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Research Output 2005 2020

2013
215 Citations (Scopus)

Intestinal colonization resistance

Lawley, T. D. & Walker, A. W., Jan 2013, In : Immunology. 138, 1, p. 1-11 11 p.

Research output: Contribution to journalLiterature review

Microbiota
Ecosystem
Anti-Bacterial Agents
Inflammation
Volatile Fatty Acids
70 Citations (Scopus)
3 Downloads (Pure)

Patent human infections with the whipworm, Trichuris trichiura, are not associated with alterations in the faecal microbiota

Cooper, P., Walker, A. W., Reyes, J., Chico, M., Salter, S. J., Vaca, M. & Parkhill, J., 4 Oct 2013, In : PloS ONE. 8, 10, 12 p., e76573.

Research output: Contribution to journalArticle

Open Access
File
Trichuris trichiura
Trichuris
Anthelmintics
Microbiota
patents
235 Citations (Scopus)
56 Downloads (Pure)

Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions

Adler, C. J., Dobney, K., Weyrich, L. S., Kaidonis, J., Walker, A. W., Haak, W., Bradshaw, C. J. A., Townsend, G., Sołtysiak, A., Alt, K. W., Parkhill, J. & Cooper, A., Apr 2013, In : Nature Genetics. 45, 4, p. 450-455 6 p.

Research output: Contribution to journalArticle

Open Access
File
Dental Plaque
Microbiota
Agriculture
Mouth Diseases
Dental Calculus
14 Citations (Scopus)

Survey of Culture, GoldenGate Assay, Universal Biosensor Assay, and 16S rRNA Gene Sequencing as Alternative Methods of Bacterial Pathogen Detection

Lindsay, B., Pop, M., Antonio, M., Walker, A. W., Mai, V., Ahmed, D., Oundo, J., Tamboura, B., Panchalingam, S., Levine, M. M., Kotloff, K., Li, S., Magder, L. S., Paulson, J. N., Liu, B., Ikumapayi, U., Ebruke, C., Dione, M., Adeyemi, M., Rance, R. & 32 others, Stares, M. D., Ukhanova, M., Barnes, B., Lewis, I., Ahmed, F., Alam, M. T., Amin, R., Siddiqui, S., Ochieng, J. B., Ouma, E., Juma, J., Mailu, E., Omore, R., O'Reilly, C. E., Hannis, J., Manalili, S., Deleon, J., Yasuda, I., Blyn, L., Ranken, R., Li, F., Housley, R., Ecker, D. J., Hossain, M. A., Breiman, R. F., Morris, J. G., McDaniel, T. K., Parkhill, J., Saha, D., Sampath, R., Stine, O. C. & Nataro, J. P., Oct 2013, In : Journal of Clinical Microbiology. 51, 10, p. 3263-3269 7 p.

Research output: Contribution to journalArticle

Biosensing Techniques
rRNA Genes
Enterotoxigenic Escherichia coli
Enteropathogenic Escherichia coli
Shigella
86 Citations (Scopus)

Therapeutic modulation of intestinal dysbiosis

Walker, A. W. & Lawley, T. D., Mar 2013, In : Pharmacological Research. 69, 1, p. 75-86 12 p.

Research output: Contribution to journalLiterature review

Dysbiosis
Microbiota
Health
Therapeutics
Probiotics
2012
19 Citations (Scopus)
3 Downloads (Pure)

Bayesian estimation of bacterial community composition from 454 sequencing data

Cheng, L., Walker, A. W. & Corander, J., Jul 2012, In : Nucleic Acids Research. 40, 12, p. 5240-5249 10 p.

Research output: Contribution to journalArticle

Open Access
File
Cluster Analysis
Statistical Models
rRNA Genes
Polymerase Chain Reaction
13 Citations (Scopus)

Fibrinogen-binding and platelet-aggregation activities of a Lactobacillus salivarius septicaemia isolate are mediated by a novel fibrinogen-binding protein

Collins, J., van Pijkeren, J-P., Svensson, L., Claesson, M. J., Sturme, M., Li, Y., Cooney, J. C., van Sinderen, D., Walker, A. W., Parkhill, J., Shannon, O. & O'Toole, P. W., Sep 2012, In : Molecular Microbiology. 85, 5, p. 862-877 16 p.

Research output: Contribution to journalArticle

Platelet Aggregation
Fibrinogen
Sepsis
Carrier Proteins
Probiotics
169 Citations (Scopus)

Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae

Stecher, B., Denzler, R., Maier, L., Bernet, F., Sanders, M. J., Pickard, D. J., Barthel, M., Westendorf, A. M., Krogfelt, K. A., Walker, A. W., Ackermann, M., Dobrindt, U., Thomson, N. R. & Hardt, W-D., 24 Jan 2012, In : PNAS. 109, 4, p. 1269-1274 6 p.

Research output: Contribution to journalArticle

Horizontal Gene Transfer
Enterobacteriaceae
Inflammation
Foster Home Care
Bacteriocin Plasmids
1 Citation (Scopus)

Intestinal Microbiology and Ecology in Inflammatory Bowel Disease

Walker, A. W., 24 Jan 2012, Crohn's Disease and Ulcerative Colitis. Baumgart, D. C. (ed.). Springer Science+Business Media, p. 85-95 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Microbiota
Microbiology
Ecology
Inflammatory Bowel Diseases
Human Body
329 Citations (Scopus)
4 Downloads (Pure)

Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice

Lawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., Goulding, D., Rad, R., Schreiber, F., Brandt, C., Deakin, L. J., Pickard, D. J., Duncan, S. H., Flint, H. J., Clark, T. G., Parkhill, J. & Dougan, G., 25 Oct 2012, In : PLoS Pathogens. 8, 10, 14 p., e1002995.

Research output: Contribution to journalArticle

Open Access
File
200 Citations (Scopus)

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells

Powell, N., Walker, A. W., Stolarczyk, E., Canavan, J. B., Gökmen, M. R., Marks, E., Jackson, I., Hashim, A., Curtis, M. A., Jenner, R. G., Howard, J. K., Parkhill, J., MacDonald, T. T. & Lord, G. M., 19 Oct 2012, In : Immunity. 37, 4, p. 674-684 11 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
Lymphocytes
Inflammation
Colitis
Ulcerative Colitis
11 Citations (Scopus)

Welcome to the plasmidome

Walker, A., Jun 2012, In : Nature Reviews Microbiology. 10, 6, p. 379 1 p.

Research output: Contribution to journalArticle

Metagenomics
Rumen
Plasmids
Genome
2011
718 Citations (Scopus)

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Walker, A. W., Ince, J., Duncan, S. H., Webster, L., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., Louis, P., McIntosh, F., Johnstone, A. M., Lobley, G. E., Parkhill, J. & Flint, H. J., Feb 2011, In : The ISME Journal. 5, 2, p. 220-230 11 p.

Research output: Contribution to journalArticle

341 Citations (Scopus)
4 Downloads (Pure)

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

Walker, A. W., Sanderson, J. D., Churcher, C., Parkes, G. C., Hudspith, B. N., Rayment, N., Brostoff, J., Parkhill, J., Dougan, G. & Petrovska, L., 10 Jan 2011, In : BioMed Central Microbiology. 11, 12 p., 7.

Research output: Contribution to journalArticle

Open Access
File
Dysbiosis
Microbiota
Inflammatory Bowel Diseases
Crohn Disease
Intestines

Ileal pouch microbial diversity

McLaughlin, S. D., Walker, A. W., Churcher, C., Clark, S. K., Tekkis, P. P., Johnson, M. W., Parkhill, J., Ciclitira, P. J., Dougan, G., Nicholls, R. J. & Petrovska, L., Oct 2011, In : Annals of Surgery. 254, 4, p. 669-670 2 p.

Research output: Contribution to journalLetter

138 Citations (Scopus)
3 Downloads (Pure)

Partitioning core and satellite taxa from within cystic fibrosis lung bacterial communities

van der Gast, C. J., Walker, A. W., Stressmann, F. A., Rogers, G. B., Scott, P., Daniels, T. W., Carroll, M. P., Parkhill, J. & Bruce, K. D., May 2011, In : The ISME Journal. 5, 5, p. 780-791 12 p.

Research output: Contribution to journalArticle

Open Access
File
cystic fibrosis
bacterial communities
Cystic Fibrosis
partitioning
lungs
82 Citations (Scopus)

Review article: faecal transplantation therapy for gastrointestinal disease

Landy, J., Al-Hassi, H. O., McLaughlin, S. D., Walker, A. W., Ciclitira, P. J., Nicholls, R. J., Clark, S. K. & Hart, A. L., Aug 2011, In : Alimentary Pharmacology & Therapeutics. 34, 4, p. 409-415 7 p.

Research output: Contribution to journalLiterature review

Gastrointestinal Diseases
Dysbiosis
Probiotics
Therapeutics
Fecal Microbiota Transplantation

Singled out

Walker, A., Jul 2011, In : Nature Reviews Microbiology. 9, 7, p. 485 1 p.

Research output: Contribution to journalArticle

Genomics
Genome
2010
8 Citations (Scopus)

A glut from the gut: metagenomics takes a giant step foward

Walker, A., May 2010, In : Nature Reviews Microbiology. 8, 5, p. 315 1 p.

Research output: Contribution to journalArticle

Metagenomics
Genome
Bacteria
34 Citations (Scopus)
4 Downloads (Pure)

Comparing the microbiota of the cystic fibrosis lung and human gut

Rogers, G. B., Carroll, M. P., Hoffman, L. R., Walker, A. W., Fine, D. A. & Bruce, K. D., 1 May 2010, In : Gut Microbes. 1, 2, p. 85-93 9 p.

Research output: Contribution to journalLiterature review

Open Access
File
Microbiota
Cystic Fibrosis
Lung
Infection
Microbiology
5 Citations (Scopus)

Gut metagenomics goes viral

Walker, A., Dec 2010, In : Nature Reviews Microbiology. 8, 12, p. 841 1 p.

Research output: Contribution to journalArticle

Metagenomics
Bacteriology
Genome
Viruses
Research
31 Citations (Scopus)

Lung infections in cystic fibrosis: deriving clinical insight from microbial complexity

Rogers, G. B., Stressmann, F. A., Walker, A. W., Carroll, M. P. & Bruce, K. D., Mar 2010, In : Expert Review of Molecular Diagnostics. 10, 2, p. 187-196 10 p.

Research output: Contribution to journalLiterature review

Cystic Fibrosis
Lung
Infection
Coinfection
Bacterial Infections
10 Citations (Scopus)
4 Downloads (Pure)

Special issue: The Human Intestinal Microbiota

Flint, H. J., O'Toole, P. W. & Walker, A. W., Nov 2010, In : Microbiology . 156, 11, p. 3203-3204 2 p.

Research output: Contribution to journalEditorial

Open Access
File
75 Citations (Scopus)

The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing

McLaughlin, S. D., Walker, A. W., Churcher, C., Clark, S. K., Tekkis, P. P., Johnson, M. W., Parkhill, J., Ciclitira, P. J., Dougan, G., Nicholls, R. J. & Petrovska, L., Jul 2010, In : Annals of Surgery. 252, 1, p. 90-98 9 p.

Research output: Contribution to journalArticle

Pouchitis
Bacteriology
Ulcerative Colitis
rRNA Genes
Adenomatous Polyposis Coli
2009
206 Citations (Scopus)

Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts

Lawley, T. D., Clare, S., Walker, A. W., Goulding, D., Stabler, R. A., Croucher, N., Mastroeni, P., Scott, P., Raisen, C., Mottram, L., Fairweather, N. F., Wren, B. W., Parkhill, J. & Dougan, G., Sep 2009, In : Infection and Immunity. 77, 9, p. 3661-3669 9 p.

Research output: Contribution to journalArticle

Clostridium difficile
Immunocompromised Host
Spores
Anti-Bacterial Agents
Clostridium Infections
4 Citations (Scopus)

Milk and two oligosaccharides

Walker, A., Jul 2009, In : Nature Reviews Microbiology. 7, 7, p. 483 1 p.

Research output: Contribution to journalArticle

Oligosaccharides
Milk
Genome
3 Citations (Scopus)

Probiotics stick it to the man

Walker, A., Dec 2009, In : Nature Reviews Microbiology. 7, 12, p. 843 1 p.

Research output: Contribution to journalArticle

Probiotics
Lactobacillus
Genomics
Genome
2008
54 Citations (Scopus)
4 Downloads (Pure)

A common genomic framework for a diverse assembly of plasmids in the symbiotic nitrogen fixing bacteria

Crossman, L. C., Castillo-Ramírez, S., McAnnula, C., Lozano, L., Vernikos, G. S., Acosta, J. L., Ghazoui, Z. F., Hernández-González, I., Meakin, G., Walker, A. W., Hynes, M. F., Young, J. P. W., Downie, J. A., Romero, D., Johnston, A. W. B., Dávila, G., Parkhill, J. & González, V., 2 Jul 2008, In : PloS ONE. 3, 7, p. e2567 9 p.

Research output: Contribution to journalArticle

Open Access
File
nitrogen-fixing bacteria
Bacteria
plasmids
Plasmids
Nitrogen
4 Citations (Scopus)

Does my genome look big in this?

Walker, A. & Langridge, G., Dec 2008, In : Nature Reviews Microbiology. 6, 12, p. 878-879 2 p.

Research output: Contribution to journalArticle

Genome
2 Citations (Scopus)

Opportunity knocks

Seth-Smith, H. & Walker, A., Sep 2008, In : Nature Reviews Microbiology. 6, 9, p. 652-653 2 p.

Research output: Contribution to journalArticle

Genome
33 Citations (Scopus)

Single-cell genomics

Walker, A. & Parkhill, J., Mar 2008, In : Nature Reviews Microbiology. 6, 3, p. 176-177 2 p.

Research output: Contribution to journalArticle

Genomics
Genome
isofenphos
82 Citations (Scopus)

The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities

Walker, A. W., Duncan, S. H., Harmsen, H. J. M., Holtrop, G., Welling, G. W. & Flint, H. J., Dec 2008, In : Environmental Microbiology. 10, 12, p. 3275-3283 9 p.

Research output: Contribution to journalArticle

2007

It's hip to be square!

Crossman, L. C. & Walker, A., Jun 2007, In : Nature Reviews Microbiology. 5, 6, p. 400-401 2 p.

Research output: Contribution to journalArticle

592 Citations (Scopus)
3 Downloads (Pure)

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., Dougan, G., von Mering, C. & Hardt, W-D., 28 Aug 2007, In : PLoS Biology. 5, 10, 13 p., e244.

Research output: Contribution to journalArticle

Open Access
File
Salmonella
Salmonella enterica
Microbiota
Pathogens
intestinal microorganisms
17 Citations (Scopus)

Say hello to our little friends

Walker, A., Aug 2007, In : Nature Reviews Microbiology. 5, 8, p. 572-573 2 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Selective colonization of insoluble substrates by human faecal bacteria

Leitch, E. C. M., Walker, A. W., Duncan, S. H., Holtrop, G. & Flint, H. J., Mar 2007, In : Environmental Microbiology. 9, 3, p. 667-679 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

This place is big enough for both of us

Walker, A. & Crossman, L. C., Feb 2007, In : Nature Reviews Microbiology. 5, 2, p. 90-92 3 p.

Research output: Contribution to journalArticle

Urbane decay

Walker, A. & Seth-Smith, H., Oct 2007, In : Nature Reviews Microbiology. 5, 10, p. 748-749 2 p.

Research output: Contribution to journalArticle

2006
11 Citations (Scopus)

Faecal matters

Walker, A., Cerdeño-Tárraga, A. & Bentley, S., Aug 2006, In : Nature Reviews Microbiology. 4, 8, p. 572-3 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Molecular approaches to the analysis of gastrointestinal microbial ecosystems

Flint, H. J., Leitch, E. C. M., Duncan, S. H., Walker, A. W., Patterson, A. J., Rincon, M. T., Scott, K. P. & Louis, P. G. H., 21 Dec 2006, Avian Gut Function in Health and Disease. Perry, G. (ed.). Wallingford, United Kingdom: CABI Publishing, p. 107-123 (Poultry Science Symposium Series; vol. 28).

Research output: Chapter in Book/Report/Conference proceedingChapter

microbial ecology
digestive system
Bacteroides
dietary carbohydrate
Firmicutes
44 Citations (Scopus)

Studies on the effect of system retention time on bacterial populations colonizing a three-stage continuous culture model of the human large gut using FISH techniques

Child, M. W., Kennedy, A., Walker, A. W., Bahrami, B., Macfarlane, S. & Macfarlane, G. T., Feb 2006, In : FEMS Microbiology Ecology. 55, 2, p. 299-310 12 p.

Research output: Contribution to journalArticle

Eubacterium
Fluorescence In Situ Hybridization
Bacteria
bacterium
Butyrates
2005
333 Citations (Scopus)