Research output per year
Research output per year
- 50 results
Search results
-
2024
Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial
Peña Carrillo, B. J., Cope, E., Gurel, S., Traslosheros, A., Kenny, A., Michot-Duval, O., Mody, N., Delibegovic, M., Philip, S., Thies, F., Blana, D. & Gabriel, B., 24 Mar 2024, (E-pub ahead of print) In: The Journal of Physiology. 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism
Helk, O., Dekeryte, R., Thompson, D., Kamli-Salino, S., Philip, S., Wilson, H., Mody, N. & Delibegovic, M., 19 Sept 2023, (Accepted/In press) In: Journal of translational medicine.Research output: Contribution to journal › Article › peer-review
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Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice
Thompson, D., Mahmood, S., Morrice, N., Kamli-Salino, S., Dekeryte, R., Hoffmann, P., Doherty, M. K., Whitfield, P. D., Delibegović, M. & Mody, N., 9 Mar 2023, In: Scientific Reports. 13, 3937.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)3 Downloads (Pure) -
2022
High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide
Plucińska, K., Mody, N., Dekeryte, R., Shearer, K., McIlroy, G., Delibegovic, M. & Platt, B., Apr 2022, In: Nutritional Neuroscience. 25, 4, p. 719-736 18 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2020
Design, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents
Patruno, I., Thompson, D., Dall'angelo, S., Windhorst, A. D., Vugts, D. J., Poot, A. J., Mody, N. & Zanda, M., 19 Aug 2020, In: ChemMedChem. 15, 16, p. 1579-1590 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)3 Downloads (Pure) -
2019
Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice
Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In: Biochemical Pharmacology. 166, p. 222-230 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)7 Downloads (Pure) -
2018
Blood Mononuclear Cell Mitochondrial Respiratory Chain Complex IV Activity Is Decreased in Multiple Sclerosis Patients: Effects of β-Interferon Treatment
Hargreaves, I., Mody, N., Land, J. & Heales, S., 20 Feb 2018, In: Journal of Clinical Medicine. 7, 2, 36.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)10 Downloads (Pure) -
Response to comment by Moxon et al
Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M. & Delibegovic, M., 2 Jan 2018, In: Clinical Science. 132, 1, p. 39-41 3 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile12 Downloads (Pure) -
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia
Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In: Cancer Research. 78, 1, p. 75-87 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)14 Downloads (Pure) -
2017
Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance
Mody, N., Nov 2017, In: Proceedings of the Nutrition Society. 76, 4, p. 597-602 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)10 Downloads (Pure) -
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis
Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M. & Delibegovic, M., 1 Oct 2017, In: Clinical Science. 131, 20, p. 2489-2501 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)20 Downloads (Pure) -
Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Ziegler, K., Whitfield, P., Mody, N., Wilson, H. M. & Delibegovic, M., 1 Aug 2017, In: Molecular Metabolism. 6, 8, p. 845-853 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)19 Downloads (Pure) -
Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
Morrice, N., McIlroy, G., Tammireddy, S. R., Reekie, J., Shearer, K. D., Doherty, M. K., Delibegovic, M., Whitfield, P. D. & Mody, N., 3 Mar 2017, In: Scientific Reports. 7, 13 p., 43782 .Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)21 Downloads (Pure) -
Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice
Lees, E. K., Banks, R., Cook, C., Hill, S., Morrice, N., Grant, L., Delibegovic, M. & Mody, N., 2017, In: Scientific Reports. 7, p. 1-10 10 p., 9977.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Citations (Scopus)13 Downloads (Pure) -
2016
Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance
Jothery, A. H. A., Vaanholt, L. M., Mody, N., Arnous, A., Lykkesfeldt, J., Bünger, L., Hill, W. G., Mitchell, S. E., Allison, D. B. & Speakman, J. R., 14 Nov 2016, In: Scientific Reports. 6, 36353.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)9 Downloads (Pure) -
Methionine restriction improves renal insulin signalling in aged kidneys
Grant, L., Lees, E. K., Forney, L. A., Mody, N., Gettys, T., Brown, P. A. J., Wilson, H. M. & Delibegovic, M., Jul 2016, In: Mechanisms of Ageing and Development. 157, p. 35-43 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)61 Downloads (Pure) -
Neuronal human BACE1 knock-in induces systemic diabetes in mice
Plucinska, K., Dekeryte, R., Koss, D., Shearer, K., Mody, N., Whitfield, P. D., Doherty, M. K., Mingarelli, M., Welch, A., Riedel, G., Delibegovic, M. & Platt, B., Jul 2016, In: Diabetologia. 59, 7, p. 1513-1523 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Citations (Scopus)19 Downloads (Pure) -
Elevated fibroblast growth factor 21 (FGF21) levels in obese, insulin resistant states are normalised by fenretinide treatment via retinoic acid signalling
Mody, N., Morrice, N., McIlroy, G. D., Shearer, K. D., McCaffery, P. J. & Delibegovic, M., Mar 2016, In: Diabetic Medicine. 33, p. 48 1 p.Research output: Contribution to journal › Abstract › peer-review
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Investigation of a Type 2 diabetes-like phenotype in a mouse model of Alzheimer's disease
Dekeryte, R., Plucinska, K., Koss, D., Shearer, K., Mody, N., Riedel, G., Platt, B. & Delibegovic, M., Mar 2016, In: Diabetic Medicine. 33, Suppl. 1, p. 82 1 p.Research output: Contribution to journal › Abstract › peer-review
Open Access -
Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
McIlroy, G., Tammireddy, S. R., Maskrey, B. H., Grant, L., Doherty, M. K., Watson, D. G., Delibegovic, M., Whitfield, P. D. & Mody, N., 15 Jan 2016, In: Biochemical Pharmacology. 100, p. 86-97 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)11 Downloads (Pure) -
2015
Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen-signaling
Shearer, K. D., Morrice, N., Henderson, C., Reekie, J., McIlroy, G., McCaffery, P. J., Delibegovic, M. & Mody, N., Aug 2015, In: Obesity. 23, 8, p. 1655-1662 8 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Comparison between beneficial effects of leucine and methionine restriction on regulation of body mass, adiposity, glucose and lipid homeostasis
Lees, E. K., Mody, N. & Delibegovic, M., Mar 2015, In: Diabetic Medicine. 32, S1, p. 47-47 1 p.Research output: Contribution to journal › Abstract › peer-review
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Mechanisms of improved glucose homeostasis by the synthetic retinoid fenretinide: altered genes, metabolites and lipids
Mody, N., McIlroy, G. D., Morrice, N. & Delibegovic, M., Mar 2015, In: Diabetic Medicine. 32, S1, p. 47-48 2 p.Research output: Contribution to journal › Abstract › peer-review
43 Citations (Scopus) -
Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice
Lees, E. K., Krol, E., Shearer, K., Mody, N., Gettys, T. W. & Delibegovic, M., Feb 2015, In: Metabolism. 64, 2, p. 305-314 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)48 Downloads (Pure) -
Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B
Owen, C., Lees, E. K., Mody, N. & Delibegovic, M., Feb 2015, In: Diabetes & Metabolism. 41, 1, p. 95-101 7 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2014
Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction
Agouni, A., Tual-Chalot, S., Chalopin, M., Duluc, L., Mody, N., Martinez, M. C., Andriantsitohaina, R. & Delibegovic, M., 15 Dec 2014, In: Biochemical Pharmacology. 92, 4, p. 607-617 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)9 Downloads (Pure) -
The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes
Mody, N. & McIlroy, G. D., 1 Oct 2014, In: Biochemical Pharmacology. 91, 3, p. 277-286 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)25 Downloads (Pure) -
Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21
Lees, E. K., Krol, E., Grant, L., Shearer, K., Wyse, C., Moncur, E., Bykowska, A. S., Mody, N., Gettys, T. & Delibegovic, M., Oct 2014, In: Aging Cell. 13, 5, p. 817-827 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile155 Citations (Scopus)11 Downloads (Pure) -
Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism
Grant, L., Shearer, K. D., Czopek, A., Lees, E. K., Owen, C., Agouni, A., Workman, J., Martin-Granados, C., Forrester, J. V., Wilson, H. M., Mody, N. & Delibegovic, M., Feb 2014, In: Diabetes. 63, 2, p. 456-470 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Citations (Scopus)31 Downloads (Pure) -
2013
Inducible Liver-Specific Knockdown of Protein Tyrosine Phosphatase 1B Improves Glucose and Lipid Homeostasis in Adult Mice
Owen, C., Lees, E. K., Grant, L., Zimmer, D. J., Mody, N., Bence, K. K. & Delibegovic, M., Oct 2013, In: Diabetologia. 56, 10, p. 2286-2296 10 p.Research output: Contribution to journal › Article › peer-review
56 Citations (Scopus) -
High fat diet-induced deterioration of cognitive deficits in hBACE1 knock-in mouse model of Alzheimer’s disease, reversal by anti-obesity, anti-diabetes compound MN101
Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., McIlroy, G. D., Riedel, G. & Platt, B., 7 Apr 2013.Research output: Contribution to conference › Poster › peer-review
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BACE1: The missing link between Alzheimer’s disease, diabetes and obesity?
Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., McIlroy, G. D., Riedel, G. & Platt, B., 11 Mar 2013.Research output: Contribution to conference › Poster › peer-review
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Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver and Hypothalamus
McIlroy, G. D., Delibegovic, M., Owen, C., Stoney, P. N., Shearer, K. D., McCaffery, P. J. & Mody, N., Mar 2013, In: Diabetes. 62, 3, p. 825-836 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Citations (Scopus)9 Downloads (Pure) -
PTP1B in the periphery: regulating insulin sensitivity and ER stress
Delibegovic, M. & Mody, N., 2013, Protein tyrosine phosphatase control of metabolism. Bence, K. K. (ed.). London: Springer , p. 91-105 15 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Citations (Scopus)46 Downloads (Pure) -
2012
Optoelectronic tweezers for the measurement of the relative stiffness of erythrocytes
Neale, S. L., Mody, N., Selman, C. & Cooper, J. M., 9 Oct 2012, Optical Trapping and Optical Micromanipulation IX. Dholakia, K. & Spalding, G. C. (eds.). SPIE, Vol. 8458.Research output: Chapter in Book/Report/Conference proceeding › Published conference contribution
7 Citations (Scopus) -
(18) Fenretinide treatment for high fat diet-induced obesity and insulin sensitivity
Henderson, C. & Mody, N., Aug 2012, In: Atherosclerosis. 223, 2, p. 532 1 p.Research output: Contribution to journal › Article › peer-review
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Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes
Hoggard, N., Agouni, A., Mody, N. & Delibegovic, M., May 2012, In: International Journal of General Medicine. 5, p. 403-411 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)9 Downloads (Pure) -
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
Owen, C., Czopek, A., Agouni, A., Grant, L., Judson, R., Lees, E. K., McIlroy, G., Göransson, O., Welch, A., Bence, K. K., Kahn, B. B., Neel, B. G., Mody, N. & Delibegovic, M., 28 Feb 2012, In: PloS ONE. 7, 2, 15 p., e32700.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)9 Downloads (Pure) -
2011
Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress
Agouni, A., Mody, N., Owen, C., Czopek, A., Zimmer, D., Bentirez-Alj, M., Bence, K. K. & Delibegovic, M., 2011, In: Biochemical Journal. 438, 2, p. 369-378 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile98 Citations (Scopus)8 Downloads (Pure) -
Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein
Mody, N., Agouni, A., McIlroy, G., Platt, B. & Delibegovic, M., 2011, In: Diabetologia. 54, 8, p. 2143-2151 9 p.Research output: Contribution to journal › Article › peer-review
70 Citations (Scopus) -
2010
In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues
Agouni, A., Owen, C., Czopek, A., Mody, N. & Delibegovic, M., 8 Oct 2010, In: Biochemical and Biophysical Research Communications. 401, 1, p. 104-111 8 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
2009
Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis
Preitner, F., Mody, N., Graham, T. E., Peroni, O. D. & Kahn, B. B., 1 Dec 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 6, p. E1420-E1429 10 p.Research output: Contribution to journal › Article › peer-review
91 Citations (Scopus) -
Protein Tyrosine Phosphatase 1B (PTP1B) in obesity and type 2 diabetes
Delibegovic, M. & Mody, N., 1 Dec 2009, In: Acta Medica Saliniana. 38, 1, p. 2-7 6 p.Research output: Contribution to journal › Article › peer-review
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2008
Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice
Mody, N., Graham, T. E., Tsuji, Y., Yang, Q. & Kahn, B. B., Apr 2008, In: American Journal of Physiology: Endocrinology and Metabolism. 294, 4, p. E785-E793 9 p.Research output: Contribution to journal › Article › peer-review
79 Citations (Scopus) -
2007
Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
Delibegovic, M., Bence, K. K., Mody, N., Hong, E-G., Ko, H. J., Kim, J. K., Kahn, B. B. & Neelt, B. G., Nov 2007, In: Molecular and Cellular Biology. 27, 21, p. 7727-7734 8 p.Research output: Contribution to journal › Article
140 Citations (Scopus) -
The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
Yan, Q-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C-H., Xu, Z., Houstis, N. E., Kahn, B. B. & Rosen, E. D., Oct 2007, In: Diabetes. 56, 10, p. 2533-2540 8 p.Research output: Contribution to journal › Article › peer-review
374 Citations (Scopus) -
2005
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L. & Kahn, B. B., 21 Jul 2005, In: Nature. 436, 7049, p. 356-62 7 p.Research output: Contribution to journal › Article › peer-review
1749 Citations (Scopus) -
2003
An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro
Mody, N., Campbell, D. G., Morrice, N., Peggie, M. & Cohen, P., 1 Jun 2003, In: Biochemical Journal. 372, 2, p. 567-575 9 p.Research output: Contribution to journal › Article › peer-review
75 Citations (Scopus) -
2001
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway
Mody, N., Leitch, J., Armstrong, C., Dixon, J. & Cohen, P., 27 Jul 2001, In: FEBS Letters. 502, 1-2, p. 21-24 4 p.Research output: Contribution to journal › Article › peer-review
230 Citations (Scopus) -
1999
Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function
Mody, N., Hermans, E., Nahorski, S. R. & Challiss, R. A., 1 Oct 1999, In: Neuropharmacology. 38, 10, p. 1485-1492 8 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus)