• 138 Citations
20142019
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Research Output 2014 2019

  • 138 Citations
  • 11 Article
  • 1 Literature review
2019
12 Citations (Scopus)
12 Downloads (Pure)

Alternative (backdoor) androgen production and masculinization in the human fetus

O'Shaughnessy, P. J., Antignac, J-P., Le Bizec, B., Morvan, M-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., Bellingham, M., Hough, D., Walker, N., Filis, P. & Fowler, P., 14 Feb 2019, In : PLoS Biology. 17, 2, e3000002.

Research output: Contribution to journalArticle

Open Access
File
androsterone
Androsterone
masculinization
androgens
Androgens

Fetal androgen exposure is a determinant of adult male metabolic health

Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., Howie, F., Fowler, P. A., Duncan, W. C. & Rae, M. T., 27 Dec 2019, In : Scientific Reports. 9, 20195.

Research output: Contribution to journalArticle

Open Access
File
Androgens
Health
Polycystic Ovary Syndrome
Liver Circulation
Intrahepatic Cholestasis
2 Citations (Scopus)
6 Downloads (Pure)

Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males

Filis, P., Walker, N., Robertson, L., Eaton-Turner, E., Ramona, L., Bellingham, M., Amezaga, M. R., Zhang, Z., Mandon-Pepin, B., Evans, N. P., Sharpe, R. M., Cotinot, C., Rees, W. D., O'Shaughnessy, P. & Fowler, P. A., Mar 2019, In : Environment International. 124, p. 98-108 10 p.

Research output: Contribution to journalArticle

Open Access
File
cancer
lipid
fertilizer
protein
culling
1 Citation (Scopus)
4 Downloads (Pure)

Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking

Walker, N., Filis, P., O'Shaughnessy, P. J., Bellingham, M. & Fowler, P. A., Mar 2019, In : Placenta. 78, p. 10-17 8 p.

Research output: Contribution to journalArticle

Open Access
File
Placenta
Smoking
Mothers
Food
Liver
2018
4 Citations (Scopus)
4 Downloads (Pure)

Maternal smoking and high BMI disrupt thyroid gland development

Filis, P., Hombach-Klonisch, S., Ayotte, P., Nagrath, N., Soffientini, U., Klonisch, T., O'Shaughnessy, P. J. & Fowler, P. A., 23 Oct 2018, In : BMC medicine . 16, 194.

Research output: Contribution to journalArticle

Open Access
File
Thyroid Gland
Body Mass Index
Smoking
Mothers
Thyrotropin
5 Citations (Scopus)
4 Downloads (Pure)

The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester

Johnston, Z. C., Bellingham, M., Filis, P., Soffientini, U., Hough, D., Bhattacharya, S., Simard, M., Hammond, G. L., King, P., O'Shaughnessy, P. J. & Fowler, P. A., 12 Feb 2018, In : BMC medicine . 16, 23.

Research output: Contribution to journalArticle

Open Access
File
Second Pregnancy Trimester
Aldosterone
Hydrocortisone
Smoking
Steroids
2017
10 Citations (Scopus)
6 Downloads (Pure)

Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells

Lucendo-Villarin, B., Filis, P., Swortwood, M. J., Huestis, M. A., Meseguer-Ripolles, J., Cameron, K., Iredale, J. P., O’Shaughnesy, P. J., Fowler, P. A. & Hay, D. C., Nov 2017, In : Archives of Toxicology. 91, 11, p. 3633-3643 11 p.

Research output: Contribution to journalArticle

Open Access
File
Maternal Exposure
Pluripotent Stem Cells
Stem cells
smoking
Smoke
23 Citations (Scopus)
6 Downloads (Pure)

Placental transporter localization and expression in the Human: the importance of species, sex, and gestational age differences

Walker, N., Filis, P., Soffientini, U., Bellingham, M., O'Shaughnessy, P. J. & Fowler, P. A., Apr 2017, In : Biology of Reproduction. 96, 4, p. 733-742 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
Placenta
Gestational Age
Fetal Development
Waste Products
Pregnancy
2016
11 Citations (Scopus)
6 Downloads (Pure)

Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences

Fowler, P. A., Filis, P., Bhattacharya, S., Le Bizec, B., Antignac, J-P., Morvan, M-L., Drake, A. J., Soffientini, U. & O'Shaughnessy, P. J., Feb 2016, In : Human Reproduction. 31, 2, p. 463-472 10 p.

Research output: Contribution to journalArticle

Open Access
File
Smoke
Sex Characteristics
Smoking
Fetus
Testosterone
18 Citations (Scopus)
5 Downloads (Pure)

The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals

Lea, R. G., Amezaga, M. R., Loup, B., Mandon-Pepin, B., Stefansdottir, A., Filis, P., Kyle, C., Zhang, Z., Allen, C., Purdie, L., Jouneau, L., Cotinot, C., Rhind, S. M., Sinclair, K. D. & Fowler, P. A., 2 Mar 2016, In : Scientific Reports. 6, p. 1-13 13 p., 22279.

Research output: Contribution to journalArticle

Open Access
File
Ovary
Environmental Exposure
Sewage
Pregnancy
Ovarian Follicle
2015
16 Citations (Scopus)
4 Downloads (Pure)

Maternal smoking dysregulates protein expression in second trimester human fetal livers in a sex-specific manner

Filis, P., Nagrath, N., Fraser, M., Hay, D. C., Iredale, J. P., O'Shaughnessy, P. & Fowler, P. A., 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 6, p. E861–E870 10 p.

Research output: Contribution to journalArticle

Open Access
File
Second Pregnancy Trimester
Liver
Smoking
Mothers
Proteins
2014
36 Citations (Scopus)

In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling

Fowler, P. A., Childs, A. J., Courant, F., MacKenzie, A., Rhind, S. M., Antignac, J-P., Le Bizec, B., Filis, P., Evans, F., Flannigan, S., Maheshwari, A., Bhattacharya, S., Monteiro, A., Anderson, R. A. & O'Shaughnessy, P. J., Jul 2014, In : Human Reproduction. 29, 7, p. 1471-1489 19 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Smoking
Analysis of Variance
Ovary