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Personal profile

Research Overview:

Professor Alison Murray is the Roland Sutton Chair of Radiology at the University of Aberdeen. She is Director of the Aberdeen Biomedical Imaging Centre www.abdn.ac.uk/ims/imaging/   Lilian Sutton Building, University of Aberdeen. This houses the 3T research magnetic resonance imaging (MRI) scanner. Research MRI facilities are located within the acute NHS hospital and are immediately adjacent to the John Mallard Positron Emission Tomography (PET) Centre and the NHS Department of Nuclear Medicine, facilitating combined studies of brain structure and function.

She leads clinical brain imaging research in structural and functional brain imaging correlates of cognitive ageing and dementia and recent work includes MRI in the Aberdeen 1936 Birth Cohort, and MRI, regional cerebral blood flow SPECT and FDG PET in clinical trials of novel Tau Aggregation Inhibitor therapies in Alzheimer's disease.  Particular interests are the relative cotributions of vascular risk factors and subclinical Alzheimer's disease to cognitve ageing and contributors to conitive researve and resilience against dementia.  She is also involved in brain imaging research in other neurodegenerative and neurodevelopmental diseases, utilising quantitative assessment of brain volumes, disease burden and function. 

She has extensive clinical experience of brain imaging in dementia, being responsible for over 500 nuclear medicine brain regional cerebral blood flow SPECT studies per annum, receptor studies in movement disorder and, previously with colleagues in Nuclear Medicine, development of national clinical positron emission service across Scotland.

She is a founding member and executive member of the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) www.sinapse.ac.uk  a successful brain imaging pooling initiative funded by the Scottish Funding Council and participating universities to develop state of the art brain imaging research training and resources across Scotland.

Research Keywords:

medicine; neuroradiology; normal cognitive ageing; dementia

Qualifications:

MB ChB (Hons), MRCP, FRCR, FRCP, PhD

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Brain Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Dementia Medicine & Life Sciences
Aptitude Medicine & Life Sciences
Magnetic Resonance Imaging Medicine & Life Sciences
Cognition Medicine & Life Sciences
Parturition Medicine & Life Sciences
Scotland Medicine & Life Sciences

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Research Output 1992 2019

A meta-analysis of genome-wide association studies of epigenetic age acceleration

McCartney, D. L., Zhang, F., Hillary, R. F., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Boutin, T. S., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Hayward, C., Evans, K. L., Chandra, T., Deary, I. J., McIntosh, A. M., Yang, J., Visscher, P. M. & 2 others, McRae, A. F. & Marioni, R. E., 6 Nov 2019, (Accepted/In press) In : PLoS Genetics.

Research output: Contribution to journalArticle

6 Downloads (Pure)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O. K. L., Zhang, Q., McRae, A. F., Walker, R. M., Morris, S. W., Redmond, P., Campbell, A., Murray, A. D., Porteous, D. J., Evans, K. L., McIntosh, A. M., Deary, I. J. & Marioni, R. E., 6 Mar 2019, In : International Journal of Obesity. 43, p. 1795-1802 8 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Body Mass Index
Parturition
Health

Associations of autozygosity with a broad range of human phenotypes

Murray, A. D., Clark, D. W., Yukinori, O., Kristjan H S, M., Mason, D., Pirastu, N. N. & consortium, ROH., 31 Oct 2019, In : Nature Communications. 10, 4957.

Research output: Contribution to journalArticle

Open Access
File
phenotype
Phenotype
Inbreeding
social factors
fertility

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

Habota, T., Sandu, A-L., Waiter, G. D., McNeil, C. J., Steele, J. D., Macfarlane, J. A., Whalley, H. C., Valentine, R., Younie, D., Crouch, N., Hawkins, E. L., Hirose, Y., Romaniuk, L., Milburn, K., Buchan, G., Coupar, T., Stirling, M., Baljit, J., MacLennan, B., Priba, L. & 20 others, Harris, M. A., Hafferty, J. D., Adams, M. J., Campbell, A. I., MacIntyre, D. J., Pattie, A., Murphy, L., Reynolds, R. M., Elliot, R., Penton-Voak, I. S., Munafò, M. R., Evans, K. L., Seckl, J. R., Wardlaw, J. M., Lawrie, S. M., Haley, C. S., Porteous, D. J., Deary, I. J., Murray, A. D. & McIntosh, A. M., 13 Nov 2019, (Accepted/In press) In : Wellcome open research.

Research output: Contribution to journalArticle

Neuroimaging
Scotland
Health
Depression
Brain

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K. A., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 21 Oct 2019, In : Journal of Alzheimer's Disease.

Research output: Contribution to journalArticle

Open Access
Atrophy
Alzheimer Disease
Brain
Therapeutics
Pharmaceutical Preparations

Prizes

Fellow of the Royal Society of Edinburgh

Alison Dorothy Murray (Recipient), 26 Feb 2018

Prize: Election to learned society

Press / Media

AI could be our radiologists of the future, amid a healthcare staff crisis

Alison Dorothy Murray

8/08/19

1 Media contribution

Press/Media: Articles in 'The Conversation'

Equipment

Radiochemistry
Technology
Cyclotrons
Diagnostic Imaging
Research