• 1919 Citations
20042020

Research output per year

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Research Output

  • 1919 Citations
  • 34 Article
  • 2 Literature review
  • 1 Editorial
2020

Ablation of Bscl2/Seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Mcilroy, G. D., Mitchell, S. E., Han, W., Delibegović, M. & Rochford, J. J., 17 Jan 2020, In : Disease Models & Mechanisms. 13, 1, 10 p., dmm042655.

Research output: Contribution to journalArticle

Open Access
File
3 Downloads (Pure)

Neurochemical characterization of brainstem Pro-opiomelanocortin cells

Georgescu, T., Lyons, D., Doslikova, B., Garcia, A. P., Marston, O., Burke, L. K., Chianese, R., Lam, B. Y. H., Yeo, G. S. H., Rochford, J. J., Garfield, A. S. & Heisler, L. K., Apr 2020, In : Endocrinology. 161, 4, p. 1-13 13 p., bqaa032.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)

Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation

Sim, M. F. M., Persiani, E., Talukder, M. M. U., McIlroy, G., Roumane, A., Edwardson, J. M. & Rochford, J., 24 Feb 2020, In : Scientific Reports. 10, 3259.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)
2019

Discovering metabolic disease gene interactions by correlated effects on cellular morphology

Jiao, Y., Ahmed, U., Sim, M. F. M., Bejar, A., Zhang, X., Talukder, M. M. U., Rice, R., Flannick, J., Podgornaia, A. I., Reilly, D. F., Engreitz, J. M., Kost-Alimova, M., Hartland, K., Mercader, J-M., Georges, S., Wagh, V., Tadin-Strapps, M., Doench, J. G., Edwardson, J. M., Rochford, J. J. & 2 others, Rosen, E. D. & Majithia, A. R., Jun 2019, In : Molecular Metabolism. 24, p. 108-119 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
5 Downloads (Pure)

Promethin is a Conserved Seipin Partner Protein

Castro, I. G., Eisenberg-Bord, M., Persiani, E., Rochford, J. J., Schuldiner, M. & Bohnert, M., Mar 2019, In : Cells. 8, 3, 268.

Research output: Contribution to journalArticle

Open Access
File
7 Downloads (Pure)

The burden of metabolic syndrome on osteoarthritic joints

Dickson, B. M., Roelofs, A. J., Rochford, J. J., Wilson, H. M. & de Bari, C., 16 Dec 2019, In : Arthritis Research & Therapy. 21, 289.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)
2018

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

McIlroy, G. D., Suchacki, K., Roelofs, A. J., Yang, W., Fu, Y., Bai, B., Wallace, R. J., de Bari, C., Cawthorn, W. P., Han, W., Delibegovic, M. & Rochford, J. J., Apr 2018, In : Molecular Metabolism. 10, p. 55-65 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
10 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
6 Downloads (Pure)

Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake

d'Agostino, G., Lyons, D., Cristiano, C., Lettieri, M., Olarte-Sanchez, C., Burke, L. K., Greenwald-Yarnell, M., Cansell, C., Doslikova, B., Georgescu, T., Blanco Martinez de Morentin, P., Myers Jr., M. G., Rochford, J. J. & Heisler, L., 2 Oct 2018, In : Cell Metabolism. 28, 4, p. 619.-630.e5 18 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
6 Downloads (Pure)
2017

Lorcaserin improves glycemic control via a melanocortin neurocircuit

Burke, L. K., Ogunnowo-Bada, E., Georgescu, T., Cristiano, C., Martinez De Morentin, P. B., Valencia-Torres, L., D'Agostino, G., Riches, C., Heeley, N., Ruan, Y., Rubinstein, M., Low, M. J., Myers, M. G., Rochford, J. J., Evans, M. L. & Heisler, L. K., Oct 2017, In : Molecular Metabolism. 6, 10, p. 1092-1102 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
9 Downloads (Pure)
2016

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

Burke, L. K., Doslikova, B., D'Agostino, G., Greenwald-Yarnell, M., Georgescu, T., Chianese, R., Martinez de Morentin, P. B., Ogunnowo-Bada, E., Cansell, C., Valencia-Torres, L., Garfield, A. S., Apergis-Schoute, J., Lam, D. D., Speakman, J. R., Rubinstein, M., Low, M. J., Rochford, J. J., Myers, M. G., Evans, M. L. & Heisler, L. K., Mar 2016, In : Molecular Metabolism. 5, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

Open Access
File
35 Citations (Scopus)
7 Downloads (Pure)
2015

Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

Talukder, M. M. U., Sim, M. F. M., O'Rahilly, S., Edwardson, J. M. & Rochford, J. J., Mar 2015, In : Molecular Metabolism. 4, 3, p. 199-209 11 p.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
8 Downloads (Pure)
2014

Analyzing the functions and structure of the human lipodystrophy protein seipin

Sim, M. F. M., Talukder, M. M. U., Dennis, R. J., Edwardson, J. M. & Rochford, J. J., 2014, In : Methods in Enzymology. 537, p. 161-175 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
4 Citations (Scopus)
2013

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms

Sim, M. F. M., Talukder, M. M. U., Dennis, R. J., O'Rahilly, S., Edwardson, J. M. & Rochford, J. J., 1 Nov 2013, In : Diabetologia. 56, 11, p. 2498-2506 9 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
5 Downloads (Pure)

Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2: C48R: A Novel Mutation in AGPAT2

Ramanathan, N., Ahmed, M., Raffan, E., Stewart, C. L., O'Rahilly, S., Semple, R. K., Raef, H. & Rochford, J. J., 2013, In : JIMD reports. 9, p. 73-80 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis

Lowe, C. E., Zhang, Q., Dennis, R. J., Aubry, E. M., O'Rahilly, S., Wakelam, M. J. O. & Rochford, J. J., Sep 2013, In : Obesity. 21, 9, p. 1823-1829 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

γ-synuclein is a novel player in the control of body lipid metabolism

Millership, S., Ninkina, N., Rochford, J. J. & Buchman, V. L., Oct 2013, In : Adipocyte. 2, 4, p. 276-280 5 p.

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)
2012

Increased lipolysis and altered lipid homeostasis protect γ-synuclein-null mutant mice from diet-induced obesity

Millership, S., Ninkina, N., Guschina, I. A., Norton, J., Brambilla, R., Oort, P. J., Adams, S. H., Dennis, R. J., Voshol, P. J., Rochford, J. J. & Buchman, V. L., 18 Dec 2012, In : PNAS. 109, 51, p. 20943-20948 6 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis

Lowe, C. E., Dennis, R. J., Obi, U., O'Rahilly, S. & Rochford, J. J., 1 Sep 2012, In : International Journal of Obesity. 36, p. 1248-1251 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain

Garfield, A. S., Chan, W. S., Dennis, R. J., Ito, D., Heisler, L. K. & Rochford, J. J., 25 Sep 2012, In : PloS ONE. 7, 9, 11 p., e45790.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
5 Downloads (Pure)
2011

Adipogenesis at a glance (vol 124, pg 2681, 2011)

Lowe, C. E., O'Rahilly, S. & Rochford, J. J., 1 Nov 2011, In : Journal of Cell Science. 124, 21, p. 3726-3726 1 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Setting the tone: reactive oxygen species and the control of appetitive melanocortin meurons

Rochford, J. J., Myers, M. G. & Heisler, L. K., 2 Nov 2011, In : Cell Metabolism. 14, 5, p. 573-574 2 p.

Research output: Contribution to journalEditorial

2 Citations (Scopus)
2010

Analysis of TBC1D4 in patients with severe insulin resistance

Dash, S., Langenberg, C., Fawcett, K. A., Semple, R. K., Romeo, S., Sharp, S., Sano, H., Lienhard, G. E., Rochford, J. J., Howlett, T., Massoud, A. F., Hindmarsh, P., Howell, S. J., Wilkinson, R. J., Lyssenko, V., Groop, L., Baroni, M. G., Barroso, I., Wareham, N. J., O'Rahilly, S. & 1 others, Savage, D. B., 1 Jun 2010, In : Diabetologia. 53, 6, p. 1239-1242 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis

Payne, V. A., Au, W-S., Lowe, C. E., Rahman, S. M., Friedman, J. E., O'Rahilly, S. & Rochford, J. J., 1 Jan 2010, In : Biochemical Journal. 425, 1, p. 215-223 9 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Lipodystrophy: metabolic insights from a rare disorder

Huang-Doran, I., Sleigh, A., Rochford, J. J., O'Rahilly, S. & Savage, D. B., 1 Dec 2010, In : Journal of Endocrinology. 207, 3, p. 245-255 11 p.

Research output: Contribution to journalLiterature review

124 Citations (Scopus)
18 Citations (Scopus)
2009

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia

Dash, S., Sano, H., Rochford, J. J., Semple, R. K., Yeo, G., Hyden, C. S. S., Soos, M. A., Clark, J., Rodin, A., Langenberg, C., Druet, C., Fawcett, K. A., Tung, Y. C. L., Wareham, N. J., Barroso, I., Lienhard, G. E., O'Rahilly, S. & Savage, D. B., 9 Jun 2009, In : PNAS. 106, 23, p. 9350-9355 6 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2008

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors

Lam, D. D., Przydzial, M. J., Ridley, S. H., Yeo, G. S. H., Rochford, J. J., O'Rahilly, S. & Heisler, L. K., Mar 2008, In : Endocrinology. 149, 3, p. 1323-1328 6 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)

Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2

Grimsey, N., Han, G-S., O'Hara, L., Rochford, J. J., Carman, G. M. & Siniossoglou, S., 24 Oct 2008, In : The Journal of Biological Chemistry. 283, 43, p. 29166-29174 9 p.

Research output: Contribution to journalArticle

Open Access
File
79 Citations (Scopus)
5 Downloads (Pure)

The human lipodystrophy gene BSCL2/Seipin may be essential for normal adipocyte differentiation

Payne, V. A., Grimsey, N., Tuthill, A., Virtue, S., Gray, S. L., Nora, E. D., Semple, R. K., O'Rahilly, S. & Rochford, J. J., Aug 2008, In : Diabetes. 57, 8, p. 2055-2060 6 p.

Research output: Contribution to journalArticle

Open Access
File
139 Citations (Scopus)
4 Downloads (Pure)

The NR4A family of orphan nuclear receptors are not required for adipogenesis

Au, W-S., Payne, V. A., O'Rahilly, S. & Rochford, J. J., Feb 2008, In : International Journal of Obesity. 32, 2, p. 388-392 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2007

Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/Enhancer-binding protein ss(C/EBP ss) and C/EBP alpha during adipogenesis

Payne, V. A., Au, W-S., Gray, S. L., Nora, E. D., Rahman, S. M., Sanders, R., Hadaschik, D., Friedman, J. E., O'Rahilly, S. & Rochford, J. J., 20 Jul 2007, In : The Journal of Biological Chemistry. 282, 29, p. 21005-21014 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways

Zhou, L., Sutton, G. M., Rochford, J. J., Semple, R. K., Lam, D. D., Oksanen, L. J., Thornton-Jones, Z. D., Clifton, P. G., Yueh, C-Y., Evans, M. L., McCrimmon, R. J., Elmquist, J. K., Butler, A. A. & Heisler, L. K., 7 Nov 2007, In : Cell Metabolism. 6, 5, p. 398-405 8 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)
2004

A family with severe insulin resistance and diabetes due to a mutation in AKT2

George, S., Rochford, J. J., Wolfrum, C., Gray, S. L., Schinner, S., Wilson, J. C., Soos, M. A., Murgatroyd, P. R., Williams, R. M., Acerini, C. L., Dunger, D. B., Barford, D., Umpleby, A. M., Wareham, N. J., Davies, H. A., Schafer, A. J., Stoffel, M., O'Rahilly, S. & Barroso, I., 28 May 2004, In : Science. 304, 5675, p. 1325-1328 4 p.

Research output: Contribution to journalArticle

357 Citations (Scopus)

ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis

Rochford, JJ., Semple, RK., Laudes, M., Boyle, KB., Christodoulides, C., Mulligan, C., Lelliott, CJ., Schinner, S., Hadaschik, D., Mahadevan, M., Sethi, JK., Vidal-Puig, A. & O'Rahilly, S., Nov 2004, In : Molecular and Cellular Biology. 24, 22, p. 9863-9872 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)

Challis, B. G., Coll, A. P., Yeo, G. S. H., Pinnock, S. B., Dickson, S. L., Thresher, R. R., Dixon, J., Zahn, D., Rochford, J. J., White, A., Oliver, R. L., Millington, G., Aparicio, S. A., Colledge, W. H., Russ, A. P., Carlton, M. B. & O'Rahilly, S., 30 Mar 2004, In : PNAS. 101, 13, p. 4695-700 6 p.

Research output: Contribution to journalArticle

276 Citations (Scopus)