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Research Output

2001

NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans

Murad, A. M. A., Leng, P., Straffon, M., Wishart, J., Macaskill, S., MacCallum, D., Schnell, N., Talibi, D., Marechal, D., Tekaia, F., d'Enfert, C., Gaillardin, C., Odds, F. C. & Brown, A. J. P., 3 Sep 2001, In : EMBO Journal. 20, 17, p. 4742-4752 11 p.

Research output: Contribution to journalArticle

267 Citations (Scopus)
2002
4 Citations (Scopus)

Influence of grapefruit juice on itraconazole plasma levels in mice and guinea pigs

MacCallum, D. M. & Odds, F. C., Aug 2002, In : Journal of Antimicrobial Chemotherapy. 50, 2, p. 219-224 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2004
211 Citations (Scopus)

GFP as a quantitative reporter of gene regulation in Candida albicans

Barelle, C., Manson, C. L., MacCallum, D. M., Odds, F. C., Gow, N. A. R. & Brown, A. J. P., Mar 2004, In : Yeast. 21, 4, p. 333-340 8 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition

Hobson, R. P., Munro, C. A., Bates, S., MacCallum, D. M., Cutler, J. E., Heinsbroek, S. E. M., Brown, G. D., Odds, F. C. & Gow, N. A. R., 17 Sep 2004, In : The Journal of Biological Chemistry. 279, p. 39628-39635 8 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection

MacCallum, D. M. & Odds, F. C., 1 Dec 2004, In : Antimicrobial Agents and Chemotherapy. 48, 12, p. 4911-4914 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Safety aspects of working with Candida albicans-infected mice

MacCallum, D. M. & Odds, F. C., 2004, In : Medical Mycology. 42, 4, p. 305-309 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence

Kelly, M. T., MacCallum, D. M., Clancy, S. D., Odds, F. C., Brown, A. J. P. & Butler, G., Aug 2004, In : Molecular Microbiology. 53, 3, p. 969-983 15 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

The Candida albicans pH-regulated KER1 gene encodes a lysine/glutamic-acid-rich plasma-membrane protein that is involved in cell aggregation

Galan, A., Casanova, M., Murgui, A., MacCallum, D. M., Odds, F. C., Gow, N. A. R. & Martínez, J. P., 2004, In : Microbiology . 150, Pt 8, p. 2641-2651 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2005

Efficacy of caspofungin and voriconazole combinations in experimental aspergillosis

MacCallum, D. M., Whyte, J. A. & Odds, F. C., 2005, In : Antimicrobial Agents and Chemotherapy. 49, p. 3697-3701 5 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans

Kunze, D., Melzer, I., Bennett, D., Sanglard, D., MacCallum, D. M., Nörskau, J., Coleman, D. C., Odds, F. C., Schäfer, W. & Hube, B., 1 Oct 2005, In : Microbiology . 151, 10, p. 3381-94 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood

Fradin, C., De Groot, P., MacCallum, D. M., Schaller, M., Klis, F., Odds, F. C. & Hube, B., 1 Apr 2005, In : Molecular Microbiology. 56, 2, p. 397-415 19 p.

Research output: Contribution to journalArticle

302 Citations (Scopus)

Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence

Munro, C. A., Bates, S., Buurman, E. T., Hughes, H. B., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A., Bain, J. M., Brand, A. C., Hamilton, S., Westwater, C., Thomson, L. M., Brown, A. J. P., Odds, F. & Gow, N. A. R., 14 Jan 2005, In : The Journal of Biological Chemistry. 280, p. 1051-1060 10 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice

MacCallum, D. M. & Odds, F. C., 1 May 2005, In : Mycoses. 48, 3, p. 151-61 11 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)
2006

Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts

MacCallum, D. M., Findon, H., Kenny, C. C., Butler, G., Haynes, K. & Odds, F. C., 1 Sep 2006, In : Infection and Immunity. 74, 9, p. 5244-5248 5 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions

Albrecht, A., Felk, A., Pichova, I., Naglik, J. R., Schaller, M., de Groot, P., MacCallum, D. M., Odds, F. C., Schäfer, W., Klis, F., Monod, M. & Hube, B., 13 Jan 2006, In : The Journal of Biological Chemistry. 281, 2, p. 688-94 7 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Niche-specific regulation of central metabolic pathways in a fungal pathogen

Barelle, C., Priest, C. L., MacCallum, D. M., Gow, N. A. R., Odds, F. C. & Brown, A. J. P., 1 Jun 2006, In : Cellular Microbiology. 8, 6, p. 961-971 11 p.

Research output: Contribution to journalArticle

Open Access
File
199 Citations (Scopus)
4 Downloads (Pure)

Peroxisomal fatty acid beta-oxidation is not essential for virulence of Candida albicans

Piekarska, K., Mol, E., van den Berg, M., Hardy, G., van den Burg, J., van Roermund, C., MacCallum, D. M., Odds, F. & Distel, B., Nov 2006, In : Eukaryotic Cell. 5, 11, p. 1847-1856 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2007

Candida Albicans: New Insights in Infection, Disease, and Treatment

MacCallum, D. M., 27 Sep 2007, New Insights in Medical Mycology. Kavanagh, K. (ed.). 1 ed. The Netherlands: Springer , p. 99-129 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Candida albicans GRX2, encoding a putative glutaredoxi, is required for virulence in a murine model

Chaves, G., Bates, S., MacCallum, D. M. & Odds, F. C., 27 Nov 2007, In : Genetics and Molecular Research. 6, 4, p. 1051-1063 13 p.

Research output: Contribution to journalArticle

Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model

Chaves, G. M., Bates, S., MacCallum, D. M. & Odds, F. C., 27 Dec 2007, In : Genetics and Molecular Research. 6, 4, p. 1051-1063 13 p.

Research output: Contribution to journalArticle

Open Access
35 Citations (Scopus)

Differential regulation of the transcriptional repressor NRG1 accounts for altered host-cell interactions in Candida albicans and Candida dubliniensis

Moran, G. P., MacCallum, D. M., Spiering, M. J., Coleman, D. C. & Sullivan, D. J., Nov 2007, In : Molecular Microbiology. 66, 4, p. 915-929 15 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Multiple functions of DOA1 in Candida albicans

Kunze, D., MacCallum, D., Odds, F. C. & Hube, B., Apr 2007, In : Microbiology . 153, 4, p. 1026-1041 16 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans

Enjalbert, B. P., MacCallum, D. M., Odds, F. C. & Brown, A. J. P., May 2007, In : Infection and Immunity. 75, 5, p. 2143-2151 9 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)
2008

Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation

Strijbis, K., van Roermund, C. W. T., Visser, W. F., Mol, E. C., van den Burg, J., MacCallum, D. M., Odds, F. C., Paramonova, E., Krom, B. P. & Distel, B., Apr 2008, In : Eukaryotic Cell. 7, 4, p. 610-618 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2009

Candida infections and modelling disease

MacCallum, D. M., 18 Nov 2009, Pathogenic Yeasts: The Yeast Handbook 2010. Ashbee, R. & Bignell, E. (eds.). 1 ed. Berlin: Springer-Verlag, p. 41-67 17 p. (The Yeast handbook).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney

Walker, L. A., MacCallum, D. M., Bertram, G., Gow, N. A. R., Odds, F. C. & Brown, A. J. P., Feb 2009, In : Fungal Genetics and Biology. 46, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

Open Access
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59 Citations (Scopus)
52 Downloads (Pure)

Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress

Enjalbert, B., Moran, G. P., Vaughan, C., Yeomans, T., MacCallum, D. M., Quinn, J., Coleman, D. C., Brown, A. J. P. & Sullivan, D. J., Apr 2009, In : Molecular Microbiology. 72, 1, p. 216-228 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
37 Citations (Scopus)
2010

a multicenter collaborative study for the standardization of Candida albicans genotyping using a polymorphic microsatellite marker

Garcia-Hermoso, D., MacCallum, D. M., Lott, T., Sampaio, P., Buitrago Serna, M-J., Grenouillet, F., Klaassen, C. & Bretagne, S., Jul 2010, In : Journal of Clinical Microbiology. 48, 7, p. 2578-2581 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

CO2 acts as a signalling molecule in populations of the fungal pathogen Candida albicans

Hall, R., De Sordi, L., MacCallum, D. M., Topal, H., Eaton, R., Bloor, J. W., Robinson, G. K., Levin, L. R., Buck, J., Wang, Y., Gow, N. A. R., Steegborn, C. & Muehlschlegel, F. A., 18 Nov 2010, In : PLoS Pathogens. 6, 11, 11 p., e1001193.

Research output: Contribution to journalArticle

Open Access
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75 Citations (Scopus)
4 Downloads (Pure)

Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model

Spiering, M. J., Moran, G. P., Chauvel, M., MacCallum, D. M., Higgins, J., Hokamp, K., Yeomans, T., d'Enfert, C., Coleman, D. C. & Sullivan, J., Feb 2010, In : Eukaryotic Cell. 9, 2, p. 251-265 15 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans

Vieira, N., Casal, M., Johansson, B., MacCallum, D. M., Brown, A. J. P. & Paiva, S., Mar 2010, In : Molecular Microbiology. 75, 6, p. 1337-1354 18 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
3 Downloads (Pure)

Genetic dissection of azole resistance mechanisms in Candida albicansand their validation in a mouse model of disseminated infection

MacCallum, D. M., Coste, A., Ischer, F., Jacobsen, M. D., Odds, F. C. & Sanglard, D., Apr 2010, In : Antimicrobial Agents and Chemotherapy. 54, 4, p. 1476-1483 8 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans

da Silva Dantas, A., Patterson, M. J., Smith, D. A., MacCallum, D. M., Erwig, L. P., Morgan, B. A. & Quinn, J., Oct 2010, In : Molecular and Cellular Biology. 30, 19, p. 4550-4563 14 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
2011

Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans

Nicholls, S., MacCallum, D. M., Kaffarnik, F. A. R., Selway, L., Peck, S. C. & Brown, A. J. P., Mar 2011, In : Fungal Genetics and Biology. 48, 3, p. 297-305 9 p.

Research output: Contribution to journalArticle

Open Access
File
46 Citations (Scopus)
5 Downloads (Pure)

A three day mouse model of Candida albicans infection outcome

MacCallum, D. M. & Odds, F., 2011, In : Mycoses. 54, Suppl. 2, p. 112 1 p.

Research output: Contribution to journalAbstract

Candida albicans induces the expansion of regulatory helper T cells in healthy humans

Whibley, N., Ormerod, A. D., MacCallum, D. M., Gow, N. A. R., Barker, R. N. & Hall, A. M., Dec 2011, In : Immunology. 135, Suppl. 1, p. 157 1 p., 397.

Research output: Contribution to journalAbstract

Candida albicans promotes the differentiation of induced CD4(+) CD25(+) Foxp3(+) regulatory T cells

Whibley, N., MacCallum, D. M., Vickers, M. A., Gow, N. A., Barker, R. N. & Hall, A. M., Dec 2011, In : Immunology. 135, Suppl. 1, p. 161 1 p.

Research output: Contribution to journalAbstract

11 Citations (Scopus)

Differential regulation of kidney and spleen cytokine responses in mice infected with a Candida albicans mannosylation mutant

Castillo, L. C., Maccallum, D. M., Brown, A. J. P., Gow, N. A. R. & Odds, F. C., Oct 2011, In : Mycoses. 54, Suppl. 2, p. 114 1 p.

Research output: Contribution to journalAbstract

Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans

Bruce, C. R., Smith, D. A., Rodgers, D., da Silva Dantas, A., MacCallum, D. M., Morgan, B. A. & Quinn, J., 2 Dec 2011, In : PloS ONE. 6, 12, 10 p., e27979.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
4 Downloads (Pure)

MAPKKK-Independent regulation of the Hog1 stress activated protein kinase in Candida albicans

Cheetham, J., MacCallum, D. M., Doris, K. S., da Silva Dantas, A., Scorfield, S., Odds, F., Smith, D. A. & Quinn, J., 9 Dec 2011, In : The Journal of Biological Chemistry. 286, p. 42002-42016 15 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
Open Access
File
33 Citations (Scopus)
5 Downloads (Pure)

Wild-type Drosophila melanogaster as an alternative model system for investigating the pathogenicity of Candida albicans

Glittenberg, M. T., Silas, S., MacCallum, D. M., Gow, N. A. R. & Ligoxygakis, P., Jul 2011, In : Disease Models & Mechanisms. 4, 4, p. 504-514 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2012

A new in vitro model of host-fungus interaction

Szabo, E. K. & MacCallum, D. M., Jun 2012, In : Mycoses. 55, s4, p. 299-299 1 p.

Research output: Contribution to journalAbstract

Candida albicans evades protective immunity by promoting the expansion of induced CD4(+) CD25(+) FoxP3(+) Helioslo regulatory T cells that enhance Th17 responses

Whibley, N. W., MacCallum, D. M., Vickers, M. A., Waldmann, H., Hori, S., Gow, N. A. R., Barker, R. N. & Hall, A. M., Sep 2012, In : Immunology. 137, s1, p. 206-206 1 p.

Research output: Contribution to journalAbstract

52 Citations (Scopus)

C-type lectin receptors and cytokines in fungal immunity

Vautier, S., Maccallum, D. M. & Brown, G. D., Apr 2012, In : Cytokine. 58, 1, p. 89-99 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Cytokine Measurement Using Cytometric Bead Arrays

Castillo-Barahona, L. C. & MacCallum, D. M., 2012, Host-Fungus Interactions: Methods and Protocols. Brand, A. C. & MacCallum, D. M. (eds.). Humana Press, Vol. 845. p. 425-434 10 p. (Methods in Molecular Biology; vol. 845, no. 6).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)