• 1693 Citations
19972020

Research output per year

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Research Output

  • 1693 Citations
  • 36 Article
  • 1 Editorial
  • 1 Literature review
  • 1 Review article
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Article
2020

Neurochemical characterization of brainstem Pro-opiomelanocortin cells

Georgescu, T., Lyons, D., Doslikova, B., Garcia, A. P., Marston, O., Burke, L. K., Chianese, R., Lam, B. Y. H., Yeo, G. S. H., Rochford, J. J., Garfield, A. S. & Heisler, L. K., Apr 2020, In : Endocrinology. 161, 4, p. 1-13 13 p., bqaa032.

Research output: Contribution to journalArticle

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2018

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. L. S., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 55.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
7 Downloads (Pure)

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

Chakera, A. J., Hurst, P. S., Spyer, G., Ogunnowo-Bada, E. O., Marsh, W. J., Riches, C. H., Yueh, C-Y., Markkula, S. P., Dalley, J. W., Cox, R. D., Macdonald, I. A., Amiel, S. A., MacLeod, K. M., Heisler, L. K., Hattersley, A. T. & Evans, M. L., Nov 2018, In : Molecular Metabolism. 17, p. 17-27 11 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
9 Downloads (Pure)

Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake

d'Agostino, G., Lyons, D., Cristiano, C., Lettieri, M., Olarte-Sanchez, C., Burke, L. K., Greenwald-Yarnell, M., Cansell, C., Doslikova, B., Georgescu, T., Blanco Martinez de Morentin, P., Myers Jr., M. G., Rochford, J. J. & Heisler, L., 2 Oct 2018, In : Cell Metabolism. 28, 4, p. 619.-630.e5 18 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
6 Downloads (Pure)

Specific Subpopulations of Hypothalamic Leptin Receptor-Expressing Neurons Mediate the Effects of Early Developmental Leptin Receptor Deletion on Energy Balance

Rupp, A. C., Allison, M. B., Jones, J. C., Patterson, C. M., Faber, C. L., Bozadjieva, N., Heisler, L. K., Seeley, R. J., Olson, D. P. & Myers Jr., M. G., Aug 2018, In : Molecular Metabolism. 14, p. 130-138 9 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
6 Downloads (Pure)
2017

Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice

Xu, P., He, Y., Cao, X., Valencia-Torres, L., Yan, X., Saito, K., Wang, C., Yang, Y., Hinton Jr., A., Zhu, L., Shu, G., Myers Jr., M. G., Wu, Q., Tong, Q., Heisler, L. K. & Xu, Y., 1 May 2017, In : Biological Psychiatry. 81, 9, p. 737-747 11 p.

Research output: Contribution to journalArticle

Open Access
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31 Citations (Scopus)
8 Downloads (Pure)

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation

Valencia-Torres, L., Olarte-Sanchez, C. M., Lyons, D. J., Georgescu, T., Greewald-Yarnell, M., Myers, M. G., Bradshaw, C. M. & Heisler, L. K., Jun 2017, In : Neuropsychopharmacology. 42, 7, p. 1511-1521 11 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
5 Downloads (Pure)

Lorcaserin improves glycemic control via a melanocortin neurocircuit

Burke, L. K., Ogunnowo-Bada, E., Georgescu, T., Cristiano, C., Martinez De Morentin, P. B., Valencia-Torres, L., D'Agostino, G., Riches, C., Heeley, N., Ruan, Y., Rubinstein, M., Low, M. J., Myers, M. G., Rochford, J. J., Evans, M. L. & Heisler, L. K., Oct 2017, In : Molecular Metabolism. 6, 10, p. 1092-1102 11 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
9 Downloads (Pure)
2016

5-HT2Aand 5-HT2Creceptors as hypothalamic targets of developmental programming in male rats

Martin-Gronert, M. S., Stocker, C. J., Wargent, E. T., Cripps, R. L., Garfield, A. S., Jovanovic, Z., D'Agostino, G., Yeo, G. S. H., Cawthorne, M. A., Arch, J. R. S., Heisler, L. K. & Ozanne, S. E., 15 Apr 2016, In : Development. 143, 8, p. 401-412 12 p.

Research output: Contribution to journalArticle

Open Access
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5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

Martin-Gronert, M. S., Stocker, C. J., Wargent, E. T., Cripps, R. L., Garfield, A. S., Jovanovic, Z., D'Agostino, G., Yeo, G. S. H., Cawthorne, M. A., Arch, J. R. S., Heisler, L. K. & Ozanne, S. E., 1 Apr 2016, In : Disease Models & Mechanisms. 9, 4, p. 401-412 12 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
4 Downloads (Pure)

Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

D'Agostino, G., Lyons, D. J., Cristiano, C., Burke, L. K., Madara, J. C., Campbell, J. N., Garcia, A. P., Land, B. B., Lowell, B. B., Dileone, R. J. & Heisler, L. K., 14 Mar 2016, In : eLife. 5, p. 1-15 15 p., 12225.

Research output: Contribution to journalArticle

Open Access
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46 Citations (Scopus)
5 Downloads (Pure)

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Yavari, A., Stocker, C. J., Ghaffari, S., Wargent, E. T., Steeples, V., Czibik, G., Pinter, K., Bellahcene, M., Woods, A., Martínez de Morentin, P. B., Cansell, C., Lam, B. Y. H., Chuster, A., Petkevicius, K., Nguyen-Tu, M-S., Martinez-Sanchez, A., Pullen, T. J., Oliver, P. L., Stockenhuber, A., Nguyen, C. & 34 others, Lazdam, M., O'Dowd, J. F., Harikumar, P., Tóth, M., Beall, C., Kyriakou, T., Parnis, J., Sarma, D., Katritsis, G., Wortmann, D. D. J., Harper, A. R., Brown, L. A., Willows, R., Gandra, S., Poncio, V., de Oliveira Figueiredo, M. J., Qi, N. R., Peirson, S. N., McCrimmon, R. J., Gereben, B., Tretter, L., Fekete, C., Redwood, C., Yeo, G. S. H., Heisler, L. K., Rutter, G. A., Smith, M. A., Withers, D. J., Carling, D., Sternick, E. B., Arch, J. R. S., Cawthorne, M. A., Watkins, H. & Ashrafian, H., 10 May 2016, In : Cell Metabolism. 23, 5, p. 821-836 16 p.

Research output: Contribution to journalArticle

Open Access
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42 Citations (Scopus)
5 Downloads (Pure)

Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite

Garfield, A. S., Davies, J. R., Burke, L. K., Furby, H. V., Wilkinson, L. S., Heisler, L. K. & Isles, A. R., 8 Dec 2016, In : Molecular brain. 9, 1, 95.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
5 Downloads (Pure)

Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats

Markkula, S. P., Lyons, D., Yueh, C-Y., Riches, C., Hurst, P., Fielding, B., Heisler, L. K. & Evans, M. L., 14 Oct 2016, In : Endocrinology. 157, 12, p. 4669–4676 8 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
4 Downloads (Pure)

Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala

Marcinkiewcz, C. A., Mazzone, C. M., D'Agostino, G., Halladay, L. R., Hardaway, J. A., DiBerto, J. F., Navarro, M., Burnham, N., Cristiano, C., Dorrier, C. E., Tipton, G. J., Ramakrishnan, C., Kozicz, T., Deisseroth, K., Thiele, T. E., McElligott, Z. A., Holmes, A., Heisler, L. K. & Kash, T. L., 1 Sep 2016, In : Nature. 537, p. 97-101 5 p., 19318.

Research output: Contribution to journalArticle

Open Access
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119 Citations (Scopus)
7 Downloads (Pure)

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

Burke, L. K., Doslikova, B., D'Agostino, G., Greenwald-Yarnell, M., Georgescu, T., Chianese, R., Martinez de Morentin, P. B., Ogunnowo-Bada, E., Cansell, C., Valencia-Torres, L., Garfield, A. S., Apergis-Schoute, J., Lam, D. D., Speakman, J. R., Rubinstein, M., Low, M. J., Rochford, J. J., Myers, M. G., Evans, M. L. & Heisler, L. K., Mar 2016, In : Molecular Metabolism. 5, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

Open Access
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35 Citations (Scopus)
7 Downloads (Pure)
2015

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice

D'Agostino, G., Cristiano, C., Lyons, D. J., Citraro, R., Russo, E., Avagliano, C., Russo, R., Raso, G. M., Meli, R., De Sarro, G., Heisler, L. K. & Calignano, A., Jul 2015, In : Molecular Metabolism. 4, 7, p. 528-536 9 p.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
8 Downloads (Pure)
2014

5-HT obesity medication efficacy via POMC activation is maintained during aging

Burke, L. K., Doslikova, B., D'Agostino, G., Garfield, A. S., Farooq, G., Burdakov, D., Low, M., Rubinstein, M., Evans, M. L., Billups, B. & Heisler, L., 22 Jul 2014, In : Endocrinology. 155, 10, p. 3732–3738 7 p.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
5 Downloads (Pure)

A Parabrachial-Hypothalamic Cholecystokinin Neurocircuit Controls Counterregulatory Responses to Hypoglycemia

Garfield, A. S., Shah, B. P., Madara, J. C., Burke, L. K., Patterson, C. M., Flak, J., Neve, R. L., Evans, M. L., Lowell, B. B., Myers, M. G. & Heisler, L. K., 2 Dec 2014, In : Cell Metabolism. 20, 6, p. 1030-1037 8 p.

Research output: Contribution to journalArticle

Open Access
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57 Citations (Scopus)
5 Downloads (Pure)

Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup

Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., Kendrick, H., Isles, A. R., Parry, A. J., Carney, S., Oakey, R. J., Heisler, L. K., Moorwood, K., Wolf, J. B. & Ward, A., 25 Feb 2014, In : PLoS Biology. 12, 2, 13 p., 1001799.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia

Garfield, A. S., Burke, L. K., Shaw, J., Evans, M. L. & Heisler, L. K., 1 Jun 2014, In : Behavioural Brain Research. 266, p. 201-206 6 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
5 Downloads (Pure)

Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance

Flak, J. N., Patterson, C. M., Garfield, A. S., D'Agostino, G., Goforth, P. B., Sutton, A. K., Malec, P. A., Wong, J-M. T., Germani, M., Jones, J. C., Rajala, M., Satin, L., Rhodes, C. J., Olson, D. P., Kennedy, R. T., Heisler, L. K. & Myers, M. G., Dec 2014, In : Nature Neuroscience. 17, 12, p. 1744-1750 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2013

5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated

Doslikova, B., Garfield, A. S., Shaw, J., Evans, M. L., Burdakov, D., Billups, B. & Heisler, L. K., 5 Jun 2013, In : Journal of Neuroscience. 33, 23, p. 9800-9804 5 p.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Profiling of glucose-sensing neurons reveals that ghrh neurons are activated by hypoglycemia

Stanley, S., Domingos, A. I., Kelly, L., Garfield, A., Damanpour, S., Heisler, L. & Friedman, J., 1 Oct 2013, In : Cell Metabolism. 18, 4, p. 596-607 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2012

Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion

Osundiji, M. A., Lam, D. D., Shaw, J., Yueh, C-Y., Markkula, S. P., Hurst, P., Colliva, C., Roda, A., Heisler, L. K. & Evans, M. L., Feb 2012, In : Diabetes. 61, 2, p. 321-328 8 p.

Research output: Contribution to journalArticle

Open Access
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40 Citations (Scopus)
6 Downloads (Pure)

Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain

Garfield, A. S., Chan, W. S., Dennis, R. J., Ito, D., Heisler, L. K. & Rochford, J. J., 25 Sep 2012, In : PloS ONE. 7, 9, 11 p., e45790.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
5 Downloads (Pure)
2011

Leptin does not directly affect CNS serotonin neurons to influence appetite

Lam, D. D., Leinninger, G. M., Louis, G. W., Garfield, A. S., Marston, O. J., Leshan, R. L., Scheller, E. L., Christensen, L., Donato, J., Xia, J., Evans, M. L., Elias, C., Dalley, J. W., Burdakov, D. I., Myers, M. G. & Heisler, L. K., 4 May 2011, In : Cell Metabolism. 13, 5, p. 584-591 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Neuropeptide Y cells represent a distinct glucose-sensing population in the lateral hypothalamus

Marston, O. J., Hurst, P., Evans, M. L., Burdakov, D. I. & Heisler, L. K., Nov 2011, In : Endocrinology. 152, 11, p. 4046-4052 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2008

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis

Xu, Y., Jones, J. E., Kohno, D., Williams, K. W., Lee, C. E., Choi, M. J., Anderson, J. G., Heisler, L. K., Zigman, J. M., Lowell, B. B. & Elmquist, J. K., 25 Nov 2008, In : Neuron. 60, 4, p. 582-589 8 p.

Research output: Contribution to journalArticle

Open Access
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193 Citations (Scopus)
6 Downloads (Pure)

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism

Kumar, K. G., Trevaskis, J. L., Lam, D. D., Sutton, G. M., Koza, R. A., Chouljenko, V. N., Kousoulas, K. G., Rogers, P. M., Kesterson, R. A., Thearle, M., Ferrante, A. W., Mynatt, R. L., Burris, T. P., Dong, J. Z., Halem, H. A., Culler, M. D., Heisler, L. K., Stephens, J. M. & Butler, A. A., 6 Dec 2008, In : Cell Metabolism. 8, 6, p. 468-481 14 p.

Research output: Contribution to journalArticle

188 Citations (Scopus)

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors

Lam, D. D., Przydzial, M. J., Ridley, S. H., Yeo, G. S. H., Rochford, J. J., O'Rahilly, S. & Heisler, L. K., Mar 2008, In : Endocrinology. 149, 3, p. 1323-1328 6 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)
2007

Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways

Zhou, L., Sutton, G. M., Rochford, J. J., Semple, R. K., Lam, D. D., Oksanen, L. J., Thornton-Jones, Z. D., Clifton, P. G., Yueh, C-Y., Evans, M. L., McCrimmon, R. J., Elmquist, J. K., Butler, A. A. & Heisler, L. K., 7 Nov 2007, In : Cell Metabolism. 6, 5, p. 398-405 8 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)
2000

Self-Defeating Personality Disorder Reconsidered

Cruz, J., Joiner, T. E., Johnson, J. G., Heisler, L. K., Spitzer, R. L. & Pettit, J. W., Mar 2000, In : Journal of Personality Disorders. 14, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1999

Knockout Corner: Neurobehavioural consequences of a serotonin 5-HT2C receptor gene mutation

Heisler, L. K. & Tecott, L. H., 1 Mar 1999, In : International Journal of Neuropsychopharmacology. 2, 1, p. 67-69 3 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Reduction of Fat and Protein Intakes But Not Carbohydrate Intake Following Acute and Chronic Fluoxetine in Female Rats

Heisler, L. K., Kanarek, R. B. & Homoleski, B., Jul 1999, In : Pharmacology Biochemistry and Behavior. 63, 3, p. 377-385 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
1997

Prior Exposure to Palatable Solutions Enhances the Effects of Naltrexone on Food Intake in Rats

Kanarek, R. B., Mathes, W. F., Heisler, L. K., Lima, R. P. & Monfared, L. S., May 1997, In : Pharmacology Biochemistry and Behavior. 57, 1-2, p. 377-381 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)