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Research Output

2020

Current concepts in tumour-derived organoids

Porter, R. J., Murray, G. & McLean, M. H., 30 Jul 2020, In : British Journal of Cancer.

Research output: Contribution to journalArticle

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman, S. O., Koelzer, V. H., Jones, H. J. S., Vazquez, E. G., Davis, H., East, J. E., Arnold, R., Koppens, M. A. J., Blake, A., Domingo, E., Cunningham, C., Beggs, A. D., Pestinger, V., Loughrey, M. B., Wang, L-M., Lannagan, T. R. M., Woods, S. L., Worthley, D., The S:CORT Consortium, Tomlinson, I. & 3 others, Dunne, P. D., Maughan, T. & Leedham, S. J., 2020, In : Gut. 69, p. 1092-1103 12 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
1 Downloads (Pure)

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

Sirinukunwattana, K., Domingo, E., Richman, S., Redmond, K. L., Blake, A., Verrill, C., Leedham, S. J., Chatzipli, A., Hardy, C., Whalley, C., Wu, C-H., Beggs, A. D., McDermott, U., Dunne, P. D., Meade, A. A., Walker, S. M., Murray, G., Samuel, L. M., Seymour, M., Tomlinson, I. & 4 others, Quirke, P., Maughan, T., Rittscher, J. & Koelzer, V. H., 20 Jul 2020, In : Gut.

Research output: Contribution to journalArticle

Open Access

Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia

Craig, S. G., Humphries, M. P., Alderdice, M., Bingham, V., Richman, S. D., Loughrey, M. B., Coleman, H. G., Viratham-Pulsawatdi, A., McCombe, K., Murray, G. I., Blake, A., Domingo, E., Robineau, J., Brown, L., Fisher, D., Seymour, M. T., Quirke, P., Bankhead, P., McQuaid, S., Lawler, M. & 4 others, McArt, D. G., Maughan, T. S., James, J. A. & Salto-Tellez, M., 20 Jul 2020, In : British Journal of Cancer.

Research output: Contribution to journalArticle

Novel biomarkers for risk stratification of Barrett’s oesophagus associated neoplastic progression–epithelial HMGB1 expression and stromal lymphocytic phenotype

Porter, R. J., Murray, G. I., Price, D. P., Petty, R. D. & McLean, M. H., 18 Feb 2020, In : British Journal of Cancer. 122, p. 545-554 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
2 Downloads (Pure)

The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation

Humphries, M. P., Craig, S. G., Kacprzyk, R., Fisher, N. C., Bingham, V., McQuaid, S., Murray, G. I., McManus, D., Turkington, R. C., James, J. & Salto-Tellez, M., 1 Jun 2020, In : BMC Cancer. 20, 11 p., 500.

Research output: Contribution to journalArticle

Open Access
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2 Downloads (Pure)
2019

Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis

Conlon, G. A. & Murray, G. I., Apr 2019, In : The Journal of pathology. 247, 5, p. 629-640 12 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
2 Downloads (Pure)

The expression of brown fat associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis

Alnabulsi, A., Cash, B., Hu, Y., Silina, L., Alnabulsi, A. & Murray, G. I., 15 Aug 2019, In : International Journal of Cancer. 145, 4, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
2 Downloads (Pure)
2018

Colorectal tumors require NUAK1 for protection from oxidative stress

Port, J. L. F., Muthalagu, N., Raja, M., Ceteci, F., Monteverde, T., Kruspig, B., Hedley, A., Kalna, G., Lilla, S., Neilson, L., Brucoli, M., Gyuraszova, K., Tait-Mulder, J., Mezna, M., Svambaryte, S., Bryson, A., Sumpton, D., McVie, A., Nixon, C., Drysdale, M. & 5 others, Esumi, H., Murray, G. I., Sansom, O. J., Zanivan, S. & Murphy, D. J., May 2018, In : Cancer Discovery. 8, 5, p. 633-647 15 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
6 Downloads (Pure)

Combined linkage and association analysis of classical Hodgkin lymphoma

Lawrie, A., Han, S., Sud, A., Hosking, F., Cezard, T., Turner, D., Clark, C., Murray, G. I., Culligan, D. J., Houlston, R. S. & Vickers, M. A., 17 Apr 2018, In : Oncotarget. 9, 29, p. 20377-20385 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
9 Downloads (Pure)

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
9 Downloads (Pure)

Extensive esophageal papillomatosis after chemoradiotherapy for squamous cell carcinoma

Siu, W., Murray, G. I., McKinlay, A. & Phull, P., Jun 2018, In : Gastrointestinal Endoscopy. 87, 6, p. 1581-1582 2 p.

Research output: Contribution to journalArticle

Laser Capture Microdissection: Methods and Protocols

Murray, G. I. (ed.), 2018, 3rd ed. Humana Press. 412 p. (Methods in Molecular Biology; vol. 1723)

Research output: Book/ReportBook

Proteomics for early detection of colorectal cancer: recent updates

Alnabulsi, A. & Murray, G. I., 2018, In : Expert Review of Proteomics. 15, 1, p. 55-63 9 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
7 Downloads (Pure)

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

Alexandrou, C., Al-Aqbi, S. S., Higgins, J. A., Boyle, W., Karmokar, A., Andreadi, C., Luo, J-L., Moore, D. A., Viskaduraki, M., Blades, M., Murray, G. I., Howells, L. M., Thomas, A., Brown, K., Cheng, P. N. & Rufini, A., 14 Aug 2018, In : Scientific Reports. 8, p. 1-14 14 p., 12096.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
6 Downloads (Pure)

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

Allen, W. L., Dunne, P. D., McDade, S., Scanlon, E., Loughrey, M., Coleman, H., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N., Jithesh, P., Arthur, K., Wilson, R., Coyle, V., McArt, D., Murray, G., Samuel, L., Nuciforo, P., Jimenez, J., Argiles, G. & 12 others, Dienstmann, R., Tabernero, J., Picariello, L., Messerini, L., Nobili, S., Mini, E., Sheahan, K., Ryan, E., Johnston, P. G., Van Schaeybroeck, S., Lawler, M. & Longley, D. B., 2018, In : JCO Precision Oncology. 2018, 2, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
9 Downloads (Pure)
2017

A Comparison of Tumour Characteristics and Oncological Outcomes in Patients with Screen-Detected and Symptomatic Colorectal Polyp Cancers

Colleran, R., Ramsay, G., Mackay, C., Parnaby, C. N. & Murray, G. I., Jun 2017.

Research output: Contribution to conferencePoster

Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer

Petty, R. D., Dahle-Smith, A., Stevenson, D. A. J., Osborne, A., Massie, D., Clark, C., Murray, G. I., Dutton, S. J., Roberts, C., Chong, I. Y., Mansoor, W., Thompson, J., Harrison, M., Chatterjee, A., Falk, S., Elyan, S., Garcia-Alonso, A., Fyfe, D. W., Wadsley, J., Chau, I. & 2 others, Ferry, D. & Miedzybrodzka, Z., Jul 2017, In : Journal of Clinical Oncology. 35, 20, p. 2279-2287 9 p.

Research output: Contribution to journalArticle

Open Access
40 Citations (Scopus)

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

Alvi, M. A., Loughrey, M. B., Dunne, P., McQuaid, S., Turkington, R., Fuchs, M-A., McGready, C., Bingham, V., Pang, B., Moore, W., Maxwell, P., Lawler, M., James, J. A., Murray, G. I., Wilson, R. H. & Salto-Tellez, M., 11 Jul 2017, In : British Journal of Cancer. 117, 2, p. 203-209 7 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
8 Downloads (Pure)

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival

Alderdice, M., Dunne, P. D., Cole, A. J., O'Reilly, P. G., McArt, D. G., Bingham, V., Fuchs, M-A., McQuaid, S., Loughrey, M. B., Murray, G. I., Samuel, L., Lawler, M., Wilson, R. H., Salto-Tellez, M. & Coyle, V. M., Sep 2017, In : Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 30, 9, p. 1287-1298 12 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
9 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
8 Downloads (Pure)

The prognostic role of Lymph Node Ratio (LNR) and other indicators in patients undergoing potentially curative rectal cancer resection

MacLeod, C., Mackay, C., Ramsay, G., Murray, G. I. & Parnaby, C., Jun 2017.

Research output: Contribution to conferencePoster

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Diamantopoulou, Z., White, G., Fadlullah, M. Z. H., Dreger, M., Pickering, K., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., Lacaud, G., Murray, G. I., Sansom, O. J., Hurlstone, A. F. L. & Malliri, A., 8 May 2017, In : Cancer Cell. 31, 5, p. 621-634 14 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
6 Downloads (Pure)
2016

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer

Swan, R., Alnabulsi, A., Cash, B., Alnabulsi, A. & Murray, G. I., 22 Jun 2016, In : Oncotarget. 7, 29, p. 46509-46527 19 p., 10224.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
6 Downloads (Pure)

Drug Transporter Gene Expression in Human Colorectal Tissue and Cell Lines: Modulation with Antiretrovirals for Microbicide Optimization

Mukhopadhya, I., Murray, G. I., Berry, S., Thomson, J., Frank, B., Gwozdz, G., Ekeruche-Makinde, J., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, E. M., Hold, G. L. & Hijazi, K., Feb 2016, In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 372-386 15 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
6 Downloads (Pure)

Extending colonic mucosal microbiome analysis - Assessment of colonic lavage as a proxy for endoscopic colonic biopsies

Watt, E., Gemmell, M. R., Berry, S., Glaire, M., Farquharson, F., Louis, P., Murray, G. I., El-Omar, E. & Hold, G. L., 25 Nov 2016, In : Microbiome. 4, 61.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
9 Downloads (Pure)

Integrative analysis of the colorectal cancer proteome: potential clinical impact

Alnabulsi, A. & Murray, G. I., Oct 2016, In : Expert Review of Proteomics. 13, 10, p. 917-927 11 p.

Research output: Contribution to journalReview article

Open Access
File
14 Citations (Scopus)
8 Downloads (Pure)

MICL controls inflammation in rheumatoid arthritis

Redelinghuys, P., Whitehead, L., Augello, A., Drummond, R. A., Levesque, J-M., Vautier, S., Reid, D. M., Kerscher, B., Taylor, J. A., Nigrovic, P. A., Wright, J., Murray, G. I., Willment, J. A., Hocking, L. J., Fernandes, M. J. G., De Bari, C., McInnes, I. B. & Brown, G. D., Jul 2016, In : Annals of the Rheumatic Diseases. 75, 7, p. 1386-1391 6 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
10 Downloads (Pure)

Progress in the development of protein biomarkers of oesophageal and gastric cancers

Coghlin, C. & Murray, G. I., Apr 2016, In : Proteomics. Clinical applications. 10, 4, p. 532-545 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Open Access
File
12 Citations (Scopus)
8 Downloads (Pure)

The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

Mohamed, A., Sun, C., De Mello, V., Selfe, J., Missiaglia, E., Shipley, J., Murray, G. I., Zammit, P. S. & Wackerhage, H., Sep 2016, In : The Journal of pathology. 240, 1, p. 3-14 12 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
7 Downloads (Pure)

Transporters for Antiretroviral Drugs in Colorectal CD4+ T Cells and Circulating α4β7 Integrin CD4+ T cells: Implications for HIV Microbicides

Mukhopadhya, I., Murray, G. I., Duncan, L., Yuecel, R., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, E., Hold, G. & Hijazi, K., 6 Sep 2016, In : Molecular Pharmaceutics. 13, 9, p. 3334-3340 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
7 Downloads (Pure)

β-Glucan exacerbates allergic airway responses to house dust mite allergen

Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., Lambrecht, B. N., Brombacher, F. & Brown, G. D., 2 Apr 2016, In : Respiratory Research. 17, p. 1-3 3 p., 35.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
6 Downloads (Pure)
2015

A Comprehensive Study of Extramural Venous Invasion in Colorectal Cancer

McClelland, D. & Murray, G. I., 15 Dec 2015, In : PloS ONE. 10, 12, 20 p., e0144987.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
6 Downloads (Pure)

Biomarkers of colorectal cancer: Recent advances and future challenges

Coghlin, C. L. & Murray, G. I., 6 Feb 2015, In : Proteomics. Clinical applications. 9, 1-2, p. 64-71 8 p.

Research output: Contribution to journalLiterature review

35 Citations (Scopus)

Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

Vautier, S., Drummond, R. A., Chen, K., Murray, G. I., Kadosh, D., Brown, A. J. P., Gow, N. A. R., MacCallum, D. M., Kolls, J. K. & Brown, G. D., Apr 2015, In : Cellular Microbiology. 17, 4, p. 445-450 6 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
7 Downloads (Pure)

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

Brown, G. T. & Murray, G. I., Nov 2015, In : The Journal of pathology. 237, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

Open Access
149 Citations (Scopus)
1 Downloads (Pure)

CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation

Zia, H., Murray, G. I., Vyhlidal, C. A., Leeder, J. S., Anwar, A. E., Bui, M. M. & Ahmed, A. A., Apr 2015, In : International journal of experimental pathology. 96, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

Dahle-Smith, A., Stevenson, D., Massie, D., Murray, G. I., Dutton, S. J., Roberts, C., Ferry, D., Osborne, A., Clark, C., Petty, R. D. & Miedzybrodzka, Z., 17 Oct 2015, In : Molecular Cytogenetics . 8, 78.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
6 Downloads (Pure)

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Hadebe, S., Kirstein, F., Fierens, K., Chen, K., Drummond, R. A., Vautier, S., Sajaniemi, S., Murray, G., Williams, D. L., Redelinghuys, P., Reinhart, T. A., Fallert Junecko, B. A., Kolls, J. K., Lambrecht, B. N., Brombacher, F. & Brown, G. D., 11 Aug 2015, In : PloS ONE. 10, 8, 17 p., e0134219.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
6 Downloads (Pure)
Open Access
File
31 Citations (Scopus)
6 Downloads (Pure)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

Matula, K., Collie-Duguid, E., Murray, G., Parikh, K., Grabsch, H. I., Tan, P., Lalwani, S., Garau, R., Ong, Y., Bain, G., Dahle-Smith, A., Urquhart, G., Bielawski, J., Finnegan, M. & Petty, R., 2015, In : BMC Cancer. 15, 762, 14 p., 762.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
7 Downloads (Pure)
2014

Increased lymph node yield in colorectal cancer is not necessarily associated with a greater number of lymph node positive cancers

O'Shea, A., Aly, O., Parnaby, C. N., Loudon, M. A., Samuel, L. M. & Murray, G. I., 13 Aug 2014, In : PloS ONE. 9, 8, 10 p., e104991.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
126 Downloads (Pure)

Influence of HPV type on prognosis in patients diagnosed with invasive cervical cancer

Cuschieri, K., Brewster, D. H., Graham, C., Nicoll, S., Williams, A. R. W., Murray, G. I., Millan, D. & Cubie, H. A., Dec 2014, In : International Journal of Cancer. 135, 11, p. 2721-2726 56 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Prognostic Value of Lymph Node Ratio and Extramural Vascular Invasion on Overall Survival for Patients Undergoing Curative Colon Cancer Resection

Parnaby, C., Scott, N., Mackay, C., Ramsay, G., Guha, A., Samuel, L., Murray, G. I. & Loudon, M., 2014, In : Colorectal Disease. 16, s2, p. 167 1 p., W045.

Research output: Contribution to journalAbstract

23 Citations (Scopus)

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation

Lourenco, F. C., Munro, J., Brown, J., Cordero, J., Stefanatos, R., Strathdee, K., Orange, C., Feller, S. M., Sansom, O. J., Vidal, M., Murray, G. I. & Olson, M. F., Mar 2014, In : Gut. 63, 3, p. 480-493 14 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
7 Downloads (Pure)

The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer

Brown, G. T., Cash, B. G., Blihoghe, D., Johansson, P., Alnabulsi, A. & Murray, G. I., 7 Mar 2014, In : PloS ONE. 9, 3, 12 p., e90776.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
5 Downloads (Pure)

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

Tremblay, A. M., Missiaglia, E., Galli, G. G., Hettmer, S., Urcia, R., Carrara, M., Judson, R. N., Thway, K., Nadal, G., Selfe, J. L., Murray, G. I., Calogero, R. A., De Bari, C., Zammit, P. S., Delorenzi, M., Wagers, A. J., Shipley, J., Wackerhage, H. & Camargo, F. D., 11 Aug 2014, In : Cancer Cell. 26, 2, p. 273-287 15 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

The role of gene regulatory networks in promoting cancer progression and metastasis

Caroline, C. & Murray, G. I., Apr 2014, In : Future Oncology. 10, 5, p. 735-748 14 p.

Research output: Contribution to journalLiterature review

9 Citations (Scopus)