• 1504 Citations
1991 …2017
If you made any changes in Pure these will be visible here soon.

Research Output 1991 2017

Filter
Article
2017
9 Citations (Scopus)
5 Downloads (Pure)

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

Hay, E. A., Khalaf, A. R., Marini, P., Brown, A., Heath, K., Sheppard, D. & MacKenzie, A., Aug 2017, In : Neuropeptides. 64, p. 101-107 7 p.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Deletion
Neuropeptides
Guide RNA
Genome

Neuropeptides-2015, Aberdeen University, Scotland

MacKenzie, A., Pinter, E. & Quinn, J., Aug 2017, In : Neuropeptides. 64, p. 1 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
7 Downloads (Pure)

Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation

Hay, E. A., Knowles, C., Kolb, A. & MacKenzie, A., Aug 2017, In : Neuropeptides. 64, p. 19-25 7 p.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Neuropeptides
Animal Models
Neuropeptide Receptors
Genetically Modified Animals
2016
6 Citations (Scopus)
5 Downloads (Pure)

Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones

Davidson, S., Shanley, L., Cowie, P., Lear, M., McGuffin, P., Quinn, J. P., Barrett, P. & MacKenzie, A., Aug 2016, In : The Pharmacogenomics Journal. 16, 4, p. 366-374 9 p.

Research output: Contribution to journalArticle

Open Access
File
Amygdala
Major Depressive Disorder
Depression
Neurons
Aptitude
2015
6 Citations (Scopus)
3 Downloads (Pure)

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells

Hay, C. W., Hunter, I., MacKenzie, A. & McEwan, I. J., 8 Oct 2015, In : PloS ONE. 10, 10, 18 p., 0139990.

Research output: Contribution to journalArticle

Open Access
File
Nucleic Acid Regulatory Sequences
Androgen Receptors
prostatic neoplasms
Primates
Prostatic Neoplasms

Determining Epigenetic Targets: A Beginner's Guide to Identifying Genome Functionality Through Database Analysis

Hay, E. A., Cowie, P. & MacKenzie, A., 2015, In : Methods in Molecular Biology. 1589, p. 29-45 17 p.

Research output: Contribution to journalArticle

Epigenomics
Genome
Databases
Human Genome
DNA Methylation
8 Citations (Scopus)

The noncoding human genome and the future of personalised medicine

Cowie, P., Hay, E. A. & MacKenzie, A., 2015, In : Expert Reviews in Molecular Medicine. 17, 20 p., e4.

Research output: Contribution to journalArticle

Precision Medicine
Human Genome
Epigenomics
Communication
Genome
2014
3 Citations (Scopus)
5 Downloads (Pure)

Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes

Richardson, T. G., Minica, C., Heron, J., Tavare, J., MacKenzie, A., Day, I., Lewis, G., Hickman, M., Vink, J. M., Gelernter, J., Kranzler, H. R., Farrer, L. A., Munafò, M. & Wynick, D., Dec 2014, In : American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 165, 8, p. 654-664 11 p.

Research output: Contribution to journalArticle

Open Access
File
Galanin
Genotype
Phenotype
Cannabis
Sample Size
6 Citations (Scopus)
5 Downloads (Pure)

Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones

Hay, C., Shanley, L., Davidson, S., Cowie, P., Lear, M., McGuffin, P., Riedel, G., McEwan, I. J. & MacKenzie, A., Sep 2014, In : Psychoneuroendocrinology. 47, p. 43-55 13 p.

Research output: Contribution to journalArticle

Open Access
File
Glucocorticoid Receptors
Substance P
Amygdala
Neurons
Genes
34 Citations (Scopus)

In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling

Fowler, P. A., Childs, A. J., Courant, F., MacKenzie, A., Rhind, S. M., Antignac, J-P., Le Bizec, B., Filis, P., Evans, F., Flannigan, S., Maheshwari, A., Bhattacharya, S., Monteiro, A., Anderson, R. A. & O'Shaughnessy, P. J., Jul 2014, In : Human Reproduction. 29, 7, p. 1471-1489 19 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Smoking
Analysis of Variance
Ovary
4 Citations (Scopus)
4 Downloads (Pure)

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR

Hay, C. W., Watt, K., Hunter, I., Lavery, D. N., MacKenzie, A. & McEwan, I. J., Oct 2014, In : Hormones and Cancer. 5, 5, p. 299-311 13 p.

Research output: Contribution to journalArticle

Open Access
File
5' Untranslated Regions
Androgen Receptors
Response Elements
Primates
Androgens
2013
10 Citations (Scopus)
4 Downloads (Pure)

Exploring the effects of polymorphisms on cis-regulatory signal transduction response

MacKenzie, A., Hing, B. & Davidson, S., Feb 2013, In : Trends in Molecular Medicine. 19, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

Open Access
File
Disease Susceptibility
Signal Transduction
Encyclopedias
Precision Medicine
Technology
5 Citations (Scopus)
5 Downloads (Pure)

Understanding the Dynamics of Gene Regulatory Systems: Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms

Cowie, P. D., MacKenzie, A. & Ross, R., 9 Jan 2013, In : Biology. 2, 1, p. 64-84 20 p.

Research output: Contribution to journalArticle

Open Access
File
Signal transduction
regulatory sequences
Regulator Genes
regulator genes
Polymorphism
2012
6 Citations (Scopus)
5 Downloads (Pure)

Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus

Nicoll, G., Davidson, S., Shanley, L., Hing, B., Lear, M., McGuffin, P., Ross, R. & MacKenzie, A., 13 Apr 2012, In : The Journal of Biological Chemistry. 287, 16, p. 12828-12834 7 p.

Research output: Contribution to journalArticle

Open Access
File
Cannabinoid Receptors
Spinal Ganglia
Hypothalamus
Hippocampus
Genes
28 Citations (Scopus)
4 Downloads (Pure)

A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity

Hing, B., Davidson, S., Lear, M., Breen, G., Quinn, J., McGuffin, P. & MacKenzie, A., 1 Apr 2012, In : Biological Psychiatry. 71, 7, p. 618-626 9 p.

Research output: Contribution to journalArticle

Open Access
File
Brain-Derived Neurotrophic Factor
Depressive Disorder
Mood Disorders
Alleles
Nucleic Acid Regulatory Sequences
2011
42 Citations (Scopus)

Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism

Davidson, S., Lear, M., Shanley, L., Hing, B., Baizan-Edge, A., Herwig, A., Quinn, J. P., Breen, G., McGuffin, P., Starkey, A., Barrett, P. & Mackenzie, A., Oct 2011, In : Neuropsychopharmacology. 36, 11, p. 2211-2221 11 p.

Research output: Contribution to journalArticle

Galanin
Amygdala
Alcoholism
Hypothalamus
Single Nucleotide Polymorphism
14 Citations (Scopus)
4 Downloads (Pure)

Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones

Shanley, L., Lear, M., Davidson, S., Ross, R. A. & MacKenzie, A., 2011, In : Journal of Neuroinflammation. 8, -, 10 p., 10.

Research output: Contribution to journalArticle

Open Access
File
Capsaicin
Sensory Receptor Cells
Substance P
Neurons
Transgenes
2010
162 Citations (Scopus)

Genome-wide association study of major recurrent depression in the U.K. population

Lewis, C. M., Ng, M. Y., Butler, A. W., Cohen-Woods, S., Uher, R., Pirlo, K., Weale, M. E., Schosser, A., Paredes, U. M., Rivera, M., Craddock, N., Owen, M. J., Jones, L., Jones, I., Korszun, A., Aitchison, K. J., Shi, J., Quinn, J. P., MacKenzie, A., Vollenweider, P. & 13 othersWaeber, G., Heath, S., Lathrop, M., Muglia, P., Barnes, M. R., Whittaker, J. C., Tozzi, F., Holsboer, F., Preisig, M., Farmer, A. E., Breen, G., Craig, I. W. & McGuffin, P., 1 Jun 2010, In : American Journal of Psychiatry. 167, 8, p. 949-957 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Case-Control Studies
Genome
Chromosomes, Human, Pair 3
Gene Frequency
13 Citations (Scopus)

Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

Shanley, L., Davidson, S., Lear, M., Thotakura, A. K., McEwan, I. J., Ross, R. A. & Mackenzie, A., 2010, In : Neuro-Signals. 18, 3, p. 173-185 13 p.

Research output: Contribution to journalArticle

Internal-External Control
Mitogen-Activated Protein Kinase Kinases
Sensory Receptor Cells
Substance P
Genomics
2009
18 Citations (Scopus)
7 Downloads (Pure)
Open Access
File
Intergenic DNA
Human Genome
Single Nucleotide Polymorphism
Computing Methodologies
Genome
2008
12 Citations (Scopus)

Prediction and characterisation of a highly conserved, remote and cAMP responsive enhancer that regulates Msx1 gene expression in cardiac neural crest and outflow tract

Miller, K. A., Davidson, S., Liaros, A., Barrow, J., Lear, M., Heine, D., Hoppler, S. & MacKenzie, A., 15 May 2008, In : Developmental Biology. 317, 2, p. 686-694 9 p.

Research output: Contribution to journalArticle

2007
26 Citations (Scopus)

A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells

Miller, K. A., Barrow, J., Collinson, J. M., Davidson, S., Lear, M., Hill, R. E. & MacKenzie, A., 15 Nov 2007, In : Developmental Biology. 311, 2, p. 665-678 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Generation of a transgenic model to address regulation and function of the human neurokinin 1 receptor (NK1R)

Vasiliou, A. S., MacKenzie, A., Morris, R., McLaughlin, L., Bubb, V. J., Haddley, K. & Quinn, J. P., Aug 2007, In : Neuropeptides. 41, 4, p. 195-205 11 p.

Research output: Contribution to journalArticle

2006
40 Citations (Scopus)

Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice

Lang, B., Song, B., Davidson, W., MacKenzie, A., Smith, N., McCaig, C. D., Harmar, A. J. & Shen, S., 3 Jul 2006, In : The Journal of Clinical Investigation. 116, 7, p. 1924-1934 11 p.

Research output: Contribution to journalArticle

Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Hydrocephalus
Cilia
Subcommissural Organ
G-Protein-Coupled Receptors
2005

Purification and characterisation of a population of EGFP- expressing cells from the developing pancreas of a neurogenin3/EGFP transgenic mouse.

Barrow, J., Bernardo, A., Blaylock, M., Duncan, L., MacKenzie, A., McCreath, K., Kind, A. J., Schneike, A., Colman, A., Hart, A. W. & Docherty, K., 2005, In : Organogenesis. 2, p. 22-27 5 p.

Research output: Contribution to journalArticle

2004
22 Citations (Scopus)

Is there a functional link between gene interdigitation and multi-species conservation of synteny blocks?

MacKenzie, A., Miller, K. A. & Collinson, J. M., Nov 2004, In : BioEssays. 26, 11, p. 1217-1224 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Post-genomic approaches to exploring neuropeptide gene mis-expression in disease

MacKenzie, A. & Quinn, J., Feb 2004, In : Neuropeptides. 38, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

2003
47 Citations (Scopus)

Tachykinin expression in cartilage and function in human articular chondrocyte mechanotransduction

Millward-Sadler, S. J., MacKenzie, A., Wright, M. O., Lee, H. S., Elliott, K., Gerrard, L., Fiskerstrand, C. E., Salter, D. M. & Quinn, J. P., Jan 2003, In : Arthritis & Rheumatism. 48, 1, p. 146-156 10 p.

Research output: Contribution to journalArticle

2000
17 Citations (Scopus)
165 Downloads (Pure)
Open Access
File
Central Nervous System
Gene Expression
Genes
Rodentia
Human Artificial Chromosomes
1999
303 Citations (Scopus)
1 Downloads (Pure)
Serotonin Plasma Membrane Transport Proteins
Rhombencephalon
Mood Disorders
Introns
Minisatellite Repeats
1997
35 Citations (Scopus)

Two enhancer domains control early aspects of the complex expression pattern of Msx1

MacKenzie, A., Purdie, L., Davidson, D., Collinson, M. & Hill, R. E., Feb 1997, In : Mechanisms of Development. 62, 1, p. 29-40 12 p.

Research output: Contribution to journalArticle

Nasal Mucosa
Epiphyses
Lac Operon
DNA
Mesoderm
1992
254 Citations (Scopus)

Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape.

MacKenzie, A., Ferguson, M. & Sharpe, P. T., 1992, In : Development. 115, 2, p. 403-420 18 p.

Research output: Contribution to journalArticle

Homeobox Genes
Tooth
Embryonic Structures
Dental Enamel
Epithelium
1991
132 Citations (Scopus)

Hox-7 expression during murine craniofacial development

MacKenzie, A., Ferguson, M. & Sharpe, P. T., 1991, In : Development. 113, 2, p. 601-611 11 p., 1685989.

Research output: Contribution to journalArticle

Choroid Plexus
External Ear
Neural Tube
Homeobox Genes
Skull
213 Citations (Scopus)

The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro

MacKenzie, A., Leeming, G., Jowett, A. & Ferguson, M., 1991, In : Development. 111, 2, p. 269-285 17 p., 1680043.

Research output: Contribution to journalArticle

Tooth Germ
Homeobox Genes
Mesoderm
Embryonic Development
Tooth