Claude Michel Wischik

Professor

    • AB25 2ZD

    • 1140 Citations
    20002019
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    Fingerprint Dive into the research topics where Claude Michel Wischik is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 16 Similar Profiles
    Alzheimer Disease Medicine & Life Sciences
    Tauopathies Medicine & Life Sciences
    tau Proteins Medicine & Life Sciences
    Transgenic Mice Medicine & Life Sciences
    Synucleins Medicine & Life Sciences
    Methylene Blue Medicine & Life Sciences
    Agglomeration Chemical Compounds
    Cerebrovascular Circulation Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output 2000 2019

    6 Downloads (Pure)
    Open Access
    File
    Aging of materials
    Brain
    Neurodegenerative diseases
    Complex networks
    Magnetic resonance

    Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

    König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

    Research output: Contribution to journalArticle

    Synucleins
    Cholinergic Agents
    Transgenic Mice
    Acetylcholine
    Choline O-Acetyltransferase
    6 Citations (Scopus)
    16 Downloads (Pure)

    Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

    Frahm, S., Melis, V., Horsley, D., Rickard, J. E., Riedel, G., Fadda, P., Scherma, M., Harrington, C. R., Wischik, C. M., Theuring, F. & Schwab, K., 26 Feb 2018, In : Behavioural Brain Research. 339, p. 153-168 16 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    alpha-Synuclein
    Transgenic Mice
    Parkinson Disease
    Lewy Body Disease
    Amphetamine
    1 Citation (Scopus)
    11 Downloads (Pure)
    Open Access
    File
    Synucleins
    Transgenic Mice
    Proteins
    Parkinson Disease
    Endopeptidase K
    1 Citation (Scopus)
    7 Downloads (Pure)

    Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

    Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In : Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Cysteine
    Alzheimer Disease
    Tauopathies
    tau Proteins
    Neurofibrillary Tangles

    Impacts

    Discovery and commercialisation of an entirely new drug for the treatment of Alzheimer's disease

    Claude Michel Wischik (Participant), Charles Robert Harrington (Participant), John Mervyn David Storey (Participant), Janet Elizabeth Rickard (Participant), David Horsley (Participant), Thomas Baddeley (Participant), Steven John Kemp (Participant), James Peter Sinclair (Participant), Claudia Zabke (Participant), F. Theuring (Participant), F Stamer (Participant), C Marshall (Participant)

    Impact: Quality of life Impacts, Economic Impacts