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Research Output 1999 2019

2019

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Fenretinide
Phenotype
Dipeptidyl Peptidase 4
Glucose
Retinol-Binding Proteins
2018
6 Downloads (Pure)
Open Access
File
Electron Transport
Interferons
Multiple Sclerosis
Blood Cells
Therapeutics
6 Citations (Scopus)
7 Downloads (Pure)

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 13 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Tyrosine Phosphatases
Leukemia
Myeloid Cells
Acute Myeloid Leukemia
Liver
6 Downloads (Pure)

Response to comment by Moxon et al

Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M. & Delibegovic, M., 2 Jan 2018, In : Clinical Science. 132, 1, p. 39-41 3 p.

Research output: Contribution to journalLetter

Open Access
File
2017
5 Citations (Scopus)
7 Downloads (Pure)
Open Access
File
Tretinoin
Vitamin A
Insulin Resistance
Homeostasis
Obesity
18 Citations (Scopus)
9 Downloads (Pure)

Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice

Lees, E. K., Banks, R., Cook, C., Hill, S., Morrice, N., Grant, L., Delibegovic, M. & Mody, N., 2017, In : Scientific Reports. 7, p. 1-10 10 p., 9977.

Research output: Contribution to journalArticle

Open Access
File
Inbred C57BL Mouse
Leucine
Methionine
Health
Glucose
14 Citations (Scopus)
12 Downloads (Pure)

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

Morrice, N., McIlroy, G. D., Tammireddy, S., Reekie, J., Shearer, K. D., Doherty, M. K., Delibegovic, M., Whitfield, P. D. & Mody, N., 3 Mar 2017, In : Scientific Reports. 7, 43782 .

Research output: Contribution to journalArticle

Open Access
File
Fenretinide
Retinoids
Insulin
Liver
Homeostasis
6 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
AMP-Activated Protein Kinases
Apolipoproteins E
Atherosclerotic Plaques
Interleukin-10
7 Citations (Scopus)
14 Downloads (Pure)
Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Atherosclerotic Plaques
Atherosclerosis
Pharmacology
Insulin Receptor
18 Citations (Scopus)
6 Downloads (Pure)

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

McIlroy, G. D., Tammireddy, S. R., Maskrey, B. H., Grant, L., Doherty, M. K., Watson, D. G., Delibegovic, M., Whitfield, P. D. & Mody, N., 15 Jan 2016, In : Biochemical Pharmacology. 100, p. 86-97 12 p.

Research output: Contribution to journalArticle

Open Access
File
Fenretinide
Adipogenesis
Retinoic Acid Receptors
Ceramides
Biosynthesis

Investigation of a Type 2 diabetes-like phenotype in a mouse model of Alzheimer's disease

Dekeryte, R., Plucinska, K., Koss, D., Shearer, K., Mody, N., Riedel, G., Platt, B. & Delibegovic, M., Mar 2016, In : Diabetic Medicine. 33, Suppl. 1, p. 82 1 p.

Research output: Contribution to journalAbstract

Open Access
14 Citations (Scopus)
7 Downloads (Pure)

Methionine restriction improves renal insulin signalling in aged kidneys

Grant, L., Lees, E. K., Forney, L. A., Mody, N., Gettys, T., Brown, P. A. J., Wilson, H. M. & Delibegovic, M., Jul 2016, In : Mechanisms of Ageing and Development. 157, p. 35-43 8 p.

Research output: Contribution to journalArticle

Open Access
File
Methionine
Insulin
Kidney
Gene Expression
Insulin Resistance
20 Citations (Scopus)
8 Downloads (Pure)

Neuronal human BACE1 knock-in induces systemic diabetes in mice

Plucinska, K., Dekeryte, R., Koss, D., Shearer, K., Mody, N., Whitfield, P. D., Doherty, M. K., Mingarelli, M., Welch, A., Riedel, G., Delibegovic, M. & Platt, B., Jul 2016, In : Diabetologia. 59, 7, p. 1513-1523 11 p.

Research output: Contribution to journalArticle

Open Access
File
Glucose
Homeostasis
Fluorodeoxyglucose F18
Lipids
Alzheimer Disease
5 Citations (Scopus)
4 Downloads (Pure)

Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance

Jothery, A. H. A., Vaanholt, L. M., Mody, N., Arnous, A., Lykkesfeldt, J., Bünger, L., Hill, W. G., Mitchell, S. E., Allison, D. B. & Speakman, J. R., 14 Nov 2016, In : Scientific Reports. 6, 36353.

Research output: Contribution to journalArticle

Open Access
File
Reproduction
Eating
Costs and Cost Analysis
Oxidative Stress
Antioxidants
9 Citations (Scopus)
42 Downloads (Pure)

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice

Lees, E. K., Krol, E., Shearer, K., Mody, N., Gettys, T. W. & Delibegovic, M., Feb 2015, In : Metabolism. 64, 2, p. 305-314 10 p.

Research output: Contribution to journalArticle

Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Lipid Metabolism
Methionine
Glucose
Liver
8 Citations (Scopus)

Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen-signaling

Shearer, K. D., Morrice, N., Henderson, C., Reekie, J., McIlroy, G. D., McCaffery, P. J., Delibegovic, M. & Mody, N., Aug 2015, In : Obesity. 23, 8, p. 1655-1662 8 p.

Research output: Contribution to journalArticle

Fenretinide
Retinoids
High Fat Diet
Estrogens
Adiposity
24 Citations (Scopus)
10 Citations (Scopus)

Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B

Owen, C., Lees, E. K., Mody, N. & Delibegovic, M., Feb 2015, In : Diabetes & Metabolism. 41, 1, p. 95-101 7 p.

Research output: Contribution to journalArticle

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Janus Kinase 2
Growth Hormone
Liver
Phosphorylation
2014
11 Citations (Scopus)
4 Downloads (Pure)

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

Agouni, A., Tual-Chalot, S., Chalopin, M., Duluc, L., Mody, N., Martinez, M. C., Andriantsitohaina, R. & Delibegovic, M., 15 Dec 2014, In : Biochemical Pharmacology. 92, 4, p. 607-617 11 p.

Research output: Contribution to journalArticle

Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Nutrition
High Fat Diet
Obesity
Fats
86 Citations (Scopus)
5 Downloads (Pure)

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

Lees, E. K., Krol, E., Grant, L., Shearer, K., Wyse, C., Moncur, E., Bykowska, A. S., Mody, N., Gettys, T. & Delibegovic, M., Oct 2014, In : Aging Cell. 13, 5, p. 817-827 11 p.

Research output: Contribution to journalArticle

Open Access
File
Methionine
Phenotype
Adiposity
Eating
Body Weight
39 Citations (Scopus)
26 Downloads (Pure)

Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism

Grant, L., Shearer, K. D., Czopek, A., Lees, E. K., Owen, C., Agouni, A., Workman, J., Martin-Granados, C., Forrester, J. V., Wilson, H. M., Mody, N. & Delibegovic, M., Feb 2014, In : Diabetes. 63, 2, p. 456-470 15 p.

Research output: Contribution to journalArticle

Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Endotoxemia
Hyperinsulinism
High Fat Diet
Myeloid Cells
19 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
Fenretinide
Medical problems
Type 2 Diabetes Mellitus
Obesity
Retinoids
2013

BACE1: the missing link between Alzheimer's disease, diabetes and obesity?

Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., Riedel, G. & Platt, B., 11 Mar 2013.

Research output: Contribution to conferencePoster

BACE1: The missing link between Alzheimer’s disease, diabetes and obesity?

Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., McIlroy, G. D., Riedel, G. & Platt, B., 11 Mar 2013.

Research output: Contribution to conferencePoster

30 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
Fenretinide
Retinoids
Hypothalamus
Obesity
Diet
40 Citations (Scopus)

Inducible Liver-Specific Knockdown of Protein Tyrosine Phosphatase 1B Improves Glucose and Lipid Homeostasis in Adult Mice

Owen, C., Lees, E. K., Grant, L., Zimmer, D. J., Mody, N., Bence, K. K. & Delibegovic, M., Oct 2013, In : Diabetologia. 56, 10, p. 2286-2296 10 p.

Research output: Contribution to journalArticle

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Homeostasis
High Fat Diet
Lipids
Glucose
3 Citations (Scopus)
46 Downloads (Pure)

PTP1B in the periphery: regulating insulin sensitivity and ER stress

Delibegovic, M. & Mody, N., 2013, Protein tyrosine phosphatase control of metabolism. Bence, K. K. (ed.). London: Springer , p. 91-105 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Endoplasmic Reticulum Stress
Insulin Resistance
Leptin
Signal Transduction
2012

(18) Fenretinide treatment for high fat diet-induced obesity and insulin sensitivity

Henderson, C. & Mody, N., Aug 2012, In : Atherosclerosis. 223, 2, p. 532 1 p.

Research output: Contribution to journalArticle

Fenretinide
High Fat Diet
Insulin Resistance
Obesity
Therapeutics
44 Citations (Scopus)
5 Downloads (Pure)

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

Owen, C., Czopek, A., Agouni, A., Grant, L., Judson, R., Lees, E. K., McIlroy, G. D., Göransson, O., Welch, A., Bence, K. K., Kahn, B. B., Neel, B. G., Mody, N. & Delibegovic, M., 28 Feb 2012, In : PloS ONE. 7, 2, 15 p., e32700.

Research output: Contribution to journalArticle

Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
protein-tyrosine-phosphatase
Lipogenesis
lipogenesis
adipocytes
3 Citations (Scopus)

Optoelectronic tweezers for the measurement of the relative stiffness of erythrocytes

Neale, S. L., Mody, N., Selman, C. & Cooper, J. M., 9 Oct 2012, Optical Trapping and Optical Micromanipulation IX. Dholakia, K. & Spalding, G. C. (eds.). SPIE, Vol. 8458.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

erythrocytes
stiffness
cells
dipoles
mice
8 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Retinol-Binding Proteins
Endoplasmic Reticulum Stress
Scotland
Adipose Tissue
2011
79 Citations (Scopus)
4 Downloads (Pure)

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

Agouni, A., Mody, N., Owen, C., Czopek, A., Zimmer, D., Bentirez-Alj, M., Bence, K. K. & Delibegovic, M., 2011, In : Biochemical Journal. 438, 2, p. 369-378 10 p.

Research output: Contribution to journalArticle

Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Endoplasmic Reticulum Stress
Liver
Obesity
Insulin
51 Citations (Scopus)
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Ribosomal Protein S6
Retinol-Binding Proteins
Glucose Intolerance
Alzheimer Disease
2010
29 Citations (Scopus)
Fasting
Insulin
Tissue
Phosphorylation
Insulin Receptor
2009
66 Citations (Scopus)

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

Preitner, F., Mody, N., Graham, T. E., Peroni, O. D. & Kahn, B. B., 1 Dec 2009, In : American Journal of Physiology: Endocrinology and Metabolism. 297, 6, p. E1420-E1429 10 p.

Research output: Contribution to journalArticle

Fenretinide
High Fat Diet
Insulin Resistance
Obesity
Liver

Protein Tyrosine Phosphatase 1B (PTP1B) in obesity and type 2 diabetes

Delibegovic, M. & Mody, N., 1 Dec 2009, In : Acta Medica Saliniana. 38, 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Type 2 Diabetes Mellitus
Obesity
Rodentia
Anti-Obesity Agents
2008
64 Citations (Scopus)

Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice

Mody, N., Graham, T. E., Tsuji, Y., Yang, Q. & Kahn, B. B., Apr 2008, In : American Journal of Physiology: Endocrinology and Metabolism. 294, 4, p. E785-E793 9 p.

Research output: Contribution to journalArticle

Retinol-Binding Proteins
Prealbumin
Insulin
Serum
Insulin Resistance
2007
121 Citations (Scopus)

Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B

Delibegovic, M., Bence, K. K., Mody, N., Hong, E-G., Ko, H. J., Kim, J. K., Kahn, B. B. & Neelt, B. G., Nov 2007, In : Molecular and Cellular Biology. 27, 21, p. 7727-7734 8 p.

Research output: Contribution to journalArticle

262 Citations (Scopus)

The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance

Yan, Q-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C-H., Xu, Z., Houstis, N. E., Kahn, B. B. & Rosen, E. D., Oct 2007, In : Diabetes. 56, 10, p. 2533-2540 8 p.

Research output: Contribution to journalArticle

Adipokines
Insulin Resistance
Obesity
Adipocytes
Lipocalin-2
2005
1419 Citations (Scopus)

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L. & Kahn, B. B., 21 Jul 2005, In : Nature. 436, 7049, p. 356-62 7 p.

Research output: Contribution to journalArticle

Retinol-Binding Proteins
Type 2 Diabetes Mellitus
Insulin Resistance
Obesity
Serum
2003
57 Citations (Scopus)

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

Mody, N., Campbell, D. G., Morrice, N., Peggie, M. & Cohen, P., 1 Jun 2003, In : Biochemical Journal. 372, 2, p. 567-575 9 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase 5
Mitogen-Activated Protein Kinase 7
Activation Analysis
MAP Kinase Kinase Kinases
Phosphorylation
2001
216 Citations (Scopus)

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

Mody, N., Leitch, J., Armstrong, C., Dixon, J. & Cohen, P., 27 Jul 2001, In : FEBS Letters. 502, 1-2, p. 21-24 4 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 7
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Phosphotransferases
Chemical activation
1999
17 Citations (Scopus)

Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function

Mody, N., Hermans, E., Nahorski, S. R. & Challiss, R. A., 1 Oct 1999, In : Neuropharmacology. 38, 10, p. 1485-1492 8 p.

Research output: Contribution to journalArticle

Tunicamycin
Metabotropic Glutamate Receptors
Cell Surface Receptors
Glycosylation
Biotinylation