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Research Output 1999 2019

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2019

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K. A., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 21 Oct 2019, In : Journal of Alzheimer's Disease.

Research output: Contribution to journalArticle

Open Access
Atrophy
Alzheimer Disease
Brain
Therapeutics
Pharmaceutical Preparations

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

Research output: Contribution to journalArticle

Open Access
File
Synucleins
Cholinergic Agents
Transgenic Mice
Acetylcholine
Choline O-Acetyltransferase

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J. & Luna-Muñoz, J., 17 Sep 2019, In : Journal of Alzheimer's Disease. 71, 2, p. 631-645 15 p.

Research output: Contribution to journalArticle

Open Access
File
tau Proteins
Neuroblastoma
Cell Cycle
Cell Division
Alzheimer Disease
2018
7 Citations (Scopus)
19 Downloads (Pure)

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

Frahm, S., Melis, V., Horsley, D., Rickard, J. E., Riedel, G., Fadda, P., Scherma, M., Harrington, C. R., Wischik, C. M., Theuring, F. & Schwab, K., 26 Feb 2018, In : Behavioural Brain Research. 339, p. 153-168 16 p.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Transgenic Mice
Parkinson Disease
Lewy Body Disease
Amphetamine
3 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Synucleins
Transgenic Mice
Proteins
Parkinson Disease
Endopeptidase K
2 Citations (Scopus)
8 Downloads (Pure)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In : Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cysteine
Alzheimer Disease
Tauopathies
tau Proteins
Neurofibrillary Tangles
6 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Prions
Alzheimer Disease
tau Proteins
Neurodegenerative Diseases
Clinical Trials
2017
10 Citations (Scopus)
13 Downloads (Pure)

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 24 Nov 2017, In : Journal of Molecular Biology. 429, 23, p. 3650-3665 16 p.

Research output: Contribution to journalArticle

Open Access
File
tau Proteins
Disulfides
Alzheimer Disease
Amyloidogenic Proteins
Neurofibrillary Tangles
50 Citations (Scopus)
8 Downloads (Pure)

Monoaminergic Neuropathology in Alzheimer's disease

Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., Silva, R. D., Giovanni, G. D., Wischik, C. M. & Hof, P. R., Apr 2017, In : Progress in Neurobiology. 151, p. 101-138 38 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
tau Proteins
Locus Coeruleus
Neuropathology
Behavioral Symptoms
19 Citations (Scopus)
15 Downloads (Pure)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 28 Nov 2017, In : Journal of Alzheimer's Disease. 61, 1, p. 435-457 24 p.

Research output: Contribution to journalArticle

Open Access
File
Phase III Clinical Trials
Alzheimer Disease
Cohort Studies
Atrophy
Activities of Daily Living
2016
11 Citations (Scopus)
4 Downloads (Pure)

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease

Lai, R. Y. K., Harrington, C. R. & Wischik, C. M., 8 Apr 2016, In : Biomolecules. 6, 2, p. 1-19 19 p., 19.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Pathology
Tubulin
Alzheimer Disease
Agglomeration
98 Citations (Scopus)
4 Downloads (Pure)

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., Dec 2016, In : The Lancet. 388, 10062, p. 2873-2884 12 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Safety
Activities of Daily Living
Therapeutics
Amyloid
2015
40 Citations (Scopus)
5 Downloads (Pure)
Open Access
File
Proteolysis
Alzheimer Disease
Agglomeration
Brain
Salts
54 Citations (Scopus)
Oxidation-Reduction
Stomach
Alzheimer Disease
Aptitude
Methylene Blue
17 Citations (Scopus)
4 Downloads (Pure)

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G. & 1 others, Theuring, F., Jun 2015, In : Cellular and Molecular Life Sciences. 72, 11, p. 2199-2222 24 p.

Research output: Contribution to journalArticle

Open Access
File
Frontotemporal Lobar Degeneration
Tauopathies
Alzheimer Disease
Phenotype
Pathology
35 Citations (Scopus)
9 Downloads (Pure)

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F. & Riedel, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 353-368 16 p.

Research output: Contribution to journalArticle

Open Access
File
Tauopathies
Methylene Blue
Transgenic Mice
Licensure
Brain
124 Citations (Scopus)
4 Downloads (Pure)

Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A. & Harrington, C. R., 22 Jan 2015, In : Journal of Alzheimer's Disease. 44, 2, p. 705-720 16 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Cerebrovascular Circulation
Regional Blood Flow
Therapeutics
Pathology
21 Citations (Scopus)
6 Downloads (Pure)

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Flores-Rodríguez, P., Ontiveros-Torres, M. A., Cárdenas-Aguayo, M. C., Luna-Arias, J. P., Meraz-Ríos, M. A., Viramontes-Pintos, A., Harrington, C. R., Wischik, C. M., Mena, R., Florán-Garduño, B. & Luna-Muñoz, J., 11 Feb 2015, In : Frontiers in Neuroscience. 9, 10 p., 33.

Research output: Contribution to journalArticle

Open Access
File
tau Proteins
Alzheimer Disease
Phosphorylation
Epitopes
Brain
2014
136 Citations (Scopus)
5 Downloads (Pure)

Tau-aggregation inhibitor therapy for Alzheimer's disease

Wischik, C. M., Harrington, C. R. & Storey, J. M. D., 15 Apr 2014, In : Biochemical Pharmacology. 88, 4, p. 529-539 11 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid
Alzheimer Disease
Agglomeration
Presenilins
Pathology
2013
13 Citations (Scopus)

Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function

Wasik, U., Schneider, G., Mietelska-Porowska, A., Mazurkiewicz, M., Fabczak, H., Weis, S., Zabke, C., Harrington, C. R., Filipek, A. & Niewiadomska, G., May 2013, In : Neurobiology of Aging. 34, 5, p. 1380-1388 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Pathology
Proteins
Transgenic Mice
Carisoprodol
2011
2 Citations (Scopus)
Polychlorinated Biphenyls
Magnetic Resonance Imaging
2009
26 Citations (Scopus)
36 Downloads (Pure)

Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe

Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M. & CC75C Collaboration Grp, 16 Dec 2009, In : The Scientific World Journal. 9, p. 1463-1475 13 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
104 Downloads (Pure)

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

Deiana, S., Harrington, C. R., Wischik, C. M. & Riedel, G., Jan 2009, In : Psychopharmacology. 202, 1-3, p. 53-65 13 p.

Research output: Contribution to journalArticle

2008
20 Citations (Scopus)

Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints

Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M. & Mena, R., Nov 2008, In : Acta Neuropathologica. 116, 5, p. 507-515 9 p.

Research output: Contribution to journalArticle

2005
3 Citations (Scopus)
2002
68 Citations (Scopus)

Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics

Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R. & Wischik, C. M., 14 Jan 2002, In : Neuroscience Letters. 317, 3, p. 161-165 5 p.

Research output: Contribution to journalArticle

2001
35 Citations (Scopus)
2000

Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease

Maruyama, H., Toji, H., Harrington, C. R., Sasaki, K., Izumi, Y., Ohnuma, T., Arai, H., Yasuda, M., Tanaka, C., Emson, P. C., Nakamura, S. & Kawakami, H., 2000, In : Archives of Neurology. 57, p. 236-240 5 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Neuropathological findings in the very old - Results from the first 101 brains of a population-based longitudinal study of dementing disorders

Xuereb, J. H., Brayne, C., Dufouil, C., Gertz, H., Wischik, C., Harrington, C., Mukaetova-Ladinska, E., McGee, M. A., O'Sullivan, A., O'Connor, D., Paykel, E. S. & Huppert, F. A., 2000, In : Annals of the New York Academy of Sciences. 903, p. 490-496 7 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease

Mukaetova-Ladinska, E. B., Garcia-Siera, F., Hurt, J., Gertz, H. J., Xuereb, J. H., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M., Jakes, R., Honer, W. G., Harrington, C. R. & Wischik, C. M., Aug 2000, In : American Journal of Pathology. 157, 2, p. 623-636 14 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

Xu, W. M., Liu, L. Z., Emson, P., Harrington, C. R., McKeith, I. G., Perry, R. H., Morris, C. M. & Charles, I. G., 2000, In : Neuroreport. 11, p. 297-299 3 p.

Research output: Contribution to journalArticle

1999
88 Citations (Scopus)

Association between Alzheimer's disease and the NOS3 gene

Dahiyat, M., Cumming, A., Harrington, C., Wischik, C., Xuereb, J., Corrigan, F., Breen, G., Shaw, D. & St Clair, D., 1999, In : Annals of Neurology. 46, p. 664-667 4 p.

Research output: Contribution to journalArticle