• 4357 Citations
20032020
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Research Output 2003 2020

  • 4357 Citations
  • 41 Article
  • 2 Abstract
  • 1 Other contribution
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Article
2020

Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Alnajjar, M., Barik, S. K., Bestwick, C., Campbell, F., Cruickshank, M., Farquharson, F., Holtrop, G., Horgan, G., Louis, P., Moar, K-M., Russell, W. R., Scobbie, L. & Hoggard, N., Jan 2020, In : Journal of Functional Foods. 64, 103597.

Research output: Contribution to journalArticle

Open Access
File
Vaccinium myrtillus
bilberries
Anthocyanins
volunteers
anthocyanins
2019
2 Citations (Scopus)
1 Downloads (Pure)

Dietary carbohydrate rather than protein intake drives colonic microbial fermentation during weight loss

Gratz, S. W., Hazim, S., Richardson, A. J., Scobbie, L., Johnstone, A. M., Fyfe, C., Holtrop, G., Lobley, G. E. & Russell, W. R., Apr 2019, In : European Journal of Nutrition. 58, 3, p. 1147-1158 12 p.

Research output: Contribution to journalArticle

Open Access
File
Dietary Carbohydrates
Fermentation
Weight Loss
Reducing Diet
Carbohydrates
2018
1 Citation (Scopus)
19 Downloads (Pure)
Open Access
File
Glutens
Bread
Cross-Over Studies
Diet
Aspergillus niger
5 Citations (Scopus)
6 Downloads (Pure)

Porcine small and large intestinal microbiota rapidly hydrolyze the masked mycotoxin deoxynivalenol-3-glucoside and release deoxynivalenol in spiked batch cultures in vitro

Gratz, S., Currie, V., Richardson, A., Duncan, G., Holtrop, G., Farquharson, F., Louis, P., Pinton, P. & Oswald, I. P., Jan 2018, In : Applied and Environmental Microbiology. 84, 2, p. 1-9 9 p., 02106-17.

Research output: Contribution to journalArticle

Open Access
File
deoxynivalenol-3-glucoside
Batch Cell Culture Techniques
Mycotoxins
deoxynivalenol
intestinal microorganisms
22 Citations (Scopus)
10 Downloads (Pure)

Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production

Reichardt, N., Vollmer, M., Holtrop, G., Farquharson, F. M., Wefers, D., Bunzel, M., Duncan, S. H., Drew, J. E., Williams, L. M., Milligan, G., Preston, T., Morrison, D., Flint, H. J. & Louis, P., 2018, In : The ISME Journal. 12, p. 610-622 13 p.

Research output: Contribution to journalArticle

Open Access
File
Volatile Fatty Acids
Butyrates
Microbiota
short chain fatty acids
butyrates
2017
23 Citations (Scopus)
12 Downloads (Pure)

Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro

Gratz, S. W., Dinesh, R., Yoshinari, T., Holtrop, G., Richardson, A. J., Duncan, G., MacDonald, S., Lloyd, A. & Farbin, J., Apr 2017, In : Molecular Nutrition & Food Research. 61, 4, 1600680.

Research output: Contribution to journalArticle

Open Access
File
Trichothecenes
Zearalenone
Upper Gastrointestinal Tract
trichothecenes
Mycotoxins
2016
5 Citations (Scopus)

Responses in whole-body amino acid kinetics to an acute, sub-clinical endotoxin challenge in lambs

Hoskin, S. O., Bremner, D. M., Holtrop, G. & Lobley, G. E., 28 Feb 2016, In : British Journal of Nutrition. 115, 4, p. 576-584 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
6 Downloads (Pure)

Whole body and splanchnic amino acid metabolism in sheep during an acute endotoxin challenge

McNeil, C. J., Hoskin, S. O., Bremner, D. M., Holtrop, G. & Lobley, G. E., Jul 2016, In : British Journal of Nutrition. 116, 2, p. 211-222 12 p.

Research output: Contribution to journalArticle

Open Access
File
Viscera
Endotoxins
Sheep
Amino Acids
Lipopolysaccharides
2015
46 Citations (Scopus)
3 Downloads (Pure)

Modelling the emergent dynamics and major metabolites of the human colonic microbiota

Kettle, H., Louis, P. G. H., Holtrop, G., Duncan, S. H. & Flint, H. J., May 2015, In : Environmental Microbiology. 17, 5, p. 1615-1630 16 p.

Research output: Contribution to journalArticle

Open Access
File
Microbiota
metabolite
Colon
metabolites
colon
11 Citations (Scopus)
Hunger
Weight Loss
Hormones
Diet
Amino Acids
2014
24 Citations (Scopus)
Environmental Monitoring
Fusarium
deoxynivalenol
urine
Urine
3 Citations (Scopus)
10 Downloads (Pure)
Open Access
File
Reducing Diet
Ketone Bodies
High Pressure Liquid Chromatography
Carbohydrates
Hunger
186 Citations (Scopus)

Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men

Salonen, A., Lahti, L., Salojärvi, J., Holtrop, G., Korpela, K., Duncan, S. H., Date, P., Farquharson, F., Johnstone, A. M., Lobley, G. E., Louis, P., Flint, H. J. & de Vos, W. M., Nov 2014, In : The ISME Journal. 8, 11, p. 2218-2230 13 p.

Research output: Contribution to journalArticle

individual variation
intestinal microorganisms
Microbiota
Fermentation
fermentation
13 Citations (Scopus)
6 Downloads (Pure)

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

Zhang, X., McGeoch, S. C., Megson, I. L., MacRury, S. M., Johnstone, A. M., Abraham, P., Pearson, D. W. M., De Roos, B., Holtrop, G., O'Kennedy, N. & Lobley, G. E., Jun 2014, In : Molecular Nutrition & Food Research. 58, 6, p. 1322-1332 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cell-Derived Microparticles
fibrinogen
noninsulin-dependent diabetes mellitus
Fibrinogen
Type 2 Diabetes Mellitus
37 Citations (Scopus)

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Zhang, X., McGeoch, S. C., Johnstone, A. M., Holtrop, G., Sneddon, A. A., Macrury, S. M., Megson, I. L., Pearson, D. W. M., Abraham, P., De Roos, B., Lobley, G. E. & O'Kennedy, N., May 2014, In : Journal of Thrombosis and Thrombolysis. 37, 4, p. 455-463 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Blood Platelets
Obesity
Matrix Metalloproteinases
P-Selectin
2013
21 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
resistant starch
metabolic syndrome
insulin resistance
Starch
Polysaccharides
2012
14 Citations (Scopus)

Diet composition is associated with endogenous formation of N-nitroso compounds in obese men.

Holtrop, G., Johnstone, A. M., Fyfe, C. & Gratz, S. W., 1 Sep 2012, In : The Journal of Nutrition. 142, 9, p. 1652-1658 7 p.

Research output: Contribution to journalArticle

Nitroso Compounds
Diet
Reducing Diet
Nitrates
Ascorbic Acid
39 Citations (Scopus)

Phylogenetic distribution of genes encoding β-glucuronidase activity in human colonic bacteria and the impact of diet on faecal glycosidase activities

McIntosh, F. M., Maison, N., Holtrop, G., Young, P., Stevens, V. J., Ince, J., Johnstone, A. M., Lobley, G., Flint, H. J. & Louis, P., 2012, In : Environmental Microbiology. 14, 8, p. 1876-1887 12 p.

Research output: Contribution to journalArticle

glycosidases
Glycoside Hydrolases
Glucuronidase
Human Activities
diet
6 Citations (Scopus)

The effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat

Wilson, F. A., Holtrop, G., Calder, A. G., Anderson, S. E., Lobley, G. E. & Rees, W., 15 Jun 2012, In : American Journal of Physiology: Endocrinology and Metabolism. 302, 12, p. E1531-E1540 10 p.

Research output: Contribution to journalArticle

Homocysteine
Methionine
Diet
Mothers
Fetus
2011
718 Citations (Scopus)

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Walker, A. W., Ince, J., Duncan, S. H., Webster, L., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., Louis, P., McIntosh, F., Johnstone, A. M., Lobley, G. E., Parkhill, J. & Flint, H. J., Feb 2011, In : The ISME Journal. 5, 2, p. 220-230 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
3 Downloads (Pure)

Food intake and dietary glycaemic index in free-living adults with and without type 2 diabetes mellitus

McGeoch, S. C., Holtrop, G., Fyfe, C., Lobley, G. E., Pearson, D. W. M., Abraham, P., Megson, I. L., Macrury, S. M. & Johnstone, A., Jun 2011, In : Nutrients. 3, 6, p. 683-693 11 p.

Research output: Contribution to journalArticle

Open Access
File
Glycemic Index
glycemic index
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
food intake
284 Citations (Scopus)
Reducing Diet
Carbohydrates
Diet
Health
Proteins
35 Citations (Scopus)

Rates of production and utilization of lactate by microbial communities from the human colon

Belenguer, A., Holtrop, G., Duncan, S. H., Anderson, S. E., Calder, A. G., Flint, H. J. & Lobley, G. E., Jul 2011, In : FEMS Microbiology Ecology. 77, 1, p. 107-119 13 p.

Research output: Contribution to journalArticle

Lactic Acid
Colon
Batch Cell Culture Techniques
Bioreactors
Starch
2010
247 Citations (Scopus)
2009
408 Citations (Scopus)

Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii

Ramirez-Farias, C., Slezak, K., Fuller, Z., Duncan, A. S., Holtrop, G. & Louis, P., 28 Feb 2009, In : British Journal of Nutrition. 101, 4, p. 541-550 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Fetal iron status regulates maternal iron metabolism during pregnancy in the rat

Gambling, L., Czopek, A., Andersen, H. S., Holtrop, G., Srai, S. K. S., Krejpcio, Z. & McArdle, H. J., 1 Apr 2009, In : American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 296, 4, p. R1063-R1070 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline

Wilson, F. A., van den Borne, J. J. G. C., Calder, A. G., O'Kennedy, N., Holtrop, G., Rees, W. & Lobley, G., Apr 2009, In : American Journal of Physiology: Endocrinology and Metabolism. 296, 4, p. E702-713 12 p.

Research output: Contribution to journalArticle

2008
5 Citations (Scopus)

Contribution of gut microbial lysine to liver and milk amino acids in lactating does

Abecia, L., Balcells, J., Fondevila, M., Belenguer, A., Holtrop, G. & Lobley, G., Oct 2008, In : British Journal of Nutrition. 100, 5, p. 977-983 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Distribution of N-15 in amino acids during N-15-leucine infusion: impact on the estimation of endogenous flows in dairy cows

Lapierre, H., Ouellet, D. R., Berthiaume, R., Martineau, R., Holtrop, G. & Lobley, G. E., Jul 2008, In : Journal of Dairy Science. 91, 7, p. 2702-2714 13 p.

Research output: Contribution to journalArticle

643 Citations (Scopus)

Human colonic microbiota associated with diet, obesity and weight loss

Duncan, S. H., Lobley, G., Holtrop, G., Ince, J., Johnstone, A., Louis, P. & Flint, H. J., Nov 2008, In : International Journal of Obesity. 32, 11, p. 1720-1724 5 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities

Walker, A. W., Duncan, S. H., Harmsen, H. J. M., Holtrop, G., Welling, G. W. & Flint, H. J., Dec 2008, In : Environmental Microbiology. 10, 12, p. 3275-3283 9 p.

Research output: Contribution to journalArticle

2007
26 Citations (Scopus)

Effect of dietary copper deficiency on iron metabolism in the pregnant rat

Andersen, H. S., Gambling, L., Holtrop, G. & McArdle, H. J., 1 Feb 2007, In : British Journal of Nutrition. 97, 2, p. 239-246 8 p.

Research output: Contribution to journalArticle

Copper
Iron
Pregnancy
Mothers
Liver
88 Citations (Scopus)

Impact of pH on Lactate Formation and Utilization by Human Fecal Microbial Communities

Belenguer, A., Duncan, S. H., Holtrop, G., Anderson, S. E., Lobley, G. E. & Flint, H. J., Oct 2007, In : Applied and Environmental Microbiology. 73, 20, p. 6526-6533 8 p.

Research output: Contribution to journalArticle

polysaccharide
lactates
microbial communities
microbial community
Lactic Acid
460 Citations (Scopus)

Reduced Dietary Intake of Carbohydrates by Obese Subjects Results in Decreased Concentrations of Butyrate and Butyrate-Producing Bacteria in Feces

Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J. & Lobley, G. E., Feb 2007, In : Applied and Environmental Microbiology. 73, 4, p. 1073-1078 6 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Selective colonization of insoluble substrates by human faecal bacteria

Leitch, E. C. M., Walker, A. W., Duncan, S. H., Holtrop, G. & Flint, H. J., Mar 2007, In : Environmental Microbiology. 9, 3, p. 667-679 13 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Maternal iron deficiency identifies critical windows for growth and cardiovascular development in the rat postimplantation embryo

Andersen, H. S., Gambling, L., Holtrop, G. & McArdle, H. J., May 2006, In : The Journal of Nutrition. 136, 5, p. 1171-1177 7 p.

Research output: Contribution to journalArticle

368 Citations (Scopus)

Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut

Belenguer, A., Duncan, S. H., Calder, A. G., Holtrop, G., Louis, P., Lobley, G. & Flint, H. J., 1 May 2006, In : Applied and Environmental Microbiology. 72, 5, p. 3593-3599 7 p.

Research output: Contribution to journalArticle

Bifidobacterium adolescentis
anaerobes
Butyrates
butyrates
Eubacterium hallii
2004
183 Citations (Scopus)

Contribution of acetate to butyrate formation by human faecal bacteria

Duncan, S. H., Holtrop, G., Lobley, G. E., Calder, A. G., Stewart, C. S. & Flint, H. J., Jun 2004, In : British Journal of Nutrition. 91, 6, p. 915-923 9 p.

Research output: Contribution to journalArticle

Butyrates
Acetates
Bacteria
Xylans
Batch Cell Culture Techniques
2003
12 Citations (Scopus)

Effect of feed intake on amino acid transfers across the ovine hindquarters

Hoskin, S. O., Savary-Auzeloux, I. C., Calder, A. G., Zuur, G. & Lobley, G., 1 Feb 2003, In : British Journal of Nutrition. 89, 2, p. 167-179 13 p.

Research output: Contribution to journalArticle

Sheep
Amino Acids
Serine
Venae Cavae
Essential Amino Acids