Anne Kiltie

Research output

Research output per year 1994 1997 1999 2000 2008 2009 2010 2011 2013 2014 2015 2017 2018 2019 2020 2021 2024

• 75 Article
• 10 Review article
• 3 Chapter
• 3 Editorial
• 5 More
  • 3 Letter
  • 2 Comment/debate

Research output per year

Research output per year

Search results

• 2024

  Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

  Kiltie, A., 2 Apr 2024, (Accepted/In press) In: Microbiome.

  Research output: Contribution to journal › Article › peer-review
• 2023

  How do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?

  Asim, F., Clarke, L., Donnelly, E., Jamal, F., Piccicacchi, L., Qadir, M., Raja, N., Samadi, C., Then, C. K. & Kiltie, A., 10 Nov 2023, In: BMJ Oncology. 2, 1, 12 p., e000107.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • gastrointestinal system 100%
  • dietary fiber 86%
  • neoplasms 79%
  • radiotherapy 61%
  • immunotherapy 59%

• Field-cycling imaging in ovarian cancer: a novel technology

  Bhagat, N., Broche, L., Shylasree, T. S., Kiltie, A. E., Bhattacharya, S. & Gurumurthy, M., 7 Aug 2023, In: International Journal of Gynecological Cancer. 33, 8, p. 1329-1330 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • Ovarian Neoplasms 100%
  • Technology 71%
  • Female Genitalia 65%
  • Combination Drug Therapy 55%
  • Cause of Death 43%
  2 Downloads (Pure)

• Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

  UROMOL Consortium, 1 Jul 2023, In: European Urology. 84, 1, p. 127-137 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Genome-Wide Association Study 100%
  • Urinary Bladder Neoplasms 91%
  • Smoking 31%
  • Meta-Analysis 19%
  • Genome 11%
  13 Citations (Scopus)
• 2022

  Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients

  Eaton, S. E., Kaczmarek, J., Mahmood, D., McDiarmid, A. M., Norarfan, A. N., Scott, E. G., Then, C. K., Tsui, H. Y. & Kiltie, A. E., 7 Dec 2022, In: British Journal of Cancer. 127, p. 2087–2098 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Dietary Fiber 100%
  • Gastrointestinal Microbiome 81%
  • Radiotherapy 56%
  • Fecal Microbiota Transplantation 19%
  • Volatile Fatty Acids 17%
  6 Citations (Scopus)

  4 Downloads (Pure)
• 2021

  Immunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells

  Kilgas, S., Kiltie, A. E. & Ramadan, K., 17 Dec 2021, In: STAR Protocols. 2, 4, 15 p., 100978.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Deoxyuridine 100%
  • Mammalian Cell 77%
  • Fluorescence Microscopy 73%
  • Single-Stranded DNA 45%
  • Genomic Instability 40%
  8 Citations (Scopus)

  4 Downloads (Pure)

• The role of dietary supplements, including biotics, glutamine, polyunsaturated fatty acids and polyphenols, in reducing gastrointestinal side effects in patients undergoing pelvic radiotherapy: A systematic review and meta-analysis

  Bartsch, B., Then, C. K., Harriss, E., Kartsonaki, C. & Kiltie, A. E., 1 Jul 2021, In: Clinical and Translational Radiation Oncology. 29, p. 11-19 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polyphenols 100%
  • Unsaturated Fatty Acids 96%
  • Glutamine 94%
  • Dietary Supplements 92%
  • Synbiotics 91%
  7 Citations (Scopus)

  9 Downloads (Pure)

• Evaluation of Loading Strategies to Improve Tumor Uptake of Gemcitabine in a Murine Orthotopic Bladder Cancer Model Using Ultrasound and Microbubbles

  Ruan, J. L., Browning, R. J., Yildiz, Y. O., Bau, L., Kamila, S., Gray, M. D., Folkes, L., Hampson, A., McHale, A. P., Callan, J. F., Vojnovic, B., Kiltie, A. E. & Stride, E., 1 Jun 2021, In: Ultrasound in Medicine and Biology. 47, 6, p. 1596-1615 20 p.

  Research output: Contribution to journal › Article › peer-review

  • bladder 100%
  • Microbubbles 93%
  • gemcitabine 82%
  • drugs 74%
  • Urinary Bladder Neoplasms 70%
  4 Citations (Scopus)

• p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

  Kilgas, S., Singh, A. N., Paillas, S., Then, C. K., Torrecilla, I., Nicholson, J., Browning, L., Vendrell, I., Konietzny, R., Kessler, B. M., Kiltie, A. E. & Ramadan, K., 25 May 2021, In: Cell Reports. 35, 8, 25 p., 109153.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ionizing Radiation 100%
  • CB-5083 91%
  • DNA Repair 76%
  • p97 ATPase 75%
  • Radiation Tolerance 47%
  19 Citations (Scopus)

  6 Downloads (Pure)

• Ultrasound-Mediated Gemcitabine Delivery Reduces the Normal-Tissue Toxicity of Chemoradiation Therapy in a Muscle-Invasive Bladder Cancer Model

  Ruan, J. L., Browning, R. J., Yildiz, Y. O., Gray, M., Bau, L., Kamila, S., Thompson, J., Elliott, A., Smart, S., McHale, A. P., Callan, J. F., Vojnovic, B., Stride, E. & Kiltie, A. E., 1 Apr 2021, In: International Journal of Radiation Oncology Biology Physics. 109, 5, p. 1472-1482 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • bladder 100%
  • Microbubbles 93%
  • toxicity 90%
  • gemcitabine 82%
  • muscles 77%
  8 Citations (Scopus)

  3 Downloads (Pure)

• SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

  Na, J., Newman, J. A., Then, C. K., Syed, J., Vendrell, I., Torrecilla, I., Ellermann, S., Ramadan, K., Fischer, R. & Kiltie, A. E., 8 Feb 2021, In: Cell Death and Disease. 12, 2, 17 p., 165.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Repair 100%
  • DNA Damage 94%
  • Peptide Hydrolases 90%
  • 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 78%
  • Exonucleases 72%
  8 Citations (Scopus)

  13 Downloads (Pure)
• 2020

  Greater utility of molecular subtype rather than epithelial-to-mesenchymal transition (EMT) markers for prognosis in high-risk non-muscle-invasive (HGT1) bladder cancer

  Ottley, E. C., Pell, R., Brazier, B., Hollidge, J., Kartsonaki, C., Browning, L., O'Neill, E. & Kiltie, A. E., 1 Oct 2020, In: Journal of Pathology: Clinical Research. 6, 4, p. 238-251 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epithelial-Mesenchymal Transition 100%
  • Urinary Bladder Neoplasms 92%
  • Carcinoma 51%
  • Tumor-Infiltrating Lymphocytes 48%
  • Muscles 46%
  10 Citations (Scopus)

  18 Downloads (Pure)

• Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation

  Then, C. K., Paillas, S., Wang, X., Hampson, A. & Kiltie, A. E., 19 Aug 2020, In: BMC Biology. 18, 16 p., 102.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bacteroides acidifaciens 100%
  • high fiber diet 66%
  • Bacteroides 60%
  • Ionizing Radiation 58%
  • relative abundance 44%
  27 Citations (Scopus)

  3 Downloads (Pure)

• The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo

  Paillas, S., Then, C. K., Kilgas, S., Ruan, J. L., Thompson, J., Elliott, A., Smart, S. & Kiltie, A. E., 1 May 2020, In: International Journal of Radiation Oncology Biology Physics. 107, 1, p. 212-221 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • romidepsin 100%
  • bladder 83%
  • Histone Deacetylase Inhibitors 72%
  • inhibitors 71%
  • Urinary Bladder Neoplasms 59%
  20 Citations (Scopus)

  4 Downloads (Pure)

• EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort: Under the Auspices of the EAU-ESMO Guidelines Committees

  Witjes, J. A., Babjuk, M., Bellmunt, J., Bruins, H. M., De Reijke, T. M., De Santis, M., Gillessen, S., James, N., Maclennan, S., Palou, J., Powles, T., Ribal, M. J., Shariat, S. F., Der Kwast, T. V., Xylinas, E., Agarwal, N., Arends, T., Bamias, A., Birtle, A., Black, P. C., & 102 othersBochner, B. H., Bolla, M., Boormans, J. L., Bossi, A., Briganti, A., Brummelhuis, I., Burger, M., Castellano, D., Cathomas, R., Chiti, A., Choudhury, A., Compérat, E., Crabb, S., Culine, S., De Bari, B., De Blok, W., J L De Visschere, P., Decaestecker, K., Dimitropoulos, K., Dominguez-Escrig, J. L., Fanti, S., Fonteyne, V., Frydenberg, M., Futterer, J. J., Gakis, G., Geavlete, B., Gontero, P., Grubmüller, B., Hafeez, S., Hansel, D. E., Hartmann, A., Hayne, D., Henry, A. M., Hernandez, V., Herr, H., Herrmann, K., Hoskin, P., Huguet, J., Jereczek-Fossa, B. A., Jones, R., Kamat, A. M., Khoo, V., Kiltie, A. E., Krege, S., Ladoire, S., Lara, P. C., Leliveld, A., Linares-Espinós, E., Løgager, V., Lorch, A., Loriot, Y., Meijer, R., Mir, M. C., Moschini, M., Mostafid, H., Müller, A-C., Müller, C. R., N'Dow, J., Necchi, A., Neuzillet, Y., Oddens, J. R., Oldenburg, J., Osanto, S., J G Oyen, W., Pacheco-Figueiredo, L., Pappot, H., Patel, M. I., Pieters, B. R., Plass, K., Remzi, M., Retz, M., Richenberg, J., Rink, M., Roghmann, F., Rosenberg, J. E., Rouprêt, M., Rouvière, O., Salembier, C., Salminen, A., Sargos, P., Sengupta, S., Sherif, A., Smeenk, R. J., Smits, A., Stenzl, A., Thalmann, G. N., Tombal, B., Turkbey, B., Lauridsen, S. V., Valdagni, R., Der Heijden, A. G. V., Van Poppel, H., Vartolomei, M. D., Veskimäe, E., Vilaseca, A., Rivera, F. A. V., Wiegel, T., Wiklund, P., Williams, A., Zigeuner, R., Horwich, A. & Willemse, P-P. M., Feb 2020, In: European Urology. 77, 2, p. 223-250 28 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Medical Oncology 100%
  • Urology 94%
  • Urinary Bladder Neoplasms 81%
  • Guidelines 54%
  • Congresses 35%
  134 Citations (Scopus)

  10 Downloads (Pure)
• 2019

  The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

  Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guérillon, C., Fielden, J., Hernandez-Carralero, E., Cabrera, E., Tullis, I. D. C., Meerang, M., Barber, P. R., Freire, R., Parsons, J., Vojnovic, B., Kiltie, A. E., Mailand, N. & Ramadan, K., 4 Nov 2019, In: EMBO Journal. 38, 21, 25 p., e102361.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-Protein Ligases 100%
  • DNA Damage 76%
  • Homeostasis 64%
  • Ataxin-3 57%
  • Proteostasis 45%
  31 Citations (Scopus)

• MRE11A Isoform Expression Associated with Outcome Following Radiotherapy in Muscle-Invasive Bladder Cancer does not Alter Cell Survival and DNA Double-Strand Break Repair Following Ionising Radiation

  Walker, A. K., Na, J., Browning, L., Humayun-Zakaria, N., Zeegers, M. P., Cheng, K. K., James, N. D., Bryan, R. T., Arnold, R. & Kiltie, A. E., 16 Aug 2019, In: Bladder Cancer. 5, 2, p. 147-157 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Double-Stranded DNA Breaks 100%
  • Ionizing Radiation 89%
  • Urinary Bladder Neoplasms 83%
  • Protein Isoforms 70%
  • Cell Survival 66%
  2 Citations (Scopus)

• MRE11 as a Predictive Biomarker of Outcome After Radiation Therapy in Bladder Cancer

  Walker, A. K., Karaszi, K., Valentine, H., Strauss, V. Y., Choudhury, A., McGill, S., Wen, K., Brown, M. D., Ramani, V., Bhattarai, S., Teo, M. T. W., Yang, L., Myers, K. A., Deshmukh, N., Denley, H., Browning, L., Love, S. B., Iyer, G., Clarke, N. W., Hall, E., & 5 othersHuddart, R., James, N. D., Hoskin, P. J., West, C. M. L. & Kiltie, A. E., 15 Jul 2019, In: International Journal of Radiation Oncology Biology Physics. 104, 4, p. 809-818 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • bladder 100%
  • biomarkers 98%
  • scoring 97%
  • radiation therapy 73%
  • Urinary Bladder Neoplasms 70%
  23 Citations (Scopus)

• Mouse Models of Muscle-invasive Bladder Cancer: Key Considerations for Clinical Translation Based on Molecular Subtypes

  Ruan, J. L., Hsu, J. W., Browning, R. J., Stride, E., Yildiz, Y. O., Vojnovic, B. & Kiltie, A. E., May 2019, In: European Urology Oncology. 2, 3, p. 239-247 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Urinary Bladder Neoplasms 100%
  • Muscles 62%
  • Molecular Models 33%
  • Disease Management 25%
  • Allografts 22%
  3 Citations (Scopus)
• 2018

  Utility of Bladder-Sparing Therapy vs Radical Cystectomy for Muscle-Invasive Bladder Cancer

  Efstathiou, J. A., Choudhury, A. & Kiltie, A. E., 21 Nov 2018, In: JAMA Surgery. 154, 2, p. 185-186 2 p.

  Research output: Contribution to journal › Letter › peer-review

• Neoadjuvant treatment for muscle-invasive bladder cancer: The past, the present, and the future

  Hermans, T. J. N., Voskuilen, C. S., van der Heijden, M. S., Schmitz-Dräger, B. J., Kassouf, W., Seiler, R., Kamat, A. M., Grivas, P., Kiltie, A. E., Black, P. C. & van Rhijn, B. W. G., Sept 2018, In: Urologic Oncology: Seminars and Original Investigations. 36, 9, p. 413-422 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neoadjuvant Therapy 100%
  • Urinary Bladder Neoplasms 83%
  • Radiation 65%
  • Cystectomy 58%
  • Muscles 52%
  30 Citations (Scopus)

• Recommendations for follow-up of muscle-invasive bladder cancer patients: A consensus by the international bladder cancer network

  Zuiverloon, T. C. M., van Kessel, K. E. M., Bivalacqua, T. J., Boormans, J. L., Ecke, T. H., Grivas, P. D., Kiltie, A. E., Liedberg, F., Necchi, A., van Rhijn, B. W., Roghmann, F., Sanchez-Carbayo, M., Schmitz-Dräger, B. J., Wezel, F. & Kamat, A. M., Sept 2018, In: Urologic Oncology: Seminars and Original Investigations. 36, 9, p. 423-431 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Urinary Bladder Neoplasms 100%
  • Muscles 62%
  • Guidelines 28%
  • Cell Biology 12%
  • Physicians 9%
  19 Citations (Scopus)

• Harnessing citizen science through mobile phone technology to screen for immunohistochemical biomarkers in bladder cancer

  Smittenaar, P., Walker, A. K., McGill, S., Kartsonaki, C., Robinson-Vyas, R. J., McQuillan, J. P., Christie, S., Harris, L., Lawson, J., Henderson, E., Howat, W., Hanby, A., Thomas, G. J., Bhattarai, S., Browning, L. & Kiltie, A. E., 17 Jul 2018, In: British Journal of Cancer. 119, 2, p. 220-229 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Citizen Science 100%
  • Cell Phone 64%
  • Crowdsourcing 56%
  • Urinary Bladder Neoplasms 50%
  • Smartphone 42%
  7 Citations (Scopus)

  6 Downloads (Pure)

• Contemporary Patterns of Multidisciplinary Care in Patients With Muscle-invasive Bladder Cancer

  Harshman, L. C., Tripathi, A., Kaag, M., Efstathiou, J. A., Apolo, A. B., Hoffman-Censits, J. H., Stadler, W. M., Yu, E. Y., Bochner, B. H., Skinner, E. C., Downs, T., Kiltie, A. E., Bajorin, D. F., Guru, K., Shipley, W. U., Steinberg, G. D., Hahn, N. M. & Sridhar, S. S., Jun 2018, In: Clinical genitourinary cancer. 16, 3, p. 213-218 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Urinary Bladder Neoplasms 100%
  • Patient Care 80%
  • Muscles 62%
  • Ambulatory Care 41%
  • Canada 37%
  13 Citations (Scopus)

• High Levels of Patient Satisfaction in Joint Uro-oncology Clinics to Assist Patient Choice in Early Prostate Cancer and Muscle-invasive Bladder Cancer

  Kiltie, A. E., Southby, R., LeMonnier, K., Binnee, J., Niederer, J., Kartsonaki, C., Camilleri, P., Sabharwal, A., Brewster, S., Crew, J. & Hamdy, F. C., Apr 2018, In: Clinical Oncology. 30, 4, p. e39 1 p.

  Research output: Contribution to journal › Letter › peer-review

  • Muscle Neoplasms 100%
  • Urinary Bladder Neoplasms 62%
  • Patient Satisfaction 61%
  • Prostatic Neoplasms 51%
  • Joints 46%

• Radiosensitization in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity

  Groselj, B., Ruan, J. L., Scott, H., Gorrill, J., Nicholson, J., Kelly, J., Anbalagan, S., Thompson, J., Stratford, M. R. L., Jevons, S. J., Hammond, E. M., Scudamore, C. L., Kerr, M. & Kiltie, A. E., Feb 2018, In: Molecular Cancer Therapeutics. 17, 2, p. 381-392 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Panobinostat 100%
  • Histone Deacetylases 73%
  • Radiation 47%
  • Nude Mice 39%
  • Urinary Bladder Neoplasms 30%
  27 Citations (Scopus)
• 2017

  Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset

  Choi, W., Ochoa, A., McConkey, D. J., Aine, M., Höglund, M., Kim, W. Y., Real, F. X., Kiltie, A. E., Milsom, I., Dyrskjøt, L. & Lerner, S. P., Sept 2017, In: European Urology. 72, 3, p. 354-365 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Atlases 100%
  • Urinary Bladder Neoplasms 89%
  • Datasets 73%
  • Genome 63%
  • Neoplasms 30%
  171 Citations (Scopus)

• No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy

  Walker, A. K., Kartsonaki, C., Collantes, E., Nicholson, J., Gilbert, D. C. & Kiltie, A. E., 25 Jul 2017, In: British Journal of Cancer. 117, 3, p. 322-325 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Anus Neoplasms 100%
  • Anal Canal 81%
  • Squamous Cell Carcinoma 60%
  • Radiotherapy 50%
  • Papillomavirus Infections 40%
  6 Citations (Scopus)

• The Impact of Histological Variants of Urothelial Carcinoma on Clinical Outcomes Following Trimodality Bladder-sparing Chemoradiation

  Kiltie, A. E. & Browning, L., Jul 2017, In: European Urology. 72, 1, p. 61-63 3 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Citations (Scopus)

• E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer

  Nicholson, J., Jevons, S. J., Groselj, B., Ellermann, S., Konietzny, R., Kerr, M., Kessler, B. M. & Kiltie, A. E., 1 Jun 2017, In: Cancer Research. 77, 11, p. 3027-3029 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Baculoviral IAP Repeat-Containing 3 Protein 100%
  • Inhibitor of Apoptosis Proteins 82%
  • Ubiquitin-Protein Ligases 67%
  • Genetic Recombination 57%
  • Urinary Bladder Neoplasms 56%
  35 Citations (Scopus)

• The National Institute for Health and Care Excellence (NICE) Guidance on Bladder Cancer; a Step in the Right Direction?

  Trainor, S., Choudhury, A., Huddart, R., Kiltie, A. E., Kockelbergh, R., Turner, W., Birtle, A. & Crabb, S. J., Jun 2017, In: Clinical Oncology. 29, 6, p. 344-347 4 p.

  Research output: Contribution to journal › Editorial › peer-review
  7 Citations (Scopus)

• Crowdsourcing for translational research: Analysis of biomarker expression using cancer microarrays

  Lawson, J., Robinson-Vyas, R. J., McQuillan, J. P., Paterson, A., Christie, S., Kidza-Griffiths, M., McDuffus, L. A., Moutasim, K. A., Shaw, E. C., Kiltie, A. E., Howat, W. J., Hanby, A. M., Thomas, G. J. & Smittenaar, P., 17 Jan 2017, In: British Journal of Cancer. 116, 2, p. 237-245 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Crowdsourcing 100%
  • Translational Medical Research 70%
  • Biomarkers 40%
  • Immunohistochemistry 24%
  • Urinary Bladder 21%
  13 Citations (Scopus)
• 2015

  Biomarkers of Tumour Radiosensitivity and Predicting Benefit from Radiotherapy

  Forker, L. J., Choudhury, A. & Kiltie, A. E., 1 Oct 2015, In: Clinical Oncology. 27, 10, p. 561-569 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Radiation Tolerance 100%
  • Tumor Biomarkers 84%
  • Radiotherapy 59%
  • Biomarkers 48%
  • Adjuvant Radiotherapy 14%
  54 Citations (Scopus)

• Bladder-sparing strategies for invasive bladder cancer

  Choudhury, A., Huddart, R. & Kiltie, A., 1 Oct 2015, Advances in Bladder Cancer Management. Future Medicine Ltd., p. 158-173 16 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Urinary Bladder Neoplasms 100%
  • Urinary Bladder 83%
  • Radiotherapy 72%
  • Patient Selection 45%
  • Therapeutics 8%

• Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of european ancestry

  Figueroa, J. D., Middlebrooks, C. D., Banday, A. R., Ye, Y., Garcia-Closas, M., Chatterjee, N., Koutros, S., Kiemeney, L. A., Rafnar, T., Bishop, T., Furberg, H., Matullo, G., Golka, K., Gago-Dominguez, M., Taylor, J. A., Fletcher, T., Siddiq, A., Cortessis, V. K., Kooperberg, C., Cussenot, O., & 30 othersBenhamou, S., Prescott, J., Porru, S., Dinney, C. P., Malats, N., Baris, D., Purdue, M. P., Jacobs, E. J., Albanes, D., Wang, Z., Chung, C. C., Vermeulen, S. H., Aben, K. K., Galesloot, T. E., Thorleifsson, G., Sulem, P., Stefansson, K., Kiltie, A. E., Harland, M., Teo, M., Offit, K., Vijai, J., Bajorin, D., Kopp, R., Fiorito, G., Guarrera, S., Sacerdote, C., Selinski, S., Hengstler, J. G. & Gerullis, H., 17 Aug 2015, In: Human Molecular Genetics. 25, 6, p. 1203-1214 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Urinary Bladder Neoplasms 100%
  • Genome-Wide Association Study 81%
  • Single Nucleotide Polymorphism 65%
  • Genome 35%
  • Genes 31%
  33 Citations (Scopus)

• Treatment of Breast and Prostate Cancer by Hypofractionated Radiotherapy: Potential Risks and Benefits

  Ray, K. J., Sibson, N. R. & Kiltie, A. E., 1 Jul 2015, In: Clinical Oncology. 27, 7, p. 420-426 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Risk Assessment 100%
  • Prostatic Neoplasms 95%
  • Radiotherapy 83%
  • Breast Neoplasms 76%
  • Appointments and Schedules 58%
  45 Citations (Scopus)

• High-throughput DNA sequencing identifies novel CtIP (RBBP8) variants in muscle-invasive bladder cancer patients

  Jevons, S. J., Green, A., Lunter, G., Kartsonaki, C., Buck, D., Piazza, P. & Kiltie, A. E., 2015, In: Bladder Cancer. 1, 1, p. 31-44 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • High-Throughput Nucleotide Sequencing 100%
  • Urinary Bladder Neoplasms 99%
  • Muscles 62%
  • Platypus 60%
  • Exons 57%
  1 Citation (Scopus)
• 2014

  Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

  Rafnar, T., Sulem, P., Thorleifsson, G., Vermeulen, S. H., Helgason, H., Saemundsdottir, J., Gudjonsson, S. A., Sigurdsson, A., Stacey, S. N., Gudmundsson, J., Johannsdottir, H., Alexiusdottir, K., Petursdottir, V., Nikulasson, S., Geirsson, G., Jonsson, T., Aben, K. K. H., Grotenhuis, A. J., Verhaegh, G. W., Dudek, A. M., & 30 othersAlfred Witjes, J., van der Heijden, A. G., Vrieling, A., Galesloot, T. E., De Juan, A., Panadero, A., Rivera, F., Hurst, C., Timothy Bishop, D., Sak, S. C., Choudhury, A., Teo, M. T. W., Arici, C., Carta, A., Toninelli, E., de Verdier, P., Rudnai, P., Gurzau, E., Koppova, K., van der Keur, K. A., Lurkin, I., Goossens, M., Kellen, E., Guarrera, S., Russo, A., Critelli, R., Sacerdote, C., Vineis, P., Krucker, C. & Kiltie, A. E., 15 Nov 2014, In: Human Molecular Genetics. 23, 20, p. 5545-5557 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Urinary Bladder Neoplasms 91%
  • Gene Components 22%
  • Whole Genome Sequencing 18%
  • Gene Frequency 15%
  40 Citations (Scopus)

• Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer

  Kerr, M., Scott, H. E., Groselj, B., Stratford, M. R. L., Karaszi, K., Sharma, N. L. & Kiltie, A. E., 1 Nov 2014, In: Clinical Cancer Research. 20, 21, p. 5435-5445 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deoxycytidine Kinase 100%
  • gemcitabine 71%
  • Urinary Bladder Neoplasms 61%
  • Ionizing Radiation 12%
  • Heterografts 10%
  18 Citations (Scopus)

• Re: Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: A systematic review

  Kiltie, A. E., Sept 2014, In: European Urology. 66, 3, p. 597-598 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Citation (Scopus)

• Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

  Sharma, A., Sharma, N. L., Lavy, C. B., Kiltie, A. E., Hamdy, F. C. & Czernuszka, J., Sept 2014, In: Journal of Materials Science. 49, 17, p. 5809-5820 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Biomimetics 100%
  • Scaffolds 97%
  • Tumors 84%
  • Environment 46%
  • Cells 26%
  4 Citations (Scopus)

• Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

  Cazier, J. B., Rao, S. R., McLean, C. M., Walker, A. L., Wright, B. J., Jaeger, E. E. M., Kartsonaki, C., Marsden, L., Yau, C., Camps, C., Kaisaki, P., Taylor, J., Catto, J. W., Tomlinson, I. P. M., Kiltie, A. E., Hamdy, F. C., Allan, C., Attar, M., Bell, J., Bentley, D., & 30 othersBroxholme, J., Buck, D., Copley, R., Cornall, R., Donnelly, P., Fiddy, S., Green, A., Gregory, L., Grocock, R., Hatton, E., Holmes, C., Hughes, L., Humburg, P., Humphray, S., Kanapin, A., Kingsbury, Z., Knight, J., Lamble, S., Lise, S., Lonie, L., Lunter, G., Martin, H., Murray, L., McCarthy, D., McVean, G., Pagnamenta, A., Piazza, P., Polanco, G., Ratcliffe, P. & Rimmer, A., 29 Apr 2014, In: Nature Communications. 5, 3756.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sequencing 100%
  • bladder 99%
  • genome 95%
  • mutations 85%
  • Whole Genome Sequencing 85%
  80 Citations (Scopus)

• Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer

  Teo, M. T. W., Dyrskjøt, L., Nsengimana, J., Buchwald, C., Snowden, H., Morgan, J., Jensen, J. B., Knowles, M. A., Taylor, G., Barrett, J. H., Borre, M., ørntoft, T. F., Bishop, D. T. & Kiltie, A. E., Apr 2014, In: Annals of Oncology. 25, 4, p. 877-883 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • High-Throughput Nucleotide Sequencing 100%
  • Urinary Bladder Neoplasms 99%
  • Radiotherapy 72%
  • Muscles 62%
  • Cystectomy 43%
  39 Citations (Scopus)

• Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours

  Martin, R. M., Kerr, M., Teo, M. T. W., Jevons, S. J., Koritzinsky, M., Wouters, B. G., Bhattarai, S. & Kiltie, A. E., 2014, In: Oncotarget. 5, 4, p. 993-1003 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Urinary Bladder Neoplasms 100%
  • Muscles 62%
  • Proteins 38%
  • Messenger RNA 34%
  • Cystectomy 33%
  12 Citations (Scopus)
• 2013

  Can γH2AX be used to personalise cancer treatment?

  Shah, K., Cornelissen, B., Kiltie, A. E. & Vallis, K. A., Dec 2013, In: Current molecular medicine. 13, 10, p. 1591-1602 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Histone 100%
  • Biological Marker 84%
  • DNA Damage 81%
  • Neoplasms 30%
  • Double-Stranded DNA Breaks 26%
  12 Citations (Scopus)

• Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression

  Groselj, B., Kerr, M. & Kiltie, A. E., Sept 2013, In: Radiotherapy and Oncology. 108, 3, p. 429-433 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Panobinostat 100%
  • Urinary Bladder Neoplasms 60%
  • Radiation-Sensitizing Agents 29%
  • Homologous Recombination 23%
  • Down-Regulation 14%
  35 Citations (Scopus)

• The emerging role of histone deacetylase (HDAC) inhibitors in urological cancers

  Sharma, N. L., Groselj, B., Hamdy, F. C. & Kiltie, A. E., Apr 2013, In: BJU International. 111, 4, p. 537-542 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Urologic Neoplasms 100%
  • Histone Deacetylase Inhibitors 83%
  • Epigenomics 26%
  • Neoplasms 22%
  • Histone Acetyltransferases 13%
  37 Citations (Scopus)

• Histone deacetylase inhibitors as radiosensitisers: Effects on DNA damage signalling and repair

  Groselj, B., Sharma, N. L., Hamdy, F. C., Kerr, M. & Kiltie, A. E., 5 Mar 2013, In: British Journal of Cancer. 108, 4, p. 748-754 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Deacetylase Inhibitors 100%
  • DNA Repair 79%
  • DNA Damage 74%
  • Radiotherapy 44%
  • Histone Deacetylases 24%
  162 Citations (Scopus)

• Imatinib radiosensitizes bladder cancer by targeting homologous recombination

  Qiao, B., Kerr, M., Groselj, B., Teo, M. T. W., Knowles, M. A., Bristow, R. G., Phillips, R. M. & Kiltie, A. E., 1 Mar 2013, In: Cancer Research. 73, 5, p. 1611-1620 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Imatinib Mesylate 100%
  • Homologous Recombination 98%
  • Urinary Bladder Neoplasms 84%
  • Lapatinib 35%
  • Radiotherapy 26%
  30 Citations (Scopus)
• 2012

  The role of microrna-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes

  Teo, M. T. W., Landi, D., Taylor, C. F., Elliott, F., Vaslin, L., Cox, D. G., Hall, J., Landi, S., Bishop, D. T. & Kiltie, A. E., Mar 2012, In: Carcinogenesis. 33, 3, p. 581-586 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Urinary Bladder Neoplasms 100%
  • DNA Repair 96%
  • MicroRNAs 87%
  • Single Nucleotide Polymorphism 87%
  • Binding Sites 80%
  97 Citations (Scopus)