• 1259 Citations
19992019
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  • 16 Similar Profiles
Alzheimer Disease Medicine & Life Sciences
Tauopathies Medicine & Life Sciences
tau Proteins Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Pathology Medicine & Life Sciences
Synucleins Medicine & Life Sciences
Methylene Blue Medicine & Life Sciences
Agglomeration Chemical Compounds

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Research Output 1999 2019

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

Research output: Contribution to journalArticle

Synucleins
Cholinergic Agents
Transgenic Mice
Acetylcholine
Choline O-Acetyltransferase
4 Citations (Scopus)
14 Downloads (Pure)

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

Frahm, S., Melis, V., Horsley, D., Rickard, J. E., Riedel, G., Fadda, P., Scherma, M., Harrington, C. R., Wischik, C. M., Theuring, F. & Schwab, K., 26 Feb 2018, In : Behavioural Brain Research. 339, p. 153-168 16 p.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Transgenic Mice
Parkinson Disease
Lewy Body Disease
Amphetamine
1 Citation (Scopus)
11 Downloads (Pure)
Open Access
File
Synucleins
Transgenic Mice
Proteins
Parkinson Disease
Endopeptidase K
1 Citation (Scopus)
7 Downloads (Pure)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In : Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cysteine
Alzheimer Disease
Tauopathies
tau Proteins
Neurofibrillary Tangles
6 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Prions
Alzheimer Disease
tau Proteins
Neurodegenerative Diseases
Clinical Trials

Impacts

Discovery and commercialisation of an entirely new drug for the treatment of Alzheimer's disease

Claude Michel Wischik (Participant), Charles Robert Harrington (Participant), John Mervyn David Storey (Participant), Janet Elizabeth Rickard (Participant), David Horsley (Participant), Thomas Baddeley (Participant), Steven John Kemp (Participant), James Peter Sinclair (Participant), Claudia Zabke (Participant), F. Theuring (Participant), F Stamer (Participant), C Marshall (Participant)

Impact: Quality of life Impacts, Economic Impacts