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Research Output 1992 2019

2019
6 Downloads (Pure)

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O. K. L., Zhang, Q., McRae, A. F., Walker, R. M., Morris, S. W., Redmond, P., Campbell, A., Murray, A. D., Porteous, D. J., Evans, K. L., McIntosh, A. M., Deary, I. J. & Marioni, R. E., 6 Mar 2019, In : International Journal of Obesity. 43, p. 1795-1802 8 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Body Mass Index
Parturition
Health
6 Downloads (Pure)
Open Access
File
Aging of materials
Brain
Neurodegenerative diseases
Complex networks
Magnetic resonance

Differences in brain functional connectivity networks between cognitive decliners and sustainers

Sandu-Giuraniuc, A-L., Waiter, G. D., Habota, T., Younie, D. A., McNeil, C. J., McIntosh, A. M. & Murray, A. D., 21 Jun 2019.

Research output: Contribution to conferenceAbstract

Functional and structural magnetic resonance imaging correlates of fatigue in patients with rheumatoid arthritis

Basu, N., Kaplan, C. M., Ichesco, E., Larkin, T., Schrepf, A., Murray, A. D., Clauw, D. J., Waiter, G. D. & Harris, R. E., 1 Oct 2019, In : Rheumatology. 58, 10, p. 1822-1830 9 p.

Research output: Contribution to journalArticle

Fatigue
Rheumatoid Arthritis
Magnetic Resonance Imaging
Brain
Putamen
6 Downloads (Pure)

Imprinting methylation in SNRPN and MEST1 in adult blood predicts cognitive ability

Lorgen-Ritchie, M., Murray, A. D., Ferguson-Smith, A. C., Richards, M., Horgan, G. W., Phillips, L. H., Hoad, G., Gall, I., Harrison, K., McNeill, G., Ito, M. & Haggarty, P., 1 Feb 2019, In : PloS ONE. 14, 2, 15 p., e0211799.

Research output: Contribution to journalArticle

Open Access
File
snRNP Core Proteins
Aptitude
Methylation
genomic imprinting
methylation

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., He, J., Fan, D., Fowdar, J., Kennedy, M., Pitcher, T., Pearson, J., Halliday, G., Kwok, J. B., Hickie, I., Lewis, S., Anderson, T., Silburn, P. A., Mellick, G. D., Harris, S. E. & 13 others, Redmond, P., Murray, A. D., Porteous, D. J., Haley, C. S., Evans, K. L., McIntosh, A. M., Yang, J., Gratten, J., Marioni, R. E., Wray, N. R., Deary, I. J., McRae, A. F. & Visscher, P. M., 23 Aug 2019, In : Genome Research. 11, 54.

Research output: Contribution to journalArticle

Open Access
File
Epigenomics
Sample Size
DNA Methylation
Mortality
Parturition

Inflammation is associated with pro-nociceptive brain connections in rheumatoid arthritis patients with concomitant fibromyalgia

Kaplan, C. M., Schrepf, A., Ichesco, E., Larkin, T., Harte, S. E., Harris, R. E., Murray, A. D., Waiter, G. D., Clauw, D. J. & Basu, N., 5 Aug 2019, In : Arthritis & Rheumatology.

Research output: Contribution to journalArticle

Fibromyalgia
Rheumatoid Arthritis
Inflammation
Brain
Parietal Lobe
3 Downloads (Pure)

Insulin resistance: Genetic associations with depression and cognition in population based cohorts

Frangou, S., Shirali, M., Adams, M. J., Howard, D. M., Gibson, J., Hall, L. S., Smith, B. H., Padmanabhan, S., Murray, A. D., Porteous, D. J., Haley, C. S., Deary, I. J., Clarke, T-K. & McIntosh, A. M., Jun 2019, In : Experimental Neurology. 316, p. 20-26 7 p.

Research output: Contribution to journalArticle

Open Access
File
Cognition
Insulin Resistance
Depression
Population
Intelligence
Open Access
Entropy
Magnetic Resonance Imaging
Brain
Somatosensory Cortex
Head
4 Citations (Scopus)

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies novel loci associated with serum lipids

Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., Schwander, K., Chasman, D. I., Lim, E., Deng, X., Guo, X., Liu, J., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F. & 31 others, Richard, M. A., Noordam, R., Baker, J., Chen, G., Aschard, H., Bartz, T. M., Ding, J., Dorajoo, R., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Zhao, W., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Evangelou, E., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F-C., Hung, Y-J., Murray, A. D. & COGENT-Kidney Consortium, Apr 2019, In : Nature Genetics. 51, 4, p. 636-648 13 p.

Research output: Contribution to journalArticle

Open Access
File
Smoking
Genome
Lipids
Serum
Genes
3 Citations (Scopus)
3 Downloads (Pure)

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Sung, Y. J., Schwander, K., Winkler, T. W., Jakupović, H., Chasman, D. I., Manning, A., Ntalla, I., Aschard, H., Brown, M. R., de las Fuentes, L., Franceschini, N., Guo, X., Vojinovic, D., Aslibekyan, S., Feitosa, M. F., Kho, M., Musani, S. K. & 218 others, Richard, M., Wang, H., Wang, Z., Bartz, T. M., Bielak, L. F., Campbell, A., Dorajoo, R., Fisher, V., Hartwig, F. P., Horimoto, A. R. V. R., Li, C., Lohman, K. K., Marten, J., Sim, X., Smith, A. V., Tajuddin, S. M., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Evangelou, E., Gao, C., Graff, M., Harris, S. E., He, M., Hsu, F-C., Jackson, A. U., Zhao, J. H., Kraja, A. T., Kühnel, B., Laguzzi, F., Lyytikäinen, L-P., Nolte, I. M., Rauramaa, R., Riaz, M., Robino, A., Rueedi, R., Stringham, H. M., Takeuchi, F., van der Most, P. J., Varga, T. V., Verweij, N., Ware, E. B., Wen, W., Li, X., Yanek, L. R., Amin, N., Arnett, D. K., Boerwinkle, E., Brumat, M., Cade, B., Canouil, M., Chen, Y-D. I., Concas, M. P., Connell, J., de Mutsert, R., de Silva, H. J., de Vries, P. S., Demirkan, A., Ding, J., Eaton, C. B., Faul, J. D., Friedlander, Y., Gabriel, K. P., Ghanbari, M., Giulianini, F., Gu, C. C., Gu, D., Harris, T. B., He, J., Heikkinen, S., Heng, C-K., Hunt, S. C., Ikram, M. A., Jonas, J. B., Koh, W-P., Komulainen, P., Krieger, J. E., Kritchevsky, S. B., Kutalik, Z., Kuusisto, J., Langefeld, C. D., Langenberg, C., Launer, L. J., Leander, K., Lemaitre, R. N., Lewis, C. E., Liang, J., Alizadeh, B. Z., Boezen, H. M., Franke, L., Navis, G., Rots, M., Swertz, M., Wolffenbuttel, B. H. R., Wijmenga, C., Liu, J., Mägi, R., Manichaikul, A., Meitinger, T., Metspalu, A., Milaneschi, Y., Mohlke, K. L., Mosley, T. H., Murray, A. D., Nalls, M. A., Nang, E-E. K., Nelson, C. P., Nona, S., Norris, J. M., Nwuba, C. V., O’Connell, J., Palmer, N. D., Papanicolau, G. J., Pazoki, R., Pedersen, N. L., Peters, A., Peyser, P. A., Polasek, O., Porteous, D. J., Poveda, A., Raitakari, O. T., Rich, S. S., Risch, N., Robinson, J. G., Rose, L. M., Rudan, I., Schreiner, P. J., Scott, R. A., Sidney, S. S., Sims, M., Smith, J. A., Snieder, H., Sofer, T., Starr, J. M., Sternfeld, B., Strauch, K., Tang, H., Taylor, K. D., Tsai, M. Y., Tuomilehto, J., Uitterlinden, A. G., van der Ende, M. Y., van Heemst, D., Voortman, T., Waldenberger, M., Wennberg, P., Wilson, G., Xiang, Y-B., Yao, J., Yu, C., Yuan, J-M., Zhao, W., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., de Faire, U., Deary, I. J., Elliott, P., Esko, T., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Kato, N., Laakso, M., Lakka, T. A., Lehtimäki, T., Magnusson, P. K. E., Oldehinkel, A. J., Penninx, B. W. J. H., Samani, N. J., Shu, X-O., van der Harst, P., Van Vliet-Ostaptchouk, J. V., Vollenweider, P., Wagenknecht, L. E., Wang, Y. X., Wareham, N. J., Weir, D. R., Wu, T., Zheng, W., Zhu, X., Evans, M. K., Franks, P. W., Gudnason, V., Hayward, C., Horta, B. L., Kelly, T. N., Liu, Y., North, K. E., Pereira, A. C., Ridker, P. M., Tai, E. S., van Dam, R. M., Fox, E. R., Kardia, S. L. R., Liu, C-T., Mook-Kanamori, D. O., Province, M. A., Redline, S., van Duijn, C. M., Rotter, J. I., Kooperberg, C. B., Gauderman, W. J., Psaty, B. M., Rice, K., Munroe, P. B., Fornage, M., Cupples, L. A., Rotimi, C. N., Morrison, A. C., Rao, D. C., Loos, R. J. F. & Study, L. C., 22 Jan 2019, In : Nature Communications. 10, 1, 11 p., 376.

Research output: Contribution to journalArticle

Open Access
File
loci
blood
cholesterol
lipids
Blood
11 Citations (Scopus)

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Understanding Society Scientific Group, Mar 2019, In : Nature Genetics. 51, 3, p. 481-493 13 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Lung
Genome-Wide Association Study
Mortality
Pharmaceutical Preparations
3 Downloads (Pure)
Open Access
File
Polypharmacy
Cohort Studies
Linear regression
Education
Health
2 Citations (Scopus)
5 Downloads (Pure)

The Neurobiology of Personal Control During Reward Learning and Its Relationship to Mood

Romaniuk, L., Sandu-Giuraniuc, A-L., Waiter, G. D., McNeil, C. J., Xueyi, S., Harris, M. A., Macfarlane, J. A., Lawrie, S. M., Deary, I. J., Murray, A. D., Delgardo, M. R., Steele, J. D., McIntosh, A. M. & Whalley, H. C., Feb 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 2, p. 190-199 10 p.

Research output: Contribution to journalArticle

Open Access
File
Neurobiology
Reward
Learning
Psychiatry
Anhedonia
Blood Vessels
Brain
Cerebral Small Vessel Diseases
White Matter
Research
2018
10 Citations (Scopus)

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Sung, Y. J., Winkler, T. W., de Las Fuentes, L., Bentley, A. R., Brown, M. R., Kraja, A. T., Schwander, K., Ntalla, I., Guo, X., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Marten, J., Musani, S. K., Li, C., Feitosa, M. F., Kilpeläinen, T. O., Richard, M. A. & 31 others, Noordam, R., Aslibekyan, S., Aschard, H., Bartz, T. M., Dorajoo, R., Liu, Y., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Warren, H. R., Zhao, W., Zhou, Y., Matoba, N., Sofer, T., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Giulianini, F., Goel, A., Harris, S. E., Hartwig, F. P., Horimoto, A. R. V. R., Murray, A. D. & CHARGE Neurology Working Group, 31 Mar 2018, In : American Journal of Human Genetics. 102, 3, p. 375-400 6 p.

Research output: Contribution to journalArticle

Open Access
Smoking
Genome
Blood Pressure
Genome-Wide Association Study
Blood Vessels
12 Citations (Scopus)
9 Downloads (Pure)

A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Schrepf, A., Kaplan, C. M., Ichesco, E., Larkin, T., Harte, S., Harris, R. E., Murray, A. D., Waiter, G. D., Clauw, D. J. & Basu, N., 8 Jun 2018, In : Nature Communications. 9, p. 1-11 11 p., 2243.

Research output: Contribution to journalArticle

Open Access
File
arthritis
Magnetic resonance imaging
Parietal Lobe
brain
Brain
8 Citations (Scopus)
10 Downloads (Pure)

Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): a questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS)

Navrady, L. B., Wolters, M. K., MacIntyre, D. J., Clarke, T-K., Campbell, A. I., Murray, A. D., Evans, K. L., Seckl, J., Haley, C., Milburn, K., Wardlaw, J. M., Porteous, D. J., Deary, I. J. & McIntosh, A. M., Feb 2018, In : International Journal of Epidemiology. 47, 1, p. 13-14G 2 p.

Research output: Contribution to journalArticle

Open Access
File

Cortical complexity predicts IQ

Sandu-Giuraniuc, A-L., Habota, T., Waiter, G. D., McNeil, C. J., Hannaford, E., Clark, H., McIntosh, A. M. & Murray, A. D., 25 Jun 2018.

Research output: Contribution to conferenceAbstract

5 Citations (Scopus)
4 Downloads (Pure)

Epigenetic prediction of complex traits and death

McCartney, D. L., Hillary, R. F., Stevenson, A. J., Ritchie, S. J., Walker, R. M., Zhang, Q., Morris, S. W., Bermingham, M. L., Campbell, A., Murray, A. D., Whalley, H. C., Gale, C. R., Porteous, D. J., Haley, C. S., McRae, A. F., Wray, N. R., Visscher, P. M., McIntosh, A. M., Evans, K. L., Deary, I. J. & 1 others, Marioni, R. E., 27 Sep 2018, In : Genome Biology. 19, 136.

Research output: Contribution to journalArticle

Open Access
File
methylation
DNA methylation
DNA Methylation
Epigenomics
epigenetics
4 Downloads (Pure)

Epigenetic signatures of starting and stopping smoking

McCartney, D. L., Stevenson, A. J., Hillary, R. F., Walker, R. M., Bermingham, M. L., Morris, S. W., Clarke, T. K., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Visscher, P. M., McIntosh, A. M., Evans, K. L., Deary, I. J. & Marioni, R. E., Nov 2018, In : EBioMedicine. 37, p. 214-220 7 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Epigenomics
Smoking
Tobacco Products
Smoking Cessation
2 Citations (Scopus)
8 Downloads (Pure)

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

Bihlmeyer, N. A., Brody, J. A., Smith, A. V., Warren, H. R., Lin, H., Isaacs, A., Liu, C-T., Marten, J., Radmanesh, F., Hall, L. M., Grarup, N., Mei, H., Müller-Nurasyid, M., Huffman, J. E., Verweij, N., Guo, X., Yao, J., Li-Gao, R., van den Berg, M., Weiss, S. & 80 others, Prins, B. P., van Setten, J., Haessler, J., Lyytikäinen, L-P., Li, M., Alonso, A., Soliman, E. Z., Bis, J. C., Austin, T., Chen, Y-D. I., Psaty, B. M., Harrris, T. B., Launer, L. J., Padmanabhan, S., Dominiczak, A., Huang, P. L., Xie, Z., Ellinor, P. T., Kors, J. A., Campbell, A., Murray, A. D., Nelson, C. P., Tobin, M. D., Bork-Jensen, J., Hansen, T., Pedersen, O., Linneberg, A., Sinner, M. F., Peters, A., Waldenberger, M., Meitinger, T., Perz, S., Kolcic, I., Rudan, I., de Boer, R. A., van der Meer, P., Lin, H. J., Taylor, K. D., de Mutsert, R., Trompet, S., Jukema, J. W., Maan, A. C., Stricker, B. H. C., Rivadeneira, F., Uitterlinden, A., Völker, U., Homuth, G., Völzke, H., Felix, S. B., Mangino, M., Spector, T. D., Bots, M. L., Perez, M., Raitakari, O. T., Kähönen, M., Mononen, N., Gudnason, V., Munroe, P. B., Lubitz, S. A., van Duijn, C. M., Newton-Cheh, C. H., Hayward, C., Rosand, J., Samani, N. J., Kanters, J. K., Wilson, J. G., Kääb, S., Polasek, O., van der Harst, P., Heckbert, S. R., Rotter, J. I., Mook-Kanamori, D. O., Eijgelsheim, M., Dörr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimäki, T., Arking, D. E. & Sotoodehnia, N., Jan 2018, In : Circulation. Genomic and precision medicine. 11, 1, e001758.

Research output: Contribution to journalArticle

Open Access
File
Sudden Cardiac Death
Statistical Models
Hispanic Americans
Muscle Cells
Genes
2 Citations (Scopus)
9 Downloads (Pure)
Open Access
File
Dementia
Biomarkers
Magnetic Resonance Imaging
Pathology
Blood Pressure
8 Citations (Scopus)
5 Downloads (Pure)

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease

McCartney, D. L., Stevenson, A. J., Walker, R. M., Gibson, J., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., McIntosh, A. M., Evans, K. L., Deary, I. J. & Marioni, R. E., 2018, In : Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 10, p. 429-437 9 p.

Research output: Contribution to journalArticle

Open Access
File
Age Factors
DNA Methylation
Alzheimer Disease
Epigenomics
Cognitive Reserve

Klotho gene polymorphism, brain structure and cognition in early-life development

De Vries, C. F., Staff, R., Noble, K. G., Muetzel, R. L., Vernooij, M. W., White, T., Waiter, G. D. & Murray, A. D., 5 Nov 2018, In : Brain Imaging and Behavior. 13 p.

Research output: Contribution to journalArticle

Open Access
Cognition
Brain
Heterozygote
Genes
Episodic Memory
13 Citations (Scopus)
5 Downloads (Pure)

Life-course determinants of cognitive reserve (CR) in cognitive aging and dementia: a systematic literature review

Chapko, D., McCormack, R., Black, C., Staff, R. & Murray, A., 2018, In : Aging & Mental Health. 22, 8, p. 915-926 12 p.

Research output: Contribution to journalArticle

Open Access
File
Cognitive Reserve
Dementia
Occupations
Cognition
Education
4 Downloads (Pure)

Neural indicators of fatigue in chronic diseases: A systematic review of MRI studies

Goni, M., Basu, N., Murray, A. D. & Waiter, G. D., 2018, In : Diagnostics. 8, 3, 24 p., 42.

Research output: Contribution to journalArticle

Open Access
File
Magnetic resonance imaging
Fatigue
Chronic Disease
Magnetic Resonance Imaging
Fatigue of materials
15 Citations (Scopus)
7 Downloads (Pure)

Neurobiologic Features of Fibromyalgia Are Also Present Among Rheumatoid Arthritis Patients

Basu, N., Kaplan, C. M., Ichesco, E., Larkin, T., Harris, R. E., Murray, A., Waiter, G. & Clauw, D. J., Jul 2018, In : Arthritis & Rheumatology. 70, 7, p. 1000-1007 8 p.

Research output: Contribution to journalArticle

Open Access
File
Fibromyalgia
Rheumatoid Arthritis
Brain
Magnetic Resonance Imaging
Pain
42 Citations (Scopus)

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., Guo, X., Lu, Y., Li, M., Jensen, R. A., Hu, Y., Huo, S., Lohman, K. K., Zhang, W., Cook, J. P., Prins, B. P. & 220 others, Flannick, J., Grarup, N., Trubetskoy, V. V., Kravic, J., Kim, Y. J., Rybin, D. V., Yaghootkar, H., Müller-Nurasyid, M., Meidtner, K., Li-Gao, R., Varga, T. V., Marten, J., Li, J., Smith, A. V., An, P., Ligthart, S., Gustafsson, S., Malerba, G., Demirkan, A., Tajes, J. F., Steinthorsdottir, V., Wuttke, M., Lecoeur, C., Preuss, M., Bielak, L. F., Graff, M., Highland, H. M., Justice, A. E., Liu, D. J., Marouli, E., Peloso, G. M., Warren, H. R., Afaq, S., Afzal, S., Ahlqvist, E., Almgren, P., Amin, N., Bang, L. B., Bertoni, A. G., Bombieri, C., Bork-Jensen, J., Brandslund, I., Brody, J. A., Burtt, N. P., Canouil, M., Chen, Y-D. I., Cho, Y. S., Christensen, C., Eastwood, S. V., Eckardt, K-U., Fischer, K., Gambaro, G., Giedraitis, V., Grove, M. L., de Haan, H. G., Hackinger, S., Hai, Y., Han, S., Tybjærg-Hansen, A., Hivert, M-F., Isomaa, B., Jäger, S., Jørgensen, M. E., Jørgensen, T., Käräjämäki, A., Kim, B-J., Kim, S. S., Koistinen, H. A., Kovacs, P., Kriebel, J., Kronenberg, F., Läll, K., Lange, L. A., Lee, J-J., Lehne, B., Li, H., Lin, K-H., Linneberg, A., Liu, C-T., Liu, J., Loh, M., Mägi, R., Mamakou, V., McKean-Cowdin, R., Nadkarni, G., Neville, M., Nielsen, S. F., Ntalla, I., Peyser, P. A., Rathmann, W., Rice, K., Rich, S. S., Rode, L., Rolandsson, O., Schönherr, S., Selvin, E., Small, K. S., Stančáková, A., Surendran, P., Taylor, K. D., Teslovich, T. M., Thorand, B., Thorleifsson, G., Tin, A., Tönjes, A., Varbo, A., Witte, D. R., Wood, A. R., Yajnik, P., Yao, J., Yengo, L., Young, R., Amouyel, P., Boeing, H., Boerwinkle, E., Bottinger, E. P., Chowdhury, R., Collins, F. S., Dedoussis, G., Dehghan, A., Deloukas, P., Ferrario, M. M., Ferrières, J., Florez, J. C., Frossard, P., Gudnason, V., Harris, T. B., Heckbert, S. R., Howson, J. M. M., Ingelsson, M., Kathiresan, S., Kee, F., Kuusisto, J., Langenberg, C., Launer, L. J., Lindgren, C. M., Männistö, S., Meitinger, T., Melander, O., Mohlke, K. L., Moitry, M., Morris, A. D., Murray, A. D., de Mutsert, R., Orho-Melander, M., Owen, K. R., Perola, M., Peters, A., Province, M. A., Rasheed, A., Ridker, P. M., Rivadineira, F., Rosendaal, F. R., Rosengren, A. H., Salomaa, V., Sheu, W. H-H., Sladek, R., Smith, B. H., Strauch, K., Uitterlinden, A. G., Varma, R., Willer, C. J., Blüher, M., Butterworth, A. S., Chambers, J. C., Chasman, D. I., Danesh, J., van Duijn, C., Dupuis, J., Franco, O. H., Franks, P. W., Froguel, P., Grallert, H., Groop, L., Han, B-G., Hansen, T., Hattersley, A. T., Hayward, C., Ingelsson, E., Kardia, S. L. R., Karpe, F., Kooner, J. S., Köttgen, A., Kuulasmaa, K., Laakso, M., Lin, X., Lind, L., Liu, Y., Loos, R. J. F., Marchini, J., Metspalu, A., Mook-Kanamori, D., Nordestgaard, B. G., Palmer, C. N. A., Pankow, J. S., Pedersen, O., Psaty, B. M., Rauramaa, R., Sattar, N., Schulze, M. B., Soranzo, N., Spector, T. D., Stefansson, K., Stumvoll, M., Thorsteinsdottir, U., Tuomi, T., Tuomilehto, J., Wareham, N. J., Wilson, J. G., Zeggini, E., Scott, R. A., Barroso, I., Frayling, T. M., Goodarzi, M. O., Meigs, J. B., Boehnke, M., Saleheen, D., Morris, A. P., Rotter, J. I. & McCarthy, M. I., 30 Apr 2018, In : Nature Genetics. 50, 4, p. 559-571 13 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Causality
Odds Ratio
Genome
Therapeutics
41 Citations (Scopus)
6 Downloads (Pure)

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., DeRosse, P., Djurovic, S. & 202 others, Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., van der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S-C., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L-P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Dan Rujescu, Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T., Deary, I. J. & Lill, C. M., 29 May 2018, In : Nature Communications. 9, 1, 2098.

Research output: Contribution to journalArticle

Open Access
File
Genetic Loci
loci
Cognition
Genes
genes
33 Citations (Scopus)

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

23andMe Research Team, 31 Dec 2018, In : Nature Neuroscience. 21, 12, p. 1656-1669 14 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Alcoholism
Psychiatry
Genome
Drinking Behavior
2017
16 Citations (Scopus)
12 Downloads (Pure)

A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)

Job, D. E., Dickie, D. A., Rodriguez, D., Robson, A., Pernet, C., Bastin, M. E., Boardman, J. P., Murray, A. D., Ahearn, T., Waiter, G. D., Staff, R. T., Deary, I. J., Shenkin, S. D. & Wardlaw, J. M., 1 Jan 2017, In : Neuroimage. 144, Part B, p. 299–304 6 p.

Research output: Contribution to journalArticle

Open Access
File
Neuroimaging
Brain
Healthy Volunteers
Diffusion Tensor Imaging
Databases
6 Citations (Scopus)
6 Downloads (Pure)
Open Access
File
Atrophy
Alzheimer Disease
Parturition
Neuroimaging
ROC Curve
6 Downloads (Pure)

A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly

Khezrian, M., Myint, P. K., McNeil, C. J. & Murray, A. D., 16 Nov 2017, In : Geriatrics. 2, 4, 36.

Research output: Contribution to journalArticle

Open Access
File
Morbidity
Phenotype
MEDLINE
Cognitive Dysfunction
6 Citations (Scopus)
5 Downloads (Pure)

Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data

Gibson, J., Russ, T. C., Adams, M. J., Clarke, T. K., Howard, D. M., Hall, L. S., Fernandez-Pujals, A. M., Wigmore, E. M., Hayward, C., Davies, G., Murray, A. D., Smith, B. H., Porteous, D. J., Deary, I. J. & McIntosh, A. M., 2017, In : Translational Psychiatry. 7, e1094.

Research output: Contribution to journalArticle

Open Access
File
Major Depressive Disorder
Alzheimer Disease
Genome
Depression
Genomics
Septum of Brain
Prefrontal Cortex
Alzheimer Disease
Atrophy
Septal Nuclei
7 Citations (Scopus)
4 Downloads (Pure)

Discovery of novel heart rate-associated loci using the Exome Chip

van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Müller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikäinen, L-P. & 101 others, Hall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S-J., Kähönen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., Macfarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orrú, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A., Vaartjes, I., Hoes, A. W., van der Meer, P., Völker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., van Duijn, C. M., Zeggini, E., Wouter Jukema, J., Asselbergs, F. W., Samani, N. J., Lehtimäki, T., Gudnason, V., Wilson, J., Lubitz, S. A., Kääb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Dörr, M., O'Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. & Munroe, P. B., 15 Jun 2017, In : Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.

Research output: Contribution to journalArticle

Open Access
File
Exome
Heart Rate
Genes
Nerve Tissue
Fetal Heart

Early Brain Development and Cognitive Ageing: A Global Challenge

Chapko, D., Sandu-Giuraniuc, A-L., McNeil, C. J. & Murray, A. D., 12 Jun 2017, In : Neuro Central.

Research output: Contribution to journalComment/debate

82 Citations (Scopus)
4 Downloads (Pure)

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)

Clarke, T-K., Adams, M. J., Davies, G., Howard, D. M., Hall, L. S., Padmanabhan, S., Murray, A. D., Smith, B. H., Campbell, A., Hayward, C., Porteous, D. J., Deary, I. J. & McIntosh, A. M., Oct 2017, In : Molecular Psychiatry. 22, 10, p. 1376-1384 9 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Alcohol Drinking
Health
Genes
Single Nucleotide Polymorphism
3 Citations (Scopus)
3 Downloads (Pure)

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

Howard, D. M., Hall, L. S., Hafferty, J. D., Zeng, Y., Adams, M. J., Clarke, T-K., Porteous, D. J., Nagy, R., Hayward, C., Smith, B. H., Murray, A. D., Ryan, N. M., Evans, K. L., Haley, C. S., Deary, I. J., Thomson, P. A. & McIntosh, A. M., 2017, In : Translational Psychiatry. 7, 1263.

Research output: Contribution to journalArticle

Open Access
File
Major Depressive Disorder
Scotland
Haplotypes
Genome
Cognition
7 Citations (Scopus)
4 Downloads (Pure)

Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder

Zeng, Y., Navarro, P., Shirali, M., Howard, D. M., Adams, M. J., Hall, L. S., Clarke, T. K., Thomson, P. A., Smith, B. H., Murray, A., Padmanabhan, S., Hayward, C., Boutin, T., MacIntyre, D. J., Lewis, C. M., Wray, N. R., Mehta, D., Penninx, B. W. J. H., Milaneschi, Y., Baune, B. T. & 20 others, Air, T., Hottenga, J. J., Mbarek, H., Castelao, E., Pistis, G., Schulze, T. G., Streit, F., Forstner, A. J., Byrne, E. M., Martin, N. G., Breen, G., Müller-Myhsok, B., Lucae, S., Kloiber, S., Domenici, E., Deary, I. J., Porteous, D. J., Haley, C. S., McIntosh, A. M. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Sep 2017, In : Biological Psychiatry. 82, 5, p. 312-321 10 p.

Research output: Contribution to journalArticle

Open Access
File
Major Depressive Disorder
Haplotypes
Genome
Single Nucleotide Polymorphism
Genes
2 Citations (Scopus)
5 Downloads (Pure)

Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank

Howard, D. M., Adams, M. J., Clarke, T-K., Wigmore, E. M., Zeng, Y., Hagenaars, S. P., Lyall, D. M., Thomson, P. A., Evans, K. L., Porteous, D. J., Nagy, R., Hayward, C., Haley, C. S., Smith, B. H., Murray, A. D., Batty, G. D., Deary, I. J. & McIntosh, A. M., 2017, In : Wellcome open research. 2, p. 1-13 13 p., 61.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Scotland
Haplotypes
Longitudinal Studies
Genes
4 Citations (Scopus)
11 Downloads (Pure)

Klotho, APOEε4, cognitive ability, brain size, atrophy and survival: A study in the Aberdeen Birth Cohort of 1936

de Vries, C. F., Staff, R. T., Harris, S. E., Chapko, D., Williams, D. S., Reichert, P., Ahearn, T., McNeil, C. J., Whalley, L. J. & Murray, A. D., Jul 2017, In : Neurobiology of Aging. 55, p. 91-98 8 p.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Heterozygote
Atrophy
Parturition
Cognition
7 Downloads (Pure)
Open Access
File
2016

A new biomarker classification system for AD, independent of cognition: Agnosticism is a start

Murray, A. D., 2 Aug 2016, In : Neurology. 87, 5, p. 456-457 2 p.

Research output: Contribution to journalEditorial

Cognition
Alzheimer Disease
Biomarkers
Amyloid
Neurology
7 Citations (Scopus)
9 Downloads (Pure)
Open Access
File
Cognition
cognitive ability
cognition
brain
Aptitude
12 Citations (Scopus)
9 Downloads (Pure)

Cerebral correlates of cognitive reserve

Whalley, L. J., Staff, R. T., Fox, H. C. & Murray, A. D., 30 Jan 2016, In : Psychiatry Research. 247, p. 65-70 6 p.

Research output: Contribution to journalArticle

Open Access
File
Cognitive Reserve
Dementia
Cerebrovascular Disorders
Brain
Pathology