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Laurent Alain Claude Trembleau

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    • AB24 3UE

    • 1075 Citations
    20002018
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    Research Output 2000 2018

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    Article
    2018
    3 Citations (Scopus)

    Physicochemical Tools: Toward a Detailed Understanding of the Architecture of Targeted Radiotherapy Nanoparticles

    Cabello, G., Nwoko, K. C., Mingarelli, M., McLaughlin, A. C., Trembleau, L., Feldmann, J., Cuesta Ciscar, A. & Smith, T. A. D., 2018, In : ACS Applied Bio Materials. 1, 5, p. 1639-1646 8 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Radiotherapy
    Nanoparticles
    Gold
    Radioisotopes
    Coatings
    2017
    4 Citations (Scopus)
    10 Downloads (Pure)

    A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

    Booth, J., Alexandru-Crivac, C-N., Rickaby, K. A., Nneoyiegbe, A. F., Umeobika, U., McEwan, A. R., Trembleau, L., Jaspars, M., Houssen, W. E. & Shalashilin, D. V., 18 May 2017, In : The Journal of Physical Chemistry Letters. 8, 10, p. 2310-2315 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Cyclization
    Peptides
    peptides
    Conformations
    proximity
    4 Citations (Scopus)
    10 Downloads (Pure)

    Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

    Alexandru-Crivac, C. N., Umeobika, C., Leikoski, N., Jokela, J., Rickaby, K., Grilo, A. M., Sjo, P., Plowright, A. T., Idress, M., Siebs, E., Nneoyi-Egbe, A., Wahlsten, M., Sivonen, K., Jaspars, M., Trembleau, L., Fewer, D. P. & Houssen Ibrahim, W. E., 4 Oct 2017, In : Chemical Communications. 53, 77, p. 10656-10659 4 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Cyclic Peptides
    Proline
    Peptides
    Substrates
    Amino acids
    2016
    15 Citations (Scopus)
    8 Downloads (Pure)

    A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

    Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., Wang, H., Rizzi, E., De Bellis, G., Naismith, J., Jaspars, M., Liu, X., Houssen, W. & Fewer, D. P., 7 Mar 2016, In : Angewandte Chemie. 128, 11, p. 3660-3663 4 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Genes
    Escherichia coli
    Biosynthetic Pathways
    Cyclic Peptides
    3 Citations (Scopus)
    8 Downloads (Pure)
    Open Access
    File
    indoles
    Crystal symmetry
    Dihedral angle
    Benzene
    Hydrogen bonds
    9 Citations (Scopus)
    6 Downloads (Pure)

    Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

    Greig, I. R., Baillie, G. L., Abdelrahman, M., Trembleau, L. & Ross, R. A., 15 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 18, p. 4403-4407 5 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Cannabinoid Receptors
    Pulse amplitude modulation
    Pharmacokinetics
    Cannabinoids
    Sulfonamides
    2 Citations (Scopus)
    4 Downloads (Pure)

    Different N—H···π interactions in two indole derivatives

    Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L. & Harrison, W. T. A., May 2016, In : Acta Crystallographica Section E: Crystallographic Communications. 72, 5, p. 699-703 5 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    indoles
    Dimers
    Conformations
    Hydrogen bonds
    Crystal structure
    1 Citation (Scopus)
    4 Downloads (Pure)
    Open Access
    File
    indoles
    Dimers
    Crystal structure
    Derivatives
    carboxylates
    2015
    4 Citations (Scopus)
    9 Downloads (Pure)
    Open Access
    File
    Cannabinoid Receptor Antagonists
    indoles
    Dimers
    Hydrogen bonds
    Crystal structure
    14 Citations (Scopus)
    6 Downloads (Pure)

    Discovery of a single monooxygenase catalyzing the carbamate formation and ring contraction in the biosynthesis of legonmycins

    Huang, S., Tabudravu, J., Elsayed, S. S., Travert, J., Peace, D., Tong, M. H., Kyeremeh, K., Kelly, S., Trembleau, L. A. C., Ebel, R. P., Jaspars, M., Yu, Y. & Deng, H., 19 Oct 2015, In : Angewandte Chemie International Edition. 54, 43, p. 12697-12701 4 p.

    Research output: Contribution to journalArticle

    Pyrrolizidine Alkaloids
    Alkaloids
    Carbamates
    Biosynthesis
    Mixed Function Oxygenases
    2014
    37 Citations (Scopus)

    In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

    Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In : Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

    Research output: Contribution to journalArticle

    Cannabinoid Receptor CB1
    Pharmacology
    rimonabant
    Dronabinol
    Appetite Depressants
    19 Citations (Scopus)

    Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria

    Tadesse, M., Svenson, J., Sepicic, K., Trembleau, L., Engqvist, M., Andersen, J. H., Jaspars, M., Stensvag, K. & Haug, T., 28 Feb 2014, In : Journal of Natural Products. 77, 2, p. 364-369 6 p.

    Research output: Contribution to journalArticle

    2013
    18 Citations (Scopus)

    Receptor conformational change induces fluoride binding despite competitive water binding

    Trembleau, L., Smith, T. A. D. & Abdelrahman, M. H., 4 Jul 2013, In : Chemical Communications. 49, 52, p. 5850-5852 3 p.

    Research output: Contribution to journalArticle

    Fluorides
    Anions
    Negative ions
    Artificial Receptors
    Boron
    2012
    85 Citations (Scopus)

    The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

    Houssen, W. E., Koehnke, J., Bent, A., Zollman, D., Morawitz, F., Shirran, S., Vendome, J., Nneoyiegbe, A. F., Trembleau, L., Botting, C. H., Smith, M. C. M., Jaspars, M. & Naismith, J. H., Aug 2012, In : Nature Structural & Molecular Biology. 19, 8, p. 767-772 6 p.

    Research output: Contribution to journalArticle

    Peptides
    Prochloron
    Subtilisin
    Biotechnology
    Biological Products
    2011
    7 Citations (Scopus)
    File
    biotin
    Labeling
    Polyethylene glycols
    marking
    Cells
    11 Citations (Scopus)
    3 Downloads (Pure)
    Open Access
    File
    Hexokinase
    Fluorodeoxyglucose F18
    Lactic Acid
    Breast Neoplasms
    Glucose
    13 Citations (Scopus)

    Development of 18F-fluorinatable dendrons and their application to cancer cell targeting

    Trembleau, L., Simpson, M., Cheyne, R. W., Escofet, I., Appleyard, M. V. C. L., Murray, K., Sharp, S., Thompson, A. M. & Smith, T. A. D., Nov 2011, In : New Journal of Chemistry. 35, 11, p. 2496-2502 7 p.

    Research output: Contribution to journalArticle

    Dendrimers
    Cells
    Biotin
    Avidin
    Sulfhydryl Compounds
    10 Citations (Scopus)
    4 Downloads (Pure)
    Open Access
    File
    biotin
    conjugation
    Labeling
    marking
    Imaging techniques
    23 Citations (Scopus)
    4 Downloads (Pure)

    Synthesis and characterisation of biologically compatible TiO2 nanoparticles

    Cheyne, R. W., Smith, T. A. D., Trembleau, L. A. C. & McLaughlin, A., 2011, In : Nanoscale Research Letters. 6, -, 423.

    Research output: Contribution to journalArticle

    Open Access
    File
    Nanoparticles
    nanoparticles
    synthesis
    acids
    Stearic acid
    2010
    9 Citations (Scopus)

    Multigram-scale synthesis of short peptides via a simplified repetitive solution-phase procedure

    Meneses, C., Nicoll, S. L. & Trembleau, L. A. C., 2010, In : Journal of Organic Chemistry. 75, 3, p. 564-569 6 p.

    Research output: Contribution to journalArticle

    Peptides
    Esters
    glycyl-arginyl-glycyl-aspartyl-serine
    Acids
    Acidification
    2007
    1 Citation (Scopus)

    5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide

    Muirhead, K. E. A., Trembleau, L. & Harrison, W. T. A., 1 Aug 2007, In : Acta Crystallographica Section E: Structure Reports Online. 63, 8, 11 p., o3389.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    5-Chloro-3-ethyl-N-[3-(morpholin-4-yl)propyl]-1H-indole-2-carboxamide

    Muirhead, K. E. A., Trembleau, L. & Harrison, W. T. A., Aug 2007, In : Acta Crystallographica Section E: Structure Reports Online. 63, 8, 11 p., o3390.

    Research output: Contribution to journalArticle

    2006
    17 Citations (Scopus)

    Lipid fluorination enables phase separation from fluid phospholipid bilayers

    Webb, S. J., Greenway, K., Bayati, M. & Trembleau, L. A. C., May 2006, In : Organic & Biomolecular Chemistry. 4, p. 2399-2407 8 p.

    Research output: Contribution to journalArticle

    2005
    20 Citations (Scopus)

    Membrane Composition Determines the Fate of Aggregated Vesicles

    Webb, S. J., Wang, X., Mart, R. J. & Trembleau, L. A. C., 2005, In : Organic & Biomolecular Chemistry. 3, p. 3615-3617 2 p.

    Research output: Contribution to journalArticle

    2004
    108 Citations (Scopus)

    Galmic, a nonpeptide galanin receptor agonist, affects behaviours in seizure, pain, and forced-swim tests

    Barfai, T., lu, X., Badie-Mahdavi, H., Barr, A. M., Mazarati, A., Hua, X. Y., Yaksh, T., Haberhauser, G., Ceide, S. C., Trembleau, L. A. C., Somogyi, L., Krock, L. & Rebek Jnr, J., 2004, In : PNAS. 101, p. 10470-10475 5 p.

    Research output: Contribution to journalArticle

    125 Citations (Scopus)

    Helical Folding of Alkanes in a Self-Assembled, Cylindrical Capsule

    Scarso, A., Trembleau, L. A. C. & Rebek Jnr, J., 2004, In : Journal of the American Chemical Society. 126, p. 13512-13518 6 p.

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Interactions Between a Surfactant and Cavitand: Blur Distinctions Between Host and Guest

    Trembleau, L. A. C. & Rebek Jnr, J., 2004, In : Chemical Communications. 1, p. 58-59 1 p.

    Research output: Contribution to journalArticle

    89 Citations (Scopus)

    Kinetically Stable Complexes in Water: The Role of Hydration and Hydrophobicity

    Biros, S. M., Ullrich, E. C., Hof, F., Trembleau, L. A. C. & Rebek Jnr, J., 2004, In : Journal of the American Chemical Society. 126, p. 2870-2876 6 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Synthesis of galmic: A nonpeptide galanin receptor agonist

    Ceide, S. C., Trembleau, L. A. C., Haberhauer, G., Somogyi, L., Bartfai, T. & Rebek Jnr, J., 2004, In : PNAS. 101, 48, p. 16727-16732 5 p.

    Research output: Contribution to journalArticle

    2003
    87 Citations (Scopus)

    Acetylcholine Recognition by a Deep, Biomimetic Pocket

    Hof, F., Trembleau, L. A. C., Ulrich, E. & Rebek Jnr, J., 2003, In : Angewandte Chemie International Edition. 42, p. 3150-3153 3 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Encapsulation Induces Helical Folding of Alkanes

    Scarso, A., Trembleau, L. A. C. & Rebek Jnr, J., 2003, In : Angewandte Chemie International Edition. 42, p. 5499-5502 3 p.

    Research output: Contribution to journalArticle

    164 Citations (Scopus)

    Helical Conformation of Alkanes in a Hydrophobic Cavitand

    Trembleau, L. A. C. & Rebek Jnr, J., 2003, In : Science. 301, p. 1219-1220 1 p.

    Research output: Contribution to journalArticle

    2000
    1 Citation (Scopus)
    Crystal structure
    crystal structure
    22 Citations (Scopus)
    Tubulin Modulators
    Furans
    Regioselectivity
    Cycloaddition
    Cycloaddition Reaction