• 1611 Citations
1993 …2019
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Research Output 1993 2019

  • 1611 Citations
  • 45 Article
  • 2 Editorial
  • 1 Literature review
  • 1 Review article
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Article
2019
3 Citations (Scopus)

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

Lowe, P. T., Dall'Angelo, S., Fleming, I. N., Piras, M., Zanda, M. & O'Hagan, D., 2019, In : Organic & Biomolecular Chemistry. 17, 6, p. 1480-1486 7 p.

Research output: Contribution to journalArticle

Open Access
File
antigens
Ligands
membranes
ligands
cancer
2018
6 Citations (Scopus)
7 Downloads (Pure)
Open Access
File
Integrins
Mitogen-Activated Protein Kinase Kinases
Talin
Pharmacology
Glioblastoma

Two Years On: How the Core Curriculum has Shaped Pharmacology Courses at the University of Aberdeen

Tucker, S., Fleming, I. N., Hislop, J. N., Murray, F., Scott, D. A. & Wallace, H. M., 2018, Pharmacology Matters, 11, 3, p. 5-7 3 p.

Research output: Contribution to specialist publicationArticle

pharmacology
curriculum
quality assurance
resources
education
2017
1 Citation (Scopus)
5 Downloads (Pure)

Design and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery

Piras, M., Andriu, A., Testa, A., Wienecke, P., Fleming, I. N. & Zanda, M., 2017, In : Synlett. 28, 20, p. 2769-2776 8 p.

Research output: Contribution to journalArticle

Open Access
File
Peptidomimetics
Paclitaxel
Drug delivery
Integrins
Tumors
4 Citations (Scopus)
6 Downloads (Pure)

High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

Piras, M., Testa, A., Fleming, I. N., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G. D., Forster, D., Williams, K. J. & Zanda, M., 20 Jul 2017, In : ChemMedChem. 12, 14, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

Open Access
File
Peptidomimetics
Integrins
Tumors
Pharmacodynamics
Click Chemistry
7 Downloads (Pure)

KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

Lazzari, P., Spiga, M., Sani, M., Zanda, M. & Fleming, I. N., 23 May 2017, In : Hypoxia. 5, p. 45-59 15 p.

Research output: Contribution to journalArticle

Open Access
File
tirapazamine
NADPH-Ferrihemoprotein Reductase
Down-Regulation
Oxidoreductases
Neoplasms
2016
10 Citations (Scopus)
5 Downloads (Pure)

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

Thompson, S., Fleming, I. N. & O’Hagan, D., 21 Mar 2016, In : Organic & Biomolecular Chemistry. 14, 11, p. 3120-3129 10 p.

Research output: Contribution to journalArticle

Open Access
File
peptides
Peptides
Cyclic Peptides
cargo
Scaffolds
13 Citations (Scopus)
5 Downloads (Pure)

Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers

Zhang, Q., Dall'Angelo, S., Fleming, I. N., Schweiger, L. F., Zanda, M. & O'Hagan, D., 25 Jul 2016, In : Chemistry : a European Journal. 22, 31, p. 10998-11004 7 p.

Research output: Contribution to journalArticle

Open Access
File
Fluorination
Peptides
Cysteine
Sulfur
Integrins
14 Citations (Scopus)
5 Downloads (Pure)

NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting

Graziadio, A., Zanda, M., Frau, S., Fleming, I. N., Musolino, M., Dall'Angelo, S., Baldassarre, M. & Piras, M., 18 May 2016, In : Bioconjugate Chemistry. 27, 5, p. 1332-1340 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclic Peptides
Peptides
Tumors
Neoplasms
Cells
12 Citations (Scopus)
5 Downloads (Pure)

Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3

Phyu, S. M., Tseng, C-C. T., Fleming, I. N. & Smith, T. A. D., 4 Nov 2016, In : Scientific Reports. 6, 36544.

Research output: Contribution to journalArticle

Open Access
File
Glycogen Synthase Kinase 3
Phosphatidylinositol 3-Kinases
Magnetic Resonance Spectroscopy
Glycogen Synthase
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
2015
16 Citations (Scopus)
5 Downloads (Pure)

A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography

Thompson, S., Onega, M., Ashworth, S., Fleming, I. N., Passchier, J. & O'Hagan, D., 2015, In : Chemical Communications. 51, 70, p. 13542-13545 4 p.

Research output: Contribution to journalArticle

Open Access
File
Positron emission tomography
Labeling
Peptides
Enzymes
Azides
10 Citations (Scopus)
10 Downloads (Pure)
Open Access
File
Metformin
Deoxyglucose
Doxorubicin
Anti-Idiotypic Antibodies
Breast Neoplasms
5 Citations (Scopus)

The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2

Lamidi, O., Sani, M., Lazzari, P., Zanda, M. & Fleming, I. N., Sep 2015, In : Journal of Cancer Research and Clinical Oncology. 141, 9, p. 1575-1583 9 p.

Research output: Contribution to journalArticle

Apoptosis
Breast Neoplasms
G2 Phase
Cell Division
Cell Cycle
2014
28 Citations (Scopus)

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions

Thompson, S., Zhang, Q., Onega, M., McMahon, S., Fleming, I., Ashworth, S., Naismith, J. H., Passchier, J. & O'Hagan, D., 18 Aug 2014, In : Angewandte Chemie International Edition. 53, 34, p. 8913-8918 6 p.

Research output: Contribution to journalArticle

Acetylene
Fluorination
Peptides
Enzymes
Positron emission tomography
10 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
Fluorodeoxyglucose F18
Breast Neoplasms
Glucose
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Drug Delivery Systems
5 Citations (Scopus)

Multifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles

Testa, A., Piras, M., Hickey, M. J., Fleming, I. N., Bushby, N., Lenz, E., Elmore, C. S. & Zanda, M., Apr 2014, In : Synlett. 25, 07, p. 1019-1025 7 p.

Research output: Contribution to journalArticle

Molecular imaging
Molecular Probes
Tritium
Deuterium
Palladium
3 Citations (Scopus)

Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

Nortcliffe, A., Fleming, I. N., Botting, N. P. & O'Hagan, D., 4 Nov 2014, In : Tetrahedron. 70, 44, p. 8343-8347 5 p.

Research output: Contribution to journalArticle

Functional groups
Nitric Oxide
Integrins
MCF-7 Cells
Cytotoxicity
35 Citations (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., McKiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H. I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Matula, K. M. & 1 others, Petty, R. D., 18 Mar 2014, In : British Journal of Cancer. 110, 6, p. 1525-1534 10 p.

Research output: Contribution to journalArticle

Leptin
Adenocarcinoma
Drug Therapy
Neoplasms
Cell Line
2013
20 Citations (Scopus)
40 Downloads (Pure)
Open Access
File
ribose
Positron emission tomography
Ribose
Integrins
Positron-Emission Tomography
14 Citations (Scopus)

Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase

Smith, T. A. D., Zanda, M. & Fleming, I. N., Aug 2013, In : Nuclear Medicine and Biology. 40, 6, p. 858-864 7 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Cell Hypoxia
AMP-Activated Protein Kinases
Fluorodeoxyglucose F18
Breast Neoplasms
15 Citations (Scopus)

Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR detectable phosphomonesters

Smith, T. A. D., Appleyard, M. V. C. L., Sharp, S., Fleming, I. N., Murray, K. & Thompson, A. M., Feb 2013, In : Cancer Chemotherapy and Pharmacology. 71, 2, p. 473-480 8 p.

Research output: Contribution to journalArticle

2012
1 Citation (Scopus)

Building PET research collaborations

Fleming, I. N., Gilbert, F. J. & Blower, P. J., Jan 2012, In : Nuclear Medicine Communications. 33, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Research
Equipment and Supplies
Neoplasms
17 Citations (Scopus)

Linear Trifluoroethylamine RGD Peptidomimetics: Stereoselective Synthesis and Integrin alphavbeta3 affinity

Piras, M., Fleming, I. N., Harrison, W. T. A. & Zanda, M., 2012, In : Synlett. 23, 20, p. 2899-2902 4 p.

Research output: Contribution to journalArticle

Integrin alphaVbeta3
Peptidomimetics
Peptides
Integrins
Assays
4 Citations (Scopus)

Positron emission tomography oncology research in the UK: a comparison with USA and Europe

Fleming, I. N., Regel, S. J., Pike, L. C., Marsden, P. K. & Gilbert, F. J., Apr 2012, In : Nuclear Medicine Communications. 33, 4, p. 341-348 8 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Research
Fluorodeoxyglucose F18
Multicenter Studies
Delivery of Health Care
5 Citations (Scopus)

Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers

Fleming, I. N., Whelan, M., Baxendale, R., Gilbert, F. J., Matthews, P. P. & Aigbirhio, F. I., Sep 2012, In : Nuclear Medicine Communications. 33, 9, p. 899-906 8 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Positron-Emission Tomography
Research Personnel
Language
Clinical Trials
13 Citations (Scopus)

Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

Aboagye, E. O., Gilbert, F. J., Fleming, I. N., Beer, A. J., Cunningham, V. J., Marsden, P. K., Visvikis, D., Gee, A. D., Groves, A. M., Kenny, L. M., Cook, G. J., Kinahan, P. E., Myers, M., Clarke, L. & Experimental Cancer Medicine Centre 13 Imaging Network Group, 1 Jul 2012, In : European Radiology. 22, 7, p. 1465-1478 14 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Clinical Trials
Neoplasms
Integrins
Perfusion
2010
20 Citations (Scopus)

Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types

Green, S. R., Choudhary, A. K. & Fleming, I. N., Nov 2010, In : British Journal of Cancer. 103, 9, p. 1391-1399 9 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Cell Death
Cytosine
Heterografts
Neoplasms
10 Citations (Scopus)

Opportunities for PET to deliver clinical benefit in cancer: breast cancer as a paradigm

Fleming, I. N., Gilbert, F. J., Miles, K. A. & Cameron, D., 6 Jul 2010, In : Cancer Imaging. 10, 1, p. 144-152 9 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Breast Neoplasms
Neoplasms
Residual Neoplasm
Cell Biology
2008
19 Citations (Scopus)

Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents

Fleming, I. N., Hogben, M., Frame, S., McClue, S. J. & Green, S. R., 2008, In : Clinical Cancer Research. 14, 13, p. 4326-4335 10 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
ErbB Receptors
roscovitine
2005
23 Citations (Scopus)

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups

Downes, C. P., Gray, A., Fairservice, A., Safrany, S. T., Batty, I. H. & Fleming, I. N., Dec 2005, In : Biochemical Society Transactions. 33, Pt 6, p. 1303-1307 5 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Cytosol
Membranes
Ligands
Proteins
2004
137 Citations (Scopus)

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., Fleming, I. N., Green, S. R., McNae, I., Wu, S-Y., McInnes, C., Zheleva, D., Walkinshaw, M. D. & Fischer, P. M., 25 Mar 2004, In : Journal of Medicinal Chemistry. 47, 7, p. 1662-1675 14 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
X Ray Crystallography
Structure-Activity Relationship
pyrimidine
Adenosine Triphosphate
53 Citations (Scopus)

Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

Watt, S. A., Kimber, W. A., Fleming, I. N., Leslie, N. R., Downes, C. P. & Lucocq, J. M., 1 Feb 2004, In : Biochemical Journal. 377, 3, p. 653-663 11 p.

Research output: Contribution to journalArticle

Immunoelectron Microscopy
Phosphatidylinositols
Microscopic examination
Proteins
Lipids
36 Citations (Scopus)

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Fleming, I. N., Batty, I. H., Prescott, A. R., Gray, A., Kular, G. S., Stewart, H. & Downes, C. P., 15 Sep 2004, In : Biochemical Journal. 382, 3, p. 857-865 9 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Cell membranes
Phosphatidylinositols
Guanosine Triphosphate
Cell Membrane
17 Citations (Scopus)
Somatomedin Receptors
1-Phosphatidylinositol 4-Kinase
Astrocytoma
Muscarinic Receptors
Somatomedins
2002
276 Citations (Scopus)

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1

Watt, S. A., Kular, G., Fleming, I. N., Downes, C. P. & Lucocq, J. M., 2002, In : Biochemical Journal. 363, Pt 3, p. 657-66 10 p.

Research output: Contribution to journalArticle

Phospholipase C delta
Phosphatidylinositols
Labeling
Cell membranes
thrombin receptor peptide SFLLRNP
2000
98 Citations (Scopus)

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

Fleming, I. N., Gray, A. & Downes, C. P., 2000, In : Biochemical Journal. 351, Pt 1, p. 173-82 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphotransferases
Swiss 3T3 Cells
Lipids
1999
125 Citations (Scopus)

Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

Fleming, I. N., Elliott, C. M., Buchanan, F. G., Downes, C. P. & Exton, J. H., 1999, In : The Journal of Biological Chemistry. 274, 18, p. 12753-8 6 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Proteins
Protein Kinases
Protein Kinase C
1998
66 Citations (Scopus)

Determination of interaction sites on the small G protein RhoA for phospholipase D

Bae, C. D., Min, D. S., Fleming, I. N. & Exton, J. H., 1998, In : The Journal of Biological Chemistry. 273, 19, p. 11596-604 9 p.

Research output: Contribution to journalArticle

Phospholipase D
Monomeric GTP-Binding Proteins
Chemical activation
Switches
Amino Acids
35 Citations (Scopus)
Phospholipase C gamma
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Platelet-Derived Growth Factor
Protein Kinase C
1997
65 Citations (Scopus)

Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C

Fleming, I. N., Elliott, C. M., Collard, J. G. & Exton, J. H., 1997, In : The Journal of Biological Chemistry. 272, 52, p. 33105-10 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Threonine
Fibroblasts
Protein Kinase C
Chemical activation
1996
133 Citations (Scopus)

Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor

Fleming, I. N., Elliott, C. M. & Exton, J. H., 1996, In : The Journal of Biological Chemistry. 271, 51, p. 33067-73 7 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
GTP Phosphohydrolases
Platelet-Derived Growth Factor
Endothelin-1
Membranes
1995
41 Citations (Scopus)

Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver

Fleming, I. N. & Yeaman, S. J., 1995, In : Biochemical Journal. 308 ( Pt 3), p. 983-9 7 p.

Research output: Contribution to journalArticle

Phosphatidate Phosphatase
Ethylmaleimide
Liver
Purification
Rats
17 Citations (Scopus)
Phosphatidate Phosphatase
Ethylmaleimide
Brain
Enzymes
Phosphatidic Acids
1993

Partial purification of cell-signalling phosphatidic acid phosphohydrolase from rat liver

Fleming, I. N. & Yeaman, S. J., 1993, In : Biochemical Society Transactions. 21, 4, p. 366S

Research output: Contribution to journalArticle

35 Citations (Scopus)

The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings

Day, C. P., James, O. F., Brown, A. S., Bennett, M. K., Fleming, I. N. & Yeaman, S. J., 1993, In : Hepatology. 18, 4, p. 832-8 7 p.

Research output: Contribution to journalArticle

Phosphatidate Phosphatase
Alcoholic Fatty Liver
Ethylmaleimide
Liver
Biliary Liver Cirrhosis