• 1774 Citations
20062020

Research output per year

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Research Output

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells

Karystinou, A., Roelofs, A. J., Neve, A., Cantatore, F. P., Wackerhage, H. & De Bari, C., 30 May 2015, In : Arthritis Research & Therapy. 17, 14 p., 147.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
8 Downloads (Pure)

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells

Coxon, F., Thompson, K., Roelofs, A. J., Ebetino, F. H. & Rogers, M. J., May 2008, In : Bone. 42, 5, p. 848-860 13 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)

The burden of metabolic syndrome on osteoarthritic joints

Dickson, B. M., Roelofs, A. J., Rochford, J. J., Wilson, H. M. & de Bari, C., 16 Dec 2019, In : Arthritis Research & Therapy. 21, 289.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
2 Downloads (Pure)

The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation

Guenther, A., Gordon, S., Tiemann, M., Burger, R., Bakker, F., Green, J. R., Baum, W., Roelofs, A. J., Rogers, M. J. & Gramatzki, M., 1 Jan 2010, In : International Journal of Cancer. 126, 1, p. 239-246 8 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts

Hirbe, A. C., Roelofs, A. J., Floyd, D. H., Deng, H., Becker, S. N., Lanigan, L. G., Apicelli, A. J., Xu, Z., Prior, J. L., Eagleton, M. C., Piwnica-Worms, D., Rogers, M. J. & Weilbaecher, K., May 2009, In : Bone. 44, 5, p. 908-916 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs

Sun, S., Blazewska, K. M., Kashemirov, B. A., Roelofs, A. J., Coxon, F. P., Rogers, M. J., Ebetino, F. H., Mckenna, M. J. & Mckenna, C. E., 13 May 2011, In : Phosphorus, Sulfur and SIlicon and the Related Elements. 186, 4, p. 970-971 2 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth

Moriceau, G., Roelofs, A. J., Brion, R., Redini, F., Ebetino, F. H., Rogers, M. J. & Heymann, D., 1 Feb 2012, In : Cancer. 118, 3, p. 750-760 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Stem Cell-based Therapeutic Strategies for Cartilage Defects and Osteoarthritis

de Bari, C. & Roelofs, A. J., Jun 2018, In : Current Opinion in Pharmacology. 40, p. 74-80 7 p.

Research output: Contribution to journalReview article

Open Access
File
30 Citations (Scopus)
10 Downloads (Pure)

Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells

Roelofs, A. J., Hulley, P. A., Meijer, A., Ebetino, F. H., Russell, R. G. G. & Shipman, C. M., 15 Sep 2006, In : International Journal of Cancer. 119, 6, p. 1254-1261 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

Kania, K., Colella, F., Riemen, A. H. K., Wang, H., Howard, K. A., Aigner, T., Dell'Accio, F., Capellini, T. D., Roelofs, A. J. & de Bari, C., 13 Jan 2020, In : Scientific Reports. 10, 157.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)

Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP

Roelofs, A. J., Jauhiainen, M., Monkkonen, H., Rogers, M. J., Monkkonen, J. & Thompson, K., Jan 2009, In : British Journal of Haematology. 144, 2, p. 245-250 6 p.

Research output: Contribution to journalArticle

Open Access
File
165 Citations (Scopus)
5 Downloads (Pure)

Molecular mechanisms of action of bisphosphonates: current status

Roelofs, A. J., Thompson, K., Gordon, S. A. & Rogers, M. J., 2006, In : Clinical Cancer Research. 12, 20 PT 2, p. 6222S-6230S 9 p.

Research output: Contribution to journalReview article

389 Citations (Scopus)

Mesenchymal stem cells for management of rheumatoid arthritis: immune modulation, repair or both?

Ansboro, S., Roelofs, A. J. & de Bari, C., 1 Mar 2017, In : Current Opinion in Rheumatology. 29, 2, p. 201-207 7 p.

Research output: Contribution to journalReview article

Open Access
File
39 Citations (Scopus)
7 Downloads (Pure)

Joint morphogenetic cells in the adult mammalian synovium

Roelofs, A. J., Zupan, J., Riemen, A. H. K., Kania, K., Ansboro, S., White, N., Clark, S. M. & De Bari, C., 16 May 2017, In : Nature Communications. 8, 15040 .

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
9 Downloads (Pure)

In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum

Cherry, H. M., Roelofs, A. J., Kurth, T. & De Bari, C., 11 Mar 2014, In : European Cells & Materials. 27, p. 185-195 11 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
6 Downloads (Pure)

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo

Roelofs, A. J., Stewart, C. A., Sun, S., Blazewska, K. M., Kashemirov, B. A., McKenna, C. E., Russell, R. G. G., Rogers, M. J., Lundy, M. W., Ebetino, F. H. & Coxon, F., Apr 2012, In : Journal of Bone and Mineral Research. 27, 4, p. 835-847 13 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Immunostaining of Skeletal Tissues

Roelofs, A. J. & De Bari, C., 8 Feb 2019, In : Methods in molecular biology (Clifton, N.J.). 1914, p. 437-450 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo

Roelofs, A. J., Coxon, F., Ebetino, F. H., Lundy, M. W., Henneman, Z. J., Nancollas, G. H., Sun, S., Blazewska, K. M., Lynn F Bala, J., Kashemirov, B. A., Khalid, A. B., McKenna, C. E. & Rogers, M. J., Mar 2010, In : Journal of Bone and Mineral Research. 25, 3, p. 606-616 11 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Fluorescently labeled risedronate and related analogues: “Magic Linker” Synthesis

Kashemirov, B. A., Bala, J. L. F., Chen, X., Ebetino, F. H., Xia, Z., Russell, R. G. G., Coxon, F., Roelofs, A. J., Rogers, M. J. & McKenna, C. E., 1 Dec 2008, In : Bioconjugate Chemistry. 19, 12, p. 2308-2310 3 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Sun, S., Błażewska, K. M., Kadina, A. P., Kashemirov, B. A., Duan, X., Triffitt, J. T., Dunford, J. E., Russell, R. G. G., Ebetino, F. H., Roelofs, A. J., Coxon, F., Lundy, M. W. & McKenna, C. E., 17 Feb 2016, In : Bioconjugate Chemistry. 27, 2, p. 329-340 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field

Zhao, Z., Watt, C., Karystinou, A., Roelofs, A. J., McCaig, C. D., Gibson, I. R. & De Bari, C., 29 Nov 2011, In : European Cells & Materials. 22, -, p. 344-358 15 p., -.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Differential Effects of Stress on Adult Hippocampal Cell Proliferation in Low and High Aggressive Mice

Veenema, A. H., De Kloet, E. R., De Wilde, M. C., Roelofs, A. J., Kawata, M., Buwalda, B., Neumann, I. D., Koolhaas, J. M. & Lucassen, P. J., Jul 2007, In : Journal of Neuroendocrinology. 19, 7, p. 489-498 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Cell-based Approaches to Joint Surface Repair: A Research Perspective

Roelofs, A. J., Rocke, J. P. J. & De Bari, C., Jul 2013, In : Osteoarthritis and Cartilage. 21, 7, p. 892-900 9 p.

Research output: Contribution to journalReview article

Open Access
File
56 Citations (Scopus)
5 Downloads (Pure)

Bone Marrow Contribution to Synovial Hyperplasia Following Joint Surface Injury

Sergijenko, A., Roelofs, A. J., Riemen, A. H. K. & De Bari, C., 13 Jul 2016, In : Arthritis Research & Therapy. 18, p. 1-11 11 p., 166.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
7 Downloads (Pure)

Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages

Roelofs, A. J., Thompson, K., Ebetino, F., Rogers, M. J. & Coxon, F., Sep 2010, In : Current Pharmaceutical Design. 16, 27, p. 2950-2960 11 p.

Research output: Contribution to journalReview article

121 Citations (Scopus)

Bisphosphonates: Mechanisms of action

Roelofs, A. J., Frank H Ebetino, F. H., Reszka, A. A., Russell, R. G. G. & Rogers, M., 13 Oct 2008, Principles of Bone Biology: Volume 2. Bilezikian, J. P., Raisz, L. G. & Martin, T. J. (eds.). 3 ed. San Diego, Ca, USA: Academic Press, Vol. 2. p. 1737-1767

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Bisphosphonates: Mechanisms of action

Roelofs, A. J., Shay, G. & Rogers, M., Jul 2012, Handbook of cancer-related bone disease. Coleman, RE., Abrahamsson, PA. & Hadji, P. (eds.). 2 ed. Bristol: BioScientifica, p. 75-99 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bisphosphonates: mechanisms of action

Roelofs, A. J. & Rogers, M., Mar 2010, Handbook of Cancer-Related Bone Disease. Coleman, R. E., Abrahamsson, P. A. & Hadji, P. (eds.). Bristol, United Kingdom: BioScientifica, p. 71-89 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells

Ford, L. A., Roelofs, A. J., Anavi-Goffer, S., Mowat, L., Simpson, D. G., Irving, A. J., Rogers, M. J., Rajnicek, A. M. & Ross, R. A., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 762-771 10 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Roelofs, A. J., Edwards, C. M., Graham, R., Russell, G., Ebetino, F. H., Rogers, M. J. & Hulley, P. A., Jul 2007, In : Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 228-235 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Apomine (TM), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo

Edwards, C. M., Mueller, G., Roelofs, A. J., Chantry, A., Perry, M., Russell, R. G. G., Van Camp, B., Guyon-Gellin, Y., Niesor, E. J., Bentzen, C. L., Vanderkerken, K. & Croucher, P. I., 15 Apr 2007, In : International Journal of Cancer. 120, 8, p. 1657-1663 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

McIlroy, G. D., Suchacki, K., Roelofs, A. J., Yang, W., Fu, Y., Bai, B., Wallace, R. J., de Bari, C., Cawthorn, W. P., Han, W., Delibegovic, M. & Rochford, J. J., Apr 2018, In : Molecular Metabolism. 10, p. 55-65 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
10 Downloads (Pure)

Activation of γδ T Cells by Bisphosphonates

Thompson, K., Roelofs, A. J., Jauhiainen, M., Mönkkönen, H., Mönkkönen, J. & Rogers, M. J., 2010, In : Advances in Experimental Medicine and Biology. 658, p. 11-20 10 p.

Research output: Contribution to journalReview article

37 Citations (Scopus)