• 1854 Citations
19952020

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1995
91 Citations (Scopus)
1996

The ectodermal control in chick limb development: Wnt-7a, Shh, Bmp-2 and Bmp-4 expression and the effect of FGF-4 on gene expression

Akita, K., Francis-West, P. & Vargesson, N., 1 Dec 1996, In : Mechanisms of Development. 60, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1997

Cell fate in the chick limb bud and relationship to gene expression

Vargesson, N., Clarke, J. D., Vincent, K., Coles, C., Wolpert, L. & Tickle, C., 15 May 1997, In : Development. 124, 10, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps

Kostakopoulou, K., Vargesson, N., Clarke, J. D., Brickell, P. M. & Tickle, C., 1 Oct 1997, In : International Journal of Developmental Biology. 41, 5, p. 747-750 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J. D., Niswander, L., McMahon, A. & Tickle, C., 1 Nov 1997, In : Development. 124, 21, p. 4393-4404 12 p.

Research output: Contribution to journalArticle

273 Citations (Scopus)
1998

Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb

Vargesson, N., Patel, K., Lewis, J. & Tickle, C., 1 Oct 1998, In : Mechanisms of Development. 77, 2, p. 197-200 4 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2001

Characterisation of hoxa gene expression in the chick limb bud in response to FGF

Vargesson, N., Kostakopoulou, K., Drossopoulou, G., Papageorgiou, S. & Tickle, C., 1 Jan 2001, In : Developmental Dynamics. 220, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Expression patterns of Slit and Robo family members during vertebrate limb development

Vargesson, N., Luria, V., Messina, I., Erskine, L. & Laufer, E., Aug 2001, In : Mechanisms of Development. 106, 1-2, p. 175-180 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
Open Access
26 Citations (Scopus)
2002

TGFbeta superfamily signalling in the developing limb vasculature

Vargesson, N., 1 Nov 2002, In : Journal of Anatomy. 201, 5, p. 422-423 2 p.

Research output: Contribution to journalArticle

2005

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

Firulli, B. A., Krawchuk, D., Centonze, V. E., Vargesson, N., Virshup, D. M., Conway, S. J., Cserjesi, P., Laufer, E. & Firulli, A. B., Apr 2005, In : Nature Genetics. 37, 4, p. 373-381 8 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine

Crosnier, C., Vargesson, N., Gschmeissner, S., Ariza-Mcnaughton, L., Morrison, A. & Lewis, J., 1 Mar 2005, In : Development. 132, p. 1093-1104 11 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)
2007

SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma

Gregory-Evans, C. Y., Moosajee, M., Hodges, M. D., Mackay, D. S., Game, L., Vargesson, N., Bloch-Zupan, A., Rüschendorf, F., Santos-Pinto, L., Wackens, G. & Gregory-Evans, K., 15 Oct 2007, In : Human Molecular Genetics. 16, 20, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2009

Negative Smad expression and regulation in the developing chick limb

Vargesson, N. & Laufer, E., 8 Apr 2009, In : PloS ONE. 4, 4, 8 p., e5173.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
6 Downloads (Pure)

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

Therapontos, C., Erskine, L., Gardner, E. R., Figg, W. D. & Vargesson, N., 26 May 2009, In : PNAS. 106, 21, p. 8573-8578 6 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)
2010

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth

Al-Jamal, K. T., Al-Jamal, W. T., Akerman, S., Podesta, J. E., Yilmazer, A., Turton, J. A., Bianco, A., Vargesson, N., Kanthou, C., Florence, A. T., Tozer, G. M. & Kostarelos, K., 2 Mar 2010, In : PNAS. 107, 9, p. 3966-3971 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Zebrafish notch signalling pathway mutants exhibit trunk vessel patterning anomalies that are secondary to somite misregulation

Therapontos, C. & Vargesson, N., Oct 2010, In : Developmental Dynamics. 239, 10, p. 2761-2768 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

The NOTCH Pathway Contributes To Cell Fate Decision In Myelopoiesis

Bugeon, L., Taylor, H., Progatzky, F., Lin, M., Ellis, C., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S., Chico, T., Zon, L., Lamb, J. & Dallman, MJ., Dec 2011, In : Haematologica. 96, 12, p. 1753-1760 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis

Lindström, N. O., Neves, C., McIntosh, R., Miedzybrodzka, Z. H., Vargesson, N. & Collinson, J. M., Mar 2011, In : Gene Expression Patterns. 11, 3-4, p. 221-232 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

Molecular analysis of regulative events in the developing chick limb

Mahony, C. & Vargesson, N., 1 Jul 2013, In : Journal of Anatomy. 223, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In : PNAS. 110, 31, p. 12703-12708 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In : PNAS. 110, 50, E4820.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues

Beedie, S. L., Peer, C. J., Pisle, S., Gardner, E. R., Mahony, C., Barnett, S., Ambrozak, A., Gütschow, M., Chau, C. H., Vargesson, N. & Figg, W. D., Oct 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2228-2237 10 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
6 Downloads (Pure)

Thalidomide-induced Teratogenesis: History and Mechanisms

Vargesson, N., Jun 2015, In : Birth Defects Research. Part C, Embryo Today: Reviews. 105, 2, p. 140-156 17 p.

Research output: Contribution to journalArticle

Open Access
File
227 Citations (Scopus)
15 Downloads (Pure)
2016

In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In : Oncotarget. 7, 22, p. 33237-33245 9 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
5 Downloads (Pure)

Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In : Vision Research. 127, p. 104-114 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
5 Downloads (Pure)

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In : Scientific Reports. 6, p. 1-10 10 p., 30038.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
6 Downloads (Pure)

Thalidomide and birth defects

Fraga, L., Diamond, A. & Vargesson, N., 2016, In : eLS. January 2016, p. 1-11 11 p., a0026052.

Research output: Contribution to journalArticle

Open Access
File
7 Downloads (Pure)
2017

A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

Sorensen, D., Sackett, A., Urban, D. J., Maier, J., Vargesson, N. & Sears, K. E., Jun 2017, In : Reproductive Toxicology. 70, p. 126-132 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
6 Downloads (Pure)

Arterial dysgenesis and limb defects: Clinical and experimental examples

Vargesson, N. & Hootnick, D. R., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 21-29 9 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
8 Downloads (Pure)

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Sun, C., De Mello, V., Mohamed, A., Quiroga, H. P. O., Garcia-Munoz, A., Al Bloshi, A., Tremblay, A. M., von Kriegsheim, A., Collie-Duguid, E., Vargesson, N., Matallanas, D., Wackerhage, H. & Zammit, P. S., Aug 2017, In : Stem Cells. 35, 8, p. 1958-1972 15 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
11 Downloads (Pure)

Teratogenesis

Vargesson, N. & Fraga, L., 15 Dec 2017, In : eLS. p. 1-7 7 p., a0026056.

Research output: Contribution to journalArticle

'The Legacy of Thalidomide' - a multidisciplinary Meeting held at the University of York, UK on September 30, 2016

Newbronner, E., Vargesson, N. & Atkin, K., 1 Mar 2017, In : Birth Defects Research. 109, 4, p. 296–299 4 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
5 Downloads (Pure)

VEGF-A and Neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

Erskine, L., Francois, U., Denti, L., Joyce, A., Tillo, M., Bruce, F., Vargesson, N. & Ruhrberg, C., Jul 2017, In : Development. 144, 13, p. 2504-2516 13 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
8 Downloads (Pure)

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Beedie, S., Diamond, A. J., Rosa Fraga, L., Figg, W. D. & Vargesson, N., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 49-59 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
14 Downloads (Pure)
2018

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Mohamed, A. D., Shah, N., Hettmer, S., Vargesson, N. & Wackerhage, H., 23 Oct 2018, In : Scientific Reports. 8, 10 p., 15674.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
9 Downloads (Pure)

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos

Mahony, C., McMenemy, S., Rafipay, A. J., Beedie, S-L., Rosa Fraga, L., Gutschow, M., Figg, W. D., Erskine, L. & Vargesson, N., 1 Mar 2018, In : Journal of Anatomy. 232, 4, p. 568-574 7 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
6 Downloads (Pure)

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities

Luo, W., Tweedie, D., Beedie, S-L., Vargesson, N., Figg, W. D., Greig, N. H. & Scerba, M. T., 1 May 2018, In : Bioorganic & Medicinal Chemistry. 26, 8, p. 1547-1559 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
7 Downloads (Pure)

Expression analysis of limb element markers during mouse embryonic development

Rafipay, A., Berg, A. L. R., Erskine, L. & Vargesson, N., 20 Nov 2018, In : Developmental Dynamics. 247, 11, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Downloads (Pure)

Lens-regulated retinoic acid signalling controls expansion of the developing eye

Smith, J. N., Walker, H. M., Thompson, H., Collinson, J. M., Vargesson, N. & Erskine, L., 10 Oct 2018, In : Development. 145, 19, dev167171.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
3 Downloads (Pure)

Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

Sagga, N., Kuffova, L., Vargesson, N., Erskine, L. & Collinson, J. M., Dec 2018, In : Stem Cell Research. 33, 12, p. 185-198 14 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
6 Downloads (Pure)

The chick limb: embryology, genetics and teratology

Davey, M. G., Towers, M., Vargesson, N. & Tickle, C., 19 Mar 2018, In : International Journal of Developmental Biology. 62, p. 85-95 11 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
6 Downloads (Pure)

The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouse

Collinson, J. M., Lindstrom, N. O., Neves, C., Wallace, K., Meharg, C., Charles, R., Fraser, A., Mbogo, I., Oras, K., Nakamoto, M., Barker, S., Duce, S., Miedzybrodzka, Z. & Vargesson, N., 8 Feb 2018, In : Development. 145, 3, dev160093.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
15 Downloads (Pure)

The Primodos components Noretheristerone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafish embryos

Brown, S., Rosa Fraga, L., Cameron, G., Erskine, L. & Vargesson, N., 13 Feb 2018, In : Scientific Reports. 8, 2917.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
8 Downloads (Pure)

The syndrome of proximal femur, fibula, and midline metatarsal long bone deficiencies

Hootnick, D. R. & Vargesson, N., 1 Sep 2018, In : Birth Defects Research. 110, 15, p. 1188-1193 6 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
2 Downloads (Pure)
2019

The teratogenic effects of thalidomide on limbs

Vargesson, N., 1 Jan 2019, In : Journal of hand surgery-European volume. 44, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
11 Downloads (Pure)

Vascular anomalies of the upper limb

Mende, K., Vargesson, N. & Sivakumar, B., 1 Mar 2019, In : Journal of hand surgery-European volume. 44, 3, p. 233-241 9 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
2 Downloads (Pure)

VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle

Figeac, N., Mohamed, A. D., Sun, C., Schönfelder, M., Matallanas, D., Garcia-Munoz, A., Missiaglia, E., Collie-Duguid, E., De Mello, V., Pobbati, A. V., Pruller, J., Jaka, O., Harridge, S. D. R., Hong, W., Shipley, J., Vargesson, N., Zammit, P. S. & Wackerhage, H., 5 Jul 2019, In : Journal of Cell Science. 132, jcs225946 .

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
3 Downloads (Pure)
2020

Positional Information – a concept underpinning our understanding of developmental biology

Vargesson, N., 1 Mar 2020, In : Developmental Dynamics. 249, 3, p. 298-312 15 p.

Research output: Contribution to journalArticle

Open Access

Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs

Beedie, S. L., Huang, P. A., Harris, E. M., Strope, J. D., Mahony, C., Chau, C. H., Vargesson, N. & Figg, W. D., 17 Jul 2020, In : The FASEB Journal. 10 p.

Research output: Contribution to journalArticle

Open Access