Research output per year
Research output per year
Personal profile
Research Profile
Research Interests
My research interests focus on investigating the evolution and function of the resident mammalian gut microbiota. Key interests include:
- the molecular mechanisms by which specific bacteria utilise different dietary components including prebiotics and fibre
- the importance of diet in modulating both the composition and activity of the microbiota
- understanding the sequential colonisation and longitudinal development of the microbiota through life
- investigating the carriage, evolution and dissemination of antimicrobial resistance genes between resident and transient members of the gut microbiota
- co-localisation of antimicrobial and other resistance genes on transmissible conjugative transposons
- identifying new commensal bacteria suitable for development as probiotics
Activities
Board Member of International Scientific Association for Probiotics and Prebiotics (ISAPP; Role of President from 2016 - 2019). 2008-present
Chair of organising committee for the biennial International Gut Microbiology symposium [Rowett/INRAE conference] 2016- present
Member of the organising committee for the Wellcome Trust Gut Microbiome annual conference (2014-2018); International Human Microbiome Conderence (2020-2022)
Member of ILSI Prebiotic Task Force - expert Groups on "short chain fatty acids" and "gut microbiota and nutrients" 2016-2019
Global Grant for Gut Health Grant Panel committee member 2018- present
External PhD student examiner - 1 - 2 students per year for various universities within UK or Europe.
Editor of Microbiology journal (2016 - 2018)
Supervision
PhD student supervision:
2010 – 2014 Local (RINH) funding Joint studentship with University College Cork, Genetic Manipulation of anaerobic gut bacteria
2011-2015 RESAS cereal SP Realizing the potential of cereal products to benefit human health
2011 – 2015 GTbiologics/Sulsa The role of the gut microbiota in inflammatory bowel disease
2017 – 2020 Elphinstone award Spread of antibiotic resistance through the food chain
2017 – 2021 A Vogel Prebiotic treatment to alleviate IBS
2017 – 2021 Jordanian govt Impact of antibiotic treatment on the evolution of mosaic genes
2018 – 2021 Kuwait govt Health impacts of B-glucan
2020 – 2023 EastBio PhD student Impact of bile salt hydrolase activities of specific gut bacteria on energy balance
2021-2025 Eastbio PhD student Carriage of antimicrobial resistance genes by Campylobacter species isolated from wildlife (collaborative with Moredun Institute)
Teaching
Other student supervision – 1 - 3 short-term (3-5 month) students (BSc Hons, MSc or French placement) annually since 2003 (total number = 35)
Lecturing (# per year) Three lectures for UoA Human Nutrition MSc course (PU5020, PU5537, RR5501); lecturer in Human Nutrition MOOC, 7 lectures for Yr 2 Microbiology (BI25M5), 2 lectures for Yr 2 Medics (MbChB Yr2 in gastrointestinal block), 2 lectures/year for Hons Microbiology, tutor group in MbChB yr 1 SSC block, practical demonstrator in 2 sessions in SM2001 yr2 foundation skills in medical sciences course. Lecturer in online Human Clinical Nutrition MSc course.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biological Sciences, PhD, Genomic analysis of potato mop-top virus
Award Date: 8 Jul 1993
Area of Expertise
- Biological Sciences
- Microbiology
- antimicrobial resistance
- Microbiomics
- gene transfer
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behavior in an obesity mouse model
Garcia-Serrano, A. M., Skoug, C., Axling, U., Korhonen, E. R., Teixeira, C., Ahrén, I. L., Mukhopadhya, I., Boteva, N., Martin, J., Scott, K., Gratz, S., Stenkula, K. G., Holm, C. & Duarte, J. M. N., 4 Nov 2023, bioRxiv.Research output: Working paper › Preprint
Open Access -
Establishing genetic manipulation for novel strains of human gut bacteria
Sheridan, P. O., Odat, M. A. & Scott, K. P., 3 Jan 2023, In: Microbiome Research Reports. 2, 1, 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)4 Downloads (Pure) -
Comparison of microbial signatures between paired faecal and rectal biopsy samples from healthy volunteers using next-generation sequencing and culturomics
Mukhopadhya, I., Martin, J. C., Shaw, S., McKinley, A. J., Gratz, S. W. & Scott, K. P., 14 Oct 2022, In: Microbiome. 10, 1, 17 p., 171.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)5 Downloads (Pure) -
Higher total faecal short chain fatty concentrations correlate with increasing proportions of butyrate and decreasing proportions of branched chain fatty acids across multiple human studies
Scott, K., LaBouyer, M., Holtrop, G., Horgan, G., Gratz, S., Belenguer, A., Smith, N., Walker, A., Duncan, S., Johnstone, A., Louis, P. & Flint, H. J., 30 Mar 2022, In: Gut Microbiome. 3, 14 p., e2.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Changes in the gut microbiota of Nigerian infants within the first year of life
Oyedemi, O. T., Shaw, S., Martin, J., Ayeni, F. A. & Scott, K., 17 Mar 2022, In: PloS ONE. 17, 3, 18 p., e0265123.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)4 Downloads (Pure)
Datasets
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GSE22245: Differential gene expression in Roseburia inulinivorans grown on inulin and starch.
Campbell, G. P. (Creator), Scott, K. (Creator), Martin, J. C. (Creator), Chassard, C. (Creator) & Clerget, M. (Creator), GEO, 22 Mar 2012
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22245 and 5 more links, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GPL10020, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM553706, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM553707, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM553708, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM553709 (show fewer)
Dataset
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Comparison of microbial signatures between paired faecal and rectal biopsy samples from healthy volunteers using next-generation sequencing and culturomics
Mukhopadhya, I. (Creator), Martin, J. C. (Creator), Shaw, S. (Creator), McKinley, A. J. (Creator), Gratz, S. (Creator) & Scott, K. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.c.6249986.v1, https://springernature.figshare.com/collections/Comparison_of_microbial_signatures_between_paired_faecal_and_rectal_biopsy_samples_from_healthy_volunteers_using_next-generation_sequencing_and_culturomics/6249986/1
Dataset
Activities
- 3 Member of advisory board
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Novo Nordisk Foundation (External organisation)
Karen Scott (Member)
2022Activity: Membership (e.g. panels, networks, committees, etc.) › Member of advisory board
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University College Cork (External organisation)
Karen Scott (Member)
Nov 2020 → …Activity: Membership (e.g. panels, networks, committees, etc.) › Member of advisory board
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The Dutch Research Council (External organisation)
Karen Scott (Member)
2019 → 2022Activity: Membership (e.g. panels, networks, committees, etc.) › Member of advisory board
Prizes
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Highly Cited Researchers™ 2022
Duncan, Sylvia (Recipient), Flint, Harry (Recipient), Francis, Jill (Recipient), Johnston, Marie (Recipient), Louis, Petra (Recipient), Prosser, James (Recipient), Scott, Karen (Recipient), Smith, Pete (Recipient) & Walker, Alan (Recipient), 2022
Prize: Other distinction
Impacts
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Commercial applications of pioneering research on the human gut microbiota
Karen Scott (Participant), Petra Louis (Participant), Alan Walker (Participant), Sylvia Duncan (Participant) & Harry Flint (Participant)
Impact: Economic and/or Commercial, Health and Wellbeing