• 1859 Citations
19952020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Literature review

Thalidomide embryopathy: an enigmatic challenge

Vargesson, N., 2013, In : ISRN Developmental Biology. 2013, 18 p., 241016.

Research output: Contribution to journalLiterature review

Open Access
File
10 Downloads (Pure)

Thalidomide-induced limb defects: resolving a 50-year-old puzzle

Vargesson, N., Dec 2009, In : BioEssays. 31, 12, p. 1327-1336 10 p.

Research output: Contribution to journalLiterature review

90 Citations (Scopus)

Vascularization of the developing chick limb bud: role of the TGFbeta signalling pathway

Vargesson, N., Jan 2003, In : Journal of Anatomy. 202, 1, p. 93-103 11 p.

Research output: Contribution to journalLiterature review

30 Citations (Scopus)
Letter

Congenital Embryonic Arterial and Skeletal Dysgeneses

Hootnick, D. R., DeSesso, J. & Vargesson, N., Jul 2016, In : RadioGraphics. 36, 4, p. 1257-1257 1 p.

Research output: Contribution to journalLetter

Regarding a limb with PFFD, fibular dimelia and mirror foot deformity

Hootnick, D. R., Vargesson, N. & Birch, J., 1 Nov 2017, In : Journal of Pediatric Orthopaedics B. 26, 6, p. 589-589 1 p.

Research output: Contribution to journalLetter

Editorial

Developmental Angiogenesis

Vargesson, N., Jun 2017, In : Reproductive Toxicology. 70, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Chapter

Thalidomide

Vargesson, N., 21 Apr 2017, Reproductive and Developmental Toxicology . Gupta, R. C. (ed.). 2nd ed. Academic Press, p. 467-479 13 p. Chapter 26

Research output: Chapter in Book/Report/Conference proceedingChapter

Thalidomide

Vargesson, N., Mar 2011, Reproductive and Developmental Toxicology. Gupta, R. (ed.). Elsevier Science , p. 395-403 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The Zebrafish

Vargesson, N., 29 Jan 2007, Manual of Animal Technology. Barnett, S. W. (ed.). Oxford, United Kingdom: Wiley-Blackwell , p. 78-84 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Article

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

Firulli, B. A., Krawchuk, D., Centonze, V. E., Vargesson, N., Virshup, D. M., Conway, S. J., Cserjesi, P., Laufer, E. & Firulli, A. B., Apr 2005, In : Nature Genetics. 37, 4, p. 373-381 8 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Mohamed, A. D., Shah, N., Hettmer, S., Vargesson, N. & Wackerhage, H., 23 Oct 2018, In : Scientific Reports. 8, 10 p., 15674.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
9 Downloads (Pure)

A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

Sorensen, D., Sackett, A., Urban, D. J., Maier, J., Vargesson, N. & Sears, K. E., Jun 2017, In : Reproductive Toxicology. 70, p. 126-132 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
6 Downloads (Pure)

Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues

Beedie, S. L., Peer, C. J., Pisle, S., Gardner, E. R., Mahony, C., Barnett, S., Ambrozak, A., Gütschow, M., Chau, C. H., Vargesson, N. & Figg, W. D., Oct 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2228-2237 10 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
6 Downloads (Pure)

Arterial dysgenesis and limb defects: Clinical and experimental examples

Vargesson, N. & Hootnick, D. R., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 21-29 9 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
8 Downloads (Pure)

Cell fate in the chick limb bud and relationship to gene expression

Vargesson, N., Clarke, J. D., Vincent, K., Coles, C., Wolpert, L. & Tickle, C., 15 May 1997, In : Development. 124, 10, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Characterisation of hoxa gene expression in the chick limb bud in response to FGF

Vargesson, N., Kostakopoulou, K., Drossopoulou, G., Papageorgiou, S. & Tickle, C., 1 Jan 2001, In : Developmental Dynamics. 220, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Sun, C., De Mello, V., Mohamed, A., Quiroga, H. P. O., Garcia-Munoz, A., Al Bloshi, A., Tremblay, A. M., von Kriegsheim, A., Collie-Duguid, E., Vargesson, N., Matallanas, D., Wackerhage, H. & Zammit, P. S., Aug 2017, In : Stem Cells. 35, 8, p. 1958-1972 15 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
11 Downloads (Pure)

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos

Mahony, C., McMenemy, S., Rafipay, A. J., Beedie, S-L., Rosa Fraga, L., Gutschow, M., Figg, W. D., Erskine, L. & Vargesson, N., 1 Mar 2018, In : Journal of Anatomy. 232, 4, p. 568-574 7 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
6 Downloads (Pure)

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine

Crosnier, C., Vargesson, N., Gschmeissner, S., Ariza-Mcnaughton, L., Morrison, A. & Lewis, J., 1 Mar 2005, In : Development. 132, p. 1093-1104 11 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities

Luo, W., Tweedie, D., Beedie, S-L., Vargesson, N., Figg, W. D., Greig, N. H. & Scerba, M. T., 1 May 2018, In : Bioorganic & Medicinal Chemistry. 26, 8, p. 1547-1559 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
7 Downloads (Pure)
91 Citations (Scopus)

Expression analysis of limb element markers during mouse embryonic development

Rafipay, A., Berg, A. L. R., Erskine, L. & Vargesson, N., 20 Nov 2018, In : Developmental Dynamics. 247, 11, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Downloads (Pure)

Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb

Vargesson, N., Patel, K., Lewis, J. & Tickle, C., 1 Oct 1998, In : Mechanisms of Development. 77, 2, p. 197-200 4 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Expression patterns of Slit and Robo family members during vertebrate limb development

Vargesson, N., Luria, V., Messina, I., Erskine, L. & Laufer, E., Aug 2001, In : Mechanisms of Development. 106, 1-2, p. 175-180 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In : Oncotarget. 7, 22, p. 33237-33245 9 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
5 Downloads (Pure)

Lens-regulated retinoic acid signalling controls expansion of the developing eye

Smith, J. N., Walker, H. M., Thompson, H., Collinson, J. M., Vargesson, N. & Erskine, L., 10 Oct 2018, In : Development. 145, 19, dev167171.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
3 Downloads (Pure)

Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

Sagga, N., Kuffova, L., Vargesson, N., Erskine, L. & Collinson, J. M., Dec 2018, In : Stem Cell Research. 33, 12, p. 185-198 14 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
6 Downloads (Pure)

Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps

Kostakopoulou, K., Vargesson, N., Clarke, J. D., Brickell, P. M. & Tickle, C., 1 Oct 1997, In : International Journal of Developmental Biology. 41, 5, p. 747-750 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Molecular analysis of regulative events in the developing chick limb

Mahony, C. & Vargesson, N., 1 Jul 2013, In : Journal of Anatomy. 223, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Negative Smad expression and regulation in the developing chick limb

Vargesson, N. & Laufer, E., 8 Apr 2009, In : PloS ONE. 4, 4, 8 p., e5173.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
6 Downloads (Pure)

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In : PNAS. 110, 31, p. 12703-12708 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Positional Information – a concept underpinning our understanding of developmental biology

Vargesson, N., 1 Mar 2020, In : Developmental Dynamics. 249, 3, p. 298-312 15 p.

Research output: Contribution to journalArticle

Open Access

Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In : Vision Research. 127, p. 104-114 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
5 Downloads (Pure)

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J. D., Niswander, L., McMahon, A. & Tickle, C., 1 Nov 1997, In : Development. 124, 21, p. 4393-4404 12 p.

Research output: Contribution to journalArticle

273 Citations (Scopus)

Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In : PNAS. 110, 50, E4820.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs

Beedie, S. L., Huang, P. A., Harris, E. M., Strope, J. D., Mahony, C., Chau, C. H., Vargesson, N. & Figg, W. D., 17 Jul 2020, In : The FASEB Journal. 10 p.

Research output: Contribution to journalArticle

Open Access

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In : Scientific Reports. 6, p. 1-10 10 p., 30038.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
6 Downloads (Pure)
Open Access
26 Citations (Scopus)

SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma

Gregory-Evans, C. Y., Moosajee, M., Hodges, M. D., Mackay, D. S., Game, L., Vargesson, N., Bloch-Zupan, A., Rüschendorf, F., Santos-Pinto, L., Wackens, G. & Gregory-Evans, K., 15 Oct 2007, In : Human Molecular Genetics. 16, 20, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth

Al-Jamal, K. T., Al-Jamal, W. T., Akerman, S., Podesta, J. E., Yilmazer, A., Turton, J. A., Bianco, A., Vargesson, N., Kanthou, C., Florence, A. T., Tozer, G. M. & Kostarelos, K., 2 Mar 2010, In : PNAS. 107, 9, p. 3966-3971 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Teratogenesis

Vargesson, N. & Fraga, L., 15 Dec 2017, In : eLS. p. 1-7 7 p., a0026056.

Research output: Contribution to journalArticle

TGFbeta superfamily signalling in the developing limb vasculature

Vargesson, N., 1 Nov 2002, In : Journal of Anatomy. 201, 5, p. 422-423 2 p.

Research output: Contribution to journalArticle

Thalidomide and birth defects

Fraga, L., Diamond, A. & Vargesson, N., 2016, In : eLS. January 2016, p. 1-11 11 p., a0026052.

Research output: Contribution to journalArticle

Open Access
File
7 Downloads (Pure)

Thalidomide-induced Teratogenesis: History and Mechanisms

Vargesson, N., Jun 2015, In : Birth Defects Research. Part C, Embryo Today: Reviews. 105, 2, p. 140-156 17 p.

Research output: Contribution to journalArticle

Open Access
File
230 Citations (Scopus)
15 Downloads (Pure)

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

Therapontos, C., Erskine, L., Gardner, E. R., Figg, W. D. & Vargesson, N., 26 May 2009, In : PNAS. 106, 21, p. 8573-8578 6 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

The chick limb: embryology, genetics and teratology

Davey, M. G., Towers, M., Vargesson, N. & Tickle, C., 19 Mar 2018, In : International Journal of Developmental Biology. 62, p. 85-95 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
6 Downloads (Pure)

The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouse

Collinson, J. M., Lindstrom, N. O., Neves, C., Wallace, K., Meharg, C., Charles, R., Fraser, A., Mbogo, I., Oras, K., Nakamoto, M., Barker, S., Duce, S., Miedzybrodzka, Z. & Vargesson, N., 8 Feb 2018, In : Development. 145, 3, dev160093.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
15 Downloads (Pure)

The ectodermal control in chick limb development: Wnt-7a, Shh, Bmp-2 and Bmp-4 expression and the effect of FGF-4 on gene expression

Akita, K., Francis-West, P. & Vargesson, N., 1 Dec 1996, In : Mechanisms of Development. 60, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

'The Legacy of Thalidomide' - a multidisciplinary Meeting held at the University of York, UK on September 30, 2016

Newbronner, E., Vargesson, N. & Atkin, K., 1 Mar 2017, In : Birth Defects Research. 109, 4, p. 296–299 4 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
5 Downloads (Pure)

The NOTCH Pathway Contributes To Cell Fate Decision In Myelopoiesis

Bugeon, L., Taylor, H., Progatzky, F., Lin, M., Ellis, C., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S., Chico, T., Zon, L., Lamb, J. & Dallman, MJ., Dec 2011, In : Haematologica. 96, 12, p. 1753-1760 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)