds and their therapeutic use

Greig, I. R., Tseng, C-C. & Zanda, M., 30 Oct 2014, Patent No. WO2014184561

Research output: Patent

ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL

Barelle, C., Finlay, J. J. W. & Darmanin-Sheehan, A., 30 Oct 2014, IPC No. C07K16/00; C07K16/18; C12N15/13, Priority date 23 Apr 2013, Priority No. US201361815043P 20130423

Research output: Patent

Antigen Receptors

Libraries

Sharks

Ligands

Squalus acanthias

N-(4-Hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and N-(4-Hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzene sulfonamides and their therapeutic use

Patel, L., Smith, S., Greig, I. R. & Williams, S., 2014, Patent No. WO2014207445

Research output: Patent

2013

18f-labelled barbiturate compounds for use as positron emission imaging agents

Greig, I. R., Zanda, M., Platt, B. & Calamai, E., 21 Mar 2013, Patent No. WO2013038153

Research output: Patent

Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use

Greig, I. R., Sheridan, R. M., Fisher, R., Tozer, M. J., Clase, J. A., Smith, A., Tufnell, A. R. & van 't Hof, R. J., 19 Sep 2013, Patent No. US2013245018

Research output: Patent

Bone and Bones

Rheumatoid Arthritis

Anistreplase

Bone Neoplasms

Psoriatic Arthritis

SINGLE DOMAIN BINDING MOLECULE

Barelle, C., Muller, M., Calabro, V., Bikker, J., Steven, J., Tchistiakova, L., Kovalenko, O. V. & Olland, A., 14 Nov 2013, IPC No. C07K16/46, Priority No. US201313889134 20130507 ; US201261643407P 20120507

Research output: Patent

Open Access

File

Complementarity Determining Regions

Patents and inventions

Serum Albumin

Amino Acids

Molecules

2 Downloads (Pure)

USE OF PLATELET GLYCOPEPTIDE IIIA EPITOPES IN THE TREATMENT OF IMMUNE THROMBOCYTOPENIC PURPURA

Urbaniak, S., Barker, R. N. & Sukati, H. M., 27 Mar 2013, IPC No. A61K38/10; A61P7/00, Patent No. EP2120992, Priority date 18 Jan 2007, Priority No. GB0701048

Research output: Patent

Open Access

Idiopathic Thrombocytopenic Purpura

Glycopeptides

Epitopes

Blood Platelets

Autoantibodies

2012

New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M. & Wood, B. A., 16 Aug 2012, Patent No. WO2012107706-A1, Priority date 11 Feb 2011

Research output: Patent

tau Proteins

Agglomeration

Purification

Salts

phenothiazine

2011

6 Downloads (Pure)

3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P. & Baddeley, T., 15 Feb 2011, Patent No. US7,888,350

Research output: Patent

File

Salt

Drugs

Alzheimer's Disease

Invention

Bone Graft System

Gibson, I. R., Skakle, J., Annaz, B. & Conway, J., 29 Dec 2011, IPC No. A61L27/46, Patent No. WO2011GB00939

Research output: Patent

Hydrogel

Silicon

Grafts

Bone

Durapatite

12 Downloads (Pure)

METHODS AND FEED COMPOSITIONS FOR MASKING OF FISH SEMIOCHEMICALS

Wadsworth, S., Vecino, J. L. G., Pino, J. & Mordue, A. J., 9 Jun 2011, IPC No. A23K1/16; A23K1/18 (2006.1), Priority date 2 Dec 2009, Priority No. NO20090003460 20091202

Research output: Patent

File

Pheromones

Fishes

Parasitic Diseases

Parasites

Water

N-(ARYLALKYL)-1H-INDOLE-2-SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

Greig, I. R., Ross, R. A., Trembleau, L. A. C., Pertwee, R. G. & Abdelrahman, M. H., 28 Feb 2011, IPC No. WO2012117216, Patent No. WO2012117216

Research output: Patent

Cannabinoid Receptors

Sulfonic Acids

Cannabinoids

Therapeutic Uses

Amides

Synthesis of Bioceramic Compositions

Gibson, I. R. & Skakle, J., 27 Jan 2011, IPC No. A61L27/12, Patent No. US20110021338

Research output: Patent

Bioceramics

Calcium

Chemical analysis

Alkalies

Silicon

TRANSFER VEHICLE FOR PRODUCING PROTEINS IN TRANSGENIC ANIMALS

Kolb, A. F., 13 Apr 2011, IPC No. C12N15/85; C12N15/90, Priority date 15 Jun 2009, Priority No. WO2009GB50677 20090615 ; GB20080010924 20080614

Research output: Patent

File

transgenic animals

gene transfer

Retroviridae

Adenoviridae

transgenes

2010

1,5-Diaryl-pyrazoles and their use as cannabinoid receptor neutral antagonists

Greig, I. R. & Ross, R. A., 25 Feb 2010, IPC No. WO2010020762, Patent No. WO2010020762

Research output: Patent

Pyrazoles

Cannabinoid Receptor Antagonists

Cannabinoid Receptors

Breast Neoplasms

Smoking

3,6-Disubstituted xanthylium salts

Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R. & Wischik, C. M., 17 Jun 2010, IPC No. WO2010/067078

Research output: Patent

Patents and inventions

Salts

Pharmaceutical Preparations

xanthylium

A method of remediating contaminated water and apparatus for the same

Killham, K. S., Paton, G. I. & Cassidy, L., 21 Jul 2010, Patent No. EP2207633

Research output: Patent

26 Downloads (Pure)

Antibodies specifically directed to a soluble form of CTLA-4

Ward, F. J., Barker, R. N. & Dahal, L. N., 2 Sep 2010, Patent No. US8697845 B2, Priority date 15 Apr 2014

Research output: Patent

File

HLA-D Antigens

Antibodies

16 Downloads (Pure)

Antigen Binding Domains from Fish

Dooley, H., Porter, A. J. R. & Flajnik, M. F., 3 Mar 2010, IPC No. C07K 16/00; 16/18; 15/63, Patent No. 1419179, Priority date 10 Aug 2001, Priority No. GB0119553; GB0210508

Research output: Patent

File

Fish

Antigens

Immunoglobulin Isotypes

DNA sequences

Aryl-phenyl-sulfonamide-cycloalkyl compounds and their use

Greig, I. R., Clase, J. A., Fisher, R., Sheridan, R. M., Smith, A., Tozer, M. J. & Tufnell, A. R., 25 Mar 2010, IPC No. WO2010/032009 , Patent No. WO2010/032009

Research output: Patent

1 Downloads (Pure)

Aryl-phenyl-sulfonamide-phenylene compounds and their use

Greig, I. R., Clase, J. A., Fisher, R., Sheridan, R. M., Smith, A., Tozer, M. J., Tufnell, A. R. & van 't Hof, R. J., 25 Mar 2010, IPC No. WO2010/032010, Patent No. WO2010/032010

Research output: Patent

File

Sulfonamides

Bone and Bones

Rheumatoid Arthritis

Bone Neoplasms

Psoriatic Arthritis

Biomedical materials

Gibson, I. R., Skakle, J., Smith, N. & Buckland, T., 23 Dec 2010, IPC No. A61K49/06, Patent No. US20100322867

Research output: Patent

gadolinium

calcium

phosphate

material

chemical

7 Downloads (Pure)

Ligands for aggregated tau molecules: WO2010034982

Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S. & Heinrich, T., 1 Apr 2010, Patent No. WO2010/034982

Research output: Patent

File

tau Proteins

Hydrates

Labels

Salts

Ligands

Materials and methods for medical imaging

Smith, T. A. D., Trembleau, L. A. C., McLaughlin, A. & Simpson, M., 2010, IPC No. WO2009056837, Patent No. GB2467494 (A)

Research output: Patent

positrons

inventions

marking

emitters

platforms

Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C. & Sinclair, J. P., 15 Jun 2010, Patent No. US7,737,138

Research output: Patent

Methylene Blue

Purification

Patents and inventions

Thiosulfonic Acids

Chlorides

Silicate-substituted hydroxyapatite

Gibson, I. R. & Skakle, J., 8 Jul 2010, IPC No. A61L27/12, Patent No. US20100173009

Research output: Patent

Silicates

Durapatite

Carbonates

Biocompatible Materials

Silicon

8 Downloads (Pure)

Vision Exercising Apparatus

Sahraie, A., 10 Jun 2010, IPC No. A61H 5/00; A61B 3/024, Priority date 17 Apr 2008, Priority No. 0513603.1

Research output: Patent

File

Display devices

Position control

2009

Apparatus for Variable Cycling the Water Depth in a Tank

Fraser, P. & Smith, L., 2009

Research output: Patent

Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions

Greig, I. R., Ralston, S., Idris, A. I. & Van't Hof, R. J., 2009, Patent No. US7598289

Research output: Patent

Methods of synthesis and/or purification of diaminophenothiazinium compounds

Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P. & Baddeley, T., 2009, Patent No. EP2057136

Research output: Patent

Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives

Greig, I. R., Teismann, P., Hanisch, U-K. & Bruck, W., 16 Sep 2009, IPC No. GB2458259, Patent No. GB2458259

Research output: Patent

Derivatives

Hydrogen

Neurodegenerative diseases

Chemical analysis

Pharmaceutical Preparations

New pharmaceutical formulation comprising cannabidiol and tetrahydrocannabivarin

Pertwee, R. G., Guy, G. W. & Whittle, B., 15 Jan 2009, IPC No. A61K31/05; A61K31/352; A61K36/185; A61P19/08;, Patent No. WO2009007697

Research output: Patent

Cannabidiol

Cannabinoid Receptor CB2

Cannabinoid Receptor CB1

Drug Compounding

Cannabinoids

2 Downloads (Pure)

Therapeutic Use of Diaminophenothiazines: WO2009044127

Wischik, C. M., Damon J., W., Storey, J. M. D. & Harrington, C. R., 9 Apr 2009, IPC No. WO2009/044127

Research output: Patent

File

Dosage Forms

Therapeutic Uses

Pharmacokinetics

Treatment and Diagnosis of Behavioural Disorders

Miedzybrodzka, Z. H., St Clair, D. M., Muller, B. M., Neves-Pereira, M. D. L. & Massie, D., 2009, IPC No. C12Q 1/68 (2006.01), Patent No. WO/2009/144480

Research output: Patent

Pharmaceutical Preparations