• 7145 Citations
19952020

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2020

Developments in understanding and applying prebiotics in research and practice: an ISAPP conference paper

Scott, K. P., Grimaldi, R., Cunningham, M., Sarbini, S. R., Wijeyesekera, A., Tang, M. L. K., Lee, J. C-Y., Yau, Y. F., Ansell, J., Theis, S., Yang, K., Menon, R., Arfsten, J., Manurung, S., Gourineni, V. & Gibson, G. R., Apr 2020, In : Journal of Applied Microbiology. 128, 4, p. 934-949 16 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2019

Heterologous gene expression in the human gut bacteria Eubacterium rectale and Roseburia inulinivorans by means of conjugative plasmids

Sheridan, P. O., Martin, J. C., Minton, N. P., Flint, H. J., O'Toole, P. W. & Scott, K. P., 1 Oct 2019, In : Anaerobe. 59, p. 131-140 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
Open Access
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The impact of antimicrobials on gut bacteria: an interview with Karen Scott

Scott, K. P., Sep 2019, In : Future Microbiology. 14, 13, p. 1081-1082 2 p.

Research output: Contribution to journalArticle

2018

Gut microbiota functions: metabolism of nutrients and other food components

Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I. & Tuhoy, K., Feb 2018, In : European Journal of Nutrition. 57, 1, p. 1-24 24 p.

Research output: Contribution to journalArticle

Open Access
File
273 Citations (Scopus)
9 Downloads (Pure)
2017

16S sequencing and functional analysis of the fecal microbiome during treatment of newly diagnosed pediatric inflammatory bowel disease

Ashton, J. J., Colquhoun, C. M., Cleary, D. W. ., Coelho, T., Haggarty, R., Mulder, I., Batra, A., Afzal, N. A., Beattie, R. M., Scott, K. P. & Ennis, S., Jun 2017, In : Medicine. 96, 26, p. 1-10 10 p., e7347.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
12 Downloads (Pure)

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K. & Reid, G., 2017, In : Nature Reviews Gastroenterology & Hepatology. 14, p. 491-502 12 p.

Research output: Contribution to journalArticle

Open Access
File
702 Citations (Scopus)
9 Downloads (Pure)

Strain-level metagenomic analysis of the fermented dairy beverage nunu highlights potential food safety risks

Walsh, A. M., Crispie, F., Daari, K., O’Sullivan, O., Martin, J. C., Arthur, C. T., Claesson, M. J., Scott, K. P. & Cotter, P. D., Aug 2017, In : Applied and Environmental Microbiology. 83, 16, 28 p., e01144-17.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
6 Downloads (Pure)

The agronomic performance and nutritional content of oat and barley varieties grown in a northern maritime environment depends on variety and growing conditions

Chappell, A., Scott, K. P., Griffiths, I. A., Cowan, A. A., Hawes, C., Wishart, J. & Martin, P., Mar 2017, In : Journal of Cereal Science. 74, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
7 Downloads (Pure)

Towards standards for human fecal sample processing in metagenomic studies

Costea, P. I., Zeller, G., Sunagawa, S., Pelletier, E., Alberti, A., Levenez, F., Tramontano, M., Driessen, M., Hercog, R., Jung, F-E., Kultima, J. R., Hayward, M. R., Coelho, L. P., Allen-Vercoe, E., Bertrand, L., Blaut, M., Brown, J. R. M., Carton, T., Cools-Portier, S., Daigneault, M. & 38 others, Derrien, M., Druesne, A., de Vos, W. M., Finlay, B. B., Flint, H. J., Guarner, F., Hattori, M., Heilig, H., Luna, R. A., van Hylckama Vlieg, J., Junick, J., Klymiuk, I., Langella, P., Le Chatelier, E., Mai, V., Manichanh, C., Martin, J. C., Mery, C., Morita, H., O'Toole, P. W., Orvain, C., Patil, K. R., Penders, J., Persson, S., Pons, N., Popova, M., Salonen, A., Saulnier, D., Scott, K. P., Singh, B., Slezak, K., Veiga, P., Versalovic, J., Zhao, L., Zoetendal, E. G., Ehrlich, S. D., Dore, J. & Bork, P., 2017, In : Nature Biotechnology. 35, p. 1069–1076 8 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)
2016

Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes

Sheridan, P. O., Martin, J. C., Lawley, T. D., Browne, H. P., Harris, H. M. B., Bernalier-Donadille, A., Duncan, S. H., O'Toole, P. W., Scott, K. P. & Flint, H. J., 9 Feb 2016, In : Microbial Genomics. 2, 2, p. 1-16 16 p., 43.

Research output: Contribution to journalArticle

Open Access
File
56 Citations (Scopus)
6 Downloads (Pure)
2015

16S rRNA gene-based profiling of the human infant gut microbiota is strongly influenced by sample processing and PCR primer choice

Walker, A. W., Martin, J. C., Scott, P., Parkhill, J., Flint, H. J. & Scott, K. P., 22 Jun 2015, In : Microbiome. 3, 26.

Research output: Contribution to journalArticle

Open Access
File
100 Citations (Scopus)
6 Downloads (Pure)

Altered Colonic Bacterial Fermentation as a Potential Pathophysiological Factor in Irritable Bowel Syndrome

Ringel-Kulka, T., Choi, C. H. W., Temas, D., Kim, A., Maier, D. M., Scott, K., Galanko, J. A. & Ringel, Y., 25 Aug 2015, In : The American journal of gastroenterology. 110, 9, p. 1339-1346 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

First-Pass Meconium Samples from Healthy Term Vaginally-Delivered Neonates: An Analysis of the Microbiota

Hansen, R., Scott, K. P., Khan, S., Martin, J. C., Berry, S. H., Stevenson, M., Okpapi, A., Munro, M. J. & Hold, G. L., 28 Jul 2015, In : PloS ONE. 10, 7, 10 p., e0133320.

Research output: Contribution to journalArticle

Open Access
File
65 Citations (Scopus)
5 Downloads (Pure)

Manipulating the gut microbiota to maintain health and treat disease

Scott, K. P., Antoine, J-M., Midtvedt, T. & van Hemert, S., 2015, In : Microbial Ecology in Health and Disease. 26, p. 25877

Research output: Contribution to journalArticle

2014

Can prebiotics and probiotics improve therapeutic outcomes for undernourished individuals?

Sheridan, P. O., Bindels, L. B., Saulnier, D. M., Reid, G., Nova, E., Holmgren, K., O'Toole, P. W., Bunn, J., Delzenne, N. & Scott, K. P., Jan 2014, In : Gut Microbes. 5, 1, p. 74-82 9 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Impact of a very low-energy diet on the fecal microbiota of obese individuals

Simões, C. D., Maukonen, J., Scott, K. P., Virtanen, K. A., Pietiläinen, K. H. & Saarela, M., Sep 2014, In : European Journal of Nutrition. 53, 6, p. 1421-1429 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

Reichardt, N., Duncan, S. H., Young, P., Belenguer, A., McWilliam Leitch, C., Scott, K. P., Flint, H. J. & Louis, P., Jun 2014, In : The ISME Journal. 8, 6, p. 1323-1335 13 p.

Research output: Contribution to journalArticle

299 Citations (Scopus)

Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro

Scott, K. P., Martin, J. C., Duncan, S. H. & Flint, H. J., Jan 2014, In : FEMS Microbiology Ecology. 87, 1, p. 30-40 11 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)
2013

Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans

Neville, B. A., Sheridan, P. O., Harris, H. M. B., Coughlan, S., Flint, H. J., Duncan, S. H., Jeffery, I. B., Claesson, M. J., Ross, R. P., Scott, K. P. & O'Toole, P. W., 23 Jul 2013, In : PloS ONE. 8, 7, 15 p., e68919.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
5 Downloads (Pure)
2012

Evaluation of novel assays to assess the influence of different iron sources on the growth of Clostridium difficile

Cernat, R. C. & Scott, K. P., Jun 2012, In : Anaerobe. 18, 3, p. 298-304 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Functional dysbiosis within the intestinal microbiota of patients with irritable bowel syndrome

Chassard, C., Dapoingny, M., Scott, K. P., Crouzet, L., Del'homme, C., Marquet, P., Martin, J. C., Pikering, G., Ardid, D., Eschalier, A., Dubray, C., Flint, H. J. & Bernalier-Donadille, A., 2012, In : Alimentary Pharmacology & Therapeutics. 35, 7, p. 828-838 11 p.

Research output: Contribution to journalArticle

191 Citations (Scopus)

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

Bindels, L. B., Porporato, P., Dewulf, E. M., Verrax, J., Neyrinck, A. M., Martin, J. C., Scott, K. P., Buc Calderon, P., Feron, O., Muccioli, G. G., Sonveaux, P., Cani, P. D. & Delzenne, N. M., 9 Oct 2012, In : British Journal of Cancer. 107, 8, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

Open Access
File
119 Citations (Scopus)
4 Downloads (Pure)

Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model

Bindels, L., Beck, R., Schakman, O., Martin, J. C., de Backer, F., Sohet, F. M., Dewulf, E. M., Pachikian, B. D., Neyrinck, A. M., Thissen, J-P., Verrax, J., Buc Calderon, P., Pot, B., Grangette, C., Cani, P. D., Scott, K. P. & Delzenne, N., 27 Jun 2012, In : PloS ONE. 7, 6, 10 p., e37971.

Research output: Contribution to journalArticle

Open Access
File
83 Citations (Scopus)
7 Downloads (Pure)
2011

Optimization of a high-throughput CTAB-based protocol for the extraction of qPCR-grade DNA from rumen fluid, plant and bacterial pure cultures

Minas, K., Mcewan, N., Newbold, C. & Scott, K. P., Dec 2011, In : FEMS Microbiology Letters. 325, 2, p. 162-169 7 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Substrate-driven gene expression in Roseburia inulinivorans: Importance of inducible enzymes in the utilization of inulin and starch

Scott, K. P., Martin, J. C., Chassard, C., Clerget, M., Potrykus, J., Campbell, G. P., Mayer, C-D., Young, P., Rucklidge, G., Ramsay, A. G. & Flint, H. J., 15 Mar 2011, In : PNAS. 108, Supplement 1, p. 4672-4679 8 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2009

Distribution of Tetracycline and Erythromycin Resistance Genes Among Human Oral and Fecal Metagenomic DNA

Seville, L. A., Patterson, A. J., Scott, K. P., Mullany, P., Quail, M. A., Parkhill, J., Ready, D., Wilson, M., Spratt, D. & Roberts, A. P., Sep 2009, In : Microbial Drug Resistance. 15, 3, p. 159-166 8 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Tetracycline resistome of the organic pig gut

Kazimierczak, K. A., Scott, K. P., Kelly, D. & Aminov, R. I., Mar 2009, In : Applied and Environmental Microbiology. 75, 6, p. 1717-1722 6 p.

Research output: Contribution to journalArticle

The Intestinal Microbiota of Irritable Bowel Syndrome Patients Is Characterized By Functional Dysbiosis

Chassard, C., Dapoigny, M. C., Scott, K. P., Del'Homme, C., Dubray, C., Eschalier, A., Flint, H. J., Bernalier-Donadille, A. & Flint, H. J., May 2009, In : Gastroenterology. 136, 5, Supplement 1, p. A214-A214 1 p.

Research output: Contribution to journalArticle

2008

A new tetracycline efflux gene, tet(40), is located in tandem with tet(O/32/O) in a human gut firmicute bacterium and in metagenomic library clones

Kazimierczak, K. A., Rincon, M. T., Patterson, A. J., Martin, J. C., Young, P., Flint, H. J. & Scott, K. P., Nov 2008, In : Antimicrobial Agents and Chemotherapy. 52, 11, p. 4001-4009 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Assessment of metabolic diversity within the intestinal microbiota from healthy humans using combined molecular and cultural approaches

Chassard, C., Scott, K. P., Marquet, P., Martin, J. C., Del'homme, C., Dapoigny, M., Flint, H. J. & Bernalier-Donadille, A., Dec 2008, In : FEMS Microbiology Ecology. 66, 3, p. 496-504 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Dietary fibre and the gut microbiota

Scott, K. P., Duncan, S. H. & Flint, H. J., Sep 2008, In : Nutrition Bulletin. 33, 3, p. 201-211 11 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Transfer of conjugative elements from rumen and human Firmicutes bacteria to Roseburia inulinivorans

Scott, K. P., Martin, J. C., Mrazek, J. & Flint, H. J., Jun 2008, In : Applied and Environmental Microbiology. 74, 12, p. 3915-3917 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2007

Distribution of specific tetracycline and erythromycin resistance genes in environmental samples assessed by macroarray detection

Patterson, A. J., Colangeli, R., Spigaglia, P. & Scott, K. P., Mar 2007, In : Environmental Microbiology. 9, 3, p. 703-715 13 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Mosaic Tetracycline Resistance Genes Are Widespread in Human and Animal Fecal Samples

Patterson, A. J., Rincon, M. T., Flint, H. J. & Scott, K. P., Mar 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 1115-1118 4 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Tetracycline susceptibility of the ingested Lactobacillus acidophilus LaCH-5 and Bifidobacterium animalis subsp lactis Bb-12 strains during antibiotic/probiotic intervention

Saarela, M., Maukonen, J., Von Wright, A., Vilpponen-Salmela, T., Patterson, A. J., Scott, K. P., Hamynen, H. & Matto, J., Mar 2007, In : International Journal of Antimicrobial Agents. 29, 3, p. 271-280 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2006

Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon

Ramsay, A. G., Scott, K. P., Martin, J. C., Rincon, M. T. & Flint, H. J., Nov 2006, In : Microbiology . 152, p. 3281-3290 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria

Kazimierczak, K. A., Flint, H. J. & Scott, K. P., Aug 2006, In : Antimicrobial Agents and Chemotherapy. 50, 8, p. 2632-2639 8 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Whole-genome transcription profiling reveals genes up-regulated by growth on fucose in the human gut bacterium "Roseburia inulinivorans"

Scott, K. P., Martin, J. C., Campbell, G. P., Mayer, C-D. & Flint, H. J., Jun 2006, In : Journal of Bacteriology. 188, 12, p. 4340-4349 10 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)
2004
35 Citations (Scopus)
2003

Characterization of XYN10B, a modular xylanase from the ruminal protozoan Polyplastron multivesiculatum, with a family 22 carbohydrate-binding module that binds to cellulose

Devillard, E., Bera-Maillet, C., Flint, H. J., Scott, K. P., Newbold, C. J., Wallace, R. J., Jouany, J. P. & Forano, E., 15 Jul 2003, In : Biochemical Journal. 373, 2, p. 495-503 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system

Duncan, S. H., Scott, K. P., Ramsay, A. G., Harmsen, H. J. M., Welling, G. W., Stewart, C. S. & Flint, H. J., Feb 2003, In : Applied and Environmental Microbiology. 69, 2, p. 1136-1142 7 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Influence of tetracycline exposure on tetracycline resistance and the carriage of tetracycline resistance genes within commensal Escherichia coli populations.

Blake, D. P., Humphrey, S. B., Scott, K. P., Hillman, K., Fenlon, D. R. & Low, J. C., 2003, In : Journal of Applied Microbiology. 94, p. 1087-1097 10 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Transformation of an oral bacterium via chromosomal integration of free DNA in the presence of human saliva

Mercer, D. K., Scott, K. P., Melville, C. M., Glover, L. A. & Flint, H. J., 2001, In : FEMS Microbiology Letters. 200, p. 163-167 5 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2000

Chromosomal integration of the green fluorescent protein gene in lactic acid bacteria and the survival of marked strains in human gut simulations

Scott, K. P., Mercer, D. K., Richardson, A. J., Melville, C. M., Glover, L. A. & Flint, H. J., 1 Jan 2000, In : FEMS Microbiology Letters. 182, 1, p. 23-27 5 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut

Scott, K. P., Melville, C. M., Barbosa, T. M. & Flint, H. J., Mar 2000, In : Antimicrobial Agents and Chemotherapy. 44, 3, p. 775-777 3 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

Organisation and variable incidence of genes concerned with the utilization of xylans in the rumen cellulolytic bacterium Ruminococcus flavefaciens

Aurilia, V., Martin, J. C., Scott, K. P., Mercer, D. K., Johnston, M. E. A. & Flint, H. J., Dec 2000, In : Anaerobe. 6, 6, p. 333-340 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)