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Research Output

2020

Agrin induces long term osteochondral regeneration by supporting repair morphogenesis

Eldridge, S., Barawi, A., Wang, H., Roelofs, A., Kaneva, M., Guan, Z., Lydon, H., Thomas, B. L., Thorup, A-S., Fernandez Fernandez, B., Caxaria, S., Strachan, D., Ali, A., Shanmuganathan, K., Pitzalis, C., Whiteford, J., Henson, F., McCaskie, A., de Bari, C. & Dell'Accio, F., 2 Sep 2020, In : Science translational medicine. 12, 559, eaax9086.

Research output: Contribution to journalArticle

Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis

Roelofs, A. J., Kania, K., Rafipay, A., Sambale, M., Kuwahara, S. T., Collins, F., Smeeton, J., Serowoky, M. A., Rowley, L., Wang, H., Gronewold, R., Kapen, C., Méndez-Ferrer, S., Little, C. B., Bateman, J. F., Pap, T., Mariani, F. V., Sherwood, J., Crump, J. G. & de Bari, C., 11 Aug 2020, (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

Kania, K., Colella, F., Riemen, A. H. K., Wang, H., Howard, K. A., Aigner, T., Dell'Accio, F., Capellini, T. D., Roelofs, A. J. & de Bari, C., 13 Jan 2020, In : Scientific Reports. 10, 157.

Research output: Contribution to journalArticle

Open Access
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3 Downloads (Pure)

Stratified glucocorticoid monotherapy is safe and effective for most cases of giant cell arteritis

Karabayas, M., Dospinescu, P., Locherty, M., Moulindu, P., Sobti, M. M., Hollick, R., de Bari, C., Robinson, S., Olson, J. & Basu, N., 29 Jun 2020, In : Rheumatology Advances in Practice.

Research output: Contribution to journalArticle

Open Access
2019

Immunostaining of Skeletal Tissues

Roelofs, A. J. & De Bari, C., 8 Feb 2019, In : Methods in molecular biology (Clifton, N.J.). 1914, p. 437-450 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Targeting anti-chondrogenic factors for the stimulation of chondrogenesis: A new paradigm in cartilage repair

Lolli, A., Colella, F., De Bari, C. & van Osch, G. J. V. M., 31 Jan 2019, In : Journal of Orthopaedic Research. 37, 1, p. 12-22 11 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

The burden of metabolic syndrome on osteoarthritic joints

Dickson, B. M., Roelofs, A. J., Rochford, J. J., Wilson, H. M. & de Bari, C., 16 Dec 2019, In : Arthritis Research & Therapy. 21, 289.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
3 Downloads (Pure)
2018

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

McIlroy, G. D., Suchacki, K., Roelofs, A. J., Yang, W., Fu, Y., Bai, B., Wallace, R. J., de Bari, C., Cawthorn, W. P., Han, W., Delibegovic, M. & Rochford, J. J., Apr 2018, In : Molecular Metabolism. 10, p. 55-65 11 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
11 Downloads (Pure)

Stem Cell-based Therapeutic Strategies for Cartilage Defects and Osteoarthritis

de Bari, C. & Roelofs, A. J., Jun 2018, In : Current Opinion in Pharmacology. 40, p. 74-80 7 p.

Research output: Contribution to journalReview article

Open Access
File
40 Citations (Scopus)
11 Downloads (Pure)
2017

Joint morphogenetic cells in the adult mammalian synovium

Roelofs, A. J., Zupan, J., Riemen, A. H. K., Kania, K., Ansboro, S., White, N., Clark, S. M. & De Bari, C., 16 May 2017, In : Nature Communications. 8, 15040 .

Research output: Contribution to journalArticle

Open Access
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50 Citations (Scopus)
14 Downloads (Pure)

Mesenchymal stem cells for management of rheumatoid arthritis: immune modulation, repair or both?

Ansboro, S., Roelofs, A. J. & de Bari, C., 1 Mar 2017, In : Current Opinion in Rheumatology. 29, 2, p. 201-207 7 p.

Research output: Contribution to journalReview article

Open Access
File
44 Citations (Scopus)
9 Downloads (Pure)

The potential role of adult stem cells in the management of the rheumatic diseases

Franceschetti, T. & De Bari, C., Jul 2017, In : Therapeutic advances in musculoskeletal disease. 9, 7, p. 165-179 15 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)
2016

Bone Marrow Contribution to Synovial Hyperplasia Following Joint Surface Injury

Sergijenko, A., Roelofs, A. J., Riemen, A. H. K. & De Bari, C., 13 Jul 2016, In : Arthritis Research & Therapy. 18, p. 1-11 11 p., 166.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
8 Downloads (Pure)

MICL controls inflammation in rheumatoid arthritis

Redelinghuys, P., Whitehead, L., Augello, A., Drummond, R. A., Levesque, J-M., Vautier, S., Reid, D. M., Kerscher, B., Taylor, J. A., Nigrovic, P. A., Wright, J., Murray, G. I., Willment, J. A., Hocking, L. J., Fernandes, M. J. G., De Bari, C., McInnes, I. B. & Brown, G. D., Jul 2016, In : Annals of the Rheumatic Diseases. 75, 7, p. 1386-1391 6 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
10 Downloads (Pure)
2015

A homeostatic function of CXCR2 signalling in articular cartilage

Sherwood, J., Bertrand, J., Nalesso, G., Poulet, B., Pitsillides, A., Brandolini, L., Karystinou, A., De Bari, C., Luyten, F. P., Pitzalis, C., Pap, T. & Dell'Accio, F., 2015, In : Annals of the Rheumatic Diseases. 74, 12, p. 2207-2215 9 p.

Research output: Contribution to journalArticle

Open Access
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35 Citations (Scopus)
8 Downloads (Pure)

Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?

De Bari, C., 1 May 2015, In : Arthritis Research & Therapy. 17, 9 p., 113.

Research output: Contribution to journalLiterature review

Open Access
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36 Citations (Scopus)
5 Downloads (Pure)

Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis

Eseonu, O. I. & De Bari, C., 1 Feb 2015, In : Rheumatology. 54, 2, p. 210-218 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells

Karystinou, A., Roelofs, A. J., Neve, A., Cantatore, F. P., Wackerhage, H. & De Bari, C., 30 May 2015, In : Arthritis Research & Therapy. 17, 14 p., 147.

Research output: Contribution to journalArticle

Open Access
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49 Citations (Scopus)
9 Downloads (Pure)

Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice

Marcus, P., De Bari, C., Dell'Accio, F. & Archer, C. W., Oct 2014, In : Cartilage. 5, 4, p. 231-240 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum

Cherry, H. M., Roelofs, A. J., Kurth, T. & De Bari, C., 11 Mar 2014, In : European Cells & Materials. 27, p. 185-195 11 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
7 Downloads (Pure)

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

Tremblay, A. M., Missiaglia, E., Galli, G. G., Hettmer, S., Urcia, R., Carrara, M., Judson, R. N., Thway, K., Nadal, G., Selfe, J. L., Murray, G. I., Calogero, R. A., De Bari, C., Zammit, P. S., Delorenzi, M., Wagers, A. J., Shipley, J., Wackerhage, H. & Camargo, F. D., 11 Aug 2014, In : Cancer Cell. 26, 2, p. 273-287 15 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)
2013

Cell-based Approaches to Joint Surface Repair: A Research Perspective

Roelofs, A. J., Rocke, J. P. J. & De Bari, C., Jul 2013, In : Osteoarthritis and Cartilage. 21, 7, p. 892-900 9 p.

Research output: Contribution to journalReview article

Open Access
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56 Citations (Scopus)
6 Downloads (Pure)

Mesenchymal stem cell niches in joint health and disease

De Bari, C., 2013, In : European Cells & Materials. 26, suppl. 3, p. 5 1 p.

Research output: Contribution to journalArticle

Prospective purification of a subpopulation of human synovial mesenchymal stem cells with enhanced chondro-osteogenic potency.

Gullo, F. & De Bari, C., Oct 2013, In : Rheumatology. 52, 10, p. 1758-1768 11 p.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)
2012

Immunostaining of skeletal tissues

Kurth, T. B. & De Bari, C., 2012, In : Methods in Molecular Biology. 816, 4, p. 321-334 14 p.

Research output: Contribution to journalArticle

File
3 Citations (Scopus)
3 Downloads (Pure)

The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells

Judson, R. N., Tremblay, A. M., Knopp, P., White, R. B., Urcia, R., De Bari, C., Zammit, P. S., Camargo, F. D. & Wackerhage, H., 15 Dec 2012, In : Journal of Cell Science. 125, 24, p. 6009-6019 11 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)
2011

Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field

Zhao, Z., Watt, C., Karystinou, A., Roelofs, A. J., McCaig, C. D., Gibson, I. R. & De Bari, C., 29 Nov 2011, In : European Cells & Materials. 22, -, p. 344-358 15 p., -.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Dual origin of mesenchymal stem cells contributing to organ growth and repair

Feng, J., Mantesso, A., De Bari, C., Nishiyama, A. & Sharpe, P. T., 19 Apr 2011, In : PNAS. 108, 16, p. 6503-6508 6 p.

Research output: Contribution to journalArticle

260 Citations (Scopus)

Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo

Kurth, T. B., Dell'Accio, F., Crouch, V., Augello, A., Sharpe, P. T. & De Bari, C., May 2011, In : Arthritis & Rheumatism. 63, 5, p. 1289-1300 12 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Future dentistry: cell therapy meets tooth and periodontal repair and regeneration

Catón, J., Bostanci, N., Remboutsika, E., De Bari, C. & Mitsiadis, T. A., May 2011, In : Journal of Cellular and Molecular Medicine. 15, 5, p. 1054-1065 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Mesenchymal differentiation propensity of a human embryonic stem cell line

Pringle, S., De Bari, C., Dell'accio, F., Przyborski, S., Cooke, M. J., Minger, S. L. & Grigoriadis, A. E., 1 Apr 2011, In : Cell Proliferation. 44, 2, p. 120-127 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Prospects of stem cell therapy in osteoarthritis

Roberts, S., Genever, P., McCaskie, A. & De Bari, C., 2011, In : Regenerative Medicine. 6, 3, p. 351-366 16 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases

MacDonald, G. I. A., Augello, A. & De Bari, C., Sep 2011, In : Arthritis & Rheumatism. 63, 9, p. 2547-2557 11 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

Nalesso, G., Sherwood, J., Bertrand, J., Pap, T., Ramachandran, M., De Bari, C., Pitzalis, C. & Dell'accio, F., May 2011, In : Journal of Cell Biology. 193, 3, p. 551-564 14 p.

Research output: Contribution to journalArticle

Open Access
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124 Citations (Scopus)
9 Downloads (Pure)
2010

Human single-chain variable fragment that specifically targets arthritic cartilage

Hughes, C., Faurholm, B., Dell'Accio, F., Manzo, A., Seed, M., Eltawil, N., Marrelli, A., Gould, D., Subang, C., Al-Kashi, A., De Bari, C., Winyard, P., Chernajovsky, Y. & Nissim, A., Apr 2010, In : Arthritis & Rheumatism. 62, 4, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches

Augello, A., Kurth, T. B. & De Bari, C., 1 Sep 2010, In : European Cells & Materials. 20, p. 121-133 13 p.

Research output: Contribution to journalArticle

229 Citations (Scopus)

Mesenchymal stem cells from development to postnatal joint homeostasis, aging, and disease

De Bari, C., Kurth, T. B. & Augello, A., Dec 2010, In : Birth Defects Research. Part C, Embryo Today: Reviews. 90, 4, p. 257-271 15 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The regulation of differentiation in mesenchymal stem cells

Augello, A. & De Bari, C., 1 Oct 2010, In : Human Gene Therapy. 21, 10, p. 1226-1238 13 p.

Research output: Contribution to journalArticle

Open Access
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231 Citations (Scopus)
6 Downloads (Pure)

Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table

Parolini, O., Alviano, F., Bergwerf, I., Boraschi, D., De Bari, C., De Waele, P., Dominici, M., Evangelista, M., Falk, W., Hennerbichler, S., Hess, D. C., Lanzoni, G., Liu, B., Marongiu, F., McGuckin, C., Mohr, S., Nolli, M. L., Ofir, R., Ponsaerts, P., Romagnoli, L. & 10 others, Solomon, A., Soncini, M., Strom, S., Surbek, D., Venkatachalam, S., Wolbank, S., Zeisberger, S., Zeitlin, A., Zisch, A. & Borlongan, C. V., 25 Feb 2010, In : Stem Cells and Development. 19, 2, p. 143-154 12 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Yap is a novel regulator of C2C12 myogenesis

Watt, K. I., Judson, R., Medlow, P., Reid, K., Kurth, T. B., Burniston, J. G., Ratkevicius, A., De Bari, C. & Wackerhage, H., 19 Mar 2010, In : Biochemical and Biophysical Research Communications. 393, 4, p. 619-624 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)
2009

A novel in vivo murine model of cartilage regeneration: Age and strain-dependent outcome after joint surface injury

Eltawil, N. M., De Bari, C., Achan, P., Pitzalis, C. & Dell'accio, F., Jun 2009, In : Osteoarthritis and Cartilage. 17, 6, p. 695-704 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Distinct mesenchymal progenitor cell subsets in the adult human synovium

Karystinou, A., Dell'Accio, F., Kurth, T. B. A., Wackerhage, H., Khan, I. M., Archer, C. W., Jones, E. A., Mitsiadis, T. A. & De Bari, C., Sep 2009, In : Rheumatology. 48, 9, p. 1057-1064 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Mesenchymal stem cells find their niches in skeletal regenerative medicine

de Bari, C., 1 Aug 2009, In : European Cells and Materials. 18, SUPPL. 1, 1 p.

Research output: Contribution to journalArticle

2008

A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells

De Bari, C., Dell'Accio, F., Karystinou, A., Guillot, P. V., Fisk, N. M., Jones, E. A., McGonagle, D., Khan, I. M., Archer, C. W., Mitsiadis, T. A., Donaldson, A. N., Luyten, F. P. & Pitzalis, C., Jan 2008, In : Arthritis & Rheumatism. 58, 1, p. 240-250 11 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)