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Research Output 2003 2019

2019
4 Downloads (Pure)

Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids

Khatib, T., Marini, P., Nunna, S., Chisholm, D. R., Whiting, A., Redfern, C., Greig, I. R. & McCaffery, P., 2 May 2019, In : Cell Communication and Signaling. 17, 16 p., 40.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Retinoids
Tretinoin
Assays
Retinoic Acid Receptors

Synthetic Retinoids for Use in RAR Mediated Conditions

Whiting, A., Chisholm, D., Valentine, R., Greig, I. R., McCaffery, P. J. A. & Alkhatib, T., 18 Apr 2019, IPC No. C07C 63/66, A61K 31/192, A61K 31/203, A61P 25/28, C07D 209/82, C07D 215/06, European Patent Office, Patent No. WO2017174999, Priority date 6 Apr 2017, Priority No. 2017050977

Research output: Patent

Retinoids
1 Citation (Scopus)

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)

Tseng, C-C., Baillie, G., Donvito, G., Mustafa, M. A., Juola, S. E., Zanato, C., Massarenti, C., Dall'angelo, S., Harrison, W. T. A., Lichtman, A. H., Ross, R. A., Zanda, M. & Greig, I. R., 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5049-5062 14 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Allosteric Site
Neuralgia
Pharmaceutical Preparations
Binding Sites
2018
1 Citation (Scopus)
5 Downloads (Pure)

Effects of glycol-split low molecular weight heparin on placental, endothelial, and anti-inflammatory pathways relevant to preeclampsia

Wat, J. M., Hawrylyshyn, K., Baczyk, D., Greig, I. R. & Kingdom, J. C., 1 Nov 2018, In : Biology of Reproduction. 99, 5, p. 1082-1090 9 p.

Research output: Contribution to journalArticle

Open Access
File
Dalteparin
Glycols
Low Molecular Weight Heparin
Pre-Eclampsia
Heparin
5 Citations (Scopus)
4 Downloads (Pure)

Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons

Mitjavila, J., Yin, D., Kulkarni, P. M., Zanato, C., Thakur, G. A., Ross, R., Greig, I., Mackie, K. & Straiker, A., Mar 2018, In : Pharmacological Research. 129, p. 475-481 7 p.

Research output: Contribution to journalArticle

Open Access
File
Cannabinoids
Cannabinoid Receptor CB1
Neurons
Ligands
Neuronal Plasticity
2 Citations (Scopus)
4 Downloads (Pure)

Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics

Tyagi, R., Maddirala, A. R., Elfawal, M., Fischer, C., Bulman, C. A., Rosa, B. A., Gao, X., Chugani, R., Zhou, M., Helander, J., Brindley, P. J., Tseng, C-C., Greig, I. R., Sakanari, J., Wildman, S. A., Aroian, R., Janetka, J. W. & Mitreva, M., 13 Jul 2018, In : ACS Infectious Diseases. 4, 7, p. 1130–1145 16 p.

Research output: Contribution to journalArticle

Open Access
File
Anthelmintics
Enzyme Inhibitors
Carnitine O-Palmitoyltransferase
Parasitic Diseases
Drug Discovery
2017
2 Citations (Scopus)
4 Downloads (Pure)

Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

Tseng, C-C., Noordali, H., Sani, M., Madhani, M., Grant, D. M., Frenneaux, M., Zanda, M. & Greig, I. R., 13 Apr 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 2780-2789 10 p.

Research output: Contribution to journalArticle

Open Access
File
Perhexiline
Pharmacokinetics
Cytochrome P-450 CYP2D6
Cardiovascular Agents
Fluorine

Synthetic retinoids for use in RAR mediated conditions

Greig, I. R., McCaffery, P. J. A., Whiting, A., Valentine, R., Chisholm, D. & Khatib, T., 12 Oct 2017, Patent No. WO2017174999

Research output: Patent

Retinoids
2016
4 Citations (Scopus)
4 Downloads (Pure)

Asymmetric Synthesis and Absolute Configuration of (+)- and (–)-Perhexiline

Tseng, C-C., Greig, I. R., Harrison, W. T. A. & Zanda, M., Jan 2016, In : Synthesis. 48, 01, p. 73-78 6 p.

Research output: Contribution to journalArticle

Open Access
File
Perhexiline
Enantiomers
Stereochemistry
X ray crystallography
9 Citations (Scopus)
6 Downloads (Pure)

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Greig, I. R., Baillie, G. L., Abdelrahman, M., Trembleau, L. & Ross, R. A., 15 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 18, p. 4403-4407 5 p.

Research output: Contribution to journalArticle

Open Access
File
Cannabinoid Receptors
Pulse amplitude modulation
Pharmacokinetics
Cannabinoids
Sulfonamides
2015
52 Citations (Scopus)
7 Downloads (Pure)

A Cannabinoid CB 1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects

Ignatowska-Jankowska, B. M., Baillie, G. L., Kinsey, S., Crowe, M., Ghosh, S., Owens, R. A., Damaj, I. M., Poklis, J., Wiley, J. L., Zanda, M., Zanato, C., Greig, I. R., Lichtman, A. H. & Ross, R. A., Dec 2015, In : Neuropsychopharmacology. 40, 13, p. 2948-2959 12 p.

Research output: Contribution to journalArticle

Open Access
File
Cannabinoid Receptor CB1
Cannabinoids
Neuralgia
Arrestin
Catalepsy
3 Citations (Scopus)

HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction

Poklis, J. L., Clay, D. J., Ignatowska-Jankowska, B. M., Zanato, C., Ross, R. A., Greig, I. R., Abdullah, R. A., Mustafa, M. A., Lichtman, A. H. & Poklis, A., 1 Jun 2015, In : Journal of analytical toxicology. 39, 5, p. 353-359 7 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
brain
Brain
High Pressure Liquid Chromatography
Pharmacology
7 Citations (Scopus)

Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice

Coste, E., Greig, I. R., Mollat, P., Rose, L., Gray, M., Ralston, S. H. & van 't Hof, R. J., 1 Jan 2015, In : Annals of the Rheumatic Diseases. 74, 1, p. 220-226 7 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Rheumatoid Arthritis
Bone
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
8 Citations (Scopus)

Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Apr 2015, In : Behavioural Pharmacology. 26, 3, p. 289-303 15 p.

Research output: Contribution to journalArticle

Sleep
Food
Endocannabinoids
REM Sleep
Arousal
5 Citations (Scopus)
8 Downloads (Pure)

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism

Menzfeld, C., John, M., van Rossum, D., Regen, T., Scheffel, J., Janova, H., Götz, A., Ribes, S., Nau, R., Borisch, A., Boutin, P., Neumann, K., Bremes, V., Wienands, J., Reichardt, H. M., Lühder, F., Tischner, D., Waetzig, V., Herdegen, T., Teismann, P. & 10 othersGreig, I., Müller, M., Pukrop, T., Mildner, A., Kettenmann, H., Brück, W., Prinz, M., Rotshenker, S., Weber, M. S. & Hanisch, U-K., Jun 2015, In : Glia. 63, 6, p. 1083-1099 17 p.

Research output: Contribution to journalArticle

Open Access
File
Tyrphostins
Inflammation
Toll-Like Receptors
Autoimmune Experimental Encephalomyelitis
Microglia
2014

Fluoro-perhexiline compounds and their therapeutic use

Greig, I. R., Tseng, C-C. & Zanda, M., 30 Oct 2014, Patent No. WO2014184561

Research output: Patent

33 Citations (Scopus)

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In : Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Pharmacology
rimonabant
Dronabinol
Appetite Depressants
2013

18f-labelled barbiturate compounds for use as positron emission imaging agents

Greig, I. R., Zanda, M., Platt, B. & Calamai, E., 21 Mar 2013, Patent No. WO2013038153

Research output: Patent

Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use

Greig, I. R., Sheridan, R. M., Fisher, R., Tozer, M. J., Clase, J. A., Smith, A., Tufnell, A. R. & van 't Hof, R. J., 19 Sep 2013, Patent No. US2013245018

Research output: Patent

Bone and Bones
Rheumatoid Arthritis
Anistreplase
Bone Neoplasms
Psoriatic Arthritis
8 Citations (Scopus)

Development of triarylsulfonamides as novel anti-inflammatory agents

Greig, I. R., Emmanuel, C., Ralston, S. & van 't Hof, R., Feb 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 3, p. 816-820 5 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Inflammation
ABD455
In Vitro Techniques
22 Citations (Scopus)

Synthesis and structure–activity relationship studies of novel tubulysin U analogues – effect on cytotoxicity of structural variations in the tubuvaline fragment

Shankar, S. P., Jagodzinska, M., Malpezzi, L., Lazzari, P., Manca, I., Greig, I. R., Sani, M. & Zanda, M., 1 Apr 2013, In : Organic & Biomolecular Chemistry. 11, 14, p. 2273-2287 15 p.

Research output: Contribution to journalArticle

Cytotoxicity
fragments
analogs
synthesis
HT29 Cells
2012
65 Citations (Scopus)

Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

Anavi-Goffer, S., Baillie, G., Irving, A., Gertsch, J., Greig, I. R., Pertwee, R. G. & Ross, R. A., 2 Jan 2012, In : The Journal of Biological Chemistry. 287, 1, p. 91-104 15 p.

Research output: Contribution to journalArticle

2011

N-(ARYLALKYL)-1H-INDOLE-2-SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

Greig, I. R., Ross, R. A., Trembleau, L. A. C., Pertwee, R. G. & Abdelrahman, M. H., 28 Feb 2011, IPC No. WO2012117216, Patent No. WO2012117216

Research output: Patent

Cannabinoid Receptors
Sulfonic Acids
Cannabinoids
Therapeutic Uses
Amides
2010

1,5-Diaryl-pyrazoles and their use as cannabinoid receptor neutral antagonists

Greig, I. R. & Ross, R. A., 25 Feb 2010, IPC No. WO2010020762, Patent No. WO2010020762

Research output: Patent

Pyrazoles
Cannabinoid Receptor Antagonists
Cannabinoid Receptors
Breast Neoplasms
Smoking

Aryl-phenyl-sulfonamide-cycloalkyl compounds and their use

Greig, I. R., Clase, J. A., Fisher, R., Sheridan, R. M., Smith, A., Tozer, M. J. & Tufnell, A. R., 25 Mar 2010, IPC No. WO2010/032009 , Patent No. WO2010/032009

Research output: Patent

2 Downloads (Pure)

Aryl-phenyl-sulfonamide-phenylene compounds and their use

Greig, I. R., Clase, J. A., Fisher, R., Sheridan, R. M., Smith, A., Tozer, M. J., Tufnell, A. R. & van 't Hof, R. J., 25 Mar 2010, IPC No. WO2010/032010, Patent No. WO2010/032010

Research output: Patent

File
Sulfonamides
Bone and Bones
Rheumatoid Arthritis
Bone Neoplasms
Psoriatic Arthritis
3 Citations (Scopus)

Discovery of biphenylketones as dual modulators of inflammation and bone loss

Greig, I. R., Coste, E., Ralston, S. H. & van't Hof, R. J., 15 Sep 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 18, p. 5548-5551 4 p.

Research output: Contribution to journalArticle

Osteitis
Osteoclasts
Modulators
Inhibitory Concentration 50
Bone
7 Citations (Scopus)

The biphenyl-carboxylate derivative ABD328 is a novel orally active antiresorptive agent

Idris, A. I., Coste, E., Greig, I. R., Ralston, S. H. & van't Hof, R. J., Dec 2010, In : Calcified Tissue International. 87, 6, p. 525-532 8 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Ketones
Osteoclasts
Osteoblasts
Bone and Bones
2009
10 Citations (Scopus)

Identification of novel biphenyl carboxylic acid derivatives as novel antiresorptive agents that do not impair parathyroid hormone-induced bone formation

Idris, A. I., Greig, I. R., Bassonga-Landao, E., Ralston, S. H. & van't Hof, R. J., 1 Jan 2009, In : Endocrinology. 150, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Osteoclasts
Carboxylic Acids
Parathyroid Hormone
Osteogenesis

Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions

Greig, I. R., Ralston, S., Idris, A. I. & Van't Hof, R. J., 2009, Patent No. US7598289

Research output: Patent

Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives

Greig, I. R., Teismann, P., Hanisch, U-K. & Bruck, W., 16 Sep 2009, IPC No. GB2458259, Patent No. GB2458259

Research output: Patent

Derivatives
Hydrogen
Neurodegenerative diseases
Chemical analysis
Pharmaceutical Preparations
2008

1,5-diaryl-pyrazoles as cannabinoid receptor neutral antagonists useful as therapeutic agents

Greig, I. R., Ross, R. A. & Pertwee, R. G., 21 Aug 2008, IPC No. A61K31/415; A61P29/00; C07D231/12; , Patent No. WO2008/099139

Research output: Patent

Pyrazoles
Cannabinoid Receptor Antagonists
Cognition
Smoking
Osteitis Deformans

2',4'-Dichloro-biphenyl-4-yl-hydroxyketones and related compounds and their use as therapeutic agents

Greig, I. R., Van T Hof, R. J. & Ralston, S., 11 Sep 2008, IPC No. US20080221220, Patent No. US20080221220

Research output: Patent

17 Citations (Scopus)

ABD56 causes osteoclast apoptosis by inhibiting the NFkappaB and ERK pathways

Idris, A. I., Mrak, E., Greig, I. R., van't Hof, R. J. & Ralston, S. H., 20 Jun 2008, In : Biochemical and Biophysical Research Communications. 371, 1, p. 94-98 4 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro

Idris, A. I., Rojas-Navea, J., Greig, I. R., van't Hof, R. J. & Ralston, S., Mar 2008, In : Calcified Tissue International. 82, 3, p. 191-201 11 p.

Research output: Contribution to journalArticle

Biphenyl-4-yl-sulfonic acid arylamines and their use as therapeutic agents

Greig, I. R., van't Hof, R. J. & Ralston, S., 2008, Patent No. WO2008/114022

Research output: Patent

Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions

Greig, I. R., Ralston, S., Van T Hof, R. J. & Mohamed, A. I. I., 18 Dec 2008, IPC No. US7598289, Patent No. US7598289

Research output: Patent

2006
14 Citations (Scopus)

Development and Characterization of Biphenylsulfonamides as Novel Inhibitors of Bone Resorption

Greig, I. R., Idris, A. I., Ralston, S. H. & van't Hof, R. J., Nov 2006, In : Journal of Medicinal Chemistry. 49, 25, p. 7487-7492 6 p.

Research output: Contribution to journalArticle

2005
232 Citations (Scopus)

Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors

Idris, A. I., van't Hof, R. J., Greig, I. R., Ridge, S., Baker, D., Ross, R. A. & Ralston, S. H., Jul 2005, In : Nature Medicine. 11, 7, p. 774-779 5 p.

Research output: Contribution to journalArticle

2004

Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders

Greig, I. R., Mohamed, A. I. I., Ralston, S., Ross, R. A. & Van T Hof, R. J., 2004, Patent No. WO2004/078261

Research output: Patent

15 Citations (Scopus)

Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors

van't Hof, R. J., Idris, A. I., Ridge, S., Dunford, J. E., Greig, I. R. & Ralston, S., Oct 2004, In : Journal of Bone and Mineral Research. 19, 10, p. 1651-1660 9 p.

Research output: Contribution to journalArticle

Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions

Ralston, S., Greig, I. R., Mohamed, A. I. I. & van't Hof, R. J., 2004, Patent No. WO2004/098582 A2; Publication date 18 November 2004

Research output: Patent

2003

Alkane diol derivatives as therapeutic agents for the treatment of bone conditions

Ralston, S., Greig, I. R., van't Hof, R. J. & Armour, K. E., 2003, Patent No. WO 03/037321 A1; Publication 8 May 2003

Research output: Patent