• 4206 Citations
19962020
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Personal profile

Research Interests:

The group’s research interests are in the mechanisms involved in the regulation of energy balance and body weight, and to determine how dysregulation leads to obesity and its associated pathologies. In particular we study the endocrine and physiological role of factors secreted by adipose tissue. A combination of in vivo and cell culture approaches is employed, integrating molecular and protein techniques into whole-organism physiology.

In particular we are interested in dietary strategies for alleviating the metabolic complications such as type 2 diabetes associated with obesity as alternatives to pharmaceutical interventions.

The genus Vaccinium (e.g. blueberry, blaeberry), has been used traditionally as a source of folk remedies for established diabetic symptoms. Berries from this family such as blueberries and blaeberries are enriched in polyphenolics recognized for their ability to provide cellular antioxidant protection, inhibit inflammatory genes, and consequently protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The association of obesity with the expression of genes in the fat which cause a low level of inflammation in this tissue suggests that eating edible berries from this genus might provide a supplementary intervention to reduce this obesity- associated inflammation and the associated insulin resistance which this low level of inflammation may be causing.

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  • 11 Similar Profiles
Leptin Medicine & Life Sciences
Anthocyanins Medicine & Life Sciences
Adipose Tissue Medicine & Life Sciences
Vaccinium myrtillus Medicine & Life Sciences
Obesity Medicine & Life Sciences
Insulin Medicine & Life Sciences
bilberries Agriculture & Biology
Vaccinium myrtillus extract Medicine & Life Sciences

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Research Output 1996 2020

Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Alnajjar, M., Barik, S. K., Bestwick, C., Campbell, F., Cruickshank, M., Farquharson, F., Holtrop, G., Horgan, G., Louis, P., Moar, K-M., Russell, W. R., Scobbie, L. & Hoggard, N., Jan 2020, In : Journal of Functional Foods. 64, 103597.

Research output: Contribution to journalArticle

Open Access
File
Vaccinium myrtillus
bilberries
Anthocyanins
volunteers
anthocyanins
Ribes
Glucosidases
Anthocyanins
Amylases
Sugars
1 Citation (Scopus)
19 Downloads (Pure)
Open Access
File
Glutens
Bread
Cross-Over Studies
Diet
Aspergillus niger
7 Citations (Scopus)
3 Downloads (Pure)

SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

Sergi, D., Campbell, F. M., Grant, C., Morris, A. C., Bachmair, E-M., Koch, C. E., McLean, F. H., Muller, A., Hoggard, N., de Roos, B., Porteiro, B., Boekschoten, M. V., McGillicuddy, F. C., Kahn, D., Nicol, P., Benzler, J., Mayer, C-D., Drew, J. E., Roche, H. M., Muller, M. & 4 others, Nogueiras, R., Diéguez, C., Tups, A. & Williams, L. M., 29 Nov 2018, In : Genes & Nutrition. 13, p. 1-14 14 p., 28.

Research output: Contribution to journalArticle

Open Access
File
High Fat Diet
Leptin
Hypothalamus
Up-Regulation
Genes
Blueberry Plants
Glucose Tolerance Test
Fruit
Healthy Volunteers
Glucose