David Malcolm St Clair

Professor

    • AB25 2ZD

    • 29012 Citations
    19992019
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    Research Output 1999 2019

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    Article
    2019
    32 Citations (Scopus)

    Genome-wide association study identifies 30 loci associated with bipolar disorder

    Stahl, E. A., Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., Mattheisen, M., Wang, Y., Coleman, J. R. I., Gaspar, H. A., de Leeuw, C. A., Steinberg, S., Pavlides, J. M. W., Trzaskowski, M., Byrne, E. M., Pers, T. H., Holmans, P. A., Richards, A. L., Abbott, L., Agerbo, E. & 33 others, Akil, H., Albani, D., Alliey-Rodriguez, N., Als, T. D., Anjorin, A., Antilla, V., Awasthi, S., Badner, J. A., Bækvad-Hansen, M., Barchas, J. D., Bass, N., Bauer, M., Belliveau, R., Bergen, S. E., Pedersen, C. B., Bøen, E., Boks, M. P., Boocock, J., Budde, M., Bunney, W., Burmeister, M., Bybjerg-Grauholm, J., Byerley, W., Casas, M., Cerrato, F., Cervantes, P., Chambert, K., Charney, A. W., Chen, D., St Clair, D., eQTLGen Consortium, BIOS Consortium & the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, 1 May 2019, In : Nature Genetics. 51, p. 793-803 11 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Bipolar Disorder
    Genome
    Neurotransmitter Transport Proteins
    Endocannabinoids

    Roles for IFT172 and primary cilia in cell migration, cell division and neocortex development

    Pruski, M., Hu, L., Wang, Y., Zhang, B. J., Zhang, L., Huang, Y., Rajnicek, A. M., St Clair, D. M., McCaig, C. D., Ding, Y-Q. & Lang, B., 4 Nov 2019, (Accepted/In press) In : Frontiers in Cell and Developmental Biology.

    Research output: Contribution to journalArticle

    Open Access
    Cilia
    Neocortex
    Cell Division
    Cell Movement
    Bardet-Biedl Syndrome
    2018
    8 Citations (Scopus)
    4 Downloads (Pure)

    Study of Novel Autoantibodies in Schizophrenia

    Whelan, R., St Clair, D., Mustard, C. J., Hallford, P. & Wei, J., 17 Oct 2018, In : Schizophrenia Bulletin. 44, 6, p. 1341-1349 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Autoantibodies
    Schizophrenia
    Immunoglobulin G
    ROC Curve
    Antigens
    2017
    5 Citations (Scopus)
    5 Downloads (Pure)

    Differential antibody responses to gliadin-derived indigestible peptides in patients with schizophrenia

    McLean, RT., Wilson, P., St Clair, D., Mustard, CJ. & Wei, J., 2017, In : Translational Psychiatry. 7, e1121.

    Research output: Contribution to journalArticle

    Open Access
    File
    Gliadin
    Antibody Formation
    Schizophrenia
    Peptides
    Antibodies
    22 Citations (Scopus)

    Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics

    Giegling, I., Hosak, L., Mössner, R., Serretti, A., Bellivier, F., Claes, S., Collier, D. A., Corrales, A., DeLisi, L. E., Gallo, C., Gill, M., Kennedy, J. L., Leboyer, M., Maier, W., Marquez, M., Massat, I., Mors, O., Muglia, P., Nöthen, M. M., Ospina-Duque, J. & 9 others, Owen, M. J., Propping, P., Shi, Y. Y., St Clair, D., Thibaut, F., Cichon, S., Mendlewicz, J., O'Donovan, M. C. & Rujescu, D., 2017, In : World Journal of Biological Psychiatry. 18, 7, p. 492-505 14 p.

    Research output: Contribution to journalArticle

    Advisory Committees
    Schizophrenia
    Consensus
    Psychiatry
    Precision Medicine
    2016
    86 Citations (Scopus)
    4 Downloads (Pure)

    An integrated genetic-epigenetic analysis of schizophrenia: Evidence for co-localization of genetic associations and differential DNA methylation

    Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, A. R., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., Kaprio, J., Toulopoulou, T., Pol, H. E. H., Bohlken, M. M., Kahn, R. S., Nenadic, I., Hultman, C. M., Murray, R. M., Collier, D. A., Bass, N. & 4 others, Gurling, H., McQuillin, A., Schalkwyk, L. & Mill, J., 30 Aug 2016, In : Genome Biology. 17, 176.

    Research output: Contribution to journalArticle

    Open Access
    File
    methylation
    genetic analysis
    DNA methylation
    DNA Methylation
    Epigenomics
    19 Citations (Scopus)
    3 Downloads (Pure)

    Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function

    Thomson, P. A., Duff, B., Blackwood, D. H. R., Romaniuk, L., Watson, A., Whalley, H. C., Li, X., Dauvermann, M. R., Moorhead, T. W. J., Bois, C., Ryan, N. M., Redpath, H., Hall, L., Morris, S. W., Van Beek, E. J. R., Roberts, N., Porteous, D. J., St Clair, D., Whitcher, B., Dunlop, J. & 5 others, Brandon, N. J., Hughes, Z. A., Hall, J., McIntosh, A. & Lawrie, S. M., 10 Aug 2016, In : npj Schizophrenia. 2, 16024.

    Research output: Contribution to journalArticle

    Open Access
    File
    Psychopathology
    Psychiatry
    Glutamic Acid
    Temporal Lobe
    Prefrontal Cortex
    6 Citations (Scopus)
    6 Downloads (Pure)

    Control of cortex development by ULK4, a rare risk gene for mental disorders including schizophrenia

    Lang, B., Zhang, L., Jiang, G., Hu, L., Lan, W., Zhao, L., Hunter, I., Pruski, M., Song, N-N., Huang, Y., Zhang, L., St Clair, D., McCaig, C. D. & Ding, Y-Q., 27 Sep 2016, In : Scientific Reports. 6, p. 1-14 14 p., 31126.

    Research output: Contribution to journalArticle

    Open Access
    File
    Mental Disorders
    Schizophrenia
    Phosphotransferases
    Genes
    Genetic Loci
    99 Citations (Scopus)

    Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

    Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., Nichols, T. E., Neale, M. C., McIntosh, A. M., Lee, P., McMahon, F. J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O. A., Gruber, O., Sachdev, P. S., Roiz-Santianez, R., Saykin, A. J. & 11 others, Ehrlich, S., Mather, K. A., Turner, J. A., Wright, M. J., O'Donovan, M. C., Thompson, P. M., Neale, B. M., Medland, S. E., Sullivan, P. F., Psychiat Genomics Consortium & ENIGMA Consortium, Mar 2016, In : Nature Neuroscience. 19, 3, p. 420-431 12 p.

    Research output: Contribution to journalArticle

    123 Citations (Scopus)

    Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

    Singh, T., Kurki, M. I., Curtis, D., Purcell, S. M., Crooks, L., McRae, J., Suvisaari, J., Chheda, H., Blackwood, D., Breen, G., Pietilinen, O., Gerety, S. S., Ayub, M., Blyth, M., Cole, T., Collier, D., Coomber, E. L., Craddock, N., Daly, M. J., Danesh, J. & 39 others, DiForti, M., Foster, A., Freimer, N. B., Geschwind, D., Johnstone, M., Joss, S., Kirov, G., Körkkö, J., Kuismin, O., Holmans, P., Hultman, C. M., Iyegbe, C., Lönnqvist, J., Mnnikkö, M., McCarroll, S. A., McGuffin, P., McIntosh, A. M., McQuillin, A., Moilanen, J. S., Moore, C., Murray, R. M., Newbury-Ecob, R., Ouwehand, W., Paunio, T., Prigmore, E., Rees, E., Roberts, D., Sambrook, J., Sklar, P., St Clair, D., Veijola, J., Walters, J. T. R., Williams, H., Sullivan, P. F., Hurles, M. E., O'Donovan, M. C., Palotie, A., Owen, M. J. & Barrett, J. C., 29 Mar 2016, In : Nature Neuroscience. 19, 4, p. 571-577 7 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Exome
    Epigenomics
    Histones
    Methylation
    2015
    43 Citations (Scopus)
    7 Downloads (Pure)

    Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

    Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J. & Saksida, L. M., 1 Oct 2015, In : Scientific Reports. 5, 5 p., 14613.

    Research output: Contribution to journalArticle

    Open Access
    File
    Mutation
    Inborn Genetic Diseases
    Brain Diseases
    Genes
    Therapeutics
    4 Downloads (Pure)

    Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness

    Johnstone, M., Maclean, A., Heyrman, L., Lenaerts, A-S., Nordin, A., Nilsson, L-G., De Rijk, P., Goossens, D., Adolfsson, R., St Clair, D. M., Hall, J., Lawrie, S. M., McIntosh, A. M., Del-Favero, J., Blackwood, D. H. R. & Pickard, B. S., Oct 2015, In : Journal of Neuropsychiatry and Clinical Neurosciences. 1, 3, p. 175-190 16 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Overlapping Genes
    Protein Binding
    Psychiatry
    Population
    Genes
    14 Citations (Scopus)
    4 Downloads (Pure)

    Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia

    Ingason, A., Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Friedl, M., Ripke, S., Sullivan, P. F., St Clair, D., Collier, D. A., O'Donovan, M. C., Mirnics, K. & Rujescu, D., 13 Oct 2015, In : Translational Psychiatry. 5, 6 p., e656.

    Research output: Contribution to journalArticle

    Open Access
    File
    Psychotic Disorders
    Schizophrenia
    N-Methyl-D-Aspartate Receptors
    Genes
    Dizocilpine Maleate
    3 Citations (Scopus)
    4 Downloads (Pure)

    Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch

    Jiang, G-Y., Dai, M-H., Huang, K., Chai, G-D., Chen, J-Y., Chen, L., Lang, B., Wang, Q-X., St Clair, D., McCaig, C., Ding, Y-Q. & Zhang, L., 7 Aug 2015, In : Scientific Reports. 5, 10 p., 12787.

    Research output: Contribution to journalArticle

    Open Access
    File
    18 Citations (Scopus)

    Prenatal Nutritional Deficiency Reprogrammed Postnatal Gene Expression in Mammal Brains: Implications for Schizophrenia

    Xu, J., He, G., Zhu, J., Zhou, X., Clair, D. S., Wang, T., Xiang, Y., Zhao, Q., Xing, Q., Liu, Y., Wang, L., Li, Q., He, L. & Zhao, X., Feb 2015, In : International Journal of Neuropsychopharmacology. 18, 4, pyu054.

    Research output: Contribution to journalArticle

    Open Access
    Malnutrition
    Mammals
    Hippocampus
    Schizophrenia
    Gene Expression
    2014
    19 Citations (Scopus)
    4 Downloads (Pure)

    An inherited duplication at the gene p21 protein-activated Kinase 7 (PAK7) is a risk factor for psychosis

    Morris, D. W., Pearson, R. D., Cormican, P., Kenny, E. M., O'Dushlaine, C. T., Perreault, L. P. L., Giannoulatou, E., Tropea, D., Maher, B. S., Wormley, B., Kelleher, E., Fahey, C., Molinos, I., Bellini, S., Pirinen, M., Strange, A., Freeman, C., Thiselton, D. L., Elves, R. L., Regan, R. & 39 others, Ennis, S., Dinan, T. G., McDonald, C., Murphy, K. C., O'Callaghan, E., Waddington, J. L., Walsh, D., O'Donovan, M., Grozeva, D., Craddock, N., Stone, J., Scolnick, E., Purcell, S., Sklar, P., Coe, B., Eichler, E. E., Ophoff, R., Buizer, J., Szatkiewicz, J., Hultman, C., Sullivan, P., Gurling, H., Mcquillin, A., St Clair, D., Rees, E., Kirov, G., Walters, J., Blackwood, D., Johnstone, M., Donohoe, G., The International Schizophrenia Consortium (ISC), SGENE+ Consortium, O'Neill, F. A., The Wellcome Trust Case Control Consortium 2 (WTCCC2), Kendler, K. S., Gill, M., Riley, B. P., Spencer, C. C. A. & Corvin, A., 15 Jun 2014, In : Human Molecular Genetics. 23, 12, p. 3316-3326 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    p21-Activated Kinases
    Psychotic Disorders
    Protein Kinases
    Schizophrenia
    Bipolar Disorder
    41 Citations (Scopus)

    Common genetic variants on 1p13.2 associate with risk of autism

    Xia, K., Guo, H., Xun, G., Zuo, L., Peng, Y., He, Y., Xiong, Z., Sun, L., Pan, Q., Long, Z., Zou, X., Lu, L., Liu, Y., Tian, D., Long, L., Liu, Y., Peng, H., Luo, X., Su, W., Liang, D. & 12 others, Dai, H., Yan, X., Feng, Y., Tang, B., Miedzybrodzka, Z., Xia, J., Zhang, Z., Luo, X., Zhang, X., St Clair, D., Zhao, J. & Zhang, F., Nov 2014, In : Molecular Psychiatry. 19, 11, p. 1212-1219 8 p.

    Research output: Contribution to journalArticle

    Autistic Disorder
    Genome-Wide Association Study
    Genetic Association Studies
    Prefrontal Cortex
    Haplotypes
    121 Citations (Scopus)

    Modeling a genetic risk for schizophrenia in iPSCs and Mice reveals neural stem cell deficits associated with adherens junctions and polarity

    Yoon, K. J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N. S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Hussaini, S. M. Q., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J. E., Hyde, T. M. & 6 others, Krauss, G., Christian, K. M., Rapoport, J. L., Weinberger, D. R., Song, H. & Ming, G. L., 3 Jul 2014, In : Cell Stem Cell. 15, 1, p. 79-91 13 p.

    Research output: Contribution to journalArticle

    Adherens Junctions
    Neural Stem Cells
    Schizophrenia
    Ependymoglial Cells
    Haploinsufficiency
    1 Citation (Scopus)

    No Association Between NRG1 and ErbB4 Genes and Psychopathological Symptoms of Schizophrenia

    Tosato, S., Zanoni, M., Bonetto, C., Tozzi, F., Francks, C., Ira, E., Tomassi, S., Bertani, M., Rujescu, D., Giegling, I., St Clair, D., Tansella, M., Ruggeri, M. & Muglia, P., 1 Dec 2014, In : NeuroMolecular Medicine. 16, 4, p. 742-751 10 p.

    Research output: Contribution to journalArticle

    Neuregulin-1
    Schizophrenia
    Genes
    Biological Phenomena
    Scotland
    35 Citations (Scopus)
    5 Downloads (Pure)

    Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility

    Lang, B., Pu, J., Hunter, I., Liu, M., Martin-Granados, C., Reilly, T. J., Gao, G-D., Guan, Z-L., Li, W-D., Shi, Y-Y., He, G., He, L., Stefansson, H., St Clair, D., Blackwood, D. H., McCaig, C. D. & Shen, S., 1 Feb 2014, In : Journal of Cell Science. 127, 3, p. 630-640 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Schizophrenia
    Phosphotransferases
    Genes
    Bipolar Disorder
    Exons
    2013
    89 Citations (Scopus)

    A comprehensive family-based replication study of schizophrenia genes

    Aberg, K. A., Liu, Y., Bukszár, J., McClay, J. L., Khachane, A. N., Andreassen, O. A., Blackwood, D., Corvin, A., Djurovic, S., Gurling, H., Ophoff, R., Pato, C. N., Pato, M. T., Riley, B., Webb, T., Kendler, K., O'Donovan, M., Craddock, N., Kirov, G., Owen, M. & 7 others, Rujescu, D., St Clair, D., Werge, T., Hultman, C. M., Delisi, L. E., Sullivan, P. & Van Den Oord, E. J., 1 Jun 2013, In : JAMA Psychiatry. 70, 6, p. 573-581 9 p.

    Research output: Contribution to journalArticle

    Open Access
    Schizophrenia
    Single Nucleotide Polymorphism
    Genes
    Meta-Analysis
    Databases

    Mosaic copy number variation in schizophrenia

    Ruderfer, D. M., Chambert, K., Moran, J., Talkowski, M., Chen, E. S., Gigek, C., Gusella, J. F., Blackwood, D. H., Corvin, A., Gurling, H. M., Hultman, C. M., Kirov, G., Magnusson, P., O'Donovan, M. C., Owen, M. J., Pato, C., St Clair, D., Sullivan, P. F., Purcell, S. M., Sklar, P. & 1 others, Ernst, C., Sep 2013, In : EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. . 21, 9, p. 1007-1011 5 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Chromosomes, Human, Pair 7
    Human Genome
    Single Nucleotide Polymorphism
    Blood Cells
    21 Citations (Scopus)
    4 Downloads (Pure)

    Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease

    Huertas-Vazquez, A., Nelson, C. P., Guo, X., Reinier, K., Uy-Evanado, A., Teodorescu, C., Ayala, J., Jerger, K., Chugh, H., Braund, P. S., Deloukas, P., Hall, A. S., Balmforth, A. J., Jones, M., Taylor, K. D., Pulit, S. L., Newton-Cheh, C., Gunson, K., Jui, J., Rotter, J. I. & 31 others, Albert, C. M., Samani, N. J., Chugh, S. S., Aerts, J., Ahmad, T., Arbury, H., Attwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barnes, C., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Hocking, L., Reid, D. M., St Clair, D. & WTCCC+, 4 Apr 2013, In : PloS ONE. 8, 4, 6 p., e59905.

    Research output: Contribution to journalArticle

    Open Access
    File
    Sudden Cardiac Death
    Coronary Artery Disease
    Genes
    death
    loci
    31 Citations (Scopus)

    Rare CNVs and tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population

    Zhao, Q., Li, T., Zhao, X., Huang, K., Wang, T., Li, Z., Ji, J., Zeng, Z., Zhang, Z., Li, K., Feng, G., St Clair, D., He, L. & Shi, Y., 1 May 2013, In : Schizophrenia Bulletin. 39, 3, p. 712-719 8 p.

    Research output: Contribution to journalArticle

    Open Access
    Single Nucleotide Polymorphism
    Schizophrenia
    Population
    Multiplex Polymerase Chain Reaction
    Real-Time Polymerase Chain Reaction
    2012
    57 Citations (Scopus)

    A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia

    The International Schizophrenia Consortium (ISC), 1 Feb 2012, In : Journal of Medical Genetics. 49, 2, p. 96-103 8 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Schizophrenia
    Genes
    Information Services
    Single Nucleotide Polymorphism
    45 Citations (Scopus)

    Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

    Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., Páramo, M., Agra, S., Brenlla, J., Martínez, S., Rivero, O., Collier, D. A., Palotie, A., Cichon, S., Nöthen, M. M., Rietschel, M., Rujescu, D., Stefansson, H., Steinberg, S., Sigurdsson, E. & 12 others, St Clair, D., Tosato, S., Werge, T., Stefansson, K., González, J. C., Valero, J., Gutiérrez-Zotes, A., Labad, A., Martorell, L., Vilella, E., Carracedo, Á. & Costas, J., 15 Jan 2012, In : Biological Psychiatry. 71, 2, p. 169-177 9 p.

    Research output: Contribution to journalArticle

    Single Nucleotide Polymorphism
    Schizophrenia
    Genome-Wide Association Study
    21 Citations (Scopus)

    HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells

    Lang, B., Alrahbeni, T. M. A., St Clair, D., Blackwood, D. H., McCaig, C. D. & Shen, S., 1 Jan 2012, In : American Journal of Stem Cells. 1, 1, p. 31-41 10 p.

    Research output: Contribution to journalArticle

    Adult Stem Cells
    Histone Deacetylases
    Neural Stem Cells
    Schizophrenia
    Neurons
    130 Citations (Scopus)

    Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia

    Kim, J. Y., Liu, C. Y., Zhang, F., Duan, X., Wen, Z., Song, J., Feighery, E., Lu, B., Rujescu, D., St Clair, D., Christian, K., Callicott, J. H., Weinberger, D. R., Song, H. & Ming, G., Mar 2012, In : Cell. 148, 5, p. 1051-1064 14 p.

    Research output: Contribution to journalArticle

    Neurogenesis
    gamma-Aminobutyric Acid
    Schizophrenia
    Depolarization
    Intrinsic Factor
    42 Citations (Scopus)

    Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis

    The Schizophrenia Psychiatric Genomic Consortium, 22 Jun 2012, In : PloS ONE. 7, 6, 7 p., e37852.

    Research output: Contribution to journalArticle

    Open Access
    File
    Risk analysis
    Psychotic Disorders
    Schizophrenia
    Genotype
    schizophrenia
    12 Citations (Scopus)

    Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder

    Vassos, E., Steinberg, S., Cichon, S., Breen, G., Sigurdsson, E., Andreassen, O. A., Djurovic, S., Morken, G., Grigoroiu-Serbanescu, M., Diaconu, C. C., Czerski, P. M., Hauser, J., Babadjanova, G., Abramova, L. I., Mühleisen, T. W., Nöthen, M. M., Rietschel, M., McGuffin, P., Clair, D. S., Gustafsson, O. & 28 others, Melle, I., Pietiläinen, O. P. H., Ruggeri, M., Tosato, S., Werge, T., Ophoff, R. A., Rujescu, D., Børglum, A. D., Mors, O., Mortensen, P. B., Demontis, D., Hollegaard, M. V., van Winkel, R., Kenis, G., De Hert, M., Réthelyi, J. M., Bitter, I., Rubino, I. A., Golimbet, V., Kiemeney, L. A., van den Berg, L. H., Franke, B., Jönsson, E. G., Farmer, A., Stefansson, H., Stefansson, K., Collier, D. A. & GROUP Consortium, 15 Oct 2012, In : Biological Psychiatry. 72, 8, p. 645-650 6 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Meta-Analysis
    Schizophrenia
    Odds Ratio
    Genome
    66 Citations (Scopus)
    4 Downloads (Pure)

    Runs of homozygosity implicate autozygosity as a schizophrenia risk factor

    Keller, M. C., Simonson, M. A., Ripke, S., Neale, B. M., Gejman, P. V., Howrigan, D. P., Lee, S. H., Lencz, T., Levinson, D. F., Sullivan, P. F., Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium & St Clair, D. M., 12 Apr 2012, In : PLoS Genetics. 8, 4, 11 p., e1002656.

    Research output: Contribution to journalArticle

    Open Access
    File
    homozygosity
    risk factor
    Schizophrenia
    risk factors
    genome
    60 Citations (Scopus)

    Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracy

    Benson, P. J., Beedie, S. A., Shephard, E., Giegling, I., Rujescu, D. & St Clair, D., 1 Nov 2012, In : Biological Psychiatry. 72, 9, p. 716-724 9 p.

    Research output: Contribution to journalArticle

    Eye Abnormalities
    Eye Movements
    Schizophrenia
    Smooth Pursuit
    Neural Networks (Computer)
    2011
    87 Citations (Scopus)

    At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia

    Hansen, T., Ingason, A., Djurovic, S., Melle, I., Fenger, M., Gustafsson, O., Jakobsen, K. D., Rasmussen, H. B., Tosato, S., Rietschel, M., Frank, J., Owen, M., Bonetto, C., Suvisaari, J., Thygesen, J. H., Pétursson, H., Lönnqvist, J., Sigurdsson, E., Giegling, I., Craddock, N. & 12 others, O'Donovan, M. C., Ruggeri, M., Cichon, S., Ophoff, R. A., Pietiläinen, O., Peltonen, L., Nöthen, M. M., Rujescu, D., St Clair, D., Collier, D. A., Andreassen, O. A. & Werge, T., 1 Jul 2011, In : Biological Psychiatry. 70, 1, p. 59-63 5 p.

    Research output: Contribution to journalArticle

    Type 2 Diabetes Mellitus
    Schizophrenia
    Comorbidity
    Antipsychotic Agents
    Life Style
    26 Citations (Scopus)

    Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area

    Kähler, A. K., Djurovic, S., Rimol, L. M., Brown, A. A., Athanasiu, L., Jönsson, E. G., Hansen, T., Gústafsson, Ó., Hall, H., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., Pietiläinen, O. P. H., Peltonen, L., Bramon, E., Collier, D., St Clair, D., Sigurdsson, E., Petursson, H. & 8 others, Rujescu, D., Melle, I., Werge, T., Steen, V. M., Dale, A. M., Matthews, R. T., Agartz, I. & Andreassen, O. A., 1 Jan 2011, In : Biological Psychiatry. 69, 1, p. 90-96 7 p.

    Research output: Contribution to journalArticle

    Genetic Association Studies
    Schizophrenia
    Carbohydrates
    Single Nucleotide Polymorphism
    Neuronal Plasticity
    140 Citations (Scopus)

    Common variants at VRK2 and TCF4 conferring risk of schizophrenia

    Steinberg, S., de Jong, S., Andreassen, O. A., Werge, T., Børglum, A. D., Mors, O., Mortensen, P. B., Gustafsson, O., Costas, J., Pietiläinen, O. P. H., Demontis, D., Papiol, S., Huttenlocher, J., Mattheisen, M., Breuer, R., Vassos, E., Giegling, I., Fraser, G., Walker, N., Tuulio-Henriksson, A. & 31 others, Suvisaari, J., Lönnqvist, J., Paunio, T., Agartz, I., Melle, I., Djurovic, S., Strengman, E., Jürgens, G., Glenthøj, B., Terenius, L., Hougaard, D. M., Ørntoft, T., Wiuf, C., Didriksen, M., Hollegaard, M. V., Nordentoft, M., van Winkel, R., Kenis, G., Abramova, L., Kaleda, V., Arrojo, M., Sanjuán, J., Arango, C., Sperling, S., Rossner, M., Ribolsi, M., Magni, V., Siracusano, A., Christiansen, C., St Clair, D. & Irish Schizophrenia Genomics Consortium, 15 Oct 2011, In : Human Molecular Genetics. 20, 20, p. 4076-4081 6 p.

    Research output: Contribution to journalArticle

    Vaccinia
    Neurogranin
    Schizophrenia
    Transcription Factors
    Phosphotransferases
    162 Citations (Scopus)

    Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

    Shi, Y., Li, Z., Xu, Q., Wang, T., Li, T., Shen, J., Zhang, F., Chen, J., Zhou, G., Ji, W., Li, B., Xu, Y., Liu, D., Wang, P., Yang, P., Liu, B., Sun, W., Wan, C., Qin, S., He, G. & 21 others, Steinberg, S., Cichon, S., Werge, T., Sigurdsson, E., Tosato, S., Palotie, A., Nöthen, M. M., Rietschel, M., Ophoff, R. A., Collier, D. A., Rujescu, D., St Clair, D., Stefansson, H., Stefansson, K., Ji, J., Wang, Q., Li, W., Zheng, L., Zhang, H., Feng, G. & He, L., 1 Dec 2011, In : Nature Genetics. 43, p. 1224-1227 4 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Population
    Genome-Wide Association Study
    Mental Disorders
    Single Nucleotide Polymorphism
    165 Citations (Scopus)

    Copy number variations of chromosome 16p13.1 region associated with schizophrenia

    Ingason, A., Rujescu, D., Cichon, S., Sigurdsson, E., Sigmundsson, T., Pietiläinen, O. P. H., Buizer-Voskamp, J. E., Strengman, E., Francks, C., Muglia, P., Gylfason, A., Gustafsson, O., Olason, P. I., Steinberg, S., Hansen, T., Jakobsen, K. D., Rasmussen, H. B., Giegling, I., Möller, H-J., Hartmann, A. & 29 others, Crombie, C., Fraser, G., Walker, N., Lonnqvist, J., Suvisaari, J., Tuulio-Henriksson, A., Bramon, E., Kiemeney, L. A., Franke, B., Murray, R., Vassos, E., Toulopoulou, T., Mühleisen, T. W., Tosato, S., Ruggeri, M., Djurovic, S., Andreassen, O. A., Zhang, Z., Werge, T., Ophoff, R. A., Rietschel, M., Nöthen, M. M., Petursson, H., Stefansson, H., Peltonen, L., Collier, D., Stefansson, K., St Clair, D. M. & GROUP Investigators, 2011, In : Molecular Psychiatry. 16, 1, p. 17-25 9 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Chromosomes
    Autistic Disorder
    Intellectual Disability
    Psychiatry
    17 Citations (Scopus)

    DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls

    Green, E. K., Grozeva, D., Sims, R., Raybould, R., Forty, L., Gordon-Smith, K., Russell, E., St. Clair, D., Young, A. H., Ferrier, I. N., Kirov, G., Jones, I., Jones, L., Owen, M. J., O'Donovan, M. C. & Craddock, N., 1 Jun 2011, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 156, 4, p. 490-492 3 p.

    Research output: Contribution to journalArticle

    Exons
    Diagnostic and Statistical Manual of Mental Disorders
    Psychotic Disorders
    Single Nucleotide Polymorphism
    Chromosomes
    45 Citations (Scopus)

    Evidence of sex-modulated association of ZNF804A with schizophrenia

    Zhang, F., Chen, Q., Ye, T., Lipska, B. K., Straub, R. E., Vakkalanka, R., Rujescu, D., St Clair, D., Hyde, T. M., Bigelow, L., Kleinman, J. E. & Weinberger, D. R., 15 May 2011, In : Biological Psychiatry. 69, 10, p. 914-917 4 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Schizophrenia
    Single Nucleotide Polymorphism
    Odds Ratio
    Genotype
    116 Citations (Scopus)

    Expanding the range of ZNF804A variants conferring risk of psychosis

    Steinberg, S., Mors, O., Børglum, A. D., Gustafsson, O., Werge, T., Mortensen, P. B., Andreassen, O. A., Sigurdsson, E., Thorgeirsson, T. E., Böttcher, Y., Olason, P., Ophoff, R. A., Cichon, S., Gudjonsdottir, I. H., Pietiläinen, O. P. H., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Athanasiu, L. & 52 others, Suvisaari, J., Lonnqvist, J., Paunio, T., Hartmann, A., Jürgens, G., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Breuer, R., Möller, H-J., Giegling, I., Glenthøj, B., Rasmussen, H. B., Mattheisen, M., Bitter, I., Réthelyi, J. M., Sigmundsson, T., Fossdal, R., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Walshe, M., Bramon, E., Vassos, E., Li, T., Fraser, G., Walker, N., Toulopoulou, T., Yoon, J., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Jönsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nöthen, M. M., Rietschel, M., Peltonen, L., Rujescu, D., Collier, D. A., Stefansson, H., St Clair, D. & Stefansson, K., Jan 2011, In : Molecular Psychiatry. 16, 1, p. 59-66 8 p.

    Research output: Contribution to journalArticle

    Psychotic Disorders
    Schizophrenia
    Bipolar Disorder
    Psychiatry
    Genome-Wide Association Study
    11 Citations (Scopus)
    5 Downloads (Pure)

    Genetic classification of populations using supervised learning

    The International Schizophrenia Consortium (ISC), 12 May 2011, In : PloS ONE. 6, 5, p. 1-12 12 p., e14802.

    Research output: Contribution to journalArticle

    Open Access
    File
    Supervised learning
    Population Genetics
    Principal component analysis
    learning
    Learning
    1211 Citations (Scopus)

    Genome-wide association study identifies five new schizophrenia loci

    Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D-Y., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., St Clair, D., Corvin, A., Gurling, H., Werge, T., Rujescu, D., Blackwood, D. H. R., Pato, C. N., Malhotra, A. K. & 31 others, Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., De Hert, M., Jönsson, E. G., Bitter, I., Pietiläinen, O. P. H., Collier, D. A., Tosato, S., Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G. & Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium, Oct 2011, In : Nature Genetics. 43, 10, p. 969-976 8 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Schizophrenia
    MicroRNAs
    Genome
    Internal-External Control
    48 Citations (Scopus)

    GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

    Fraser, G., Genetic Risk and Outcome in Psychosis (GROUP) & The International Schizophrenia Consortium (ISC), 1 Nov 2011, In : Molecular Psychiatry. 16, 11, p. 1117-1129 13 p.

    Research output: Contribution to journalArticle

    Data Mining
    Genome-Wide Association Study
    Cardiomyopathies
    Schizophrenia
    Odds Ratio
    330 Citations (Scopus)

    Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

    Reilly, M. P., Li, M., He, J., Ferguson, J. F., Stylianou, I. M., Mehta, N. N., Burnett, M. S., Devaney, J. M., Knouff, C. W., Thompson, J. R., Horne, B. D., Stewart, A. F. R., Assimes, T. L., Wild, P. S., Allayee, H., Nitschke, P. L., Patel, R. S., Martinelli, N., Girelli, D., Quyyumi, A. A. & 14 others, Anderson, J. L., Erdmann, J., Hall, A. S., Schunkert, H., Quertermous, T., Blankenberg, S., Hazen, S. L., Roberts, R., Kathiresan, S., Samani, N. J., Epstein, S. E., Rader, D. J., Myocardial Infarction Genetics Consortium & St Clair, D., 29 Jan 2011, In : The Lancet. 377, 9763, p. 383-392 10 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Coronary Artery Disease
    Myocardial Infarction
    Phenotype
    Organized Financing
    817 Citations (Scopus)

    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

    Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., Blackwood, D., Corvin, A., Flickinger, M., Guan, W., Mattingsdal, M., McQuillin, A., Kwan, P., Wienker, T. F., Daly, M., Dudbridge, F., Holmans, P. A. & 31 others, Lin, D., Burmeister, M., Greenwood, T. A., Hamshere, M. L., Muglia, P., Smith, E. N., Zandi, P. P., Nievergelt, C. M., McKinney, R., Shilling, P. D., Schork, N. J., Bloss, C. S., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A., Hipolito, M., Coryell, W., Rice, J., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W., Li, J., Breen, G., St Clair, D. & Psychiatric GWAS Consortium Bipolar Disorder Working Group, Oct 2011, In : Nature Genetics. 43, 10, p. 977-983 7 p.

    Research output: Contribution to journalArticle

    Genome-Wide Association Study
    Bipolar Disorder
    Single Nucleotide Polymorphism
    Calcium Channels
    Sample Size
    151 Citations (Scopus)

    Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

    The International Schizophrenia Consortium (ISC), 2011, In : Molecular Psychiatry. 16, 3, p. 286-292 7 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Cell Adhesion
    Schizophrenia
    Cell Adhesion Molecules
    Cell Membrane
    42 Citations (Scopus)

    Polygenic dissection of the bipolar phenotype

    Hamshere, M. L., O'Donovan, M. C., Jones, I. R., Jones, L., Kirov, G., Green, E. K., Moskvina, V., Grozeva, D., Bass, N., McQuillin, A., Gurling, H., St Clair, D., Young, A. H., Ferrier, I. N., Farmer, A., McGuffin, P., Sklar, P., Purcell, S., Holmans, P. A., Owen, M. J. & 1 others, Craddock, N., 1 Apr 2011, In : British Journal of Psychiatry. 198, 4, p. 284-288 5 p.

    Research output: Contribution to journalArticle

    Bipolar Disorder
    Dissection
    Phenotype
    Schizophrenia
    Psychotic Disorders
    45 Citations (Scopus)

    Prevention and schizophrenia: the role of dietary factors

    McGrath, J., Brown, A. & St Clair, D., Mar 2011, In : Schizophrenia Bulletin. 37, 2, p. 272-283 12 p.

    Research output: Contribution to journalArticle

    Schizophrenia
    Micronutrients
    Starvation
    Folic Acid
    Vitamin D
    13 Citations (Scopus)

    Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia

    Chen, J., Lee, G., Fanous, A. H., Zhao, Z., Jia, P., O'Neill, A., Walsh, D., Kendler, K. S., Chen, X., The International Schizophrenia Consortium (ISC) & St Clair, D., Sep 2011, In : Schizophrenia Research. 131, 1-3, p. 43-51 9 p.

    Research output: Contribution to journalArticle

    Data Mining
    Genome-Wide Association Study
    Schizophrenia
    Linkage Disequilibrium
    Haplotypes
    2010
    97 Citations (Scopus)
    4 Downloads (Pure)

    Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function

    Raychaudhuri, S., Korn, J. M., McCarroll, S. A., The International Schizophrenia Consortium (ISC), Altshuler, D., Sklar, P., Purcell, S., Daly, M. J. & St Clair, D. M., 9 Sep 2010, In : PLoS Genetics. 6, 9, 12 p., e1001097.

    Research output: Contribution to journalArticle

    Open Access
    File
    brain
    Schizophrenia
    gene
    Brain
    Genes