• 8686 Citations
19992019

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2019

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman, S. O., Koelzer, V. H., Jones, H. J. S., Vazquez, E. G., Davis, H., East, J. E., Arnold, R., Koppens, M. A. J., Blake, A., Domingo, E., Cunningham, C., Beggs, A. D., Pestinger, V., Loughrey, M. B., Wang, L-M., Lannagan, T. R. M., Woods, S. L., Worthley, D., The S:CORT Consortium, Tomlinson, I. & 3 others, Dunne, P. D., Maughan, T. & Leedham, S. J., 28 Sep 2019, In : Gut. 12 p.

Research output: Contribution to journalArticle

Open Access

Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis

Conlon, G. A. & Murray, G. I., Apr 2019, In : The Journal of pathology. 247, 5, p. 629-640 12 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)

The expression of brown fat associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis

Alnabulsi, A., Cash, B., Hu, Y., Silina, L., Alnabulsi, A. & Murray, G. I., 15 Aug 2019, In : International Journal of Cancer. 145, 4, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
2018

Colorectal tumors require NUAK1 for protection from oxidative stress

Port, J. L. F., Muthalagu, N., Raja, M., Ceteci, F., Monteverde, T., Kruspig, B., Hedley, A., Kalna, G., Lilla, S., Neilson, L., Brucoli, M., Gyuraszova, K., Tait-Mulder, J., Mezna, M., Svambaryte, S., Bryson, A., Sumpton, D., McVie, A., Nixon, C., Drysdale, M. & 5 others, Esumi, H., Murray, G. I., Sansom, O. J., Zanivan, S. & Murphy, D. J., May 2018, In : Cancer Discovery. 8, 5, p. 633-647 15 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
4 Downloads (Pure)

Combined linkage and association analysis of classical Hodgkin lymphoma

Lawrie, A., Han, S., Sud, A., Hosking, F., Cezard, T., Turner, D., Clark, C., Murray, G. I., Culligan, D. J., Houlston, R. S. & Vickers, M. A., 17 Apr 2018, In : Oncotarget. 9, 29, p. 20377-20385 9 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
7 Downloads (Pure)

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 13 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
7 Downloads (Pure)

Extensive esophageal papillomatosis after chemoradiotherapy for squamous cell carcinoma

Siu, W., Murray, G. I., McKinlay, A. & Phull, P., Jun 2018, In : Gastrointestinal Endoscopy. 87, 6, p. 1581-1582 2 p.

Research output: Contribution to journalArticle

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

Alexandrou, C., Al-Aqbi, S. S., Higgins, J. A., Boyle, W., Karmokar, A., Andreadi, C., Luo, J-L., Moore, D. A., Viskaduraki, M., Blades, M., Murray, G. I., Howells, L. M., Thomas, A., Brown, K., Cheng, P. N. & Rufini, A., 14 Aug 2018, In : Scientific Reports. 8, p. 1-14 14 p., 12096.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
4 Downloads (Pure)

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

Allen, W. L., Dunne, P. D., McDade, S., Scanlon, E., Loughrey, M., Coleman, H., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N., Jithesh, P., Arthur, K., Wilson, R., Coyle, V., McArt, D., Murray, G., Samuel, L., Nuciforo, P., Jimenez, J., Argiles, G. & 12 others, Dienstmann, R., Tabernero, J., Picariello, L., Messerini, L., Nobili, S., Mini, E., Sheahan, K., Ryan, E., Johnston, P. G., Van Schaeybroeck, S., Lawler, M. & Longley, D. B., 2018, In : JCO Precision Oncology. 2018, 2, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)
2017

Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer

Petty, R. D., Dahle-Smith, A., Stevenson, D. A. J., Osborne, A., Massie, D., Clark, C., Murray, G. I., Dutton, S. J., Roberts, C., Chong, I. Y., Mansoor, W., Thompson, J., Harrison, M., Chatterjee, A., Falk, S., Elyan, S., Garcia-Alonso, A., Fyfe, D. W., Wadsley, J., Chau, I. & 2 others, Ferry, D. & Miedzybrodzka, Z., Jul 2017, In : Journal of Clinical Oncology. 35, 20, p. 2279-2287 9 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

Alvi, M. A., Loughrey, M. B., Dunne, P., McQuaid, S., Turkington, R., Fuchs, M-A., McGready, C., Bingham, V., Pang, B., Moore, W., Maxwell, P., Lawler, M., James, J. A., Murray, G. I., Wilson, R. H. & Salto-Tellez, M., 11 Jul 2017, In : British Journal of Cancer. 117, 2, p. 203-209 7 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
6 Downloads (Pure)

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival

Alderdice, M., Dunne, P. D., Cole, A. J., O'Reilly, P. G., McArt, D. G., Bingham, V., Fuchs, M-A., McQuaid, S., Loughrey, M. B., Murray, G. I., Samuel, L., Lawler, M., Wilson, R. H., Salto-Tellez, M. & Coyle, V. M., Sep 2017, In : Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 30, 9, p. 1287-1298 12 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
7 Downloads (Pure)
7 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
7 Citations (Scopus)
4 Downloads (Pure)

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Diamantopoulou, Z., White, G., Fadlullah, M. Z. H., Dreger, M., Pickering, K., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., Lacaud, G., Murray, G. I., Sansom, O. J., Hurlstone, A. F. L. & Malliri, A., 8 May 2017, In : Cancer Cell. 31, 5, p. 621-634 14 p.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
4 Downloads (Pure)
2016
15 Citations (Scopus)
4 Downloads (Pure)

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer

Swan, R., Alnabulsi, A., Cash, B., Alnabulsi, A. & Murray, G. I., 22 Jun 2016, In : Oncotarget. 7, 29, p. 46509-46527 19 p., 10224.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
4 Downloads (Pure)

Drug Transporter Gene Expression in Human Colorectal Tissue and Cell Lines: Modulation with Antiretrovirals for Microbicide Optimization

Mukhopadhya, I., Murray, G. I., Berry, S., Thomson, J., Frank, B., Gwozdz, G., Ekeruche-Makinde, J., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, E. M., Hold, G. L. & Hijazi, K., Feb 2016, In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 372-386 15 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
4 Downloads (Pure)

Extending colonic mucosal microbiome analysis - Assessment of colonic lavage as a proxy for endoscopic colonic biopsies

Watt, E., Gemmell, M. R., Berry, S., Glaire, M., Farquharson, F., Louis, P., Murray, G. I., El-Omar, E. & Hold, G. L., 25 Nov 2016, In : Microbiome. 4, 61.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
7 Downloads (Pure)

MICL controls inflammation in rheumatoid arthritis

Redelinghuys, P., Whitehead, L., Augello, A., Drummond, R. A., Levesque, J-M., Vautier, S., Reid, D. M., Kerscher, B., Taylor, J. A., Nigrovic, P. A., Wright, J., Murray, G. I., Willment, J. A., Hocking, L. J., Fernandes, M. J. G., De Bari, C., McInnes, I. B. & Brown, G. D., Jul 2016, In : Annals of the Rheumatic Diseases. 75, 7, p. 1386-1391 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
7 Downloads (Pure)

Progress in the development of protein biomarkers of oesophageal and gastric cancers

Coghlin, C. & Murray, G. I., Apr 2016, In : Proteomics. Clinical applications. 10, 4, p. 532-545 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Open Access
File
10 Citations (Scopus)
6 Downloads (Pure)

The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

Mohamed, A., Sun, C., De Mello, V., Selfe, J., Missiaglia, E., Shipley, J., Murray, G. I., Zammit, P. S. & Wackerhage, H., Sep 2016, In : The Journal of pathology. 240, 1, p. 3-14 12 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
5 Downloads (Pure)

Transporters for Antiretroviral Drugs in Colorectal CD4+ T Cells and Circulating α4β7 Integrin CD4+ T cells: Implications for HIV Microbicides

Mukhopadhya, I., Murray, G. I., Duncan, L., Yuecel, R., Shattock, R., Kelly, C., Iannelli, F., Pozzi, G., El-Omar, E., Hold, G. & Hijazi, K., 6 Sep 2016, In : Molecular Pharmaceutics. 13, 9, p. 3334-3340 7 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
5 Downloads (Pure)

β-Glucan exacerbates allergic airway responses to house dust mite allergen

Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., Lambrecht, B. N., Brombacher, F. & Brown, G. D., 2 Apr 2016, In : Respiratory Research. 17, p. 1-3 3 p., 35.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
4 Downloads (Pure)
2015

A Comprehensive Study of Extramural Venous Invasion in Colorectal Cancer

McClelland, D. & Murray, G. I., 15 Dec 2015, In : PloS ONE. 10, 12, 20 p., e0144987.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
4 Downloads (Pure)

Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

Vautier, S., Drummond, R. A., Chen, K., Murray, G. I., Kadosh, D., Brown, A. J. P., Gow, N. A. R., MacCallum, D. M., Kolls, J. K. & Brown, G. D., Apr 2015, In : Cellular Microbiology. 17, 4, p. 445-450 6 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
4 Downloads (Pure)

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

Brown, G. T. & Murray, G. I., Nov 2015, In : The Journal of pathology. 237, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

Open Access
136 Citations (Scopus)
1 Downloads (Pure)

CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation

Zia, H., Murray, G. I., Vyhlidal, C. A., Leeder, J. S., Anwar, A. E., Bui, M. M. & Ahmed, A. A., Apr 2015, In : International journal of experimental pathology. 96, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

Dahle-Smith, A., Stevenson, D., Massie, D., Murray, G. I., Dutton, S. J., Roberts, C., Ferry, D., Osborne, A., Clark, C., Petty, R. D. & Miedzybrodzka, Z., 17 Oct 2015, In : Molecular Cytogenetics . 8, 78.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
4 Downloads (Pure)

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Hadebe, S., Kirstein, F., Fierens, K., Chen, K., Drummond, R. A., Vautier, S., Sajaniemi, S., Murray, G., Williams, D. L., Redelinghuys, P., Reinhart, T. A., Fallert Junecko, B. A., Kolls, J. K., Lambrecht, B. N., Brombacher, F. & Brown, G. D., 11 Aug 2015, In : PloS ONE. 10, 8, 17 p., e0134219.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
28 Citations (Scopus)
4 Downloads (Pure)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

Matula, K., Collie-Duguid, E., Murray, G., Parikh, K., Grabsch, H. I., Tan, P., Lalwani, S., Garau, R., Ong, Y., Bain, G., Dahle-Smith, A., Urquhart, G., Bielawski, J., Finnegan, M. & Petty, R., 2015, In : BMC Cancer. 15, 762, 14 p., 762.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
5 Downloads (Pure)
2014

Increased lymph node yield in colorectal cancer is not necessarily associated with a greater number of lymph node positive cancers

O'Shea, A., Aly, O., Parnaby, C. N., Loudon, M. A., Samuel, L. M. & Murray, G. I., 13 Aug 2014, In : PloS ONE. 9, 8, 10 p., e104991.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
124 Downloads (Pure)

Influence of HPV type on prognosis in patients diagnosed with invasive cervical cancer

Cuschieri, K., Brewster, D. H., Graham, C., Nicoll, S., Williams, A. R. W., Murray, G. I., Millan, D. & Cubie, H. A., Dec 2014, In : International Journal of Cancer. 135, 11, p. 2721-2726 56 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation

Lourenco, F. C., Munro, J., Brown, J., Cordero, J., Stefanatos, R., Strathdee, K., Orange, C., Feller, S. M., Sansom, O. J., Vidal, M., Murray, G. I. & Olson, M. F., Mar 2014, In : Gut. 63, 3, p. 480-493 14 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
5 Downloads (Pure)

The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer

Brown, G. T., Cash, B. G., Blihoghe, D., Johansson, P., Alnabulsi, A. & Murray, G. I., 7 Mar 2014, In : PloS ONE. 9, 3, 12 p., e90776.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
3 Downloads (Pure)

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

Tremblay, A. M., Missiaglia, E., Galli, G. G., Hettmer, S., Urcia, R., Carrara, M., Judson, R. N., Thway, K., Nadal, G., Selfe, J. L., Murray, G. I., Calogero, R. A., De Bari, C., Zammit, P. S., Delorenzi, M., Wagers, A. J., Shipley, J., Wackerhage, H. & Camargo, F. D., 11 Aug 2014, In : Cancer Cell. 26, 2, p. 273-287 15 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., McKiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H. I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Matula, K. M. & 1 others, Petty, R. D., 18 Mar 2014, In : British Journal of Cancer. 110, 6, p. 1525-1534 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2013

Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential?

McLean, M. H., Thomson, A. J., Murray, G. I., Fyfe, N., Hold, G. L. & El-Omar, E. M., 25 Jun 2013, In : British Journal of Cancer. 108, 12, p. 2537-2541 5 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
30 Downloads (Pure)

Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis

Baker, A-M., Bird, D., Welti, J. C., Gourlaouen, M., Lang, G., Murray, G. I., Reynolds, A. R., Cox, T. R. & Erler, J. T., 15 Jan 2013, In : Cancer Research. 73, 2, p. 583-594 12 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Raf kinase inhibitor protein expression combined with peritoneal involvement and lympho-vascular invasion predicts prognosis in Dukes B colorectal cancer patients.

Doyle, B., Hagan, S., Al-Mulla, F., Scott, L., Harden, S., Paul, J., Mulcahy, H., Murray, G. I., Sheahan, K., O'Sullivan, J. & Kolch, W., Feb 2013, In : Histopathology. 62, 3, p. 505-510 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

Myant, K. B., Cammereri, P., McGhee, E. J., Ridgway, R. A., Huels, D. J., Cordero, J. B., Schwitalla, S., Kalna, G., Ogg, E-L., Athineos, D., Timpson, P., Vidal, M., Murray, G. I., Greten, F. R., Anderson, K. I. & Sansom, O. J., 6 Jun 2013, In : Cell Stem Cell. 12, 6, p. 761-773 13 p.

Research output: Contribution to journalArticle

198 Citations (Scopus)
2012

Cellular apoptosis susceptibility (chromosome segragation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer

Alnabulsi, A., Agouni, A., Mitra, S., Garcia-Murillas, I., Carpenter, B., Bird, S. & Murray, G. I., Dec 2012, In : The Journal of pathology. 228, 4, p. 471-481 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Dectin-1 is not required for controlling Candida albicans colonisation of the gastrointestinal tract

Vautier, S., Drummond, R. A., Redelinghuys, P., Murray, G. I., Maccallum, D. M. & Brown, G. D., Dec 2012, In : Infection and Immunity. 80, 12, p. 4216-4222 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Familial collagenous colitis involving a 6-year old child

Phull, P., Vijayan, B., Bisset, W. M. & Murray, G. I., Jun 2012, In : Journal of Crohn's and Colitis. 6, 5, p. 606-609 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Is the number of lymph nodes retrieved in laparoscopic colorectal cancer resections related to the learning curve of the surgeon?

Aly, O., McDonald, E., Watkins, C., Murray, G. I. & Aly, E. H., 2012, In : Journal of Solid Tumors. 2, 1, p. 16-21 6 p.

Research output: Contribution to journalArticle

Open Access

Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps-a putative role of semaphorins 3F and 3A

Graf, N., McLean, M. H., Capellino, S., Scholmerich, J., Murray, G. I., El-Omar, E. M. & Straub, R. H., Feb 2012, In : Neurogastroenterology and Motility. 24, 2, p. 120-e83 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)