• 5209 Citations
19992020

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2020

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G. & Niewiadomska, G., 2020, In : Brain Communications. 2, 1, 17 p., fcaa033.

Research output: Contribution to journalArticle

Open Access
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Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 19 May 2020, In : Journal of Alzheimer's Disease. 75, 2, p. 501-519 19 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
1 Downloads (Pure)

Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R. & Wischik, C. M., 31 Mar 2020, In : Current Alzheimer Research. 17, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

The interoceptive hippocampus: Mouse brain endocrine receptor expression highlights a dentate gyrus (DG)-cornu ammonis (CA) challenge-sufficiency axis

Lathe, R., Singadia, S., Jordan, C. & Riedel, G., 15 Jan 2020, In : PloS ONE. 15, 1, e0227575.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
5 Downloads (Pure)
2019

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 26 Nov 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 931-946 16 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
6 Downloads (Pure)

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

Research output: Contribution to journalArticle

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1 Citation (Scopus)
3 Downloads (Pure)

Of mice and motion: Behavioural-EEG phenotyping of Alzheimer’s disease mouse models

Crouch, B., Yeap, J. M., Pais, B., Riedel, G. & Platt, B., 1 May 2019, In : Journal of Neuroscience Methods. 319, p. 89-98 10 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
4 Downloads (Pure)

Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride

Mietelska-Porowska, A., Gasiorowska, A., Palasz, E., Koss, D. J., Riedel, G. & Niewiadomska, G., 1 May 2019, In : Journal of Neuroscience Methods. 319, p. 47-59 13 p.

Research output: Contribution to journalArticle

2018

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

Frahm, S., Melis, V., Horsley, D., Rickard, J. E., Riedel, G., Fadda, P., Scherma, M., Harrington, C. R., Wischik, C. M., Theuring, F. & Schwab, K., 26 Feb 2018, In : Behavioural Brain Research. 339, p. 153-168 16 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
26 Downloads (Pure)
Open Access
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9 Citations (Scopus)
13 Downloads (Pure)

Between and within laboratory reliability of mouse behaviour recorded in home-cage and open-field

Robinson, L., Spruijt, B. & Riedel, G., 15 Apr 2018, In : Journal of Neuroscience Methods. 300, p. 10-19 10 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
7 Downloads (Pure)

Detection of time-, frequency- and direction-resolved communication within brain networks

Crouch, B., Sommerlade, L., Veselcic, P., Riedel, G., Schelter, B. & Platt, B., 29 Jan 2018, In : Scientific Reports. 8, 1825.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
10 Downloads (Pure)

Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse

Plucińska, K., Crouch, B., Yeap, J. M., Stoppelkamp, S., Riedel, G. & Platt, B., 7 Aug 2018, In : Journal of Alzheimer's Disease. 65, 1, p. 165-180 15 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
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Spatial learning and flexibility in 129S2/SvHsd and C57BL/6J mouse strains using different variants of the Barnes maze

Riedel, G., Robinson, L. & Crouch, B., 31 Dec 2018, In : Behavioural Pharmacology. 29, 8, p. 688-700 13 p.

Research output: Contribution to journalArticle

2017

Parvalbumin-containing GABA cells and schizophrenia: experimental model based on targeted gene delivery through adeno-associated viruses

Woloszynowska-Fraser, M. U., Wulff, P. & Riedel, G., Dec 2017, In : Behavioural Pharmacology. 28, 8, p. 630-641 12 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
8 Downloads (Pure)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 28 Nov 2017, In : Journal of Alzheimer's Disease. 61, 1, p. 435-457 24 p.

Research output: Contribution to journalArticle

Open Access
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35 Citations (Scopus)
24 Downloads (Pure)
2016

Evidence for a Role of Adaptive Immune Response in the Disease Pathogenesis of the MPTP Mouse Model of Parkinson’s Disease

Martin, H. L., Santoro, M., Mustafa, S., Riedel, G., Forrester, J. V. & Teismann, P., Mar 2016, In : Glia. 64, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
6 Downloads (Pure)

In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin

Santoro, M., Maetzler, W., Stathakos, P., Martin, H. L., Hobert, M. A., Rattray, T. W., Gasser, T., Forrester, J. V., Berg, D., Tracey, K. J., Riedel, G. & Teismann, P., Jul 2016, In : Neurobiology of Disease. 91, p. 59-68 10 p.

Research output: Contribution to journalArticle

Open Access
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29 Citations (Scopus)
7 Downloads (Pure)

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology

Koss, D. J., Robinson, L., Drever, B. D., Plucinska, K., Stoppelkamp, S., Veselcic, P., Riedel, G. & Platt, B., Jul 2016, In : Neurobiology of Disease. 91, p. 105-123 19 p.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
7 Downloads (Pure)

Neuronal human BACE1 knock-in induces systemic diabetes in mice

Plucinska, K., Dekeryte, R., Koss, D., Shearer, K., Mody, N., Whitfield, P. D., Doherty, M. K., Mingarelli, M., Welch, A., Riedel, G., Delibegovic, M. & Platt, B., Jul 2016, In : Diabetologia. 59, 7, p. 1513-1523 11 p.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
13 Downloads (Pure)

TracMouse: A computer aided movement analysis script for the mouse inverted horizontal grid test

Niewiadomski, W., Palasz, E., Skupinska, M., Zylinski, M., Steczkowska, M., Gasiorowska, A., Niewiadomska, G. & Riedel, G., 16 Dec 2016, In : Scientific Reports. 6, 39331.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
7 Downloads (Pure)
2015

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G. & 1 others, Theuring, F., Jun 2015, In : Cellular and Molecular Life Sciences. 72, 11, p. 2199-2222 24 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
6 Downloads (Pure)

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F. & Riedel, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 353-368 16 p.

Research output: Contribution to journalArticle

Open Access
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42 Citations (Scopus)
11 Downloads (Pure)

Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Mounsey, R. B., Mustafa, S., Robinson, L., Ross, R. A., Riedel, G., Pertwee, R. G. & Teismann, P., Nov 2015, In : Experimental Neurology. 273, p. 36-44 9 p.

Research output: Contribution to journalArticle

Open Access
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29 Citations (Scopus)
6 Downloads (Pure)

MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol

Deiana, S., Watanabe, A., Yamasaki, Y., Amada, N., Kikuchi, T., Stott, C. & Riedel, G., Dec 2015, In : Behavioural Pharmacology. 26, 8 , p. 748-65 18 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Apr 2015, In : Behavioural Pharmacology. 26, 3, p. 289-303 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility

Murray, A. J., Woloszynowska-Fraser, M. U., Ansel-Bollepalli, L., Cole, K. L. H., Foggetti, A., Crouch, B., Riedel, G. & Wulff, P., 26 Nov 2015, In : Scientific Reports. 5, 14 p., 16778.

Research output: Contribution to journalArticle

Open Access
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50 Citations (Scopus)
9 Downloads (Pure)

Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits

Koss, D. J., Robinson, L., Mietelska-Porowska, A., Gasiorowska, A., Sepcic, K., Turk, T., Jaspars, M., Niewiadomska, G., Scott, R. H., Platt, B. & Riedel, G., Dec 2015, In : Cellular and Molecular Life Sciences. 72, 23, p. 4613-4632 20 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Progressive age-related changes in sleep and EEG profiles in the PLB1(Triple) mouse model of Alzheimer's disease

Jyoti, A., Plano, A., Riedel, G. & Platt, B., Oct 2015, In : Neurobiology of Aging. 36, 10, p. 2768-2784 17 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014
25 Citations (Scopus)

Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones

Hay, C., Shanley, L., Davidson, S., Cowie, P., Lear, M., McGuffin, P., Riedel, G., McEwan, I. J. & MacKenzie, A., Sep 2014, In : Psychoneuroendocrinology. 47, p. 43-55 13 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
7 Downloads (Pure)

Impaired hippocampus-dependent spatial flexibility and sociability represent autism-like phenotypes in GluK2 mice

Micheau, J., Vimeney, A., Normand, E., Mulle, C. & Riedel, G., Sep 2014, In : Hippocampus. 24, 9, p. 1059-1069 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Knock-in of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like PhenoTypes

Plucinska, K., Crouch, B., Koss, D., Robinson, L., Riedel, G. & Platt, B., 6 Aug 2014, In : Journal of Neuroscience. 34, 32, p. 10710-10728 19 p.

Research output: Contribution to journalArticle

Open Access
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36 Citations (Scopus)
9 Downloads (Pure)
2013

18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

Calamai, E., Dall'Angelo, S., Koss, D., Domarkas, J., McCarthy, T. J., Mingarelli, M., Riedel, G., Schweiger, L. F., Welch, A. E., Platt, B. & Zanda, M., 2013, In : Chemical Communications. 49, 8, p. 792-794 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1(Triple) Alzheimer mouse

Koss, D. J., Drever, B. D., Stoppelkamp, S., Riedel, G. & Platt, B., Jul 2013, In : Cellular and Molecular Life Sciences. 70, 14, p. 2585-2601 17 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice

Robinson, L., Plano, A., Cobb, S. & Riedel, G., 1 Aug 2013, In : Behavioural Brain Research. 250, p. 148-156 9 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
5 Downloads (Pure)

Mapping Changes in Mouse Brain Metabolism with PET/CT

Welch, A., Mingarelli, M., Riedel, G. & Platt, B., 1 Nov 2013, In : Journal of Nuclear Medicine. 54, 11, p. 1946-1953 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent

Ryan, D., Koss, D., Porcu, E., Woodcock, H., Robinson, L., Platt, B. & Riedel, G., Jul 2013, In : Cellular and Molecular Life Sciences. 70, 14, p. 2603-2619 17 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Store-operated Ca(2+) entry in hippocampal neurons: regulation by protein tyrosine phosphatase PTP1B

Koss, D. J., Riedel, G., Bence, K. & Platt, B., Feb 2013, In : Cell Calcium. 53, 2, p. 125-138 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2012

Inference of Granger causal time-dependent influences in noisy multivariate time series

Sommerlade, L., Thiel, M., Platt, B., Plano, A., Riedel, G., Grebogi, C., Timmer, J. & Schelter, B. O., 15 Jan 2012, In : Journal of Neuroscience Methods. 203, 1, p. 173-185 13 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system

Lewis, S. E. M., Paro, R., Borriello, L., Simon, L., Robinson, L., Dincer, Z., Riedel, G., Battista, N. & Maccarrone, M., Oct 2012, In : International journal of andrology. 35, 5, p. 731-740 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome

Robinson, L., Guy, J., McKay, L., Brockett, E., Spike, R. C., Selfridge, J., De Sousa, D., Merusi, C., Riedel, G., Bird, A. & Cobb, S. R., Sep 2012, In : Brain. 135, 9, p. 2699-2710 12 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour

Deiana, S., Watanabe, A., Yamasaki, Y., Amada, N., Arthur, M., Fleming, S., Woodcock, H., Dorward, P., Pigliacampo, B., Close, S., Platt, B. & Riedel, G., Feb 2012, In : Psychopharmacology. 219, 3, p. 859-873 15 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)
2011

Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1

Platt, B., Drever, B., Koss, D., Stoppelkamp, S., Jyoti, A., Plano, A., Utan, A., Merrick, G., Ryan, D., Melis, V., Wan, H., Mingarelli, M., Porcu, E., Scrocchi, L., Welch, A. & Riedel, G., 11 Nov 2011, In : PloS ONE. 6, 11, 13 p., e27068.

Research output: Contribution to journalArticle

Open Access
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74 Citations (Scopus)
7 Downloads (Pure)

Acetylcholine: Future research and perspectives

van der Zee, E., Platt, B. & Riedel, G., 10 Aug 2011, In : Behavioural Brain Research. 221, 2, p. 583-586 4 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Acetylcholine has mulitple facets in brain function and disease

Riedel, G., Platt, B. & van der Zee, E., 2011, In : Behavioural Brain Research. 221, p. 333 1 p.

Research output: Contribution to journalArticle

A pilot study into the effects of the CB1 cannabinoid receptor agonist, WIN55,212-2 or the antagonist/inverse agonist AM251 on sleep in rats

Goonawardena, A. V., Plano, A., Robinson, L., Platt, B., Hampson, R. E. & Riedel, G., 1 Dec 2011, In : Sleep Disorders. 2011, 7 p., 178469.

Research output: Contribution to journalArticle

Cannabinoids alter spontaneous firing, bursting, and cell synchrony of hippocampal principal cells

Goonawardena, A. V., Riedel, G. & Hampson, R. E., May 2011, In : Hippocampus. 21, 5, p. 520-531 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
Open Access
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23 Citations (Scopus)
7 Downloads (Pure)