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Research Output 2008 2020

2020

Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma

Magat, J. M., Thomas, J. L., Dumouchel, J. P., Murray, F., Li, W. X. & Li, J., 8 Jan 2020, (Accepted/In press) In : The Journal of Immunology.

Research output: Contribution to journalArticle

2019

Deletion of caveolin scaffolding domain alters cancer cell migration

Okada, S., Raja, S. A., Okerblom, J., Boddu, A., Horikawa, Y., Ray, S., Okada, H., Kawamura, I., Murofushi, Y., Murray, F. & Patel, H. H., 2019, In : Cell Cycle. 18, 11, p. 1268-1280 13 p.

Research output: Contribution to journalArticle

Caveolins
Caveolin 1
Cell Movement
Neoplasms
HeLa Cells
1 Downloads (Pure)

Student-created video resources can enhance medical science practical class assessment

Malcolm, C. J., Kirkman, J., Jenkinson, A. M., Hislop, J. N., Murray, F. & Scott, D. A., 2019.

Research output: Contribution to conferencePaper

Open Access
File
video
science
resources
student
sports science
2018
23 Citations (Scopus)
5 Downloads (Pure)

GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets

Insel, P. A., Sriram, K., Wiley, S. Z., Wilderman, A., Katakia, T., McCann, T., Yokouchi, H., Zhang, L., Corriden, R., Liu, D., Feigin, M., French, R. P., Lowy, A. M. & Murray, F., May 2018, In : Frontiers in Pharmacology. 9, p. 1-11 11 p., 431.

Research output: Contribution to journalArticle

Open Access
File
G-Protein-Coupled Receptors
Biomarkers
Neoplasms
Adenocarcinoma
Therapeutics
7 Citations (Scopus)
4 Downloads (Pure)

GPCRs in pulmonary arterial hypertension: tipping the balance

Iyinikkel, J. & Murray, F., Aug 2018, In : British Journal of Pharmacology. 175, 15, p. 3063-3079 17 p.

Research output: Contribution to journalReview article

Open Access
File
Pulmonary Hypertension
Pulmonary Artery
Smooth Muscle Myocytes
Blood Vessels
Lung
4 Downloads (Pure)

Student perceptions of Objective Structured Practical Examination (OSPE) assessments

Malcolm, C. J., Kirkman, J., Jenkinson, A., Hislop, J. N., Murray, F. & Scott, D. A., 20 Dec 2018.

Research output: Contribution to conferencePoster

File
examination
student
pharmacology
physiology
staff

Two Years On: How the Core Curriculum has Shaped Pharmacology Courses at the University of Aberdeen

Tucker, S., Fleming, I. N., Hislop, J. N., Murray, F., Scott, D. A. & Wallace, H. M., Nov 2018, Pharmacology Matters, 11, 3, p. 5-7 3 p.

Research output: Contribution to specialist publicationFeatured article

pharmacology
curriculum
quality assurance
resources
education
2017
1 Citation (Scopus)
8 Downloads (Pure)

Assessing the consequences of environmental impacts: variation in species responses has unpredictable functional effects

Murray, F., Widdicombe, S., McNeill, C. L. & Douglas, A., 2017, In : Marine Ecology Progress Series. 583, p. 35-47 13 p.

Research output: Contribution to journalArticle

Open Access
File
environmental impact
ecosystems
ecosystem function
group effect
bioturbation
2 Citations (Scopus)
5 Downloads (Pure)

Functional Magnetic Resonance Imaging for In Vivo Quantification of Pulmonary Hypertension in the Sugen 5416/hypoxia mouse

Breen, E. C., Scadeng, M., Lai, N. C., Murray, F. & Bigby, T. L. T. D., 1 Mar 2017, In : Experimental Physiology. 102, 3, p. 347–353 6 p.

Research output: Contribution to journalArticle

Open Access
File
Pulmonary Hypertension
Magnetic Resonance Imaging
Heart Ventricles
Hypoxia
Pressure Transducers

Gender Bias in G Protein-Coupled Receptor Expression in Human Pulmonary Artery Smooth Muscle Cells

Iyinikkel, J., Saunders, F., Walker, C. & Murray, F., Apr 2017, In : The FASEB Journal. 31, Suppl 1, 1 p., 1016.11.

Research output: Contribution to journalAbstract

Novel G protein-coupled receptors in Pancreatic Beta cells

Saunders, F., Iyinikkel, J., Lima, M., Thompson, D., Delibegovic, M., Docherty, K. & Murray, F., Apr 2017, In : FASEB JOURNAL. 31, Suppl. 1, 1 p., 1052.1.

Research output: Contribution to journalAbstract

2015
14 Citations (Scopus)

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

Lee, J., Kim, T. H., Murray, F., Li, X., Choi, S. S., Broide, D. H., Corr, M., Lee, J., Webster, N. J. G., Insel, P. A. & Raz, E., 3 Feb 2015, In : PNAS. 112, 5, p. 1529-34 6 p.

Research output: Contribution to journalArticle

Cyclic AMP
Dendritic Cells
Immunity
Asthma
Heterotrimeric GTP-Binding Proteins
43 Citations (Scopus)
4 Downloads (Pure)

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

Aznar, N., Midde, K. K., Dunkel, Y., Lopez-Sanchez, I., Pavlova, Y., Marivin, A., Barbazán, J., Murray, F., Nitsche, U., Janssen, K-P., Willert, K., Goel, A., Abal, M., Garcia-Marcos, M. & Ghosh, P., 30 Jun 2015, In : eLife. 4, 40 p., e07091.

Research output: Contribution to journalArticle

Open Access
File
Frizzled Receptors
GTP-Binding Proteins
Chemical activation
Tumors
Neoplasms
24 Citations (Scopus)

G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets

Insel, P. A., Wilderman, A., Zambon, A. C., Snead, A. N., Murray, F., Aroonsakool, N., McDonald, D. S., Zhou, S., McCann, T., Zhang, L., Sriram, K., Chinn, A. M., Michkov, A. V., Lynch, R. M., Overland, A. C. & Corriden, R., Jul 2015, In : Molecular Pharmacology. 88, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Therapeutics
Orphaned Children
Human Genome
Ligands

Interleukin 33 And Its Receptor, St2, Participate In The Development Of Pulmonary Arterial Hypertension In A Mouse Model

Lerner, A. D., Lai, N. C., Tsui, C., Breen, E., Murray, F. & Bigby, T. D., 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 1 p., A5284.

Research output: Contribution to journalAbstract

Quantitative Functional Cardiac Magnetic Resonance Imaging in Mice with Pulmonary Arterial Hypertension

Breen, E., Scadeng, M., Murray, F. & Bigby, T., Apr 2015, In : The FASEB Journal. 29, 1 supplement 662.8, 1 p.

Research output: Contribution to journalAbstract

11 Citations (Scopus)
6 Downloads (Pure)

The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP

McKean, J. S., Murray, F., Gibson, G., Shewan, D. A., Tucker, S. J. & Nixon, G. F., 1 Sep 2015, In : Cardiovascular Research. 107, 4, p. 546-555 10 p.

Research output: Contribution to journalArticle

Open Access
File
beraprost
Vascular Smooth Muscle
Cyclic AMP
Smooth Muscle Myocytes
Cell Movement
2014
57 Citations (Scopus)

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis

Lopez-Sanchez, I., Dunkel, Y., Roh, Y-S., Mittal, Y., De Minicis, S., Muranyi, A., Singh, S., Shanmugam, K., Aroonsakool, N., Murray, F., Ho, S. B., Seki, E., Brenner, D. A. & Ghosh, P., Jul 2014, In : Nature Communications. 5, p. 1-18 18 p., 4451.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
fibrosis
hubs
liver
Liver Cirrhosis

G protein-coupled receptor expression and function in pulmonary artery smooth muscle cells: new targets in pulmonary arterial hypertension

McDonald, D., Aroonsakool, N., Kwon, O., Insel, P. & Murray, F., Apr 2014, In : The FASEB Journal. 28, Suppl 1, 1 p., 1090.3.

Research output: Contribution to journalAbstract

Interleukin-33 in pulmonary arterial hypertension: a role in disease pathogenesis?

Aroonsakool, N., Titone, D., Li, J., Dumouchel, J., Lombardi, S., Kim, N., Poch, D., Bigby, T. & Murray, F., Apr 2014, In : The FASEB Journal. 28, 1, 1 p., 1090.4.

Research output: Contribution to journalAbstract

15 Citations (Scopus)

Renal phosphate wasting in the absence of adenylyl cyclase 6

Fenton, R. A., Murray, F., Dominguez Rieg, J. A., Tang, T., Levi, M. & Rieg, T., Dec 2014, In : Journal of the American Society of Nephrology. 25, 12, p. 2822-2834 13 p.

Research output: Contribution to journalArticle

Phosphates
Parathyroid Hormone
Kidney
Lysosomes
Adenylyl Cyclases
2013
12 Citations (Scopus)

Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome

Guibinga, G-H., Murray, F., Barron, N., Pandori, W. & Hrustanovic, G., 15 Nov 2013, In : Human Molecular Genetics. 22, 22, p. 4502-15 14 p.

Research output: Contribution to journalArticle

Lesch-Nyhan Syndrome
Hypoxanthine Phosphoribosyltransferase
Guanine
MicroRNAs
Genes
15 Citations (Scopus)
4 Downloads (Pure)

HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?

Guibinga, G-H., Murray, F. & Barron, N., 14 May 2013, In : PloS ONE. 8, 5, p. 1-11 11 p., e63333.

Research output: Contribution to journalArticle

Open Access
File
Lesch-Nyhan Syndrome
Adenylate Kinase
AMP-activated protein kinase
hypoxanthine
Hypoxanthine
14 Citations (Scopus)
B-Cell Chronic Lymphocytic Leukemia
Cyclic AMP
Lymphoma
Leukemia
Cyclic AMP-Dependent Protein Kinases
2012
32 Citations (Scopus)

Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets

Li, X., Murray, F., Koide, N., Goldstone, J., Dann, S. M., Chen, J., Bertin, S., Fu, G., Weinstein, L. S., Chen, M., Corr, M., Eckmann, L., Insel, P. A. & Raz, E., 1 Mar 2012, In : The Journal of Clinical Investigation. 122, 3, p. 963-973 11 p.

Research output: Contribution to journalArticle

Open Access
2011
58 Citations (Scopus)

Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling

Horikawa, Y. T., Panneerselvam, M., Kawaraguchi, Y., Tsutsumi, Y. M., Ali, S. S., Balijepalli, R. C., Murray, F., Head, B. P., Niesman, I. R., Rieg, T., Vallon, V., Insel, P. A., Patel, H. H. & Roth, D. M., 31 May 2011, In : Journal of the American College of Cardiology. 57, 22, p. 2273-2283 11 p.

Research output: Contribution to journalArticle

232 Citations (Scopus)

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H-H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., Iakoucheva, L. M., Krastoshevsky, O., Krause, V., Larach-Walters, V., Welsh, D. K., Craig, D., Kelsoe, J. R., Gershon, E. S., Leal, S. M., Aquila, M. D. & 10 others, Morris, D. W., Gill, M., Corvin, A., Insel, P. A., McClellan, J., King, M-C., Karayiorgou, M., Levy, D. L., DeLisi, L. E. & Sebat, J., 24 Mar 2011, In : Nature. 471, 7339, p. 499-503 5 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (vol 471, pg 499, 2011)

Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H-H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., Iakoucheva, L. M., Krastoshevsky, O., Krause, V., Larach-Walters, V., Welsh, D. K., Craig, D., Kelsoe, J. R., Gershon, E. S., Leal, S. M., Aquila, M. D. & 10 others, Morris, D. W., Gill, M., Corvin, A., Insel, P. A., McClellan, J., King, M-C., Karayiorgou, M., Levy, D. L., DeLisi, L. E. & Sebat, J., 2 Jun 2011, In : Nature. 474, 7349, p. 114-114 1 p.

Research output: Contribution to journalLetter

2008
67 Citations (Scopus)

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

Zhang, L., Murray, F., Zahno, A., Kanter, J. R., Chou, D., Suda, R., Fenlon, M., Rassenti, L., Cottam, H., Kipps, T. J. & Insel, P. A., 9 Dec 2008, In : PNAS. 105, 49, p. 19532-19537 6 p.

Research output: Contribution to journalArticle