• 1134 Citations
20002020

Research output per year

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Research Output

2020

A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms

Schaefer, K., Dambuza, I. M., Dall'angelo, S., Trembleau, L., Zanda, M., Brown, G. D., Netea, M. G. & Gow, N. A. R., 17 Jul 2020, In : Microorganisms. 8, 7, 14 p., 1066.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)

Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis

Maglangit, F., Alrashdi, S., Renault, J., Trembleau, L., Victoria, C., Tong, M. H., Wang, S., Kyeremeh, K. & Deng, H., 28 Mar 2020, In : Organic & Biomolecular Chemistry. 18, 12, p. 2219-2222 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structure‐based design, synthesis and bioactivity of a new anti‐TNFα cyclopeptide

Idress, M., Milne, B. F., Thompson, G. S., Trembleau, L., Jaspars, M. & Houssen, W. E., 19 Feb 2020, In : Molecules. 25, 4, 11 p., 922.

Research output: Contribution to journalArticle

Open Access
File
3 Downloads (Pure)
2019

Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

Liu, Y., Su, L., Fang, Q., Tabudravu, J., Yang, X., Rickaby, K., Trembleau, L., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 20 Dec 2019, In : Journal of Organic Chemistry. 84, 24, p. 16323-16328 6 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
1 Downloads (Pure)
2018

Physicochemical Tools: Toward a Detailed Understanding of the Architecture of Targeted Radiotherapy Nanoparticles

Cabello, G., Nwoko, K. C., Mingarelli, M., McLaughlin, A. C., Trembleau, L., Feldmann, J., Cuesta Ciscar, A. & Smith, T. A. D., 2018, In : ACS Applied Bio Materials. 1, 5, p. 1639-1646 8 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
3 Downloads (Pure)
2017

A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

Booth, J., Alexandru-Crivac, C-N., Rickaby, K. A., Nneoyiegbe, A. F., Umeobika, U., McEwan, A. R., Trembleau, L., Jaspars, M., Houssen, W. E. & Shalashilin, D. V., 18 May 2017, In : The Journal of Physical Chemistry Letters. 8, 10, p. 2310-2315 6 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
13 Downloads (Pure)

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

Alexandru-Crivac, C. N., Umeobika, C., Leikoski, N., Jokela, J., Rickaby, K., Grilo, A. M., Sjo, P., Plowright, A. T., Idress, M., Siebs, E., Nneoyi-Egbe, A., Wahlsten, M., Sivonen, K., Jaspars, M., Trembleau, L., Fewer, D. P. & Houssen Ibrahim, W. E., 4 Oct 2017, In : Chemical Communications. 53, 77, p. 10656-10659 4 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
12 Downloads (Pure)

Cyclic Peptides – A Look to the Future

Idress, M., Alexandru-Crivac, C. N., Jaspars, M., Trembleau, L. A. C., Houssen Ibrahim, W. E-S. M., Rickaby, K. A. & Dalponte, L., 15 Dec 2017, Cyclic Peptides: From Bioorganic Synthesis to Applications . Koehnke, J., Naismith, J. & van der Donk, W. A. (eds.). UK: Royal Society of Chemistry (Great Britain) , p. 340-373 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., Wang, H., Rizzi, E., De Bellis, G., Naismith, J., Jaspars, M., Liu, X., Houssen, W. & Fewer, D. P., 7 Mar 2016, In : Angewandte Chemie. 128, 11, p. 3660-3663 4 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
10 Downloads (Pure)
3 Citations (Scopus)
11 Downloads (Pure)

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Greig, I. R., Baillie, G. L., Abdelrahman, M., Trembleau, L. & Ross, R. A., 15 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 18, p. 4403-4407 5 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
8 Downloads (Pure)

Different N—H···π interactions in two indole derivatives

Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L. & Harrison, W. T. A., May 2016, In : Acta Crystallographica Section E: Crystallographic Communications. 72, 5, p. 699-703 5 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
6 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
7 Downloads (Pure)
2015
Open Access
File
4 Citations (Scopus)
11 Downloads (Pure)

Discovery of a single monooxygenase catalyzing the carbamate formation and ring contraction in the biosynthesis of legonmycins

Huang, S., Tabudravu, J., Elsayed, S. S., Travert, J., Peace, D., Tong, M. H., Kyeremeh, K., Kelly, S., Trembleau, L. A. C., Ebel, R. P., Jaspars, M., Yu, Y. & Deng, H., 19 Oct 2015, In : Angewandte Chemie International Edition. 54, 43, p. 12697-12701 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
6 Downloads (Pure)
2014

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In : Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria

Tadesse, M., Svenson, J., Sepicic, K., Trembleau, L., Engqvist, M., Andersen, J. H., Jaspars, M., Stensvag, K. & Haug, T., 28 Feb 2014, In : Journal of Natural Products. 77, 2, p. 364-369 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

Receptor conformational change induces fluoride binding despite competitive water binding

Trembleau, L., Smith, T. A. D. & Abdelrahman, M. H., 4 Jul 2013, In : Chemical Communications. 49, 52, p. 5850-5852 3 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2012

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

Houssen, W. E., Koehnke, J., Bent, A., Zollman, D., Morawitz, F., Shirran, S., Vendome, J., Nneoyiegbe, A. F., Trembleau, L., Botting, C. H., Smith, M. C. M., Jaspars, M. & Naismith, J. H., Aug 2012, In : Nature Structural & Molecular Biology. 19, 8, p. 767-772 6 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)
2011
File
7 Citations (Scopus)
2 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
5 Downloads (Pure)

Development of 18F-fluorinatable dendrons and their application to cancer cell targeting

Trembleau, L., Simpson, M., Cheyne, R. W., Escofet, I., Appleyard, M. V. C. L., Murray, K., Sharp, S., Thompson, A. M. & Smith, T. A. D., Nov 2011, In : New Journal of Chemistry. 35, 11, p. 2496-2502 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

N-(ARYLALKYL)-1H-INDOLE-2-SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

Greig, I. R., Ross, R. A., Trembleau, L. A. C., Pertwee, R. G. & Abdelrahman, M. H., 28 Feb 2011, IPC No. WO2012117216, Patent No. WO2012117216

Research output: Patent

Open Access
File
10 Citations (Scopus)
7 Downloads (Pure)

Synthesis and characterisation of biologically compatible TiO2 nanoparticles

Cheyne, R. W., Smith, T. A. D., Trembleau, L. A. C. & McLaughlin, A., 2011, In : Nanoscale Research Letters. 6, -, 423.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
6 Downloads (Pure)
2010

Materials and methods for medical imaging

Smith, T. A. D., Trembleau, L. A. C., McLaughlin, A. & Simpson, M., 2010, IPC No. WO2009056837, Patent No. GB2467494 (A)

Research output: Patent

Multigram-scale synthesis of short peptides via a simplified repetitive solution-phase procedure

Meneses, C., Nicoll, S. L. & Trembleau, L. A. C., 2010, In : Journal of Organic Chemistry. 75, 3, p. 564-569 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2007

5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide

Muirhead, K. E. A., Trembleau, L. & Harrison, W. T. A., 1 Aug 2007, In : Acta Crystallographica Section E: Structure Reports Online. 63, 8, 11 p., o3389.

Research output: Contribution to journalArticle

1 Citation (Scopus)

5-Chloro-3-ethyl-N-[3-(morpholin-4-yl)propyl]-1H-indole-2-carboxamide

Muirhead, K. E. A., Trembleau, L. & Harrison, W. T. A., Aug 2007, In : Acta Crystallographica Section E: Structure Reports Online. 63, 8, 11 p., o3390.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2006

Galanin Agonists

Bartfai, T., Conde Ceide, S., Haberhauer, G., Laszlo, S., Rebek, J. J. & Trembleau, L. A. C., 2006

Research output: Patent

Lipid fluorination enables phase separation from fluid phospholipid bilayers

Webb, S. J., Greenway, K., Bayati, M. & Trembleau, L. A. C., May 2006, In : Organic & Biomolecular Chemistry. 4, p. 2399-2407 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2005

Membrane Composition Determines the Fate of Aggregated Vesicles

Webb, S. J., Wang, X., Mart, R. J. & Trembleau, L. A. C., 2005, In : Organic & Biomolecular Chemistry. 3, p. 3615-3617 2 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2004

Galmic, a nonpeptide galanin receptor agonist, affects behaviours in seizure, pain, and forced-swim tests

Barfai, T., lu, X., Badie-Mahdavi, H., Barr, A. M., Mazarati, A., Hua, X. Y., Yaksh, T., Haberhauser, G., Ceide, S. C., Trembleau, L. A. C., Somogyi, L., Krock, L. & Rebek Jnr, J., 2004, In : PNAS. 101, p. 10470-10475 5 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Helical Folding of Alkanes in a Self-Assembled, Cylindrical Capsule

Scarso, A., Trembleau, L. A. C. & Rebek Jnr, J., 2004, In : Journal of the American Chemical Society. 126, p. 13512-13518 6 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Interactions Between a Surfactant and Cavitand: Blur Distinctions Between Host and Guest

Trembleau, L. A. C. & Rebek Jnr, J., 2004, In : Chemical Communications. 1, p. 58-59 1 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Kinetically Stable Complexes in Water: The Role of Hydration and Hydrophobicity

Biros, S. M., Ullrich, E. C., Hof, F., Trembleau, L. A. C. & Rebek Jnr, J., 2004, In : Journal of the American Chemical Society. 126, p. 2870-2876 6 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Synthesis of galmic: A nonpeptide galanin receptor agonist

Ceide, S. C., Trembleau, L. A. C., Haberhauer, G., Somogyi, L., Bartfai, T. & Rebek Jnr, J., 2004, In : PNAS. 101, 48, p. 16727-16732 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2003

Acetylcholine Recognition by a Deep, Biomimetic Pocket

Hof, F., Trembleau, L. A. C., Ulrich, E. & Rebek Jnr, J., 2003, In : Angewandte Chemie International Edition. 42, p. 3150-3153 3 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Encapsulation Induces Helical Folding of Alkanes

Scarso, A., Trembleau, L. A. C. & Rebek Jnr, J., 2003, In : Angewandte Chemie International Edition. 42, p. 5499-5502 3 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Helical Conformation of Alkanes in a Hydrophobic Cavitand

Trembleau, L. A. C. & Rebek Jnr, J., 2003, In : Science. 301, p. 1219-1220 1 p.

Research output: Contribution to journalArticle

173 Citations (Scopus)
2000
1 Citation (Scopus)
22 Citations (Scopus)