Nigel Hoggard


    • AB25 2ZD

    • 4183 Citations
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    Research Interests:

    The group’s research interests are in the mechanisms involved in the regulation of energy balance and body weight, and to determine how dysregulation leads to obesity and its associated pathologies. In particular we study the endocrine and physiological role of factors secreted by adipose tissue. A combination of in vivo and cell culture approaches is employed, integrating molecular and protein techniques into whole-organism physiology.

    In particular we are interested in dietary strategies for alleviating the metabolic complications such as type 2 diabetes associated with obesity as alternatives to pharmaceutical interventions.

    The genus Vaccinium (e.g. blueberry, blaeberry), has been used traditionally as a source of folk remedies for established diabetic symptoms. Berries from this family such as blueberries and blaeberries are enriched in polyphenolics recognized for their ability to provide cellular antioxidant protection, inhibit inflammatory genes, and consequently protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The association of obesity with the expression of genes in the fat which cause a low level of inflammation in this tissue suggests that eating edible berries from this genus might provide a supplementary intervention to reduce this obesity- associated inflammation and the associated insulin resistance which this low level of inflammation may be causing.

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    • 15 Similar Profiles
    Leptin Medicine & Life Sciences
    Adipose Tissue Medicine & Life Sciences
    Vaccinium myrtillus Medicine & Life Sciences
    Obesity Medicine & Life Sciences
    Insulin Medicine & Life Sciences
    bilberries Agriculture & Biology
    Vaccinium myrtillus extract Medicine & Life Sciences
    Anthocyanins Medicine & Life Sciences

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    Research Output 1996 2019

    Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

    Alnajjar, M., Barik, S. K., Bestwick, C., Campbell, F., Cruickshank, M., Farquharson, F., Holtrop, G., Horgan, G., Louis, P., Moar, K-M., Russell, W. R., Scobbie, L. & Hoggard, N., 31 Oct 2019, In : Journal of Functional Foods. 103597.

    Research output: Contribution to journalArticle

    Open Access
    Vaccinium myrtillus
    1 Citation (Scopus)
    19 Downloads (Pure)
    Open Access
    Cross-Over Studies
    Aspergillus niger
    5 Citations (Scopus)
    3 Downloads (Pure)

    SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

    Sergi, D., Campbell, F. M., Grant, C., Morris, A. C., Bachmair, E-M., Koch, C. E., McLean, F. H., Muller, A., Hoggard, N., de Roos, B., Porteiro, B., Boekschoten, M. V., McGillicuddy, F. C., Kahn, D., Nicol, P., Benzler, J., Mayer, C-D., Drew, J. E., Roche, H. M., Muller, M. & 4 others, Nogueiras, R., Diéguez, C., Tups, A. & Williams, L. M., 29 Nov 2018, In : Genes & Nutrition. 13, p. 1-14 14 p., 28.

    Research output: Contribution to journalArticle

    Open Access
    High Fat Diet
    Blueberry Plants
    Glucose Tolerance Test
    Healthy Volunteers
    55 Citations (Scopus)
    4 Downloads (Pure)

    The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases

    Williams, L. M., Campbell, F. M., Drew, J. E., Koch, C., Hoggard, N., Rees, W. D., Kamolrat, T., Thi Ngo, H., Steffensen, I-L., Gray, S. R. & Tups, A., 29 Aug 2014, In : PloS ONE. 9, 8, 19 p., e106159.

    Research output: Contribution to journalArticle

    Open Access
    Glucose Intolerance
    High Fat Diet
    high fat diet
    Inbred C57BL Mouse