Caroline Barelle

2021

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

Ubah, O. C., Lake, E. W., Gunaratne, G. S., Gallant, J. P., Fernie, M., Robertson, A. J., Marchant, J. S., Bold, T. D., Langlois, R. A., Matchett, W. E., Thiede, J. M., Shi, K., Yin, L., Moeller, N. H., Banerjee, S., Ferguson, L., Kovaleva, M., Porter, A. J., Aihara, H., LeBeau, A. M., & 1 othersBarelle, C. J., 16 Dec 2021, In: Nature Communications. 12, 1, 12 p., 7325.

Research output: Contribution to journal › Article › peer-review

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21 Citations (Scopus)

5 Downloads (Pure)

Non-Alcoholic Steatohepatitis (NASH) - A Review of a Crowded Clinical Landscape, Driven by a Complex Disease

Fraile, J. M., Palliyil, S., Barelle, C., Porter, A. J. & Kovaleva, M., 22 Sept 2021, In: Drug design, development and therapy. 15, p. 3997-4009 13 p.

Research output: Contribution to journal › Review article › peer-review

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59 Citations (Scopus)

4 Downloads (Pure)

2020

In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development

Ubah, O., Porter, A. J. & Barelle, C. J., 3 Feb 2020, In: Journal of Immunology Research. 2020, p. 7283239 14 p., 7283239.

Research output: Contribution to journal › Article › peer-review

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12 Citations (Scopus)

4 Downloads (Pure)

2019

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand

Pepple, K. L., Wilson, L., Van Gelder, R. N., Kovaleva, M., Ubah, O. C., Steven, J., Barelle, C. J. & Porter, A., Sept 2019, In: Translational vision science & technology. 8, 5, 13 p., 11.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

6 Downloads (Pure)

Oriented attachment of VNAR proteins, Q2 via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance

Nogueira, J. C. F., Greene, M. K., Richards, D. A., Furby, A. O., Steven, J., Porter, A., Barelle, C., Scott, C. J. & Chudasama, V., 7 Jul 2019, In: Chemical Communications. 55, 53, p. 7671-7674 4 p.

Research output: Contribution to journal › Article › peer-review

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15 Citations (Scopus)

10 Downloads (Pure)

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Ubah, O. C., Steven, J., Porter, A. J. & Barelle, C. J., Mar 2019, In: Frontiers in Immunology. 10, 12 p., 526.

Research output: Contribution to journal › Article › peer-review

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18 Citations (Scopus)

13 Downloads (Pure)

2018

Next-generation flexible formats of VNAR domains expand the drug platform’s utility and developability

Ubah, O. C., Buschhaus, M. J., Ferguson, L., Kovaleva, M., Steven, J., Porter, A. J. & Barelle, C. J., 31 Oct 2018, In: Biochemical Society Transactions. 46, 6, p. 1559-1565 7 p.

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

2017

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralising Potency and Multifunctionality, Generated for Therapeutic Development

Ubah, O. C., Steven, J., Kovaleva, M., Ferguson, L., Barelle, C., Porter, A. J. R. & Barelle, C. J., 22 Dec 2017, In: Frontiers in Immunology. 8, 13 p., 1780.

Research output: Contribution to journal › Article › peer-review

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28 Citations (Scopus)

14 Downloads (Pure)

2016

Phage Display Derived IgNAR V Region Binding Domains for Therapeutic Development

Ubah, O. C., Barelle, C. J., Buschhaus, M. J. & Porter, A. J., 2016, In: Current Pharmaceutical Design. 22, 43, p. 6519-6526 8 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

2015

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins

Barelle, C. & Porter, A., 1 Sept 2015, In: Antibodies. 4, 3, p. 240-258 18 p.

Research output: Contribution to journal › Article › peer-review

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32 Citations (Scopus)

8 Downloads (Pure)

Structural insights and biomedical potential of IgNAR scaffolds from sharks

Zielonka, S., Empting, M., Grzeschik, J., Könning, D., Barelle, C. & Kolmar, H., 2015, In: mAbs. 7, 1, p. 15-25 11 p.

Research output: Contribution to journal › Article › peer-review

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103 Citations (Scopus)

7 Downloads (Pure)

2014

ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL

Barelle, C., Finlay, J. J. W. & Darmanin-Sheehan, A., 30 Oct 2014, IPC No. C07K16/00; C07K16/18; C12N15/13, Priority date 23 Apr 2013, Priority No. US201361815043P 20130423

Research output: Patent

Shark variable new antigen receptor biologics: a novel technology platform for therapeutic drug development

Kovaleva, M., Ferguson, L., Steven, J., Porter, A. & Barelle, C., 2014, In: Expert opinion on biological therapy. 14, 10, p. 1527-1539 13 p.

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

2013

SINGLE DOMAIN BINDING MOLECULE

Barelle, C., Muller, M., Calabro, V., Bikker, J., Steven, J., Tchistiakova, L., Kovalenko, O. V. & Olland, A., 14 Nov 2013, IPC No. C07K16/46, Priority No. US201313889134 20130507 ; US201261643407P 20120507

Research output: Patent

Open Access

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64 Downloads (Pure)

Atypical antigen recognition mode of a shark immunoglobulin new antigen receptor (IgNAR) variable domain characterized by humanization and structural analysis

Kovalenko, O. V., Olland, A., Piché-Nicholas, N., Godbole, A., King, D., Svenson, K., Calabro, V., Müller, M. R., Barelle, C., Somers, W., Gill, D. S., Mosyak, L. & Tchistiakova, L., 14 Jun 2013, In: The Journal of Biological Chemistry. 288, 24, p. 17408-17419 12 p.

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

2012

Generation and isolation of target-specific single-domain antibodies from shark immune repertoires

Müller, M. R., O'Dwyer, R., Kovaleva, M., Rudkin, F., Dooley, H. & Barelle, C., 1 Oct 2012, Methods in Molecular Biology: Antibody Engineering. Chames, P. (ed.). Humana Press, Vol. 907. p. 177-194 18 p. (Methods and Protocols).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

30 Citations (Scopus)

Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias)

Smith, L. E., Crouch, K., Cao, W., Müller, M. R., Wu, L., Steven, J., Lee, M., Liang, M., Flajnik, M. F., Shih, H. H., Barelle, C., Paulsen, J., Gill, D. S. & Dooley, H., Apr 2012, In: Developmental and Comparative Immunology. 36, 4, p. 665-679 15 p.

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

Müller, M. R., Saunders, K., Grace, C., Jin, M., Piche-Nicholas, N., Steven, J., O'Dwyer, R., Wu, L., Khetemenee, L., Vugmeyster, Y., Hickling, T. P., Tchistiakova, L., Olland, S., Gill, D., Jensen, A. & Barelle, C., 2012, In: mAbs. 4, 6, p. 673-685 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Citations (Scopus)

2009

Shark novel antigen receptors: the next generation of biologic therapeutics?

Barelle, C., Gill, D. S. & Charlton, K., 20 Oct 2009, Pharmaceutical Biotechnology. Guzman, C. A. & Feuerstein, G. Z. (eds.). New York: Springer , Vol. 655. p. 49-62 14 p. (Advances in Experimental Medicine and Biology; vol. 655).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

44 Citations (Scopus)

2008

Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy

Douglass, A., Wallace, K., Koruth, M., Barelle, C., Porter, A. J. & Wright, M. C., Dec 2008, In: Hepatology International. 2, 4, p. 405-15 11 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo

Barelle, C., Duncan, V. M. S., Brown, A. J. P., Gow, N. A. R. & Odds, F. C., Feb 2008, In: Journal of Antimicrobial Chemotherapy. 61, 2, p. 315-322 8 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

2006

Niche-specific regulation of central metabolic pathways in a fungal pathogen

Barelle, C., Priest, C. L., MacCallum, D. M., Gow, N. A. R., Odds, F. C. & Brown, A. J. P., 1 Jun 2006, In: Cellular Microbiology. 8, 6, p. 961-971 11 p.

Research output: Contribution to journal › Article › peer-review

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261 Citations (Scopus)

7 Downloads (Pure)

Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching

Barelle, C., Richard, M. L., Gaillardin, C., Gow, N. A. R. & Brown, A. J. P., Feb 2006, In: Eukaryotic Cell. 5, 2, p. 359-367 9 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

2005

Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes

Copping, V. M. S., Barelle, C., Hube, B., Gow, N. A. R., Brown, A. J. P. & Odds, F. C., May 2005, In: Journal of Antimicrobial Chemotherapy. 55, 5, p. 645-654 10 p.

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

2004

GFP as a quantitative reporter of gene regulation in Candida albicans

Barelle, C., Manson, C. L., MacCallum, D. M., Odds, F. C., Gow, N. A. R. & Brown, A. J. P., Mar 2004, In: Yeast. 21, 4, p. 333-340 8 p.

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

2000

CIp10, an efficient and convenient integrating vector for Candida albicans

Murad, A. M. A., Lee, P. R., Broadbent, I. D., Barelle, C. & Brown, A. J. P., 15 Mar 2000, In: Yeast. 16, 4, p. 325-327 3 p.

Research output: Contribution to journal › Article › peer-review

281 Citations (Scopus)

Gene regulation during morphogenesis in Candida albicans

Brown, A. J., Barelle, C., Budge, S., Duncan, J., Harris, S., Lee, P. R., Leng, P., Macaskill, S., Abdul Murad, A. M., Ramsdale, M., Wiltshire, C., Wishart, J. A. & Gow, N. A., 2000, Dimorphism in Human Pathogenic and Apathogenic Yeasts. Ernst, J. F. & Schmidt, A. (eds.). Karger, p. 112-125 14 p. (Contributions to Microbiology; vol. 5).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

12 Citations (Scopus)

1996

Evidence for an active fibrinolytic system in normal human bone marrow

McWilliam, N. A., Robbie, L. A., Barelle, C., Adey, G., Prasad, S., Bennett, B. & Booth, N. A., Apr 1996, In: British Journal of Haematology. 93, 1, p. 170-6 7 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Caroline Barelle

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