David Malcolm St Clair

Professor

    • AB25 2ZD

    • 26174 Citations
    19992019
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    Research Output 1999 2019

    2006
    101 Citations (Scopus)
    3 Downloads (Pure)

    Generation Scotland: the Scottish Family Health Study - a new resource for researching genes and heritability

    Smith, B. H., Campbell, H., Blackwood, D., Connell, J., Connor, M., Deary, I. J., Dominiczak, A. F., Fitzpatrick, B., Ford, I., Jackson, C., Haddow, G., Kerr, S., Lindsay, R., McGilchrist, M., Morton, R., Murray, G., Palmer, C. N. A., Pell, J. P., Ralston, S. H., St Clair, D. & 6 othersSullivan, F., Watt, G., Wolf, R., Wright, A., Porteous, D. & Morris, A. D., 2 Oct 2006, In : BMC Medical Genetics. 7, 9 p., 74.

    Research output: Contribution to journalArticle

    Open Access
    File
    56 Citations (Scopus)

    Genetic association between schizophrenia and the DISC1 gene in the Scottish population

    Zhang, F., Sarginson, J. E., Crombie, C. M., Walker, N., St Clair, D. & Shaw, D., Mar 2006, In : American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 141B, 2, p. 155-159 5 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Single Nucleotide Polymorphism
    Population
    Genes
    Microsatellite Repeats
    41 Citations (Scopus)

    Global visual scanning abnormalities in schizophrenia and bipolar disorder

    Bestelmeyer, P., Tatler, B. W., Phillips, L. H., Fraser, G., Benson, P. J. & St Clair, D. M., Jul 2006, In : Schizophrenia Research. 87, 1-3, p. 212-222 10 p.

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Meta-analysis of association between ApoE epsilon 4 allele and schizophrenia

    Xu, M. Q., St Clair, D. M. & He, L., Jun 2006, In : Schizophrenia Research. 84, 2-3, p. 228-235 8 p.

    Research output: Contribution to journalArticle

    42 Citations (Scopus)
    4 Downloads (Pure)

    Paraoxonase gene polymorphisms and haplotype analysis in a stroke population

    Pasdar, A., Ross-Adams, H., Cumming, A., Cheung, J., Whalley, L., St Clair, D. & MacLeod, M. J., 21 Mar 2006, In : BMC Medical Genetics. 7, 6 p., 28.

    Research output: Contribution to journalArticle

    Open Access
    File
    12 Citations (Scopus)

    Population-based and family-based association studies of an (AC)n dinucleotide repeat in alpha-7 nicotinic receptor subunit gene and schizophrenia

    Fan, J. B., Ma, J., Li, X. W., Zhang, C. S., Sun, W. W., He, G., Gu, N. F., Feng, G. Y., St Clair, D. M. & He, L., Jun 2006, In : Schizophrenia Research. 84, 2-3, p. 222-227 6 p.

    Research output: Contribution to journalArticle

    Poster Presentation - Design and validatio nof DNA pools in an ischaemic stroke population

    Ross-Adams, H. E., Pasdar, A., St Clair, D. M. & MacLeod, M. J., May 2006.

    Research output: Contribution to conferenceOther

    Study of CETP gene polymophisms and ischaemic stroke in a Scottish population, using pooled DNA samples

    Pasdar, A., Ross-Adams, H. E., St Clair, D. M. & MacLeod, M. J., Jun 2006.

    Research output: Contribution to conferenceOther

    2005

    ABCA1 gene polymoprhism and lipid profile in a Scottish population

    Pasdar, A., Cumming, A. M., St Clair, D. M. & MacLeod, M. J., 2005.

    Research output: Contribution to conferenceAbstract

    32 Citations (Scopus)

    Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia

    Zhang, F., St Clair, D., Liu, X., Sun, X., Sham, P. C., Crombie, C., Ma, X., Wang, Q., Meng, H., Deng, W., Yates, P., Hu, X., Walker, N., Murray, R. M., Collier, D. A. & Li, T., 2005, In : Genes, Brain, and Behavior. 4, p. 444-448 5 p.

    Research output: Contribution to journalArticle

    215 Citations (Scopus)

    Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population

    Helgadottir, A., Gretasdottir, S., St Clair, D. M., Maolescu, A., Cheung, J. K. S., Thorleifsson, G., Pasdar, A., Grant, S. F., Whalley, L. J., Hakonarson, H., Thorsteinsdottir, U., Kong, A., Gulcher, J. R., Stefansson, K. & MacLeod, M. J., Mar 2005, In : American Journal of Human Genetics. 76, 3, p. 505-509 4 p.

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease

    Pritchard, A., Harris, J., Pritchard, C. W., St Clair, D., Lemmon, H., Lambert, J. C., Chartier-Harlin, M. C., Hayes, A., Thaker, U., Iwatsubo, T., Mann, D. M. A. & Lendon, C., 2005, In : Neuroscience Letters. 382, p. 221-226 6 p.

    Research output: Contribution to journalArticle

    225 Citations (Scopus)

    BDNF gene is a risk factor for schizophrenia in a Scottish population

    Neves-Pereira, M. D. L., Cheung, J. K. S., Pasdar, A., Zhang, F., Breen, G. D., Yates, P., Crombie, C. M., Walker, N. & St Clair, D. M., Jan 2005, In : Molecular Psychiatry. 10, p. 208-212 4 p.

    Research output: Contribution to journalArticle

    204 Citations (Scopus)

    Catechol-O-Methyltransferase Gene Val/Met Functional Polymophism and Risk of Schizophrenia: A Large-Scale Association Study plus Meta-Analysis

    Bo Fan, J., Shun Zhang, C., Fan Gu, N., Wang Li, X., Wei Sun, W., Yan Wang, H., Yin Feng, G., St Clair, D. M. & He, L., 2005, In : Biological Psychiatry. 57, p. 139-144 5 p.

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Functional analysis of a recurrent missense mutation in Notch3 in CADASIL

    Haritunians, T., Chow, T., De Lange, P. J., Nichols, J. T., Ghavimi, D., Dorrani, N., St Clair, D. M., Weinmaster, G. & Schanen, C., Sep 2005, In : Journal of Neurology, Neurosurgery & Psychiatry. 76, 9, p. 1242-1248 6 p.

    Research output: Contribution to journalArticle

    CADASIL
    Missense Mutation
    Ligands
    Furin
    Mutation

    Identifying potential risk haplotypes for schizophrenia at DTNBP1 locus in Han Chinese and Scottish populations

    Li, T., Zhang, F., Liu, X., Sun, X., Sham, P. C., Crombie, C. M., Ma, X., Wang 1, Q., Deng, H. M. W., Yates, P., Hurko, X., Walker, N., Murray, R. M., Collier, D. A. & St Clair, D. M., 2005, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

    49 Citations (Scopus)

    Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations

    Li, T., Zhang, F., Liu, X., Sun, X., Sham, P. C., Crombie, C., Ma, X., Wang, Q., Meng, H., Deng, W., Yates, P., Hu, X., Walker, N., Murray, R. M., St Clair, D. & Collier, D. A., 2005, In : Molecular Psychiatry. 10, p. 1037-1044 8 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Polymorphisms in the TSHR (thyrotropin receptor) gene on chromosome 14q31 are not associated with mental retardation in the iodine-deficient areas of China

    Guo, T. W., Zhang, F. C., Gao, J. J., Bian, L., Gao, X. C., Ma, J., Yang, M. S., Ji, Q., Duan, S. W., Zheng, Z. J., Li, R. L., Feng, G. Y., St Clair, D. & He, L., 2005, In : Neuroscience Letters. 382, p. 179-184 6 p.

    Research output: Contribution to journalArticle

    477 Citations (Scopus)

    Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961

    St Clair, D. M., Xu, M., Wang, P., Yu, Y., Fang, Y., Feng, Z., Zheng, X., Gu, N., Feng, G., Sham, P. & He, L., Aug 2005, In : JAMA. 294, 5, p. 557-562 5 p.

    Research output: Contribution to journalArticle

    2004

    A case control and family based association study of the neuregulin1 gene and schizophrenia

    Zhao, X., Shi, Y., Tang, J., Tang, R., Yu, L., Gu, N., Feng, G., Zhu, S., Liu, H., Xing, Y., Zhao, S., Sang, H., Guan, Y., St Clair, D. & He, L., 2004, In : Journal of Medical Genetics. 41, p. 31-34 4 p.

    Research output: Contribution to journalArticle

    96 Citations (Scopus)

    A case control and family based association study of the neuregulin 1 gene and schizophrenia

    Zhao, X., Shi, Y., Tang, J., Tang, R., Yu, L., Gu, N., Feng, G., Zhu, S. M., Liu, H., Xing, Y., Xhao, S., Sang, H., Guan, Y., St Clair, D. M. & He, L., 2004, In : Journal of Medical Genetics. 41, p. 31-34 3 p.

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Candidate gene association studies of the alpha4 (CHRNA4) and beta2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease

    Cook, L. J., Horrobin, L. W., Taylor, A. E., Brayne, C., Evans, J. G., Xuereb, J., Cairns, N. J., Pritchard, A., Lemmon, H. A., Mann, D., St Clair, D. M., Turic, D., Hollingworth, P., Moore, P. J., Jehu, L., Archer, N., Walter, S., Foy, C., Edmondson, A. & Powell, J., 2004, In : Neuroscience Letters. 358, p. 142-146 4 p.

    Research output: Contribution to journalLetter

    118 Citations (Scopus)

    Confirmation and refinement of an at risk cluster halotype for schizophrenia suggests the EST cluster Hs 977362 as a potential susceptibility gene in the neuregulib-1 locus

    Corvin, A. P., Morris, D. W., McGhee, K., Schwaiger, S., Scully, P., Quinn, J., Meagner, D., St Clair, D. M., Waddington, J. & Gill, M., 2004, In : Molecular Psychiatry. 9, p. 208-213 5 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Distribution of apolioprotein E allele frequencies of the Han Chinese in an iodine-deficient mountainous area.

    Gao, J., Zhang, F., Guo, T., Gao, X., Duan, S., Wang, H., Zheng, Z., Huang, T., Feng, G., St Clair, D. M. & He, L., 2004, In : Annals of Human Biology. 31, p. 578-585 7 p.

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Family-based association study of synapsin II and schizophrenia

    Chen, Q., He, G., Qin, W., Chen, Q. Y., Zhao, X., Duan, S. W., Liu, X. M., Feng, G. Y., Xu, Y. F., St Clair, D. M., Li, M., Wang, J. H., Xing, Y. L., Shi, J. G. & He, L., 2004, In : American Journal of Human Genetics. 75(5), p. 873-877 4 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Family based association study of the monoamine oxidase A gene promoter polymorphisms and schizophrenia

    Fan, J., Yang, M. S., Tang, J. X., He, L., Xing, Y. L., Shi, J. G., Zhao, S. M., Zhu, S. M., Ji, L. P., Gu, N. F., Feng, G. Y. & St Clair, D. M., 2004, In : Schizophrenia Research. 67, p. 107-109 2 p.

    Research output: Contribution to journalArticle

    Genotype and haplotype analysis of ABCA1 gene in ischaemic stroke

    Pasdar, A., St Clair, D. M. & MacLeod, M. J., Jan 2004, In : Stroke. 35, p. 253-340 87 p.

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease

    Zhang, Y., Hayes, A., Pritchard, A., Thaker, U., Haque, M. S., Lemmon, H., Harris, J., Cumming, A., Lambert, J. C., Chartier-Harlin, M. C., St Clair, D., Iwatsubo, T., Mann, D. M. & Lendon, C. L., 20 May 2004, In : Neuroscience Letters. 362, 2, p. 99-102 4 p.

    Research output: Contribution to journalArticle

    Interleukin-6
    Alzheimer Disease
    Pathology
    Brain
    Amyloid beta-Protein Precursor
    11 Citations (Scopus)

    Logical reasoning deficits in schizophrenia

    Goel, V., Bartolo, A., St Clair, D. M. & Venneri, A., 2004, In : Schizophrenia Research. 66, p. 87-88 1 p.

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort

    Pritchard, A., St Clair, D., Lemmon, H., Mann, D. M. A. & Lendon, C., Aug 2004, In : Neuroscience Letters. 366, 2, p. 126-129 4 p.

    Research output: Contribution to journalArticle

    Chromosomes, Human, Pair 12
    LDL Receptors
    Lectins
    Alzheimer Disease
    Genes
    62 Citations (Scopus)

    Positive association of the DIO2 (Deiodinase type 2) gene with mental retardation in the iodeine deficient areas of China

    Guo, T. W., Zhang, F., Yang, M. S., Gao, X. C., Bian, L., Duan, S. W., Zhen, Z. J., Gao, J. J., Wang, H., Li, R. L., Feng, G. Y., St Clair, D. M. & He, L., 2004, In : Journal of Medical Genetics. 41, 8, p. 585-590 6 p.

    Research output: Contribution to journalArticle

    Iodide Peroxidase
    Intellectual Disability
    China
    Iodine
    Genes

    Poster Presentation - Replication study of PDE4D and ALOX5AP gene variants in a scottish stroke population.

    Gretarsdottir, S., Helgadottir, A., St Clair, D. M., Manolescu, A., Cheung, J. K. S., Thorleifsson, G., Pasdar, A. & Thorsteinsdottir, U., Oct 2004.

    Research output: Contribution to conferenceOther

    40 Citations (Scopus)

    Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients

    Breen, G. D., Harward, A. J., Gregory, K., Collier, D., St Clair, D. M. & Williams, R., 2004, In : Bipolar Disorders. 6, p. 56-161 105 p.

    Research output: Contribution to journalArticle

    2003
    32 Citations (Scopus)

    A family-based association study of T1945C polymorphism in the proline dehydrogenase gene and schizophrenia in the Chinese population

    Fan, J. B., Ma, J., Zhang, C. S., Tang, J. X., Gu, N. F., Feng, G. Y., St Clair, D. M. & He, L., 2003, In : Neuroscience Letters. 338(3), p. 252-254 2 p.

    Research output: Contribution to journalLetter

    6 Citations (Scopus)

    Apolipoprotein-491 promoter polymorphism is an independent risk factor for Alzheimer's disease

    Yang, J. D., Feng, G. Y., Zhang, J., Cheung, J., St Clair, D. M., He, L. & Ichimura, K., 2003, In : Neuroscience Letters. p. 215-216 1 p.

    Research output: Contribution to journalLetter

    16 Citations (Scopus)

    Apolipoprotein E-491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population

    Yang, J. D., Feng, G. Y., Zhang, J., Cheung, J., St Clair, D. & He, L., 2003, In : Neuroscience Letters. 350, p. 25-28 4 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Association of APOE gene with schizophrenia in Chinese: a possible risk facator in times of malnutrition

    Liu, W. Q., Breen, G., Zhang, J. G., Li, S., Gu, N. F., Feng, G. Y., Bai, S. C., Shen, T., Yu, A., Xue, H., St Clair, D. & He, L., 1 Aug 2003, In : Schizophrenia Research. 62, 3, p. 225-230 6 p.

    Research output: Contribution to journalArticle

    Apolipoproteins E
    Malnutrition
    Schizophrenia
    Gene Frequency
    Genotype
    464 Citations (Scopus)

    Association of Neuregulin 1 with schizophrenia confirmed in a Scottish population

    Stefansson, H., Sarginson, J., Kong, A., Yates, P., Steinthorsdottir, V., Gudfinnsson, E., Gunnarsdottir, S., Walker, N., Peturrsson, H., Crombie, C. M., Ingason, A., Gulcher, J. R., Stefansson, J. R. & St Clair, D. M., Jan 2003, In : American Journal of Human Genetics. 72, 1, p. 83-87 4 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Paraxonase genes (PON1, PON2 and PON3) polymorphisms and lipid profile in a Scottish population

    Pasdar, A., MacLeod, M. J., St Clair, D. M. & Cumming, A. M., 2003. 233 p.

    Research output: Contribution to conferenceAbstract

    The influence of the 4 allele of the apolipoprotein E gene on childhood IQ, non-verbal reasoning in old age, and lifetime cognitive change

    Deary, I. J., Whalley, L. J., St Clair, D. M., Breen, G. D., Leaper, S., Lemmon, H. A., Hayward, C. & Starr, J. M., Jan 2003, In : Intelligence. 31, 1, p. 85-92 7 p.

    Research output: Contribution to journalArticle

    2002
    45 Citations (Scopus)

    A family-based and case-control association study of the NOTCH4 gene and schizophrenia

    Fan, J. B., Tang, J. X., Gu, N. F., Feng, G. Y., Zou, F. G., Xing, Y. L., Shi, J. G., Zhao, S. M., Zhu, S. M., Ji, L. P., Sun, W. W., Zheng, Y. L., Liu, W. Q., Breen, G., St. Clair, D. & He, L., 3 Jan 2002, In : Molecular Psychiatry. 7, p. 100-103 4 p.

    Research output: Contribution to journalArticle

    Case-Control Studies
    Schizophrenia
    Haplotypes
    Population
    Genes
    49 Citations (Scopus)

    Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease?

    Green, E. K., Harris, J. M., Lemmon, H. A., Lambert, J. C., Chartier-Harlin, M. C., St Clair, D. M., Mann, A., Iwatsubo, T. & Lendon, C., 2002, In : Neurology. 58, p. 1566-1568 2 p.

    Research output: Contribution to journalArticle

    89 Citations (Scopus)

    Contribution of APOE promoter polymorphisms to Alzheimer's disease risk

    Lambert, J. C., Araria-Goumidi, L., Myllykangas, L., Ellis, C., Wang, J. C., Bullido, M. J., Harris, J. M., Artiga, M. J., Hernandez, D., Kwon, J. M., Frigard, B., Petersen, R. C., Cumming, A. M., Pasquier, F., Sastre, I., Tienari, P. J., Frank, A., Sulkava, R., Morris, J. C., St Clair, D. & 11 othersMann, D. M., Wavrant-DeVrieze, F., Ezquerra-Trabalon, M., Amouyel, P., Hardy, J., Haltia, M., Valdivieso, F., Goate, A. M., Perez-Tur, J., Lendon, C. L. & Chartier-Harlin, M. C., 2002, In : Neurology. 59, p. 59-66 8 p.

    Research output: Contribution to journalArticle

    68 Citations (Scopus)

    Family-based abd case-control association studies of NOTCH4 and schizophrenia

    Fan, J. B., Tang, J. X., Gu, N. F., Feng, F. G., Zou, F. G., Xing, Y. L., Shi, J. G., Zhao, S. M., Zhu, S. M., Ji, L. P., Sun, W. W., Zheng, Y. L., Liu, W. Q., Breen, G. D. & St Clair, D. M., 2002, In : Molecular Psychiatry. 7, p. 100-103 3 p.

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Family based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population

    Fan, J. B., Chen, W. Y., Tang, J. X., Li, S., Gu, N. F., Feng, G. Y., Breen, G., St Clair, D. & He, L., 2002, In : Molecular Psychiatry. 7, 5, p. 446-447 2 p.

    Research output: Contribution to journalEditorial