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Research Output 1999 2019

2019

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

Research output: Contribution to journalArticle

Synucleins
Cholinergic Agents
Transgenic Mice
Acetylcholine
Choline O-Acetyltransferase

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J. & Luna-Muñoz, J., 14 Aug 2019, In : Journal of Alzheimer's Disease. 15 p.

Research output: Contribution to journalArticle

Open Access
File
tau Proteins
Neuroblastoma
Cell Cycle
Cell Division
Alzheimer Disease
2018
6 Citations (Scopus)
17 Downloads (Pure)

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

Frahm, S., Melis, V., Horsley, D., Rickard, J. E., Riedel, G., Fadda, P., Scherma, M., Harrington, C. R., Wischik, C. M., Theuring, F. & Schwab, K., 26 Feb 2018, In : Behavioural Brain Research. 339, p. 153-168 16 p.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Transgenic Mice
Parkinson Disease
Lewy Body Disease
Amphetamine
1 Citation (Scopus)
11 Downloads (Pure)
Open Access
File
Synucleins
Transgenic Mice
Proteins
Parkinson Disease
Endopeptidase K
1 Citation (Scopus)
8 Downloads (Pure)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In : Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cysteine
Alzheimer Disease
Tauopathies
tau Proteins
Neurofibrillary Tangles
6 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Prions
Alzheimer Disease
tau Proteins
Neurodegenerative Diseases
Clinical Trials
2017
10 Citations (Scopus)
13 Downloads (Pure)

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 24 Nov 2017, In : Journal of Molecular Biology. 429, 23, p. 3650-3665 16 p.

Research output: Contribution to journalArticle

Open Access
File
tau Proteins
Disulfides
Alzheimer Disease
Amyloidogenic Proteins
Neurofibrillary Tangles

LMTM DECREASES α-SYNUCLEIN PATHOLOGY AND REDUCES BEHAVIOURAL DEFECTS IN α-SYNUCLEIN TRANSGENIC MICE

Schwab, K., Frahm, S., Magbagbeolu, M., A. Goatman, E., R. Harrington, C., M. Wischik, C. & Theuring, F., 1 Jul 2017, In : Alzheimer's and Dementia. 13, 7 Suppl., p. P945-P945 1 p., P3-041.

Research output: Contribution to journalAbstract

46 Citations (Scopus)
8 Downloads (Pure)

Monoaminergic Neuropathology in Alzheimer's disease

Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., Silva, R. D., Giovanni, G. D., Wischik, C. M. & Hof, P. R., Apr 2017, In : Progress in Neurobiology. 151, p. 101-138 38 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
tau Proteins
Locus Coeruleus
Neuropathology
Behavioral Symptoms
17 Citations (Scopus)
15 Downloads (Pure)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D. & 2 othersHarrington, C. R. & Wischik, C. M., 28 Nov 2017, In : Journal of Alzheimer's Disease. 61, 1, p. 435-457 24 p.

Research output: Contribution to journalArticle

Open Access
File
Phase III Clinical Trials
Alzheimer Disease
Cohort Studies
Atrophy
Activities of Daily Living
2016
11 Citations (Scopus)
4 Downloads (Pure)

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease

Lai, R. Y. K., Harrington, C. R. & Wischik, C. M., 8 Apr 2016, In : Biomolecules. 6, 2, p. 1-19 19 p., 19.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Pathology
Tubulin
Alzheimer Disease
Agglomeration
2 Citations (Scopus)

Assays for the Screening and Characterization of Tau Aggregation Inhibitors

Rickard, J. E., Horsley, D., Wischik, C. M. & Harrington, C. R., 15 Dec 2016, Tau Protein: Methods and Protocols. Smet-Nocca, C. (ed.). Springer , Vol. 1523. p. 129-140 12 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

tau Proteins
Tauopathies
Immunoassay
Recombinant Proteins
Alzheimer Disease
93 Citations (Scopus)
4 Downloads (Pure)

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., Dec 2016, In : The Lancet. 388, 10062, p. 2873-2884 12 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Safety
Activities of Daily Living
Therapeutics
Amyloid
1 Citation (Scopus)

Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease

Wischik, C. M., Storey, J. M. D., Wischik, D. J. & Harrington, C. R., 15 Jun 2016, Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Wolfe, M. S. (ed.). Elsevier Inc., p. 385-436 52 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tauopathies
Alzheimer Disease
Functional Neuroimaging
Methylene Blue
Amyloid
120 Citations (Scopus)
8 Downloads (Pure)

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., Wischik, C. & Hof, P. R., Mar 2016, In : Biomolecules. 6, 1, 27 p., 6.

Research output: Contribution to journalReview article

Open Access
File
Tauopathies
tau Proteins
Alzheimer Disease
Agglomeration
Pathology
2015
39 Citations (Scopus)
5 Downloads (Pure)
Open Access
File
Proteolysis
Alzheimer Disease
Agglomeration
Brain
Salts
54 Citations (Scopus)
Oxidation-Reduction
Stomach
Alzheimer Disease
Aptitude
Methylene Blue
17 Citations (Scopus)
4 Downloads (Pure)

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G. & 1 othersTheuring, F., Jun 2015, In : Cellular and Molecular Life Sciences. 72, 11, p. 2199-2222 24 p.

Research output: Contribution to journalArticle

Open Access
File
Frontotemporal Lobar Degeneration
Tauopathies
Alzheimer Disease
Phenotype
Pathology
35 Citations (Scopus)
9 Downloads (Pure)

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F. & Riedel, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 353-368 16 p.

Research output: Contribution to journalArticle

Open Access
File
Tauopathies
Methylene Blue
Transgenic Mice
Licensure
Brain
122 Citations (Scopus)
4 Downloads (Pure)

Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A. & Harrington, C. R., 22 Jan 2015, In : Journal of Alzheimer's Disease. 44, 2, p. 705-720 16 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Cerebrovascular Circulation
Regional Blood Flow
Therapeutics
Pathology
20 Citations (Scopus)
6 Downloads (Pure)

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Flores-Rodríguez, P., Ontiveros-Torres, M. A., Cárdenas-Aguayo, M. C., Luna-Arias, J. P., Meraz-Ríos, M. A., Viramontes-Pintos, A., Harrington, C. R., Wischik, C. M., Mena, R., Florán-Garduño, B. & Luna-Muñoz, J., 11 Feb 2015, In : Frontiers in Neuroscience. 9, 10 p., 33.

Research output: Contribution to journalArticle

Open Access
File
tau Proteins
Alzheimer Disease
Phosphorylation
Epitopes
Brain
2014
132 Citations (Scopus)
5 Downloads (Pure)

Tau-aggregation inhibitor therapy for Alzheimer's disease

Wischik, C. M., Harrington, C. R. & Storey, J. M. D., 15 Apr 2014, In : Biochemical Pharmacology. 88, 4, p. 529-539 11 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid
Alzheimer Disease
Agglomeration
Presenilins
Pathology
20 Citations (Scopus)

The molecular pathology of Alzheimer's disease

Harrington, C. R., Feb 2012, In : Neuroimaging Clinics of North America. 22, 1, p. 11-22 12 p.

Research output: Contribution to journalLiterature review

Molecular Pathology
Amyloid
Dementia
Alzheimer Disease
Tauopathies
2011
6 Downloads (Pure)
File
Salt
Drugs
Alzheimer's Disease
Invention
2 Citations (Scopus)
Polychlorinated Biphenyls
Magnetic Resonance Imaging
2010
Patents and inventions
Salts
Pharmaceutical Preparations
xanthylium
7 Downloads (Pure)
File
tau Proteins
Hydrates
Labels
Salts
Ligands
132 Downloads (Pure)

Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

Wischik, C. M., Wischik, D. J., Storey, J. M. D. & Harrington, C. R., 2010, Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.). Cambridge, Vol. 1. p. 210-232 23 p. (RSC Drug Discovery Series).

Research output: Chapter in Book/Report/Conference proceedingChapter

File
Tauopathies
Methylene Blue
Alzheimer Disease
Disease Progression
Mitochondrial Turnover
2009
26 Citations (Scopus)
36 Downloads (Pure)

Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe

Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M. & CC75C Collaboration Grp, 16 Dec 2009, In : The Scientific World Journal. 9, p. 1463-1475 13 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
104 Downloads (Pure)

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

Deiana, S., Harrington, C. R., Wischik, C. M. & Riedel, G., Jan 2009, In : Psychopharmacology. 202, 1-3, p. 53-65 13 p.

Research output: Contribution to journalArticle

2 Downloads (Pure)

Therapeutic Use of Diaminophenothiazines: WO2009044127

Wischik, C. M., Damon J., W., Storey, J. M. D. & Harrington, C. R., 9 Apr 2009, IPC No. WO2009/044127

Research output: Patent

File
Dosage Forms
Therapeutic Uses
Pharmacokinetics
1 Downloads (Pure)
File
2008
20 Citations (Scopus)

Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints

Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M. & Mena, R., Nov 2008, In : Acta Neuropathologica. 116, 5, p. 507-515 9 p.

Research output: Contribution to journalArticle

2007
2 Downloads (Pure)
File
Synucleins
Parkinson Disease
Proteins
2005
3 Citations (Scopus)

Inhibition of tau-tau-association

Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M. & Klug, A., 2005, Patent No. US Patent 6,953,794B2; Granted 11/10/05

Research output: Patent

2004

Alzheimer's disease

Wischik, C. M., Harrington, C. R. & Roth, M., 2004, The Oxford Companion to The Mind. Gregory, R. L. (ed.). 2 ed. Oxford: Oxford University Press, p. 24-27 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2003

Naphthoquinone-type inhibitors of protein aggregation

Wischik, C. M., Horsley, D., Rickard, J. E. & Harrington, C. R., 2003, Patent No. WO 03/007933; published 30.01.03

Research output: Patent

2002

Inhibition of tau-tau-association

Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M. & Klug, A., 2002, Patent No. EP0817969; Application Granted 20/06/02

Research output: Patent

68 Citations (Scopus)

Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics

Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R. & Wischik, C. M., 14 Jan 2002, In : Neuroscience Letters. 317, 3, p. 161-165 5 p.

Research output: Contribution to journalArticle

7 Downloads (Pure)
File
3 Downloads (Pure)
File

Neurofibrillary labels

Wischik, C. M., Harrington, C. R., Rickard, J. E. & Horsley, D., 2002, Patent No. WO 02/075318 A2; published 26.09.02

Research output: Patent

2001
35 Citations (Scopus)

Dementia with Lewy bodies

Harrington, C. R., 2001, The Encyclopedia of Aging. A Comprehensive Resource in Gerontology and Geriatrics, 3rd Edition. G.L. Maddox, et al., Editors. Springer Publishing Company, New York. The Encyclopedia of Aging. A Comprehensive Resource in Gerontology and Geriatrics, 3rd Edition. G.L. Maddox, et al., Editors. Springer Publishing Company, New York, p. 280-282 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Loss of synaptic, but not cytoskeletal proteins in the cerebellum of people with chronic schizophrenia

Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R. & Wischik, C. M., 15 Apr 2001, In : Schizophrenia Research. 49, Suppl. 1, p. 55 1 p.

Research output: Contribution to journalAbstract

Prion diseases

Harrington, C. R., 2001, The Encyclopedia of Aging: A Comprehensive Resource in Gerontology and Geriatrics. Maddox, G. L. (ed.). 3 ed. New York: Springer , p. 817-819 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter