David Malcolm St Clair

Professor

    • AB25 2ZD

    • 26188 Citations
    19992019
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    Research Output 1999 2019

    2011
    806 Citations (Scopus)

    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

    Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., Blackwood, D., Corvin, A., Flickinger, M., Guan, W., Mattingsdal, M., McQuillin, A., Kwan, P., Wienker, T. F., Daly, M., Dudbridge, F., Holmans, P. A. & 31 othersLin, D., Burmeister, M., Greenwood, T. A., Hamshere, M. L., Muglia, P., Smith, E. N., Zandi, P. P., Nievergelt, C. M., McKinney, R., Shilling, P. D., Schork, N. J., Bloss, C. S., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A., Hipolito, M., Coryell, W., Rice, J., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W., Li, J., Breen, G., St Clair, D. & Psychiatric GWAS Consortium Bipolar Disorder Working Group, Oct 2011, In : Nature Genetics. 43, 10, p. 977-983 7 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Bipolar Disorder
    Single Nucleotide Polymorphism
    Calcium Channels
    Sample Size
    150 Citations (Scopus)

    Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

    The International Schizophrenia Consortium (ISC), 2011, In : Molecular Psychiatry. 16, 3, p. 286-292 7 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Cell Adhesion
    Schizophrenia
    Cell Adhesion Molecules
    Cell Membrane
    42 Citations (Scopus)

    Polygenic dissection of the bipolar phenotype

    Hamshere, M. L., O'Donovan, M. C., Jones, I. R., Jones, L., Kirov, G., Green, E. K., Moskvina, V., Grozeva, D., Bass, N., McQuillin, A., Gurling, H., St Clair, D., Young, A. H., Ferrier, I. N., Farmer, A., McGuffin, P., Sklar, P., Purcell, S., Holmans, P. A., Owen, M. J. & 1 othersCraddock, N., 1 Apr 2011, In : British Journal of Psychiatry. 198, 4, p. 284-288 5 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Dissection
    Phenotype
    Schizophrenia
    Psychotic Disorders
    45 Citations (Scopus)

    Prevention and schizophrenia: the role of dietary factors

    McGrath, J., Brown, A. & St Clair, D., Mar 2011, In : Schizophrenia Bulletin. 37, 2, p. 272-283 12 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Micronutrients
    Starvation
    Folic Acid
    Vitamin D
    12 Citations (Scopus)

    Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia

    Chen, J., Lee, G., Fanous, A. H., Zhao, Z., Jia, P., O'Neill, A., Walsh, D., Kendler, K. S., Chen, X., The International Schizophrenia Consortium (ISC) & St Clair, D., Sep 2011, In : Schizophrenia Research. 131, 1-3, p. 43-51 9 p.

    Research output: Contribution to journalArticle

    Data Mining
    Genome-Wide Association Study
    Schizophrenia
    Linkage Disequilibrium
    Haplotypes
    2010
    97 Citations (Scopus)
    4 Downloads (Pure)

    Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function

    Raychaudhuri, S., Korn, J. M., McCarroll, S. A., The International Schizophrenia Consortium (ISC), Altshuler, D., Sklar, P., Purcell, S., Daly, M. J. & St Clair, D. M., 9 Sep 2010, In : PLoS Genetics. 6, 9, 12 p., e1001097.

    Research output: Contribution to journalArticle

    Open Access
    File
    brain
    Schizophrenia
    gene
    Brain
    Genes

    A classification model of schizophrenia using a multivariate eye movement phenotype

    Benson, P. J., Beedie, S. A., Giegling, I., Rujescu, D. & St Clair, D. M., 2010, In : European Psychiatry. 25, S1, p. 611 1 p., P01-398.

    Research output: Contribution to journalAbstract

    35 Citations (Scopus)

    A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

    GROUP Investigators, 1 Apr 2010, In : Human Molecular Genetics. 19, 7, p. 1379-1386 8 p.

    Research output: Contribution to journalArticle

    Meta-Analysis
    Schizophrenia
    Genes
    Chromosome Mapping
    Linkage Disequilibrium
    2 Citations (Scopus)

    Erratum to: evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging

    Nicodemus, K. K., Callicott, J. H., Higier, R. G., Luna, A., Nixon, C., Lipska, B. K., Vakkalanka, R., Giegling, I., Rujescu, D., St Clair, D. M., Muglia, P., Shugart, Y. Y. & Weinberger, D. R., 1 Apr 2010, In : Human Genetics. 127, 4, p. 453-454 2 p.

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging

    Nicodemus, K. K., Callicott, J. H., Higier, R. G., Luna, A., Nixon, D. C., Lipska, B. K., Vakkalanka, R., Giegling, I., Rujescu, D., St Clair, D., Muglia, P., Shugart, Y. Y. & Weinberger, D. R., Apr 2010, In : Human Genetics. 127, 4, p. 441-452 12 p.

    Research output: Contribution to journalArticle

    Functional Neuroimaging
    Single Nucleotide Polymorphism
    Schizophrenia
    Exons
    Logistic Models

    Frontal brain function and visual exploration of natural scenes in schizophrenia

    Beedie, S. A., St Clair, D. M. & Rujescu, D., 2010, In : European Psychiatry. 25, S1, p. 1104 1 p., P03-124.

    Research output: Contribution to journalAbstract

    Schizophrenia
    Saccades
    Brain
    Ocular Fixation
    Neuropsychological Tests
    563 Citations (Scopus)

    Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

    Craddock, N., Hurles, M. E., Cardin, N., Pearson, R. D., Plagnol, V., Robson, S., Vukcevic, D., Barnes, C., Conrad, D. F., Giannoulatou, E., Holmes, C., Marchini, J. L., Stirrups, K., Tobin, M. D., Wain, L. V., Yau, C., Aerts, J., Ahmad, T., Andrews, T. D., Arbury, H. & 31 othersAttwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G. D., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Byrnes, J., Caesar, S., Clee, C. M., Coffey, A. J., Connell, J. M. C., Cooper, J. D., Hocking, L., Reid, D. M., St Clair, D. M., Webster, J. & Wellcome Trust Case Control Consortium, 1 Apr 2010, In : Nature. 464, 7289, p. 713-720 8 p.

    Research output: Contribution to journalArticle

    426 Citations (Scopus)

    Meta-analysis and imputation refines the association of 15q25 with smoking quantity

    Liu, J. Z., Tozzi, F., Waterworth, D. M., Pillai, S. G., Muglia, P., Middleton, L., Berrettini, W., Knouff, C. W., Yuan, X., Waeber, G., Vollenweider, P., Preisig, M., Wareham, N. J., Zhao, J. H., Loos, R. J. F., Barroso, I., Khaw, K-T., Grundy, S., Barter, P., Mahley, R. & 31 othersKesaniemi, A., McPherson, R., Vincent, J. B., Strauss, J., Kennedy, J. L., Farmer, A., McGuffin, P., Day, R., Matthews, K., Bakke, P., Gulsvik, A., Lucae, S., Ising, M., Brueckl, T., Horstmann, S., Wichmann, H-E., Rawal, R., Dahmen, N., Lamina, C., Polasek, O., Zgaga, L., Huffman, J., Campbell, S. E., Kooner, J., Chambers, J. C., Burnett, M. S., Devaney, J. M., Pichard, A. D., Kent, K. M., St Clair, D. M. & Wellcome Trust Case Control Consortium, May 2010, In : Nature Genetics. 42, 5, p. 436-440 5 p.

    Research output: Contribution to journalArticle

    Single Nucleotide Polymorphism
    Meta-Analysis
    Smoking
    Genome
    Population Control

    Multivariate eye movement psychophysiology accurately differentiates schizophrenia cases from unaffected controls

    Benson, P. J., Beedie, S. A., Geigling, I., Rujescu, D. & St. Clair, D., Apr 2010, In : Schizophrenia Research. 117, 2-3, p. 248-249 2 p.

    Research output: Contribution to journalArticle

    97 Citations (Scopus)

    Penetrance for copy number variants associated with schizophrenia

    Vassos, E., Collier, D. A., Holden, S., Patch, C., Rujescu, D., St Clair, D. M. & Lewis, C. M., 1 Sep 2010, In : Human Molecular Genetics. 19, 17, p. 3477-3481 5 p.

    Research output: Contribution to journalArticle

    Penetrance
    Schizophrenia
    DiGeorge Syndrome
    Bayes Theorem
    Genetic Counseling

    Perseverative eye movements in obsessive-compulsive disorder and schizophrenia

    Shephard, E., Beedie, S. A., Kuriakose, J., Benson, P. J. & St Clair, D. M., Sep 2010, In : Perception. 39, ECVP Abstract Supplement, p. 37 1 p.

    Research output: Contribution to journalAbstract

    Eye movements
    Obsessive-Compulsive Disorder
    Eye Movements
    Schizophrenia
    Saccades
    26 Citations (Scopus)

    Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia

    Xu, M., Xing, Q., Li, S., Zheng, Y., Wu, S., Gao, R., Yu, L., Guo, T., Yang, Y., Liu, J., Zhang, A., Zhao, X., He, G., Zhou, J., Wang, L., Xuan, J., Du, J., Li, X., Feng, G., Lin, Z. & 4 othersXu, Y., St Clair, D. M., Lin, Z. & He, L., 16 Aug 2010, In : Progress in Neuro -Psychopharmacology & Biological Psychiatry. 34, 6, p. 1026-1032 7 p.

    Research output: Contribution to journalArticle

    Dopamine Plasma Membrane Transport Proteins
    Clozapine
    Chlorpromazine
    Minisatellite Repeats
    Haplotypes
    135 Citations (Scopus)

    Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia

    Grozeva, D., Kirov, G., Ivanov, D., Jones, I. R., Jones, L., Green, E. K., St Clair, D. M., Young, A. H., Ferrier, N., Farmer, A. E., McGuffin, P., Holmans, P. A., Owen, M. J., O'Donovan, M. C., Craddock, N. & Wellcome Trust Case Control Consortium, Apr 2010, In : Archives of General Psychiatry. 67, 4, p. 318-327 10 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Schizophrenia
    Disease Susceptibility
    Human Genome
    Autistic Disorder

    Scanpaths as a generalised deficit in schizophrenia

    Beedie, S. A., Shephard, E., Giegling, I., Rujescu, D., St Clair, D. M. & Benson, P. J., Sep 2010, In : Perception. 39, ECVP Abstract Supplement, p. 34 1 p.

    Research output: Contribution to journalAbstract

    95 Citations (Scopus)

    Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotypeGABAA receptors in bipolar disorder

    Craddock, N., Jones, L., Jones, I. R., Kirov, G., Green, E. K., Grozeva, D., Moskvina, V., Nikolov, I., Hamshere, M. L., Vukcevic, D., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., Norton, N., Breen, G. D., St Clair, D. M., Collier, D. A., Young, A. H., Ferrier, I. N. & 6 othersFarmer, A., McGuffin, P., Holmans, P. A., Donnelly, P., Owen, M. J. & O'Donovan, M. C., Feb 2010, In : Molecular Psychiatry. 15, 2, p. 146-153 8 p.

    Research output: Contribution to journalArticle

    24 Citations (Scopus)
    Genetic Testing
    Schizophrenia
    Linkage Disequilibrium
    HapMap Project
    Genes
    2009
    75 Citations (Scopus)

    A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression

    Knight, H. M., Pickard, B. S., Maclean, A., Malloy, M. P., Soares, D. C., McRae, A. F., Condie, A., White, A., Hawkins, W., McGhee, K., van Beck, M., MacIntyre, D. J., Starr, J. M., Deary, I. J., Visscher, P. M., Porteous, D. J., Cannon, R. E., St Clair, D., Muir, W. J. & Blackwood, D. H. R., 11 Dec 2009, In : American Journal of Human Genetics. 85, 6, p. 833-46 14 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Chromosome Aberrations
    Schizophrenia
    Genes
    Mutation
    341 Citations (Scopus)
    2 Downloads (Pure)

    A genome-wide investigation of SNPs and CNVs in schizophrenia

    Need, A. C., Ge, D., Weale, M. E., Maia, J., Feng, S., Heinzen, E. L., Shianna, K. V., Yoon, W., Kasperaviciute, D., Gennarelli, M., Strittmatter, W. J., Bonvicini, C., Rossi, G., Jayathilake, K., Cola, P. A., McEvoy, J. P., Keefe, R. S. E., Fisher, E. M. C., St Jean, P. L., Giegling, I. & 13 othersHartmann, A. M., Möller, H-J., Ruppert, A., Fraser, G., Crombie, C., Middleton, L. T., St Clair, D., Roses, A. D., Muglia, P., Francks, C., Rujescu, D., Meltzer, H. Y. & Goldstein, D. B., 6 Feb 2009, In : PLoS Genetics. 5, 2, 19 p., e1000373.

    Research output: Contribution to journalArticle

    Open Access
    File
    single nucleotide polymorphism
    Single Nucleotide Polymorphism
    Schizophrenia
    polymorphism
    genome
    50 Citations (Scopus)

    An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis

    Prata, D. P., Breen, G., Osborne, S., Munro, J., St. Clair, D. & Collier, D., Jun 2009, In : Psychiatric Genetics. 19, 3, p. 113-116 4 p.

    Research output: Contribution to journalArticle

    Neuregulin-1
    Mood Disorders
    Bipolar Disorder
    Schizophrenia
    Alleles
    2596 Citations (Scopus)

    Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

    St Clair, D. M., Purcell, M., Wray, N. R., Stone, J., Visscher, P. M., O'Donovan, M. C., Sullivan, P. F., Sklar, P. & The International Schizophrenia Consortium (ISC), 6 Aug 2009, In : Nature. 460, 7256, p. 748-752 5 p.

    Research output: Contribution to journalLetter

    Bipolar Disorder
    Schizophrenia
    Delusions
    Genome-Wide Association Study
    Hallucinations
    1167 Citations (Scopus)

    Common variants conferring risk of schizophrenia

    Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., Mortensen, P. B., Sigurdsson, E., Gustafsson, O., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Suvisaari, J., Lonnqvist, J., Paunio, T., Børglum, A. D. & 31 othersHartmann, A., Fink-Jensen, A., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Böttcher, Y., Olesen, J., Breuer, R., Möller, H-J., Giegling, I., Rasmussen, H. B., Timm, S., Mattheisen, M., Bitter, I., Réthelyi, J. M., Magnusdottir, B. B., Sigmundsson, T., Olason, P., Masson, G., Gulcher, J. R., Haraldsson, M., Fossdal, R., Thorgeirsson, T. E., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Franke, B., Strengman, E., Walker, N., St Clair, D. & Genetic Risk and Outcome in Psychosis (GROUP), 6 Aug 2009, In : Nature. 460, 7256, p. 744-747 4 p.

    Research output: Contribution to journalLetter

    Schizophrenia
    Neurogranin
    Genome-Wide Association Study
    Major Histocompatibility Complex
    Genes
    70 Citations (Scopus)

    Copy number variation and schizophrenia

    St Clair, D., Jan 2009, In : Schizophrenia Bulletin. 35, 1, p. 9-12 4 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Psychiatry
    Mutation
    Genetic Counseling
    Mutation Rate
    83 Citations (Scopus)

    Deregulation of EIF4E: a novel mechanism for autism

    Neves-Pereira, M., Muller, B., Massie, D., Williams, J. H. G., O'Brien, P. C. M., Hughes, A., Shen, S-B., St Clair, D. & Miedzybrodzka, Z., Nov 2009, In : Journal of Medical Genetics. 46, 11, p. 759-765 7 p.

    Research output: Contribution to journalArticle

    338 Citations (Scopus)

    Disruption of the neurexin 1 gene is associated with schizophrenia

    Rujescu, D., Ingason, A., Cichon, S., Pietiläinen, O. P. H., Barnes, M. R., Toulopoulou, T., Picchioni, M., Vassos, E., Ettinger, U., Bramon, E., Murray, R., Ruggeri, M., Tosato, S., Bonetto, C., Steinberg, S., Sigurdsson, E., Sigmundsson, T., Petursson, H., Gylfason, A., Olason, P. I. & 31 othersHardarsson, G., Jonsdottir, G. A., Gustafsson, O., Fossdal, R., Giegling, I., Möller, H-J., Hartmann, A. M., Hoffmann, P., Crombie, C., Fraser, G., Walker, N., Lonnqvist, J., Suvisaari, J., Tuulio-Henriksson, A., Djurovic, S., Melle, I., Andreassen, O. A., Hansen, T., Werge, T., Kiemeney, L. A., Franke, B., Veltman, J., Buizer-Voskamp, J. E., Sabatti, C., Ophoff, R. A., Rietschel, M., Nöthen, M. M., Stefansson, K., Peltonen, L., St Clair, D. & GROUP Investigators, 2009, In : Human Molecular Genetics. 18, 5, p. 988-996 9 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Genes
    Exons
    Iceland
    Gene Dosage
    73 Citations (Scopus)

    Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

    Hamshere, M. L., Green, E. K., Jones, I. R., Jones, L., Moskvina, V., Kirov, G., Grozeva, D., Nikolov, I., Vukcevic, D., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., Breen, G., St Clair, D., Collier, D. A., Young, A. H., Ferrier, I. N., Farmer, A., McGuffin, P. & 4 othersHolmans, P. A., Owen, M. J., O'Donovan, M. C. & Craddock, N., 1 Jul 2009, In : British Journal of Psychiatry. 195, 1, p. 23-29 7 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Psychotic Disorders
    Single Nucleotide Polymorphism
    Phenotype
    Psychiatry
    317 Citations (Scopus)

    Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions

    The International Schizophrenia Consortium (ISC), 26 Jun 2009, In : PLoS Genetics. 5, 6, e1000534.

    Research output: Contribution to journalArticle

    Open Access
    Single Nucleotide Polymorphism
    genomics
    gene
    Genes
    genes
    132 Citations (Scopus)

    Prenatal malnutrition and adult schizophrenia: Further evidence from the 1959-1961 Chinese famine

    Xu, M-Q., Sun, W-S., Liu, B-X., Feng, G-Y., Yu, L., Yang, L., He, G., Sham, P., Susser, E., St Clair, D. & He, L., May 2009, In : Schizophrenia Bulletin. 35, 3, p. 568-576 9 p.

    Research output: Contribution to journalArticle

    Starvation
    Malnutrition
    Schizophrenia
    Pregnancy
    Psychiatry
    68 Citations (Scopus)
    4 Downloads (Pure)

    The impact of divergence time on the nature of population structure: an example from Iceland

    Price, A. L., Helgason, A., Palsson, S., Stefansson, H., St Clair, D., Andreassen, O. A., Reich, D., Kong, A. & Stefansson, K., 5 Jun 2009, In : PLoS Genetics. 5, 6, 10 p., e1000505.

    Research output: Contribution to journalArticle

    Open Access
    File
    Iceland
    population structure
    divergence
    Population
    genetic drift

    Treatment and Diagnosis of Behavioural Disorders

    Miedzybrodzka, Z. H., St Clair, D. M., Muller, B. M., Neves-Pereira, M. D. L. & Massie, D., 2009, IPC No. C12Q 1/68 (2006.01), Patent No. WO/2009/144480

    Research output: Patent

    Pharmaceutical Preparations
    2008
    46 Citations (Scopus)

    Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder

    Prata, D., Breen, G. D., Osborne, S., Munro, J., St Clair, D. M. & Collier, D., 5 Sep 2008, In : American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B, 6, p. 914-917 4 p.

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population

    Ma, J., Fan, J-B., Bian, L., Zhang, C-S., Li, X-W., Gu, N-F., Feng, G-Y., St Clair, D. M. & He, L., 30 May 2008, In : Psychiatry Research. 159, 1-2, p. 245-249 5 p.

    Research output: Contribution to journalArticle

    1128 Citations (Scopus)

    Rare chromosomal deletions and duplications increase risk of schizophrenia

    Stone, J. L., O'Donovan, M. C., Gurling, H., Kirov, G. K., Blackwood, D. H. R., Corvin, A., Craddock, N. J., Gill, M., Hultman, C. M., Lichtenstein, P., McQuillin, A., Pato, C. N., Ruderfer, D. M., Owen, M. J., St Clair, D., Sullivan, P. F., Sklar, P., Purcell, S. M., Scolnick, E. M., Holmans, P. A. & 31 othersGeorgieva, L., Nikolov, I., Norton, N., Williams, H., Williams, N. M., Toncheva, D., Milanova, V., Thelander, E. F., Morris, D. W., O'Dushlaine, C. T., Kenny, E., Waddington, J. L., Choudhury, K., Datta, S., Pimm, J., Thirumalai, S., Puri, V., Krasucki, R., Lawrence, J., Quested, D., Bass, N., Curtis, D., Crombie, C., Fraser, G., Kwan, S. L., Muir, W. J., McGhee, K. A., Pickard, B., Malloy, P., Maclean, A. W. & The International Schizophrenia Consortium (ISC), 11 Sep 2008, In : Nature. 455, 7210, p. 237-241 5 p.

    Research output: Contribution to journalLetter

    195 Citations (Scopus)

    Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1

    Shen, S., Lang, B., Nakamoto, C., Zhang, F., Pu, J., Kuan, S-L., Chatzi, C., He, S., Mackie, I., Brandon, N. J., Marquis, K. L., Day, M., Hurko, O., McCaig, C. D., Riedel, G. & St Clair, D., 22 Oct 2008, In : Journal of Neuroscience. 28, 43, p. 10893-10904 12 p.

    Research output: Contribution to journalArticle

    Transgenic Mice
    Schizophrenia
    Phenotype
    Bacterial Artificial Chromosomes
    GABAergic Neurons
    2007
    6826 Citations (Scopus)

    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

    Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., Ouwehand, W. H., Samani, N. J., Todd, J. A., Donnelly, P., Barrett, J. C., Davison, D., Easton, D., Evans, D., Leung, H-T., Marchini, J. L., Morris, A. P., Spencer, C. C. A. & 31 othersTobin, M. D., Attwood, A. P., Boorman, J. P., Cant, B., Everson, U., Hussey, J. M., Jolley, J. D., Knight, A. S., Koch, K., Meech, E., Nutland, S., Prowse, C. V., Stevens, H. E., Taylor, N. C., Walters, G. R., Walker, N. M., Watkins, N. A., Winzer, T., Jones, R. W., McArdle, W. L., Ring, S. M., Strachan, D. P., Pembrey, M., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, E. K. & Biol RA Genet & Genom Study Syndicate, Wellcome Trust Case Control Consortium, Breast Canc Susceptib Collaborat, 7 Jun 2007, In : Nature. 447, 7145, p. 661-678 18 p.

    Research output: Contribution to journalLiterature review

    361 Citations (Scopus)

    Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

    Nejentsev, S., Howson, J. M. M., Walker, N. M., Szeszko, J., Field, S. F., Stevens, H. E., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, L. M., Smyth, D., Bailey, R., Cooper, J. D., Ribas, G., Campbell, R. D., Clayton, D. G., Todd, J. A., Burton, P. R. & 191 othersCardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., Ouwehand, W. H., Samani, N. J., Donnelly, P., Barrett, J. C., Davison, D., Easton, D., Evans, D., Leung, H. T., Marchini, J. L., Morris, A. P., Spencer, C. C. A., Tobin, M. D., Attwood, A. P., Boorman, J. P., Cant, B., Everson, U., Hussey, J. M., Jolley, J. D., Knight, A. S., Koch, K., Meech, E., Nutland, S., Prowse, C. V., Taylor, N. C., Walters, G. R., Watkins, N. A., Winzer, T., Jones, R. W., McArdle, W. L., Ring, S. M., Strachan, D. P., Pembrey, M., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, E. K., Grozeva, D., Hamshere, M. L., Holmans, P. A., Jones, I. R., Kirov, G., Moskvina, V., Nikolov, I., O'Donovan, M. C., Owen, M. J., Collier, D. A., Elkin, A., Farmer, A., Williamson, R., McGuffin, P., Young, A. H., Ferrier, I. N., Ball, S. G., Balmforth, A. J., Barrett, J. H., Bishop, D. T., Iles, M. M., Maqbool, A., Yuldasheva, N., Hall, A. S., Braund, P. S., Dixon, R. J., Mangino, M., Stevens, S., Thompson, J. R., Bredin, F., Tremelling, M., Parkes, M., Drummond, H., Lees, C. W., Nimmo, E. R., Satsangi, J., Fisher, S. A., Forbes, A., Lewis, C. M., Onnie, C. M., Prescott, N. J., Sanderson, J., Mathew, C. G., Barbour, J., Mohiuddin, M. K., Todhunter, C. E., Mansfield, J. C., Tariq, A., Cummings, F. R., Jewell, D. P., Webster, J., Brown, M. J., Lathrop, G. M., Connell, J., Dominiczak, A., Braga Marcano, C. A., Burke, B., Dobson, R., Gungadoo, J., Lee, K. L., Munroe, P. B., Newhouse, S. J., Onipinla, A., Wallace, C., Xue, M., Caulfield, M., Farrall, M., Barton, A., Bruce, I. N., Donovan, H., Eyre, S., Gilbert, P. D., Hider, S. L., Hinks, A. M., John, S. L., Potter, C., Silman, A. J., Symmons, D. P. M., Thomson, W., Worthington, J., Dunger, D. B., Widmer, B., Frayling, T. M., Freathy, R. M., Lango, H., Perry, J. R. B., Shields, B. M., Weedon, M. N., Hattersley, A. T., Hitman, G. A., Walker, M., Elliott, K. S., Groves, C. J., Lindgren, C. M., Rayner, N. W., Timpson, N. J., Zeggini, E., Newport, M., Sirugo, G., Lyons, E., Vannberg, F., Hill, A. V. S., Bradbury, L. A., Farrar, C., Pointon, J. J., Wordsworth, P., Brown, M. A., Franklyn, J. A., Heward, J. M., Simmonds, M. J., Gough, S. C. L., Seal, S., Stratton, M. R., Rahman, N., Ban, M., Goris, A., Sawcer, S. J., Compston, A., Conway, D., Jallow, M., Rockett, K. A., Bryan, C., Bumpstead, S. J., Chaney, A., Downes, K., Ghori, J., Gwilliam, R., Hunt, S. E., Inouye, M., Keniry, A., King, E., McGinnis, R., Potter, S., Ravindrarajah, R., Whittaker, P., Withers, D., Cardin, N. J., Ferreira, T., Pereira-Gale, J., Hallgrimsdóttir, I. B., Howie, B. N., Su, Z., Yik, Y. T., Vukcevic, D., Bentley, D. & Compston, A., 6 Dec 2007, In : Nature. 450, 7171, p. 887-892 6 p.

    Research output: Contribution to journalArticle

    MHC Class I Genes
    HLA-A Antigens
    HLA-B Antigens
    Major Histocompatibility Complex
    Type 1 Diabetes Mellitus
    229 Citations (Scopus)

    LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia

    Francks, C., Maegawa, S., Laurén, J., Abrahams, B. S., Velayos-Baeza, A., Medland, S. E., Colella, S., Groszer, M., McAuley, E. Z., Caffrey, T. M., Timmusk, T., Pruunsild, P., Koppel, I., Lind, P. A., Matsumoto-Itaba, N., Nicod, J., Xiong, L., Joober, R., Enard, W., Krinsky, B. & 22 othersNanba, E., Richardson, A. J., Riley, B. P., Martin, N. G., Strittmatter, S. M., Möller, H-J., Rujescu, D., St Clair, D., Muglia, P., Roos, J. L., Fisher, S. E., Wade-Martins, R., Rouleau, G. A., Stein, J. F., Karayiorgou, M., Geschwind, D. H., Ragoussis, J., Kendler, K. S., Airaksinen, M. S., Oshimura, M., DeLisi, L. E. & Monaco, A. P., Dec 2007, In : Molecular Psychiatry. 12, 12, p. 1129-1139 11 p.

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    LRRTM1 protein is located in the endoplasmic reticulum (ER) in mammalian cells

    Francks, C., Maegawa, S., Laurén, J., Abrahams, B. S., Velayos-Baeza, A., Medland, S. E., Colella, S., Groszer, M., McAuley, E. Z., Caffrey, T. M., Timmusk, T., Pruunsild, P., Koppel, I., Lind, P. A., Matsumoto-Itaba, N., Nicod, J., Xiong, L., Joober, R., Enard, W., Krinsky, B. & 22 othersNanba, E., Richardson, A. J., Riley, B. P., Martin, N. G., Strittmatter, S. M., Möller, H. J., Rujescu, D., St. Clair, D., Muglia, P., Roos, J. L., Fisher, S. E., Wade-Martins, R., Rouleau, G. A., Stein, J. F., Karayiorgou, M., Geschwind, D. H., Ragoussis, J., Kendler, K. S., Airaksinen, M. S., Oshimura, M., Delisi, L. E. & Monaco, A. P., 1 Dec 2007, In : Molecular Psychiatry. 12, 1 p., 1057.

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Visual scan paths in first-episode schizophrenia and cannabis-induced psychosis

    Benson, P. J., Leonards, U., Lothian, R. M., St Clair, D. M. & Merlo, M. C. G., 1 Jul 2007, In : Journal of Psychiatry and Neuroscience. 32, 4, p. 267-274 8 p.

    Research output: Contribution to journalArticle

    2006
    2 Citations (Scopus)

    An association study between the transthyretin (TTR) gene and mental retardation

    Li, J., Gao, J. J., Zhang, F. C., Xing, Q. H., Dang, F. L., Gao, X. C., Duan, S. W., Zheng, Z. J., Qian, X. Q., Qin, W., Li, X. W., Han, Y. F., Li, J., Feng, G. Y., St Clair, D. M. & He, L., 2006, In : European Archives of Psychiatry and Clinical Neuroscience. 256, 4, p. 230-235 6 p.

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Association analysis of the glycogen synthase kinase-3 beta gene in bipolar disorder

    Nishiguchi, N., Breen, G., Russ, C., St Clair, D. & Collier, D., 2006, In : Neuroscience Letters. 394, p. 243-245 3 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Association of the dysbindin gene with bipolar affective disorder

    Breen, G., Prata, D., Osborne, S., Munro, J., Sinclair, M., Li, T., Staddon, S., Dempster, D., Sainz, R., Arroyo, B., Kerwin, R. W., St. Clair, D. & Collier, D., Sep 2006, In : American Journal of Psychiatry. 163, 9, p. 1636-1638 3 p.

    Research output: Contribution to journalArticle

    Mood Disorders
    Bipolar Disorder
    Schizophrenia
    Genes
    Haplotypes
    62 Citations (Scopus)

    Association study of CHRFAM7A copy number and 2bp deletion polymorphisms with schizophrenia and bipolar affective disorder

    Flomen, R. H., Collier, D. A., Osborne, S., Munro, J., Breen, G., St Clair, D. M. & Makoff, A. J., 2006, In : American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 141B, 6, p. 571-575 5 p.

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

    Prata, D. P., Breen, G., Munro, J., Sinclair, M., Osborne, S., Li, T., Kerwin, R., St. Clair, D. & Collier, D. A., Dec 2006, In : Psychiatric Genetics. 16, 6, p. 229-230 2 p.

    Research output: Contribution to journalLetter

    68 Citations (Scopus)

    Evaluation of a susceptibility gene for schizophrenia: Genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples

    Talkowski, M. E., Seltman, H., Bassett, A. S., Brzustowicz, L. M., Chen, X., Chowdari, K. V., Collier, D. A., Cordeiro, Q., Corvin, A. P., Deshpande, S. N., Egan, M. F., Gill, M., Kendler, K. S., Kirov, G., Heston, L. L., Levitt, P., Lewis, D. A., Li, T., Mimics, K., Morris, D. W. & 16 othersNorton, N., O'Donovan, M. C., Owen, M. J., Richard, C., Semwal, P., Sobell, J. L., St Clair, D. M., Straub, R. E., Thelma, B. K., Vallada, H., Weinberger, D. R., Williams, N. M., Wood, J., Zhang, F., Devlin, B. & Nimgaonkar, V. L., 15 Jul 2006, In : Biological Psychiatry. 60, 2, p. 152-162 11 p.

    Research output: Contribution to journalArticle

    55 Citations (Scopus)

    Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations

    Ma, J., Qin, W., Wang, X. Y., Guo, T. W., Bian, L., Duan, S. W., Li, X. W., Zou, F. G., Fang, Y. R., Fang, J. X., Feng, G. Y., Gu, N. F., St Clair, D. M. & He, L., 2006, In : Molecular Psychiatry. 11, p. 479-487 9 p.

    Research output: Contribution to journalArticle