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19992019
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Research Output 1999 2019

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2019
68 Citations (Scopus)

Genome-wide association study identifies 30 loci associated with bipolar disorder

Stahl, E. A., Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., Mattheisen, M., Wang, Y., Coleman, J. R. I., Gaspar, H. A., de Leeuw, C. A., Steinberg, S., Pavlides, J. M. W., Trzaskowski, M., Byrne, E. M., Pers, T. H., Holmans, P. A., Richards, A. L., Abbott, L., Agerbo, E. & 33 others, Akil, H., Albani, D., Alliey-Rodriguez, N., Als, T. D., Anjorin, A., Antilla, V., Awasthi, S., Badner, J. A., Bækvad-Hansen, M., Barchas, J. D., Bass, N., Bauer, M., Belliveau, R., Bergen, S. E., Pedersen, C. B., Bøen, E., Boks, M. P., Boocock, J., Budde, M., Bunney, W., Burmeister, M., Bybjerg-Grauholm, J., Byerley, W., Casas, M., Cerrato, F., Cervantes, P., Chambert, K., Charney, A. W., Chen, D., St Clair, D., eQTLGen Consortium, BIOS Consortium & the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, 1 May 2019, In : Nature Genetics. 51, p. 793-803 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Bipolar Disorder
Genome
Neurotransmitter Transport Proteins
Endocannabinoids

Roles for IFT172 and primary cilia in cell migration, cell division and neocortex development

Pruski, M., Hu, L., Yang, C., Wang, Y., Zhang, J-B., Zhang, L., Huang, Y., Rajnicek, A. M., St Clair, D., McCaig, C. D., Lang, B. & Ding, Y-Q., Nov 2019, In : Frontiers in Cell and Developmental Biology. 7, 287.

Research output: Contribution to journalArticle

Open Access
File
Cilia
Neocortex
Cell Division
Cell Movement
Bardet-Biedl Syndrome
2018
10 Citations (Scopus)
4 Downloads (Pure)

Study of Novel Autoantibodies in Schizophrenia

Whelan, R., St Clair, D., Mustard, C. J., Hallford, P. & Wei, J., 17 Oct 2018, In : Schizophrenia Bulletin. 44, 6, p. 1341-1349 9 p.

Research output: Contribution to journalArticle

Open Access
File
Autoantibodies
Schizophrenia
Immunoglobulin G
ROC Curve
Antigens
2017
5 Citations (Scopus)
5 Downloads (Pure)

Differential antibody responses to gliadin-derived indigestible peptides in patients with schizophrenia

McLean, RT., Wilson, P., St Clair, D., Mustard, CJ. & Wei, J., 2017, In : Translational Psychiatry. 7, e1121.

Research output: Contribution to journalArticle

Open Access
File
Gliadin
Antibody Formation
Schizophrenia
Peptides
Antibodies
24 Citations (Scopus)

Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics

Giegling, I., Hosak, L., Mössner, R., Serretti, A., Bellivier, F., Claes, S., Collier, D. A., Corrales, A., DeLisi, L. E., Gallo, C., Gill, M., Kennedy, J. L., Leboyer, M., Maier, W., Marquez, M., Massat, I., Mors, O., Muglia, P., Nöthen, M. M., Ospina-Duque, J. & 9 others, Owen, M. J., Propping, P., Shi, Y. Y., St Clair, D., Thibaut, F., Cichon, S., Mendlewicz, J., O'Donovan, M. C. & Rujescu, D., 2017, In : World Journal of Biological Psychiatry. 18, 7, p. 492-505 14 p.

Research output: Contribution to journalArticle

Advisory Committees
Schizophrenia
Consensus
Psychiatry
Precision Medicine
2016
93 Citations (Scopus)
4 Downloads (Pure)

An integrated genetic-epigenetic analysis of schizophrenia: Evidence for co-localization of genetic associations and differential DNA methylation

Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, A. R., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., Kaprio, J., Toulopoulou, T., Pol, H. E. H., Bohlken, M. M., Kahn, R. S., Nenadic, I., Hultman, C. M., Murray, R. M., Collier, D. A., Bass, N. & 4 others, Gurling, H., McQuillin, A., Schalkwyk, L. & Mill, J., 30 Aug 2016, In : Genome Biology. 17, 176.

Research output: Contribution to journalArticle

Open Access
File
methylation
genetic analysis
DNA methylation
DNA Methylation
Epigenomics
19 Citations (Scopus)
3 Downloads (Pure)

Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function

Thomson, P. A., Duff, B., Blackwood, D. H. R., Romaniuk, L., Watson, A., Whalley, H. C., Li, X., Dauvermann, M. R., Moorhead, T. W. J., Bois, C., Ryan, N. M., Redpath, H., Hall, L., Morris, S. W., Van Beek, E. J. R., Roberts, N., Porteous, D. J., St Clair, D., Whitcher, B., Dunlop, J. & 5 others, Brandon, N. J., Hughes, Z. A., Hall, J., McIntosh, A. & Lawrie, S. M., 10 Aug 2016, In : npj Schizophrenia. 2, 16024.

Research output: Contribution to journalArticle

Open Access
File
Psychopathology
Psychiatry
Glutamic Acid
Temporal Lobe
Prefrontal Cortex
8 Citations (Scopus)
6 Downloads (Pure)

Control of cortex development by ULK4, a rare risk gene for mental disorders including schizophrenia

Lang, B., Zhang, L., Jiang, G., Hu, L., Lan, W., Zhao, L., Hunter, I., Pruski, M., Song, N-N., Huang, Y., Zhang, L., St Clair, D., McCaig, C. D. & Ding, Y-Q., 27 Sep 2016, In : Scientific Reports. 6, p. 1-14 14 p., 31126.

Research output: Contribution to journalArticle

Open Access
File
Mental Disorders
Schizophrenia
Phosphotransferases
Genes
Genetic Loci
103 Citations (Scopus)

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., Nichols, T. E., Neale, M. C., McIntosh, A. M., Lee, P., McMahon, F. J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O. A., Gruber, O., Sachdev, P. S., Roiz-Santianez, R., Saykin, A. J. & 11 others, Ehrlich, S., Mather, K. A., Turner, J. A., Wright, M. J., O'Donovan, M. C., Thompson, P. M., Neale, B. M., Medland, S. E., Sullivan, P. F., Psychiat Genomics Consortium & ENIGMA Consortium, Mar 2016, In : Nature Neuroscience. 19, 3, p. 420-431 12 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

Singh, T., Kurki, M. I., Curtis, D., Purcell, S. M., Crooks, L., McRae, J., Suvisaari, J., Chheda, H., Blackwood, D., Breen, G., Pietilinen, O., Gerety, S. S., Ayub, M., Blyth, M., Cole, T., Collier, D., Coomber, E. L., Craddock, N., Daly, M. J., Danesh, J. & 39 others, DiForti, M., Foster, A., Freimer, N. B., Geschwind, D., Johnstone, M., Joss, S., Kirov, G., Körkkö, J., Kuismin, O., Holmans, P., Hultman, C. M., Iyegbe, C., Lönnqvist, J., Mnnikkö, M., McCarroll, S. A., McGuffin, P., McIntosh, A. M., McQuillin, A., Moilanen, J. S., Moore, C., Murray, R. M., Newbury-Ecob, R., Ouwehand, W., Paunio, T., Prigmore, E., Rees, E., Roberts, D., Sambrook, J., Sklar, P., St Clair, D., Veijola, J., Walters, J. T. R., Williams, H., Sullivan, P. F., Hurles, M. E., O'Donovan, M. C., Palotie, A., Owen, M. J. & Barrett, J. C., 29 Mar 2016, In : Nature Neuroscience. 19, 4, p. 571-577 7 p.

Research output: Contribution to journalArticle

Schizophrenia
Exome
Epigenomics
Histones
Methylation
2015
46 Citations (Scopus)
8 Downloads (Pure)

Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J. & Saksida, L. M., 1 Oct 2015, In : Scientific Reports. 5, 5 p., 14613.

Research output: Contribution to journalArticle

Open Access
File
Mutation
Inborn Genetic Diseases
Brain Diseases
Genes
Therapeutics
4 Downloads (Pure)

Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness

Johnstone, M., Maclean, A., Heyrman, L., Lenaerts, A-S., Nordin, A., Nilsson, L-G., De Rijk, P., Goossens, D., Adolfsson, R., St Clair, D. M., Hall, J., Lawrie, S. M., McIntosh, A. M., Del-Favero, J., Blackwood, D. H. R. & Pickard, B. S., Oct 2015, In : Journal of Neuropsychiatry and Clinical Neurosciences. 1, 3, p. 175-190 16 p.

Research output: Contribution to journalArticle

Open Access
File
Overlapping Genes
Protein Binding
Psychiatry
Population
Genes
15 Citations (Scopus)
4 Downloads (Pure)

Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia

Ingason, A., Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Friedl, M., Ripke, S., Sullivan, P. F., St Clair, D., Collier, D. A., O'Donovan, M. C., Mirnics, K. & Rujescu, D., 13 Oct 2015, In : Translational Psychiatry. 5, 6 p., e656.

Research output: Contribution to journalArticle

Open Access
File
Psychotic Disorders
Schizophrenia
N-Methyl-D-Aspartate Receptors
Genes
Dizocilpine Maleate
3 Citations (Scopus)
4 Downloads (Pure)

Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch

Jiang, G-Y., Dai, M-H., Huang, K., Chai, G-D., Chen, J-Y., Chen, L., Lang, B., Wang, Q-X., St Clair, D., McCaig, C., Ding, Y-Q. & Zhang, L., 7 Aug 2015, In : Scientific Reports. 5, 10 p., 12787.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)

Prenatal Nutritional Deficiency Reprogrammed Postnatal Gene Expression in Mammal Brains: Implications for Schizophrenia

Xu, J., He, G., Zhu, J., Zhou, X., Clair, D. S., Wang, T., Xiang, Y., Zhao, Q., Xing, Q., Liu, Y., Wang, L., Li, Q., He, L. & Zhao, X., Feb 2015, In : International Journal of Neuropsychopharmacology. 18, 4, pyu054.

Research output: Contribution to journalArticle

Open Access
Malnutrition
Mammals
Hippocampus
Schizophrenia
Gene Expression
2014
20 Citations (Scopus)
4 Downloads (Pure)

An inherited duplication at the gene p21 protein-activated Kinase 7 (PAK7) is a risk factor for psychosis

Morris, D. W., Pearson, R. D., Cormican, P., Kenny, E. M., O'Dushlaine, C. T., Perreault, L. P. L., Giannoulatou, E., Tropea, D., Maher, B. S., Wormley, B., Kelleher, E., Fahey, C., Molinos, I., Bellini, S., Pirinen, M., Strange, A., Freeman, C., Thiselton, D. L., Elves, R. L., Regan, R. & 39 others, Ennis, S., Dinan, T. G., McDonald, C., Murphy, K. C., O'Callaghan, E., Waddington, J. L., Walsh, D., O'Donovan, M., Grozeva, D., Craddock, N., Stone, J., Scolnick, E., Purcell, S., Sklar, P., Coe, B., Eichler, E. E., Ophoff, R., Buizer, J., Szatkiewicz, J., Hultman, C., Sullivan, P., Gurling, H., Mcquillin, A., St Clair, D., Rees, E., Kirov, G., Walters, J., Blackwood, D., Johnstone, M., Donohoe, G., The International Schizophrenia Consortium (ISC), SGENE+ Consortium, O'Neill, F. A., The Wellcome Trust Case Control Consortium 2 (WTCCC2), Kendler, K. S., Gill, M., Riley, B. P., Spencer, C. C. A. & Corvin, A., 15 Jun 2014, In : Human Molecular Genetics. 23, 12, p. 3316-3326 11 p.

Research output: Contribution to journalArticle

Open Access
File
p21-Activated Kinases
Psychotic Disorders
Protein Kinases
Schizophrenia
Bipolar Disorder
44 Citations (Scopus)

Common genetic variants on 1p13.2 associate with risk of autism

Xia, K., Guo, H., Xun, G., Zuo, L., Peng, Y., He, Y., Xiong, Z., Sun, L., Pan, Q., Long, Z., Zou, X., Lu, L., Liu, Y., Tian, D., Long, L., Liu, Y., Peng, H., Luo, X., Su, W., Liang, D. & 12 others, Dai, H., Yan, X., Feng, Y., Tang, B., Miedzybrodzka, Z., Xia, J., Zhang, Z., Luo, X., Zhang, X., St Clair, D., Zhao, J. & Zhang, F., Nov 2014, In : Molecular Psychiatry. 19, 11, p. 1212-1219 8 p.

Research output: Contribution to journalArticle

Autistic Disorder
Genome-Wide Association Study
Genetic Association Studies
Prefrontal Cortex
Haplotypes
126 Citations (Scopus)

Modeling a genetic risk for schizophrenia in iPSCs and Mice reveals neural stem cell deficits associated with adherens junctions and polarity

Yoon, K. J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N. S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Hussaini, S. M. Q., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J. E., Hyde, T. M. & 6 others, Krauss, G., Christian, K. M., Rapoport, J. L., Weinberger, D. R., Song, H. & Ming, G. L., 3 Jul 2014, In : Cell Stem Cell. 15, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

Adherens Junctions
Neural Stem Cells
Schizophrenia
Ependymoglial Cells
Haploinsufficiency
3 Citations (Scopus)

No Association Between NRG1 and ErbB4 Genes and Psychopathological Symptoms of Schizophrenia

Tosato, S., Zanoni, M., Bonetto, C., Tozzi, F., Francks, C., Ira, E., Tomassi, S., Bertani, M., Rujescu, D., Giegling, I., St Clair, D., Tansella, M., Ruggeri, M. & Muglia, P., 1 Dec 2014, In : NeuroMolecular Medicine. 16, 4, p. 742-751 10 p.

Research output: Contribution to journalArticle

Neuregulin-1
Schizophrenia
Genes
Biological Phenomena
Scotland
37 Citations (Scopus)
5 Downloads (Pure)

Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility

Lang, B., Pu, J., Hunter, I., Liu, M., Martin-Granados, C., Reilly, T. J., Gao, G-D., Guan, Z-L., Li, W-D., Shi, Y-Y., He, G., He, L., Stefansson, H., St Clair, D., Blackwood, D. H., McCaig, C. D. & Shen, S., 1 Feb 2014, In : Journal of Cell Science. 127, 3, p. 630-640 11 p.

Research output: Contribution to journalArticle

Open Access
File
Schizophrenia
Phosphotransferases
Genes
Bipolar Disorder
Exons
2013
93 Citations (Scopus)

A comprehensive family-based replication study of schizophrenia genes

Aberg, K. A., Liu, Y., Bukszár, J., McClay, J. L., Khachane, A. N., Andreassen, O. A., Blackwood, D., Corvin, A., Djurovic, S., Gurling, H., Ophoff, R., Pato, C. N., Pato, M. T., Riley, B., Webb, T., Kendler, K., O'Donovan, M., Craddock, N., Kirov, G., Owen, M. & 7 others, Rujescu, D., St Clair, D., Werge, T., Hultman, C. M., Delisi, L. E., Sullivan, P. & Van Den Oord, E. J., 1 Jun 2013, In : JAMA Psychiatry. 70, 6, p. 573-581 9 p.

Research output: Contribution to journalArticle

Open Access
Schizophrenia
Single Nucleotide Polymorphism
Genes
Meta-Analysis
Databases

Mosaic copy number variation in schizophrenia

Ruderfer, D. M., Chambert, K., Moran, J., Talkowski, M., Chen, E. S., Gigek, C., Gusella, J. F., Blackwood, D. H., Corvin, A., Gurling, H. M., Hultman, C. M., Kirov, G., Magnusson, P., O'Donovan, M. C., Owen, M. J., Pato, C., St Clair, D., Sullivan, P. F., Purcell, S. M., Sklar, P. & 1 others, Ernst, C., Sep 2013, In : EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. . 21, 9, p. 1007-1011 5 p.

Research output: Contribution to journalArticle

Schizophrenia
Chromosomes, Human, Pair 7
Human Genome
Single Nucleotide Polymorphism
Blood Cells
21 Citations (Scopus)
4 Downloads (Pure)

Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease

Huertas-Vazquez, A., Nelson, C. P., Guo, X., Reinier, K., Uy-Evanado, A., Teodorescu, C., Ayala, J., Jerger, K., Chugh, H., Braund, P. S., Deloukas, P., Hall, A. S., Balmforth, A. J., Jones, M., Taylor, K. D., Pulit, S. L., Newton-Cheh, C., Gunson, K., Jui, J., Rotter, J. I. & 31 others, Albert, C. M., Samani, N. J., Chugh, S. S., Aerts, J., Ahmad, T., Arbury, H., Attwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barnes, C., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Hocking, L., Reid, D. M., St Clair, D. & WTCCC+, 4 Apr 2013, In : PloS ONE. 8, 4, 6 p., e59905.

Research output: Contribution to journalArticle

Open Access
File
Sudden Cardiac Death
Coronary Artery Disease
Genes
death
loci
32 Citations (Scopus)

Rare CNVs and tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population

Zhao, Q., Li, T., Zhao, X., Huang, K., Wang, T., Li, Z., Ji, J., Zeng, Z., Zhang, Z., Li, K., Feng, G., St Clair, D., He, L. & Shi, Y., 1 May 2013, In : Schizophrenia Bulletin. 39, 3, p. 712-719 8 p.

Research output: Contribution to journalArticle

Open Access
Single Nucleotide Polymorphism
Schizophrenia
Population
Multiplex Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction
2012
58 Citations (Scopus)

A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia

The International Schizophrenia Consortium (ISC), 1 Feb 2012, In : Journal of Medical Genetics. 49, 2, p. 96-103 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Schizophrenia
Genes
Information Services
Single Nucleotide Polymorphism
47 Citations (Scopus)

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., Páramo, M., Agra, S., Brenlla, J., Martínez, S., Rivero, O., Collier, D. A., Palotie, A., Cichon, S., Nöthen, M. M., Rietschel, M., Rujescu, D., Stefansson, H., Steinberg, S., Sigurdsson, E. & 12 others, St Clair, D., Tosato, S., Werge, T., Stefansson, K., González, J. C., Valero, J., Gutiérrez-Zotes, A., Labad, A., Martorell, L., Vilella, E., Carracedo, Á. & Costas, J., 15 Jan 2012, In : Biological Psychiatry. 71, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Schizophrenia
Genome-Wide Association Study
22 Citations (Scopus)

HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells

Lang, B., Alrahbeni, T. M. A., St Clair, D., Blackwood, D. H., McCaig, C. D. & Shen, S., 1 Jan 2012, In : American Journal of Stem Cells. 1, 1, p. 31-41 10 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Histone Deacetylases
Neural Stem Cells
Schizophrenia
Neurons
133 Citations (Scopus)

Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia

Kim, J. Y., Liu, C. Y., Zhang, F., Duan, X., Wen, Z., Song, J., Feighery, E., Lu, B., Rujescu, D., St Clair, D., Christian, K., Callicott, J. H., Weinberger, D. R., Song, H. & Ming, G., Mar 2012, In : Cell. 148, 5, p. 1051-1064 14 p.

Research output: Contribution to journalArticle

Neurogenesis
gamma-Aminobutyric Acid
Schizophrenia
Depolarization
Intrinsic Factor
44 Citations (Scopus)

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis

The Schizophrenia Psychiatric Genomic Consortium, 22 Jun 2012, In : PloS ONE. 7, 6, 7 p., e37852.

Research output: Contribution to journalArticle

Open Access
File
Risk analysis
Psychotic Disorders
Schizophrenia
Genotype
schizophrenia
13 Citations (Scopus)

Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder

Vassos, E., Steinberg, S., Cichon, S., Breen, G., Sigurdsson, E., Andreassen, O. A., Djurovic, S., Morken, G., Grigoroiu-Serbanescu, M., Diaconu, C. C., Czerski, P. M., Hauser, J., Babadjanova, G., Abramova, L. I., Mühleisen, T. W., Nöthen, M. M., Rietschel, M., McGuffin, P., Clair, D. S., Gustafsson, O. & 28 others, Melle, I., Pietiläinen, O. P. H., Ruggeri, M., Tosato, S., Werge, T., Ophoff, R. A., Rujescu, D., Børglum, A. D., Mors, O., Mortensen, P. B., Demontis, D., Hollegaard, M. V., van Winkel, R., Kenis, G., De Hert, M., Réthelyi, J. M., Bitter, I., Rubino, I. A., Golimbet, V., Kiemeney, L. A., van den Berg, L. H., Franke, B., Jönsson, E. G., Farmer, A., Stefansson, H., Stefansson, K., Collier, D. A. & GROUP Consortium, 15 Oct 2012, In : Biological Psychiatry. 72, 8, p. 645-650 6 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Meta-Analysis
Schizophrenia
Odds Ratio
Genome
67 Citations (Scopus)
4 Downloads (Pure)

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor

Keller, M. C., Simonson, M. A., Ripke, S., Neale, B. M., Gejman, P. V., Howrigan, D. P., Lee, S. H., Lencz, T., Levinson, D. F., Sullivan, P. F., Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium & St Clair, D. M., 12 Apr 2012, In : PLoS Genetics. 8, 4, 11 p., e1002656.

Research output: Contribution to journalArticle

Open Access
File
homozygosity
risk factor
Schizophrenia
risk factors
genome
64 Citations (Scopus)

Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracy

Benson, P. J., Beedie, S. A., Shephard, E., Giegling, I., Rujescu, D. & St Clair, D., 1 Nov 2012, In : Biological Psychiatry. 72, 9, p. 716-724 9 p.

Research output: Contribution to journalArticle

Eye Abnormalities
Eye Movements
Schizophrenia
Smooth Pursuit
Neural Networks (Computer)
2011
92 Citations (Scopus)

At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia

Hansen, T., Ingason, A., Djurovic, S., Melle, I., Fenger, M., Gustafsson, O., Jakobsen, K. D., Rasmussen, H. B., Tosato, S., Rietschel, M., Frank, J., Owen, M., Bonetto, C., Suvisaari, J., Thygesen, J. H., Pétursson, H., Lönnqvist, J., Sigurdsson, E., Giegling, I., Craddock, N. & 12 others, O'Donovan, M. C., Ruggeri, M., Cichon, S., Ophoff, R. A., Pietiläinen, O., Peltonen, L., Nöthen, M. M., Rujescu, D., St Clair, D., Collier, D. A., Andreassen, O. A. & Werge, T., 1 Jul 2011, In : Biological Psychiatry. 70, 1, p. 59-63 5 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Schizophrenia
Comorbidity
Antipsychotic Agents
Life Style
26 Citations (Scopus)

Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area

Kähler, A. K., Djurovic, S., Rimol, L. M., Brown, A. A., Athanasiu, L., Jönsson, E. G., Hansen, T., Gústafsson, Ó., Hall, H., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., Pietiläinen, O. P. H., Peltonen, L., Bramon, E., Collier, D., St Clair, D., Sigurdsson, E., Petursson, H. & 8 others, Rujescu, D., Melle, I., Werge, T., Steen, V. M., Dale, A. M., Matthews, R. T., Agartz, I. & Andreassen, O. A., 1 Jan 2011, In : Biological Psychiatry. 69, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Schizophrenia
Carbohydrates
Single Nucleotide Polymorphism
Neuronal Plasticity
142 Citations (Scopus)

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

Steinberg, S., de Jong, S., Andreassen, O. A., Werge, T., Børglum, A. D., Mors, O., Mortensen, P. B., Gustafsson, O., Costas, J., Pietiläinen, O. P. H., Demontis, D., Papiol, S., Huttenlocher, J., Mattheisen, M., Breuer, R., Vassos, E., Giegling, I., Fraser, G., Walker, N., Tuulio-Henriksson, A. & 31 others, Suvisaari, J., Lönnqvist, J., Paunio, T., Agartz, I., Melle, I., Djurovic, S., Strengman, E., Jürgens, G., Glenthøj, B., Terenius, L., Hougaard, D. M., Ørntoft, T., Wiuf, C., Didriksen, M., Hollegaard, M. V., Nordentoft, M., van Winkel, R., Kenis, G., Abramova, L., Kaleda, V., Arrojo, M., Sanjuán, J., Arango, C., Sperling, S., Rossner, M., Ribolsi, M., Magni, V., Siracusano, A., Christiansen, C., St Clair, D. & Irish Schizophrenia Genomics Consortium, 15 Oct 2011, In : Human Molecular Genetics. 20, 20, p. 4076-4081 6 p.

Research output: Contribution to journalArticle

Vaccinia
Neurogranin
Schizophrenia
Transcription Factors
Phosphotransferases
164 Citations (Scopus)

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Shi, Y., Li, Z., Xu, Q., Wang, T., Li, T., Shen, J., Zhang, F., Chen, J., Zhou, G., Ji, W., Li, B., Xu, Y., Liu, D., Wang, P., Yang, P., Liu, B., Sun, W., Wan, C., Qin, S., He, G. & 21 others, Steinberg, S., Cichon, S., Werge, T., Sigurdsson, E., Tosato, S., Palotie, A., Nöthen, M. M., Rietschel, M., Ophoff, R. A., Collier, D. A., Rujescu, D., St Clair, D., Stefansson, H., Stefansson, K., Ji, J., Wang, Q., Li, W., Zheng, L., Zhang, H., Feng, G. & He, L., 1 Dec 2011, In : Nature Genetics. 43, p. 1224-1227 4 p.

Research output: Contribution to journalArticle

Schizophrenia
Population
Genome-Wide Association Study
Mental Disorders
Single Nucleotide Polymorphism
167 Citations (Scopus)

Copy number variations of chromosome 16p13.1 region associated with schizophrenia

Ingason, A., Rujescu, D., Cichon, S., Sigurdsson, E., Sigmundsson, T., Pietiläinen, O. P. H., Buizer-Voskamp, J. E., Strengman, E., Francks, C., Muglia, P., Gylfason, A., Gustafsson, O., Olason, P. I., Steinberg, S., Hansen, T., Jakobsen, K. D., Rasmussen, H. B., Giegling, I., Möller, H-J., Hartmann, A. & 29 others, Crombie, C., Fraser, G., Walker, N., Lonnqvist, J., Suvisaari, J., Tuulio-Henriksson, A., Bramon, E., Kiemeney, L. A., Franke, B., Murray, R., Vassos, E., Toulopoulou, T., Mühleisen, T. W., Tosato, S., Ruggeri, M., Djurovic, S., Andreassen, O. A., Zhang, Z., Werge, T., Ophoff, R. A., Rietschel, M., Nöthen, M. M., Petursson, H., Stefansson, H., Peltonen, L., Collier, D., Stefansson, K., St Clair, D. M. & GROUP Investigators, 2011, In : Molecular Psychiatry. 16, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Schizophrenia
Chromosomes
Autistic Disorder
Intellectual Disability
Psychiatry
17 Citations (Scopus)

DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls

Green, E. K., Grozeva, D., Sims, R., Raybould, R., Forty, L., Gordon-Smith, K., Russell, E., St. Clair, D., Young, A. H., Ferrier, I. N., Kirov, G., Jones, I., Jones, L., Owen, M. J., O'Donovan, M. C. & Craddock, N., 1 Jun 2011, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 156, 4, p. 490-492 3 p.

Research output: Contribution to journalArticle

Exons
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Single Nucleotide Polymorphism
Chromosomes
45 Citations (Scopus)

Evidence of sex-modulated association of ZNF804A with schizophrenia

Zhang, F., Chen, Q., Ye, T., Lipska, B. K., Straub, R. E., Vakkalanka, R., Rujescu, D., St Clair, D., Hyde, T. M., Bigelow, L., Kleinman, J. E. & Weinberger, D. R., 15 May 2011, In : Biological Psychiatry. 69, 10, p. 914-917 4 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Schizophrenia
Single Nucleotide Polymorphism
Odds Ratio
Genotype
117 Citations (Scopus)

Expanding the range of ZNF804A variants conferring risk of psychosis

Steinberg, S., Mors, O., Børglum, A. D., Gustafsson, O., Werge, T., Mortensen, P. B., Andreassen, O. A., Sigurdsson, E., Thorgeirsson, T. E., Böttcher, Y., Olason, P., Ophoff, R. A., Cichon, S., Gudjonsdottir, I. H., Pietiläinen, O. P. H., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T., Athanasiu, L. & 52 others, Suvisaari, J., Lonnqvist, J., Paunio, T., Hartmann, A., Jürgens, G., Nordentoft, M., Hougaard, D., Norgaard-Pedersen, B., Breuer, R., Möller, H-J., Giegling, I., Glenthøj, B., Rasmussen, H. B., Mattheisen, M., Bitter, I., Réthelyi, J. M., Sigmundsson, T., Fossdal, R., Thorsteinsdottir, U., Ruggeri, M., Tosato, S., Strengman, E., Kiemeney, L. A., Melle, I., Djurovic, S., Abramova, L., Kaleda, V., Walshe, M., Bramon, E., Vassos, E., Li, T., Fraser, G., Walker, N., Toulopoulou, T., Yoon, J., Freimer, N. B., Cantor, R. M., Murray, R., Kong, A., Golimbet, V., Jönsson, E. G., Terenius, L., Agartz, I., Petursson, H., Nöthen, M. M., Rietschel, M., Peltonen, L., Rujescu, D., Collier, D. A., Stefansson, H., St Clair, D. & Stefansson, K., Jan 2011, In : Molecular Psychiatry. 16, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Schizophrenia
Bipolar Disorder
Psychiatry
Genome-Wide Association Study
12 Citations (Scopus)
5 Downloads (Pure)

Genetic classification of populations using supervised learning

The International Schizophrenia Consortium (ISC), 12 May 2011, In : PloS ONE. 6, 5, p. 1-12 12 p., e14802.

Research output: Contribution to journalArticle

Open Access
File
Supervised learning
Population Genetics
Principal component analysis
learning
Learning
1236 Citations (Scopus)

Genome-wide association study identifies five new schizophrenia loci

Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D-Y., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., St Clair, D., Corvin, A., Gurling, H., Werge, T., Rujescu, D., Blackwood, D. H. R., Pato, C. N., Malhotra, A. K. & 31 others, Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., De Hert, M., Jönsson, E. G., Bitter, I., Pietiläinen, O. P. H., Collier, D. A., Tosato, S., Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G. & Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium, Oct 2011, In : Nature Genetics. 43, 10, p. 969-976 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Schizophrenia
MicroRNAs
Genome
Internal-External Control
50 Citations (Scopus)

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

Fraser, G., Genetic Risk and Outcome in Psychosis (GROUP) & The International Schizophrenia Consortium (ISC), 1 Nov 2011, In : Molecular Psychiatry. 16, 11, p. 1117-1129 13 p.

Research output: Contribution to journalArticle

Data Mining
Genome-Wide Association Study
Cardiomyopathies
Schizophrenia
Odds Ratio
333 Citations (Scopus)

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

Reilly, M. P., Li, M., He, J., Ferguson, J. F., Stylianou, I. M., Mehta, N. N., Burnett, M. S., Devaney, J. M., Knouff, C. W., Thompson, J. R., Horne, B. D., Stewart, A. F. R., Assimes, T. L., Wild, P. S., Allayee, H., Nitschke, P. L., Patel, R. S., Martinelli, N., Girelli, D., Quyyumi, A. A. & 14 others, Anderson, J. L., Erdmann, J., Hall, A. S., Schunkert, H., Quertermous, T., Blankenberg, S., Hazen, S. L., Roberts, R., Kathiresan, S., Samani, N. J., Epstein, S. E., Rader, D. J., Myocardial Infarction Genetics Consortium & St Clair, D., 29 Jan 2011, In : The Lancet. 377, 9763, p. 383-392 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Coronary Artery Disease
Myocardial Infarction
Phenotype
Organized Financing
848 Citations (Scopus)

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., Blackwood, D., Corvin, A., Flickinger, M., Guan, W., Mattingsdal, M., McQuillin, A., Kwan, P., Wienker, T. F., Daly, M., Dudbridge, F., Holmans, P. A. & 31 others, Lin, D., Burmeister, M., Greenwood, T. A., Hamshere, M. L., Muglia, P., Smith, E. N., Zandi, P. P., Nievergelt, C. M., McKinney, R., Shilling, P. D., Schork, N. J., Bloss, C. S., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A., Hipolito, M., Coryell, W., Rice, J., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W., Li, J., Breen, G., St Clair, D. & Psychiatric GWAS Consortium Bipolar Disorder Working Group, Oct 2011, In : Nature Genetics. 43, 10, p. 977-983 7 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Bipolar Disorder
Single Nucleotide Polymorphism
Calcium Channels
Sample Size
153 Citations (Scopus)

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

The International Schizophrenia Consortium (ISC), 2011, In : Molecular Psychiatry. 16, 3, p. 286-292 7 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Cell Adhesion
Schizophrenia
Cell Adhesion Molecules
Cell Membrane
43 Citations (Scopus)

Polygenic dissection of the bipolar phenotype

Hamshere, M. L., O'Donovan, M. C., Jones, I. R., Jones, L., Kirov, G., Green, E. K., Moskvina, V., Grozeva, D., Bass, N., McQuillin, A., Gurling, H., St Clair, D., Young, A. H., Ferrier, I. N., Farmer, A., McGuffin, P., Sklar, P., Purcell, S., Holmans, P. A., Owen, M. J. & 1 others, Craddock, N., 1 Apr 2011, In : British Journal of Psychiatry. 198, 4, p. 284-288 5 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Dissection
Phenotype
Schizophrenia
Psychotic Disorders
46 Citations (Scopus)

Prevention and schizophrenia: the role of dietary factors

McGrath, J., Brown, A. & St Clair, D., Mar 2011, In : Schizophrenia Bulletin. 37, 2, p. 272-283 12 p.

Research output: Contribution to journalArticle

Schizophrenia
Micronutrients
Starvation
Folic Acid
Vitamin D
13 Citations (Scopus)

Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia

Chen, J., Lee, G., Fanous, A. H., Zhao, Z., Jia, P., O'Neill, A., Walsh, D., Kendler, K. S., Chen, X., The International Schizophrenia Consortium (ISC) & St Clair, D., Sep 2011, In : Schizophrenia Research. 131, 1-3, p. 43-51 9 p.

Research output: Contribution to journalArticle

Data Mining
Genome-Wide Association Study
Schizophrenia
Linkage Disequilibrium
Haplotypes
2010
98 Citations (Scopus)
4 Downloads (Pure)

Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function

Raychaudhuri, S., Korn, J. M., McCarroll, S. A., The International Schizophrenia Consortium (ISC), Altshuler, D., Sklar, P., Purcell, S., Daly, M. J. & St Clair, D. M., 9 Sep 2010, In : PLoS Genetics. 6, 9, 12 p., e1001097.

Research output: Contribution to journalArticle

Open Access
File
brain
Schizophrenia
gene
Brain
Genes