• 929 Citations
20102018
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Research Output 2010 2018

  • 929 Citations
  • 13 Article
  • 1 Chapter
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Article
2018
2 Citations (Scopus)
4 Downloads (Pure)

mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol

González-García, I., Martinez de Morentin, P. B., Estévez-Salguero, Á., Contreras, C., Romero-Picó, A., Fernø, J., Nogueiras, R., Diéguez, C., Tena-Sempere, M., Tovar, S. & López, M., Sep 2018, In : Journal of Endocrinology. 238, 3, p. 177-186 9 p.

Research output: Contribution to journalArticle

Open Access
File
Appetite Depressants
Arcuate Nucleus of Hypothalamus
Sirolimus
AIDS-Related Complex
Estradiol
16 Citations (Scopus)
5 Downloads (Pure)

Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake

d'Agostino, G., Lyons, D., Cristiano, C., Lettieri, M., Olarte-Sanchez, C., Burke, L. K., Greenwald-Yarnell, M., Cansell, C., Doslikova, B., Georgescu, T., Blanco Martinez de Morentin, P., Myers Jr., M. G., Rochford, J. J. & Heisler, L., 2 Oct 2018, In : Cell Metabolism. 28, 4, p. 619.-630.e5 18 p.

Research output: Contribution to journalArticle

Open Access
File
Receptor, Serotonin, 5-HT2C
Solitary Nucleus
Obesity
Eating
Pro-Opiomelanocortin
2017
59 Citations (Scopus)
5 Downloads (Pure)

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

Martínez-Sánchez, N., Seoane-Collazo, P., Contreras, C., Varela, L., Villarroya, J., Rial-Pensado, E., Buqué, X., Aurrekoetxea, I., Delgado, T. C., Vázquez-Martínez, R., González-García, I., Roa, J., Whittle, A. J., Gomez-Santos, B., Velagapudi, V., Tung, Y. C. L., Morgan, D. A., Voshol, P. J., Martínez de Morentin, P. B., López-González, T. & 21 others, Liñares-Pose, L., Gonzalez, F., Chatterjee, K., Sobrino, T., Medina-Gómez, G., Davis, R. J., Casals, N., Orešič, M., Coll, A. P., Vidal-Puig, A., Mittag, J., Tena-Sempere, M., Malagón, M. M., Diéguez, C., Martínez-Chantar, M. L., Aspichueta, P., Rahmouni, K., Nogueiras, R., Sabio, G., Villarroya, F. & López, M., 5 Jul 2017, In : Cell Metabolism. 26, 1, p. 212-229 17 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Endoplasmic Reticulum Stress
Brown Adipose Tissue
Thyroid Hormones
Lipogenesis
9 Citations (Scopus)
8 Downloads (Pure)

Lorcaserin improves glycemic control via a melanocortin neurocircuit

Burke, L. K., Ogunnowo-Bada, E., Georgescu, T., Cristiano, C., Martinez De Morentin, P. B., Valencia-Torres, L., D'Agostino, G., Riches, C., Heeley, N., Ruan, Y., Rubinstein, M., Low, M. J., Myers, M. G., Rochford, J. J., Evans, M. L. & Heisler, L. K., Oct 2017, In : Molecular Metabolism. 6, 10, p. 1092-1102 11 p.

Research output: Contribution to journalArticle

Open Access
File
Melanocortins
Type 2 Diabetes Mellitus
Receptor, Serotonin, 5-HT2C
Glucose
Pro-Opiomelanocortin
2016
41 Citations (Scopus)
4 Downloads (Pure)

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Yavari, A., Stocker, C. J., Ghaffari, S., Wargent, E. T., Steeples, V., Czibik, G., Pinter, K., Bellahcene, M., Woods, A., Martínez de Morentin, P. B., Cansell, C., Lam, B. Y. H., Chuster, A., Petkevicius, K., Nguyen-Tu, M-S., Martinez-Sanchez, A., Pullen, T. J., Oliver, P. L., Stockenhuber, A., Nguyen, C. & 34 others, Lazdam, M., O'Dowd, J. F., Harikumar, P., Tóth, M., Beall, C., Kyriakou, T., Parnis, J., Sarma, D., Katritsis, G., Wortmann, D. D. J., Harper, A. R., Brown, L. A., Willows, R., Gandra, S., Poncio, V., de Oliveira Figueiredo, M. J., Qi, N. R., Peirson, S. N., McCrimmon, R. J., Gereben, B., Tretter, L., Fekete, C., Redwood, C., Yeo, G. S. H., Heisler, L. K., Rutter, G. A., Smith, M. A., Withers, D. J., Carling, D., Sternick, E. B., Arch, J. R. S., Cawthorne, M. A., Watkins, H. & Ashrafian, H., 10 May 2016, In : Cell Metabolism. 23, 5, p. 821-836 16 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Obesity
Hyperphagia
Mutation
Ghrelin
12 Citations (Scopus)

Molecular mechanisms of appetite and obesity: a role for brain AMPK

Martínez de Morentin, P. B., Urisarri, A., Couce, M. L. & López, M., 1 Oct 2016, In : Clinical Science. 130, 19, p. 1697-709 13 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Appetite
Obesity
Brain
Nutritional Requirements
34 Citations (Scopus)
6 Downloads (Pure)

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons

Burke, L. K., Doslikova, B., D'Agostino, G., Greenwald-Yarnell, M., Georgescu, T., Chianese, R., Martinez de Morentin, P. B., Ogunnowo-Bada, E., Cansell, C., Valencia-Torres, L., Garfield, A. S., Apergis-Schoute, J., Lam, D. D., Speakman, J. R., Rubinstein, M., Low, M. J., Rochford, J. J., Myers, M. G., Evans, M. L. & Heisler, L. K., Mar 2016, In : Molecular Metabolism. 5, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

Open Access
File
Pro-Opiomelanocortin
Sex Characteristics
Energy Metabolism
Obesity
Neurons
2015
33 Citations (Scopus)

Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats

Martínez de Morentin, P. B., Lage, R., González-García, I., Ruíz-Pino, F., Martins, L., Fernández-Mallo, D., Gallego, R., Fernø, J., Señarís, R., Saha, A. K., Tovar, S., Diéguez, C., Nogueiras, R., Tena-Sempere, M. & López, M., Mar 2015, In : Endocrinology. 156, 3, p. 947-960 14 p.

Research output: Contribution to journalArticle

Open Access
Malonyl Coenzyme A
Appetite Depressants
AMP-Activated Protein Kinases
Fatty Acid Synthases
Brown Adipose Tissue
2014
46 Citations (Scopus)

Hypothalamic mTOR: the rookie energy sensor

Martínez de Morentin, P. B., Martinez-Sanchez, N., Roa, J., Ferno, J., Nogueiras, R., Tena-Sempere, M., Dieguez, C. & Lopez, M., Jan 2014, In : Current molecular medicine. 14, 1, p. 3-21 19 p.

Research output: Contribution to journalArticle

Sirolimus
Homeostasis
Sensors
Nutrients
Cell signaling
55 Citations (Scopus)

Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats

Seoane-Collazo, P., Martinez De Morentin, P. B., Ferno, J., Dieguez, C., Nogueiras, R. & Lopez, M., May 2014, In : Endocrinology. 155, 5, p. 1679-1689 11 p.

Research output: Contribution to journalArticle

Nicotine
Obesity
Fat-Restricted Diet
Diet
Liver
2012
11 Citations (Scopus)

Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

González, C. R., Martínez de Morentin, P. B., Martínez-Sánchez, N., Gómez-Díaz, C., Lage, R., Varela, L., Diéguez, C., Nogueiras, R., Castaño, J. P. & López, M., 23 Apr 2012, In : Brain Research. 1450, p. 40-48 9 p.

Research output: Contribution to journalArticle

Hyperthyroidism
Neuropeptides
Brain
Amygdala
Hypothalamus
101 Citations (Scopus)

Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase

Martinez De Morentin, P. B., Whittle, A. J., Fernø, J., Nogueiras, R., Diéguez, C., Vidal-Puig, A. & López, M., Apr 2012, In : Diabetes. 61, 4, p. 807-817 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Nicotine
Brown Adipose Tissue
Hypothalamus
Appetite Depressants
2010
409 Citations (Scopus)

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

López, M., Varela, L., Vázquez, M. J., Rodríguez-Cuenca, S., González, C. R., Velagapudi, V. R., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., Martínez de Morentin, P. B., Tovar, S., Nogueiras, R., Carling, D., Lelliott, C., Gallego, R., Oresic, M., Chatterjee, K., Saha, A. K., Rahmouni, K. & 2 others, Diéguez, C. & Vidal-Puig, A., Sep 2010, In : Nature Medicine. 16, 9, p. 1001-1008 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Neurology
Energy balance
Metabolism
Hypothalamus