• 4270 Citations
19962020

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Personal profile

Research Interests:

The group’s research interests are in the mechanisms involved in the regulation of energy balance and body weight, and to determine how dysregulation leads to obesity and its associated pathologies. In particular we study the endocrine and physiological role of factors secreted by adipose tissue. A combination of in vivo and cell culture approaches is employed, integrating molecular and protein techniques into whole-organism physiology.

In particular we are interested in dietary strategies for alleviating the metabolic complications such as type 2 diabetes associated with obesity as alternatives to pharmaceutical interventions.

The genus Vaccinium (e.g. blueberry, blaeberry), has been used traditionally as a source of folk remedies for established diabetic symptoms. Berries from this family such as blueberries and blaeberries are enriched in polyphenolics recognized for their ability to provide cellular antioxidant protection, inhibit inflammatory genes, and consequently protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The association of obesity with the expression of genes in the fat which cause a low level of inflammation in this tissue suggests that eating edible berries from this genus might provide a supplementary intervention to reduce this obesity- associated inflammation and the associated insulin resistance which this low level of inflammation may be causing.

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Research Output

Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Alnajjar, M., Barik, S. K., Bestwick, C., Campbell, F., Cruickshank, M., Farquharson, F., Holtrop, G., Horgan, G., Louis, P., Moar, K-M., Russell, W. R., Scobbie, L. & Hoggard, N., Jan 2020, In : Journal of Functional Foods. 64, 103597.

Research output: Contribution to journalArticle

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  • 1 Citation (Scopus)
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    23 Downloads (Pure)

    SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

    Sergi, D., Campbell, F. M., Grant, C., Morris, A. C., Bachmair, E-M., Koch, C. E., McLean, F. H., Muller, A., Hoggard, N., de Roos, B., Porteiro, B., Boekschoten, M. V., McGillicuddy, F. C., Kahn, D., Nicol, P., Benzler, J., Mayer, C-D., Drew, J. E., Roche, H. M., Muller, M. & 4 others, Nogueiras, R., Diéguez, C., Tups, A. & Williams, L. M., 29 Nov 2018, In : Genes & Nutrition. 13, p. 1-14 14 p., 28.

    Research output: Contribution to journalArticle

    Open Access
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  • 7 Citations (Scopus)
    4 Downloads (Pure)