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Research Output 1995 2019

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Article
2019
Open Access
Developmental Biology
Embryonic Development
Regeneration
Extremities
3 Citations (Scopus)
9 Downloads (Pure)

The teratogenic effects of thalidomide on limbs

Vargesson, N., 1 Jan 2019, In : Journal of hand surgery-European volume. 44, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

Open Access
File
Thalidomide
Extremities
Morning Sickness
Ectromelia
Erythema Nodosum
2 Citations (Scopus)

Vascular anomalies of the upper limb

Mende, K., Vargesson, N. & Sivakumar, B., 1 Mar 2019, In : Journal of hand surgery-European volume. 44, 3, p. 233-241 9 p.

Research output: Contribution to journalArticle

Open Access
File
Upper Extremity
Blood Vessels
Terminology
Hand
Pathology
2 Citations (Scopus)
1 Downloads (Pure)

VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle

Figeac, N., Mohamed, A. D., Sun, C., Schönfelder, M., Matallanas, D., Garcia-Munoz, A., Missiaglia, E., Collie-Duguid, E., De Mello, V., Pobbati, A. V., Pruller, J., Jaka, O., Harridge, S. D. R., Hong, W., Shipley, J., Vargesson, N., Zammit, P. S. & Wackerhage, H., 5 Jul 2019, In : Journal of Cell Science. 132, jcs225946 .

Research output: Contribution to journalArticle

Open Access
File
Muscle Development
Skeletal Muscle
Muscles
Myoblasts
Alveolar Rhabdomyosarcoma
2018
1 Citation (Scopus)
3 Downloads (Pure)

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Mohamed, A. D., Shah, N., Hettmer, S., Vargesson, N. & Wackerhage, H., 23 Oct 2018, In : Scientific Reports. 8, 10 p., 15674.

Research output: Contribution to journalArticle

Open Access
File
Embryonal Rhabdomyosarcoma
Myoblasts
Oncogenes
Rhabdomyosarcoma
Gene Expression
4 Citations (Scopus)
4 Downloads (Pure)

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos

Mahony, C., McMenemy, S., Rafipay, A. J., Beedie, S-L., Rosa Fraga, L., Gutschow, M., Figg, W. D., Erskine, L. & Vargesson, N., 1 Mar 2018, In : Journal of Anatomy. 232, 4, p. 568-574 7 p.

Research output: Contribution to journalArticle

Open Access
File
neurotoxicity
limbs (animal)
limb
embryo
Chickens
4 Citations (Scopus)
5 Downloads (Pure)

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities

Luo, W., Tweedie, D., Beedie, S-L., Vargesson, N., Figg, W. D., Greig, N. H. & Scerba, M. T., 1 May 2018, In : Bioorganic & Medicinal Chemistry. 26, 8, p. 1547-1559 13 p.

Research output: Contribution to journalArticle

Open Access
File
Nitrites
Nitration
Thioamides
phthalimidine
5 Downloads (Pure)

Expression analysis of limb element markers during mouse embryonic development

Rafipay, A., Berg, A. L. R., Erskine, L. & Vargesson, N., 20 Nov 2018, In : Developmental Dynamics. 247, 11, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

Open Access
File
Embryonic Development
Extremities
Intermediate Filaments
Ligaments
Tendons
1 Citation (Scopus)

Lens-regulated retinoic acid signalling controls expansion of the developing eye

Smith, J. N., Walker, H. M., Thompson, H., Collinson, J. M., Vargesson, N. & Erskine, L., 10 Oct 2018, In : Development. 145, 19, dev167171.

Research output: Contribution to journalArticle

Open Access
File
Tretinoin
Lenses
Crystalline Lens
Retina
Collagen
4 Citations (Scopus)
4 Downloads (Pure)

Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

Sagga, N., Kuffova, L., Vargesson, N., Erskine, L. & Collinson, J. M., Dec 2018, In : Stem Cell Research. 33, 12, p. 185-198 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Cycle
Stem Cells
Epithelial Cells
Deoxyuridine
S Phase
8 Citations (Scopus)
4 Downloads (Pure)

The chick limb: embryology, genetics and teratology

Davey, M. G., Towers, M., Vargesson, N. & Tickle, C., 19 Mar 2018, In : International Journal of Developmental Biology. 62, p. 85-95 11 p.

Research output: Contribution to journalArticle

Open Access
File
Teratology
Embryology
Extremities
Chick Embryo
Vertebrates
2 Citations (Scopus)
6 Downloads (Pure)

The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouse

Collinson, J. M., Lindstrom, N. O., Neves, C., Wallace, K., Meharg, C., Charles, R., Fraser, A., Mbogo, I., Oras, K., Nakamoto, M., Barker, S., Duce, S., Miedzybrodzka, Z. & Vargesson, N., 8 Feb 2018, In : Development. 145, 3, dev160093.

Research output: Contribution to journalArticle

Open Access
File
Charcot-Marie-Tooth Disease
Clubfoot
Lim Kinases
Motor Neurons
Sciatic Nerve
4 Citations (Scopus)
6 Downloads (Pure)

The Primodos components Noretheristerone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafish embryos

Brown, S., Rosa Fraga, L., Cameron, G., Erskine, L. & Vargesson, N., 13 Feb 2018, In : Scientific Reports. 8, 2917.

Research output: Contribution to journalArticle

Open Access
File
Ethinyl Estradiol
Zebrafish
Acetates
Embryonic Structures
Embryonic Development
1 Citation (Scopus)

The syndrome of proximal femur, fibula, and midline metatarsal long bone deficiencies

Hootnick, D. R. & Vargesson, N., 1 Sep 2018, In : Birth Defects Research. 110, 15, p. 1188-1193 6 p.

Research output: Contribution to journalArticle

Open Access
File
Fibula
Metatarsal Bones
Femur
Bone
Extremities
2017
4 Citations (Scopus)
4 Downloads (Pure)

A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

Sorensen, D., Sackett, A., Urban, D. J., Maier, J., Vargesson, N. & Sears, K. E., Jun 2017, In : Reproductive Toxicology. 70, p. 126-132 7 p.

Research output: Contribution to journalArticle

Open Access
File
Monodelphis
Teratogenesis
Thalidomide
Opossums
Defects
10 Citations (Scopus)
6 Downloads (Pure)

Arterial dysgenesis and limb defects: Clinical and experimental examples

Vargesson, N. & Hootnick, D. R., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 21-29 9 p.

Research output: Contribution to journalArticle

Open Access
File
Teratogens
Extremities
Defects
Thalidomide
Blood Vessels
19 Citations (Scopus)
9 Downloads (Pure)

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Sun, C., De Mello, V., Mohamed, A., Quiroga, H. P. O., Garcia-Munoz, A., Al Bloshi, A., Tremblay, A. M., von Kriegsheim, A., Collie-Duguid, E., Vargesson, N., Matallanas, D., Wackerhage, H. & Zammit, P. S., Aug 2017, In : Stem Cells. 35, 8, p. 1958-1972 15 p.

Research output: Contribution to journalArticle

Open Access
File
Muscle Cells
Muscle Development
Skeletal Muscle
Stem Cells
Regeneration

Teratogenesis

Vargesson, N. & Fraga, L., 15 Dec 2017, In : eLS. p. 1-7 7 p., a0026056.

Research output: Contribution to journalArticle

Teratogenesis
Teratogens
Teratology
Rubella virus
Environmental Pollutants
1 Citation (Scopus)
3 Downloads (Pure)

'The Legacy of Thalidomide' - a multidisciplinary Meeting held at the University of York, UK on September 30, 2016

Newbronner, E., Vargesson, N. & Atkin, K., 1 Mar 2017, In : Birth Defects Research. 109, 4, p. 296–299 4 p.

Research output: Contribution to journalArticle

Open Access
File
Thalidomide
Survivors
Pharmaceutical Preparations
Morning Sickness
Fetal Diseases
8 Citations (Scopus)
6 Downloads (Pure)

VEGF-A and Neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

Erskine, L., Francois, U., Denti, L., Joyce, A., Tillo, M., Bruce, F., Vargesson, N. & Ruhrberg, C., Jul 2017, In : Development. 144, 13, p. 2504-2516 13 p.

Research output: Contribution to journalArticle

Open Access
File
Neuropilin-1
Vascular Endothelial Growth Factor A
Blood Vessels
Axons
Neurons
4 Citations (Scopus)
9 Downloads (Pure)

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Beedie, S., Diamond, A. J., Rosa Fraga, L., Figg, W. D. & Vargesson, N., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 49-59 10 p.

Research output: Contribution to journalArticle

Open Access
File
Preclinical Drug Evaluations
Angiogenesis Inhibitors
Vertebrates
Assays
Screening
2016
20 Citations (Scopus)
3 Downloads (Pure)

In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In : Oncotarget. 7, 22, p. 33237-33245 9 p.

Research output: Contribution to journalArticle

Open Access
File
Thalidomide
Zebrafish
Chickens
Embryonic Structures
Leprosy
1 Citation (Scopus)
3 Downloads (Pure)

Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In : Vision Research. 127, p. 104-114 11 p.

Research output: Contribution to journalArticle

Open Access
File
Zebrafish
Noise
Vertebrates
Equipment and Supplies
21 Citations (Scopus)
4 Downloads (Pure)

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In : Scientific Reports. 6, p. 1-10 10 p., 30038.

Research output: Contribution to journalArticle

Open Access
File
Angiogenesis Inhibitors
Chickens
Embryonic Structures
Blood Vessels
Teratogens
5 Downloads (Pure)

Thalidomide and birth defects

Fraga, L., Diamond, A. & Vargesson, N., 2016, In : eLS. January 2016, p. 1-11 11 p., a0026052.

Research output: Contribution to journalArticle

Open Access
File
Thalidomide
Ectromelia
Teratogenesis
Antiemetics
Inner Ear
2015
16 Citations (Scopus)
4 Downloads (Pure)

Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues

Beedie, S. L., Peer, C. J., Pisle, S., Gardner, E. R., Mahony, C., Barnett, S., Ambrozak, A., Gütschow, M., Chau, C. H., Vargesson, N. & Figg, W. D., Oct 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2228-2237 10 p.

Research output: Contribution to journalArticle

Open Access
File
Thalidomide
Embryonic Structures
Zebrafish
carboxyamido-triazole
Human Umbilical Vein Endothelial Cells
174 Citations (Scopus)
10 Downloads (Pure)

Thalidomide-induced Teratogenesis: History and Mechanisms

Vargesson, N., Jun 2015, In : Birth Defects Research. Part C, Embryo Today: Reviews. 105, 2, p. 140-156 17 p.

Research output: Contribution to journalArticle

Open Access
File
Teratogenesis
Thalidomide
History
Pharmaceutical Preparations
Morning Sickness
2013
3 Citations (Scopus)

Molecular analysis of regulative events in the developing chick limb

Mahony, C. & Vargesson, N., 1 Jul 2013, In : Journal of Anatomy. 223, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

molecular analysis
limbs (animal)
limb
Extremities
chicks
32 Citations (Scopus)

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In : PNAS. 110, 31, p. 12703-12708 6 p.

Research output: Contribution to journalArticle

Thalidomide
Zebrafish
Chickens
Embryonic Structures
Anti-Inflammatory Agents
3 Citations (Scopus)

Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In : PNAS. 110, 50, E4820.

Research output: Contribution to journalArticle

2011
9 Citations (Scopus)

The NOTCH Pathway Contributes To Cell Fate Decision In Myelopoiesis

Bugeon, L., Taylor, H., Progatzky, F., Lin, M., Ellis, C., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S., Chico, T., Zon, L., Lamb, J. & Dallman, MJ., Dec 2011, In : Haematologica. 96, 12, p. 1753-1760 8 p.

Research output: Contribution to journalArticle

Myelopoiesis
Fishes
Embryonic Structures
Fertilization
Flow Cytometry
10 Citations (Scopus)

Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis

Lindström, N. O., Neves, C., McIntosh, R., Miedzybrodzka, Z. H., Vargesson, N. & Collinson, J. M., Mar 2011, In : Gene Expression Patterns. 11, 3-4, p. 221-232 12 p.

Research output: Contribution to journalArticle

Lim Kinases
Embryonic Development
Actin Depolymerizing Factors
Proteins
Epithelial-Mesenchymal Transition
2010
57 Citations (Scopus)

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth

Al-Jamal, K. T., Al-Jamal, W. T., Akerman, S., Podesta, J. E., Yilmazer, A., Turton, J. A., Bianco, A., Vargesson, N., Kanthou, C., Florence, A. T., Tozer, G. M. & Kostarelos, K., 2 Mar 2010, In : PNAS. 107, 9, p. 3966-3971 6 p.

Research output: Contribution to journalArticle

Dendrimers
Lysine
Growth
Neoplasms
Chorioallantoic Membrane
10 Citations (Scopus)

Zebrafish notch signalling pathway mutants exhibit trunk vessel patterning anomalies that are secondary to somite misregulation

Therapontos, C. & Vargesson, N., Oct 2010, In : Developmental Dynamics. 239, 10, p. 2761-2768 8 p.

Research output: Contribution to journalArticle

Somites
Zebrafish
Blood Vessels
Pseudopodia
Cues
2009
9 Citations (Scopus)
4 Downloads (Pure)

Negative Smad expression and regulation in the developing chick limb

Vargesson, N. & Laufer, E., 8 Apr 2009, In : PloS ONE. 4, 4, 8 p., e5173.

Research output: Contribution to journalArticle

Open Access
File
limbs (animal)
Gene expression
Transforming Growth Factor beta
Extremities
chicks
155 Citations (Scopus)

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

Therapontos, C., Erskine, L., Gardner, E. R., Figg, W. D. & Vargesson, N., 26 May 2009, In : PNAS. 106, 21, p. 8573-8578 6 p.

Research output: Contribution to journalArticle

Thalidomide
Extremities
Blood Vessels
Teratogenesis
Fetal Diseases
2007
42 Citations (Scopus)

SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma

Gregory-Evans, C. Y., Moosajee, M., Hodges, M. D., Mackay, D. S., Game, L., Vargesson, N., Bloch-Zupan, A., Rüschendorf, F., Santos-Pinto, L., Wackens, G. & Gregory-Evans, K., 15 Oct 2007, In : Human Molecular Genetics. 16, 20, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

Labyrinth Diseases
Coloboma
Single Nucleotide Polymorphism
Tooth
Chromosomes
2005
124 Citations (Scopus)

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

Firulli, B. A., Krawchuk, D., Centonze, V. E., Vargesson, N., Virshup, D. M., Conway, S. J., Cserjesi, P., Laufer, E. & Firulli, A. B., Apr 2005, In : Nature Genetics. 37, 4, p. 373-381 8 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine

Crosnier, C., Vargesson, N., Gschmeissner, S., Ariza-Mcnaughton, L., Morrison, A. & Lewis, J., 1 Mar 2005, In : Development. 132, p. 1093-1104 11 p.

Research output: Contribution to journalArticle

2002

TGFbeta superfamily signalling in the developing limb vasculature

Vargesson, N., 1 Nov 2002, In : Journal of Anatomy. 201, 5, p. 422-423 2 p.

Research output: Contribution to journalArticle

transforming growth factor beta
Transforming Growth Factor beta
Embryonic Development
Blood Vessels
limb
2001
27 Citations (Scopus)

Characterisation of hoxa gene expression in the chick limb bud in response to FGF

Vargesson, N., Kostakopoulou, K., Drossopoulou, G., Papageorgiou, S. & Tickle, C., 1 Jan 2001, In : Developmental Dynamics. 220, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

Limb Buds
Gene Expression
53 Citations (Scopus)

Expression patterns of Slit and Robo family members during vertebrate limb development

Vargesson, N., Luria, V., Messina, I., Erskine, L. & Laufer, E., Aug 2001, In : Mechanisms of Development. 106, 1-2, p. 175-180 5 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
Open Access
1998
43 Citations (Scopus)

Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb

Vargesson, N., Patel, K., Lewis, J. & Tickle, C., 1 Oct 1998, In : Mechanisms of Development. 77, 2, p. 197-200 4 p.

Research output: Contribution to journalArticle

Extremities
Vertebrates
Mesoderm
Notch Receptors
Limb Buds
1997
135 Citations (Scopus)

Cell fate in the chick limb bud and relationship to gene expression

Vargesson, N., Clarke, J. D., Vincent, K., Coles, C., Wolpert, L. & Tickle, C., 15 May 1997, In : Development. 124, 10, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

Limb Buds
Mesoderm
Gene Expression
Population
Genes
13 Citations (Scopus)

Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps

Kostakopoulou, K., Vargesson, N., Clarke, J. D., Brickell, P. M. & Tickle, C., 1 Oct 1997, In : International Journal of Developmental Biology. 41, 5, p. 747-750 4 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 4
Amphibians
Mesoderm
Vertebrates
Extremities
270 Citations (Scopus)

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J. D., Niswander, L., McMahon, A. & Tickle, C., 1 Nov 1997, In : Development. 124, 21, p. 4393-4404 12 p.

Research output: Contribution to journalArticle

Hedgehogs
Extremities
Mesoderm
Alkaline Phosphatase
Hedgehog Proteins
1996
15 Citations (Scopus)

The ectodermal control in chick limb development: Wnt-7a, Shh, Bmp-2 and Bmp-4 expression and the effect of FGF-4 on gene expression

Akita, K., Francis-West, P. & Vargesson, N., 1 Dec 1996, In : Mechanisms of Development. 60, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

Ectoderm
Extremities
Gene Expression
Mesoderm
Cartilage
1995
90 Citations (Scopus)
Rhombencephalon
Zebrafish
Mesencephalon
Tretinoin
Gastrulation