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  • 1704 Citations
  • 69 Article
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  • 1 Chapter
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2020

A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite

Maglangit, F., Fang, Q., Kyeremeh, K., Sternberg, J. M., Ebel, R. & Deng, H., 2020, In : Molecules. 25, 2, 256.

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An unusual metal-bound 4-fluorothreonine transaldolase from Streptomyces sp. MA37 catalyses promiscuous transaldol reactions

Wu, L., Tong, M. H., Raab, A., Fang, Q., Wang, S., Kyeremeh, K., Yu, Y. & Deng, H., May 2020, In : Applied Microbiology and Biotechnology. 104, p. 3885-3896 12 p.

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Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis

Maglangit, F., Alrashdi, S., Renault, J., Trembleau, L., Victoria, C., Tong, M. H., Wang, S., Kyeremeh, K. & Deng, H., 28 Mar 2020, In : Organic & Biomolecular Chemistry. 18, 12, p. 2219-2222 4 p.

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1 Citation (Scopus)

Fluorine biocatalysis

Wu, L., Maglangit, F. & Deng, H., Apr 2020, In : Current Opinion in Chemical Biology. 55, p. 119-126 6 p.

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1 Citation (Scopus)

Identification of 5-Fluoro-5-Deoxy-Ribulose as a Shunt Fluorometabolite in Streptomyces sp. MA37

Wu, L., Tong, M. H., Kyeremeh, K. & Deng, H., 10 Jul 2020, In : Biomolecules. 10, 7, 11 p., 1023.

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Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm

Li, Y., Liu, Y., Li, Q., Tian, T., Zhou, W., Cui, Y., Wang, X., cheng, X., Ding, Q., Wang, X., Wu, J., Deng, H., Li, Y., Meng, X., Deng, Z., Hong, X. & Xiao, Y., 14 Mar 2020, In : Chemical Science. 11, 10, p. 2621-2626 6 p.

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2 Citations (Scopus)
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Novel South African Rare Actinomycete Kribbellaspeibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners

Acquah, K. S., Beukes, D. R., Warner, D. F., Meyers, P. R., Sunassee, S. N., Maglangit, F., Deng, H., Jaspars, M. & Gammon, D. W., 29 Jun 2020, In : Molecules. 25, 13, 12 p., 2979.

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Signalling and Bioactive Metabolites from Streptomyces sp. RK44

Fang, Q., Maglangit, F., Wu, L., Ebel, R., Kyeremeh, K., Andersen, J. H., Annang, F., Perez de Nanclares, G., Reyes, F. & Deng, H., 22 Jan 2020, In : Molecules. 25, 3, 460.

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2 Citations (Scopus)
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Targeted isolation of indole alkaloids from Streptomyces sp. CT37

Fang, Q., Maglangit, F., Mugat, M., Urwald, C., Kyeremeh, K. & Deng, H., Mar 2020, In : Molecules. 25, 5, 10 p., 1108.

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2019

Accramycin A, a New Aromatic Polyketide, from the Soil Bacterium, Streptomyces sp. MA37

Maglangit, F., Fang, Q., Leman, V., Soldatou, S., Ebel, R., Kyeremeh, K. & Deng, H., 17 Sep 2019, In : Molecules. 24, 18, 3384.

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8 Citations (Scopus)
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A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

Zeng, X., Chen, Z., Tang, L., Yang, H., Liu, N., Zhou, H., Li, Y., Wu, J., Deng, Z., Yu, Y., Deng, H., Hong, X. & Xiao, Y., 28 Feb 2019, In : Chemical Communications. 55, 17, p. 2541-2544 4 p.

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13 Citations (Scopus)

Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

Liu, Y., Su, L., Fang, Q., Tabudravu, J., Yang, X., Rickaby, K., Trembleau, L., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 20 Dec 2019, In : Journal of Organic Chemistry. 84, 24, p. 16323-16328 6 p.

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Investigation of Penicillin Binding Protein (PBP)-like Peptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis

Zhou, Y., Lin, X., Xu, C., Shen, Y., Wang, S-P., Liao, H., Li, L., Deng, H. & Lin, H-W., 16 May 2019, In : Cell chemical biology. 26, 5, p. 737-744 8 p.

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5 Citations (Scopus)

In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid

Yun, X., Zhang, Q., Lv, M., Deng, H., Deng, Z. & Yu, Y., 21 Jan 2019, In : Organic & Biomolecular Chemistry. 17, 3, p. 454-460 7 p.

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2 Citations (Scopus)

LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products

Tabudravu, J. N., Pellissier, L., Smith, A. J., Subko, K., Autréau, C., Feussner, K., Hardy, D., Butler, D., Kidd, R., Milton, E. J., Deng, H., Ebel, R., Salonna, M., Gissi, C., Montesanto, F., Kelly, S. M., Milne, B. F., Cimpan, G. & Jaspars, M., 2019, In : Journal of Natural Products. 82, 2, p. 211-220 10 p.

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3 Citations (Scopus)
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Legonoxamines A-B, two new hydroxamate siderophores from the soil bacterium, Streptomyces sp. MA37

Maglangit, F., Tong, M. H., Jaspars, M., Kyeremeh, K. & Deng, H., 3 Jan 2019, In : Tetrahedron Letters. 60, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Mn-Loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging

Zhou, H., Yang, H., Tang, L., Wang, Y., Li, Y., Liu, N., Zeng, X., Yan, Y., Wu, J., Chen, S., Xiao, L., Yu, Y., Deng, Z., Deng, H., Hong, X. & Xiao, Y., 21 Aug 2019, In : Journal of Materials Chemistry A. 7, 31, p. 9448-9454 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Novel electrochemical nanoswitch biosensor based on self-assembled pH-sensitive continuous circular DNA

Chen, X., Yao, L., Wang, Y. C., Chen, Q., Deng, H., Lin, Z. Y. & Yang, H. H., 15 Apr 2019, In : Biosensors and Bioelectronics. 131, p. 274-279 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

α-D-glucopyranosyl-(1→2)-[6-O-(L-tryptophanyl)-β-D-fructofuranoside]

Kyeremeh, K., Kwain, S., Tetevi, G. M., Camas, A. S., Camas, M., Dofuor, A. K., Deng, H. & Jaspars, M., 16 Jun 2019, In : MolBank. 2019, 2, 11 p., M1066.

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2018

Deletion of the epigenetic regulator GcnE in Aspergillus niger FGSC A1279 activates the production of multiple polyketide metabolites

Wang, B., Li, X., Yu, D., Chen, X., Tabudravu, J., Deng, H. & Pan, L., 31 Dec 2018, In : Microbiological Research. 217, p. 101-107 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-Dependent Reductase

Zhou, Y., Lin, X., Williams, S. R., Liu, L., Shen, Y., Wang, S-P., Sun, F., Xu, S., Deng, H., Leadlay, P. F. & Lin, H-W., 17 Aug 2018, In : ACS Chemical Biology. 13, 8, p. 2153-2160 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Paenidigyamycin A, Potent Antiparasitic Imidazole Alkaloid from the Ghanaian Paenibacillus sp. DE2SH

Osei, E., Kwain, S., Mawuli, G. T., Anang, A. K., Owusu, K. B-A., Camas, M., Camas, A. S., Ohashi, M., Alexandru-Crivac, C-N., Deng, H., Jaspars, M. & Kyeremeh, K., 24 Dec 2018, In : Marine Drugs. 17, 1, 9.

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2 Citations (Scopus)
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Profiling of secondary metabolite gene clusters regulated by LaeA in Aspergillus niger FGSC A1279 based on genome sequencing and transcriptome analysis

Wang, B., Lv, Y., Li, X., Lin, Y., Deng, H. & Pan, L., 28 Feb 2018, In : Research in Microbiology. 169, 2, p. 67-77 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2017

(±)-Hippolide J – A Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the Marine Sponge Hippospongia lachne

Jiao, W. H., Hong, L. L., Sun, J. B., Piao, S. J., Chen, G. D., Deng, H., Wang, S. P., Yang, F. & Lin, H. W., 30 Jun 2017, In : European Journal of Organic Chemistry. 2017, 24, p. 3421-3426 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Dissection of the neocarazostatin: a C4 alkyl side chain biosynthesis by in vitro reconstitution

Su, L., Zhang, R., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 14 May 2017, In : Organic & Biomolecular Chemistry. 15, 18, p. 3843-3848 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040

Sonnenschein, E. C., Stierhof, M., Goralczyk, S., Vabre, F. M., Pellissier, L., Hanssen, K. Ø., de la Cruz, M., Díaz, C., de Witte, P., Copmans, D., Andersen, J. H., Hansen, E., Kristoffersen, V., Tormo, J. R., Ebel, R., Milne, B. F., Deng, H., Gram, L., Jaspars, M. & Tabudravu, J. N., 4 May 2017, In : Tetrahedron. 73, 18, p. 2633-2637 5 p.

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7 Citations (Scopus)
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Targeted Dereplication of Microbial Natural Products by High-Resolution MS and Predicted LC Retention Time

Chervin, J., Stierhof, M., Tong, M. H., Peace, D., Hansen, K. Ø., Urgast, D. S., Andersen, J. H., Yu, Y., Ebel, R., Kyeremeh, K., Paget, V., Cimpan, G., Wyk, A. V., Deng, H., Jaspars, M. & Tabudravu, J. N., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1370-1377 8 p.

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16 Citations (Scopus)
6 Downloads (Pure)
2016

A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation

Su, L., Lv, M., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 2016, In : Organic & Biomolecular Chemistry. 14, 37, p. 8679-8684 6 p.

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10 Citations (Scopus)
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Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Ma, L., Li, Y., Meng, L., Deng, H., Li, Y., Zhang, Q. & Diao, A., 2016, In : RSC Advances. 32, 6, p. 27047-27051 5 p.

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19 Citations (Scopus)
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2015

Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps

Huang, S., Elsayed, S. S., Lv, M., Tabudravu, J., Rateb, M. E., Gyampoh, R., Kyeremeh, K., Ebel, R., Jaspars, M., Deng, Z., Yu, Y. & Deng, H., 17 Dec 2015, In : Chemistry & Biology. 22, 12, p. 1633-1642 10 p.

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18 Citations (Scopus)
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Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert

Elsayed, S. S., Trusch, F., Deng, H., Raab, A., Prokes, I., Busarakam, K., Asenjo, J. A., Andrews, B. A., van West, P., Bull, A. T., Goodfellow, M., Yi, Y., Ebel, R., Jaspars, M. & Rateb, M. E., 2015, In : Journal of Organic Chemistry. 80, 20, p. 10252-10260 9 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Discovery of a single monooxygenase catalyzing the carbamate formation and ring contraction in the biosynthesis of legonmycins

Huang, S., Tabudravu, J., Elsayed, S. S., Travert, J., Peace, D., Tong, M. H., Kyeremeh, K., Kelly, S., Trembleau, L. A. C., Ebel, R. P., Jaspars, M., Yu, Y. & Deng, H., 19 Oct 2015, In : Angewandte Chemie International Edition. 54, 43, p. 12697-12701 4 p.

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19 Citations (Scopus)
6 Downloads (Pure)

Draft Genome Sequence of Streptomyces sp. Strain CT34, Isolated from a Ghanaian Soil Sample

Zhai, Y., Cheng, B., Hu, J., Kyeremeh, K., Wang, X., Jaspars, M., Deng, H., Deng, Z-X. & Hong, K., 2015, In : Genome Announcements. 3, 1, 01508-14.

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4 Citations (Scopus)
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Enzymatic fluorination and biotechnological development of the fluorinase

O'Hagan, D. & Deng, H., 28 Jan 2015, In : Chemical Reviews. 115, 2, p. 634-649 16 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137

Huang, S., Tong, M. H., Qin, Z., Deng, Z., Deng, H. & Yu, Y., 1 Mar 2015, In : Anti-Cancer Agents in Medicinal Chemistry. 15, 3, p. 277-284 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R,3S,4S)-5-Fluoro-2,3,4-trihydroxypentanoic acid

Ma, L., Bartholome, A., Tong, M. H., Qin, Z., Yu, Y., Shepherd, T., Kyeremeh, K., Deng, H. & O’Hagan, D., 2015, In : Chemical Science. 6, 2, p. 1414-1419 6 p.

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24 Citations (Scopus)
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Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces Isolate

Rateb, M. E., Zhai, Y., Ehrner, E., Rath, C., Wang, X., Tabudravu, J., Ebel, R. P., Bibb, M., Kyeremeh, K., Dorrestein, P., Hong, K., Jaspars, M. & Deng, H., 2015, In : Organic & Biomolecular Chemistry. 13, 37, p. 9585-9592 8 p.

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17 Citations (Scopus)
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2014

Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310

Kyeremeh, K., Acquah, K., Sazak, A., Houssen, W. E., Tabudravu, J., Deng, H. & Jaspars, M., 14 Feb 2014, In : Marine Drugs. 12, 2, p. 999-1012 13 p., 12.

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31 Citations (Scopus)
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Butrepyrazinone, a New Pyrazinone with an Unusual Methylation Pattern from a Ghanaian Verrucosispora sp. K51G

Kyeremeh, K., Acquah, K., Camas, M., Tabudravu, J., Houssen, W. E., Deng, H. & Jaspars, M., 16 Oct 2014, In : Marine Drugs. 12, 10, p. 5197-5208 12 p.

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19 Citations (Scopus)
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Disruption of a methyltransferase gene in actinomycin G gene cluster in Streptomyces iakyrus increases the production of phenazinomycin

Qin, Z., Wang, X., Rateb, M., Ass'ad, L. A., Jaspars, M., Deng, Z., Yu, Y. & Deng, H., Mar 2014, In : FEMS Microbiology Letters. 352, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

Huang, S., Ma, L., Tong, M. H., Yu, Y., O'Hagan, D. & Deng, H., 21 Jul 2014, In : Organic & Biomolecular Chemistry. 27, 12, p. 4828-4831 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Identification of Fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by Genome Mining

Deng, H., Ma, L., Bandaranayaka, N., Qin, Z., Mann, G., Kyeremeh, K., Yu, Y., Shepherd, T., Naismith, J. & O'Hagan, D., 10 Feb 2014, In : ChemBioChem. 15, 3, p. 364-368 5 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2013

Dithiolopyrrolone Natural Products: Isolation, Synthesis and Biosynthesis

Qin, Z., Huang, S., Yu, Y. & Deng, H., 17 Oct 2013, In : Marine Drugs. 11, 10, p. 3970-3997 28 p.

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27 Citations (Scopus)
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Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

Wang, X., Tabudravu, J., Rateb, M., Annand, K. J., Qin, Z., Jaspars, M., Deng, Z., Yu, Y. & Deng, H., Jun 2013, In : Molecular BioSystems. 9, 6, p. 1286-1289 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
7 Citations (Scopus)

The fish pathogen Yersinia ruckeri produces holomycin and uses an RNA methyltransferase for self-resistance

Qin, Z., Baker, A. T., Raab, A., Huang, S., Wang, T., Yu, Y., Jaspars, M., Secombes, C. J. & Deng, H., 24 May 2013, In : The Journal of Biological Chemistry. 288, 21, p. 14688-14697 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2 Downloads (Pure)

Tianchimycins A-B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis

Wang, X., Tabudravu, J., Jaspars, M. & Deng, H., 29 Jul 2013, In : Tetrahedron. 69, 30, p. 6060-6064 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2011

Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp

Rateb, M. E., Houssen, W. E., Arnold, M., Abdelrahman, M. H., Deng, H., Harrison, W. T. A., Okoro, C. K., Asenjo, J. A., Andrews, B. A., Ferguson, G., Bull, A. T., Goodfellow, M., Ebel, R. & Jaspars, M., Jun 2011, In : Journal of Natural Products. 74, 6, p. 1491-1499 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)