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2019

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 1 Aug 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

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2018
Open Access
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Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 13 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
8 Downloads (Pure)
2017
Open Access
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5 Citations (Scopus)
8 Downloads (Pure)

Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice

Lees, E. K., Banks, R., Cook, C., Hill, S., Morrice, N., Grant, L., Delibegovic, M. & Mody, N., 2017, In : Scientific Reports. 7, p. 1-10 10 p., 9977.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
10 Downloads (Pure)

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

Morrice, N., McIlroy, G. D., Tammireddy, S., Reekie, J., Shearer, K. D., Doherty, M. K., Delibegovic, M., Whitfield, P. D. & Mody, N., 3 Mar 2017, In : Scientific Reports. 7, 43782 .

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
13 Downloads (Pure)
Open Access
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7 Citations (Scopus)
14 Downloads (Pure)
Open Access
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8 Citations (Scopus)
17 Downloads (Pure)
2016

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

McIlroy, G. D., Tammireddy, S. R., Maskrey, B. H., Grant, L., Doherty, M. K., Watson, D. G., Delibegovic, M., Whitfield, P. D. & Mody, N., 15 Jan 2016, In : Biochemical Pharmacology. 100, p. 86-97 12 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
7 Downloads (Pure)

Methionine restriction improves renal insulin signalling in aged kidneys

Grant, L., Lees, E. K., Forney, L. A., Mody, N., Gettys, T., Brown, P. A. J., Wilson, H. M. & Delibegovic, M., Jul 2016, In : Mechanisms of Ageing and Development. 157, p. 35-43 8 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
14 Downloads (Pure)

Neuronal human BACE1 knock-in induces systemic diabetes in mice

Plucinska, K., Dekeryte, R., Koss, D., Shearer, K., Mody, N., Whitfield, P. D., Doherty, M. K., Mingarelli, M., Welch, A., Riedel, G., Delibegovic, M. & Platt, B., Jul 2016, In : Diabetologia. 59, 7, p. 1513-1523 11 p.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
10 Downloads (Pure)

Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance

Jothery, A. H. A., Vaanholt, L. M., Mody, N., Arnous, A., Lykkesfeldt, J., Bünger, L., Hill, W. G., Mitchell, S. E., Allison, D. B. & Speakman, J. R., 14 Nov 2016, In : Scientific Reports. 6, 36353.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
5 Downloads (Pure)
2015

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice

Lees, E. K., Krol, E., Shearer, K., Mody, N., Gettys, T. W. & Delibegovic, M., Feb 2015, In : Metabolism. 64, 2, p. 305-314 10 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
43 Downloads (Pure)

Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen-signaling

Shearer, K. D., Morrice, N., Henderson, C., Reekie, J., McIlroy, G. D., McCaffery, P. J., Delibegovic, M. & Mody, N., Aug 2015, In : Obesity. 23, 8, p. 1655-1662 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B

Owen, C., Lees, E. K., Mody, N. & Delibegovic, M., Feb 2015, In : Diabetes & Metabolism. 41, 1, p. 95-101 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2014

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

Agouni, A., Tual-Chalot, S., Chalopin, M., Duluc, L., Mody, N., Martinez, M. C., Andriantsitohaina, R. & Delibegovic, M., 15 Dec 2014, In : Biochemical Pharmacology. 92, 4, p. 607-617 11 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
5 Downloads (Pure)

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

Lees, E. K., Krol, E., Grant, L., Shearer, K., Wyse, C., Moncur, E., Bykowska, A. S., Mody, N., Gettys, T. & Delibegovic, M., Oct 2014, In : Aging Cell. 13, 5, p. 817-827 11 p.

Research output: Contribution to journalArticle

Open Access
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88 Citations (Scopus)
6 Downloads (Pure)

Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism

Grant, L., Shearer, K. D., Czopek, A., Lees, E. K., Owen, C., Agouni, A., Workman, J., Martin-Granados, C., Forrester, J. V., Wilson, H. M., Mody, N. & Delibegovic, M., Feb 2014, In : Diabetes. 63, 2, p. 456-470 15 p.

Research output: Contribution to journalArticle

Open Access
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39 Citations (Scopus)
27 Downloads (Pure)
Open Access
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19 Citations (Scopus)
5 Downloads (Pure)
2013
Open Access
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30 Citations (Scopus)
5 Downloads (Pure)

Inducible Liver-Specific Knockdown of Protein Tyrosine Phosphatase 1B Improves Glucose and Lipid Homeostasis in Adult Mice

Owen, C., Lees, E. K., Grant, L., Zimmer, D. J., Mody, N., Bence, K. K. & Delibegovic, M., Oct 2013, In : Diabetologia. 56, 10, p. 2286-2296 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2012

(18) Fenretinide treatment for high fat diet-induced obesity and insulin sensitivity

Henderson, C. & Mody, N., Aug 2012, In : Atherosclerosis. 223, 2, p. 532 1 p.

Research output: Contribution to journalArticle

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

Owen, C., Czopek, A., Agouni, A., Grant, L., Judson, R., Lees, E. K., McIlroy, G. D., Göransson, O., Welch, A., Bence, K. K., Kahn, B. B., Neel, B. G., Mody, N. & Delibegovic, M., 28 Feb 2012, In : PloS ONE. 7, 2, 15 p., e32700.

Research output: Contribution to journalArticle

Open Access
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44 Citations (Scopus)
6 Downloads (Pure)
Open Access
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8 Citations (Scopus)
5 Downloads (Pure)
2011

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

Agouni, A., Mody, N., Owen, C., Czopek, A., Zimmer, D., Bentirez-Alj, M., Bence, K. K. & Delibegovic, M., 2011, In : Biochemical Journal. 438, 2, p. 369-378 10 p.

Research output: Contribution to journalArticle

Open Access
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80 Citations (Scopus)
5 Downloads (Pure)
52 Citations (Scopus)
2010
29 Citations (Scopus)
2009

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

Preitner, F., Mody, N., Graham, T. E., Peroni, O. D. & Kahn, B. B., 1 Dec 2009, In : American Journal of Physiology: Endocrinology and Metabolism. 297, 6, p. E1420-E1429 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Protein Tyrosine Phosphatase 1B (PTP1B) in obesity and type 2 diabetes

Delibegovic, M. & Mody, N., 1 Dec 2009, In : Acta Medica Saliniana. 38, 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

2008

Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice

Mody, N., Graham, T. E., Tsuji, Y., Yang, Q. & Kahn, B. B., Apr 2008, In : American Journal of Physiology: Endocrinology and Metabolism. 294, 4, p. E785-E793 9 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2007

Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B

Delibegovic, M., Bence, K. K., Mody, N., Hong, E-G., Ko, H. J., Kim, J. K., Kahn, B. B. & Neelt, B. G., Nov 2007, In : Molecular and Cellular Biology. 27, 21, p. 7727-7734 8 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance

Yan, Q-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C-H., Xu, Z., Houstis, N. E., Kahn, B. B. & Rosen, E. D., Oct 2007, In : Diabetes. 56, 10, p. 2533-2540 8 p.

Research output: Contribution to journalArticle

264 Citations (Scopus)
2005

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L. & Kahn, B. B., 21 Jul 2005, In : Nature. 436, 7049, p. 356-62 7 p.

Research output: Contribution to journalArticle

1431 Citations (Scopus)
2003

An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro

Mody, N., Campbell, D. G., Morrice, N., Peggie, M. & Cohen, P., 1 Jun 2003, In : Biochemical Journal. 372, 2, p. 567-575 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2001

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

Mody, N., Leitch, J., Armstrong, C., Dixon, J. & Cohen, P., 27 Jul 2001, In : FEBS Letters. 502, 1-2, p. 21-24 4 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)
1999

Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function

Mody, N., Hermans, E., Nahorski, S. R. & Challiss, R. A., 1 Oct 1999, In : Neuropharmacology. 38, 10, p. 1485-1492 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)