Roger Pertwee

Research output

Research output per year 1970 1995 1997 1998 1999 2000 2001 2002 2004 2005 2006 2007 2008 2009 2010 2012 2013 2014 2015 2016 2023

• 177 Article
• 48 Chapter
• 15 Literature review
• 9 Patent
• 20 More
  • 6 Comment/debate
  • 5 Book
  • 4 Poster
  • 2 Editorial
  • 1 Published conference contribution
  • 1 Other
  • 1 Abstract

Research output per year

Research output per year

Search results

• 2023

  Cyclic AMP Assay Using Human Cannabinoid CB₂ Receptor-Transfected Cells

  Marini, P., Cascio, M. G. & Pertwee, R. G., 9 Oct 2023, Endocannabinoid Signaling.. Maccarrone, M. (ed.). New York: HUMANA PRESS INC, Vol. 2576. p. 171-179 9 p. (Methods in Molecular Biology; vol. 2576).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Cannabinoid Receptor CB2 100%
  • Cyclic AMP 69%
  • Cricetulus 37%
  • G-Protein-Coupled Receptors 35%
  • Ligands 24%

• Displacement Binding Assay Using Human Cannabinoid CB₂ Receptor-Transfected Cells

  Cascio, M. G., Marini, P. & Pertwee, R. G., 9 Oct 2023, Endocannabinoid Signaling. : Methods in Molecular Biology. Maccarrone, M. (ed.). New York: HUMANA PRESS INC, Vol. 2576. p. 111-118 8 p. (Methods in Molecular Biology; vol. 2576).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Cannabinoid Receptor CB2 100%
  • Phytochemicals 76%
  • Cricetulus 75%

• The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models

  Tucci, P., Brown, I., Bewick, G. S., Pertwee, R. G. & Marini, P., 11 Feb 2023, In: International Journal of Molecular Sciences. 24, 4, 14 p., 3620.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androgens 100%
  • Cannabinoid 2 Receptor Agonist 90%
  • 3,3'-diindolylmethane 86%
  • Cannabinoid Receptor CB2 73%
  • Cannabinoid 65%
  3 Citations (Scopus)

  2 Downloads (Pure)

• M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter

  Marini, P., Cowie, P., Ayar, A., Bewick, G. S., Barrow, J., Pertwee, R. G., MacKenzie, A. & Tucci, P., 9 Jan 2023, In: International Journal of Molecular Sciences. 24, 2, 18 p., 1308.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cannabinoids 100%
  • Cannabinoid Receptor CB1 63%
  • Cannabinoid 62%
  • Calcium Signaling 58%
  • genes 58%
  5 Downloads (Pure)
• 2022

  Motor-like Tics are Mediated by CB2 Cannabinoid Receptor-dependent and Independent Mechanisms Associated with Age and Sex

  Gorberg, V., Borisov, V., Greig, I., Pertwee, R., McCaffery, P. & Anavi-Goffer, S., Aug 2022, In: Molecular Neurobiology. 59, p. 5070-5083 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • HU 308 100%
  • Cannabinoid Receptor CB2 96%
  • 4-iodoamphetamine 91%
  • Tics 88%
  • Tourette Syndrome 33%
  1 Citation (Scopus)

  1 Downloads (Pure)

• Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2

  Raphael-Mizrahi, B., Attar-Namdar, M., Chourasia, M., Cascio, M. G., Shurki, A., Tam, J., Neuman, M., Rimmerman, N., Vogel, Z., Shteyer, A., Pertwee, R. G., Zimmer, A., Kogan, N. M., Bab, I. & Gabet, Y., 23 May 2022, In: eLife. e65834.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • osteogenic growth peptide 100%
  • Osteogenic 65%
  • Cannabinoid 65%
  • Cannabinoid Receptors 65%
  • Hormone 51%
  5 Citations (Scopus)
• 2020

  Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity

  Brizzi, A., Aiello, F., Boccella, S., Cascio, M. G., De Petrocellis, L., Frosini, M., Gado, F., Ligresti, A., Luongo, L., Marini, P., Mugnaini, C., Pessina, F., Corelli, F., Maione, S., Manera, C., Pertwee, R. G. & Di Marzo, V., 1 Jun 2020, In: Bioorganic and Medicinal Chemistry. 28, 11, 11 p., 115513.

  Research output: Contribution to journal › Article › peer-review

  • olivetol 100%
  • Cannabinoid 60%
  • Cannabinoid Receptors 59%
  • Amides 56%
  • Cannabinoid Receptor Affecting Agent 34%
  2 Citations (Scopus)

• Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

  Brown, I., Lee, J., Sneddon, A. A., Cascio, M. G., Pertwee, R. G., Wahle, K. W. J., Rotondo, D. & Heys, S. D., May 2020, In: Prostaglandins, Leukotrienes and Essential Fatty Acids. 156, p. 102024 10 p., 102024.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Endocannabinoid 100%
  • Ethanolamine 90%
  • Endocannabinoids 81%
  • Breast Neoplasms 42%
  • Growth 33%
  26 Citations (Scopus)

  4 Downloads (Pure)

• Disease associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics

  Hay, E. A., Cowie, P., McEwan, A. R., Ross, R., Pertwee, R. G. & MacKenzie, A., 1 Jan 2020, In: Human Mutation. 41, 1, p. 291-298 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cannabinoids 100%
  • Pharmacogenetics 97%
  • Genes 34%
  • Conserved Sequence 20%
  • Nucleic Acid Regulatory Sequences 19%
  5 Citations (Scopus)

  10 Downloads (Pure)
• 2019

  Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury

  Georgieva, M., Wei, Y., Dumitrascuta, M., Pertwee, R., Finnerup, N. B. & Huang, W., Dec 2019, In: Pain. 160, 12, p. 2724-2742 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuralgia 100%
  • Spinal Cord Injuries 93%
  • Docosahexaenoic Acids 85%
  • Neuroglia 85%
  • Fatty Acids 82%
  17 Citations (Scopus)

  10 Downloads (Pure)

• Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour

  Hay, E. A., McEwan, A., Wilson, D., Barrett, P., D'Agostino, G., Pertwee, R. G. & MacKenzie, A., Nov 2019, In: Psychoneuroendocrinology. 109, p. 104407 8 p., 104407.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Addictive Behavior 100%
  • Cannabinoid Receptors 92%
  • Cannabinoids 85%
  • Clustered Regularly Interspaced Short Palindromic Repeats 56%
  • Alcohols 54%
  14 Citations (Scopus)

  9 Downloads (Pure)

• A synthetic analogue of cannabidiolic acid that acts like a positive allosteric modulator at 5-HT1A receptors

  Alcina, A. G., Stevenson, L. A., Haj, C., Smoum, R., Mechoulam, R., Hislop, J. N. & Pertwee, R. G., Aug 2019, In: British Journal of Pharmacology. 176, 16, p. 3011-3012 2 p., OC011.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • cannabidiolic acid 100%
  • Receptor, Serotonin, 5-HT1A 61%
  • Cannabis 52%
  • Nausea 43%
  • Vomiting 42%

• Identification of the First Synthetic Allosteric Modulator of the CB₂ Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

  Gado, F., Di Cesare Mannelli, L., Lucarini, E., Bertini, S., Cappelli, E., Digiacomo, M., Stevenson, L. A., Macchia, M., Tuccinardi, T., Ghelardini, C., Pertwee, R. G. & Manera, C., 10 Jan 2019, In: Journal of Medicinal Chemistry. 62, 1, p. 276-287 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabinoid Receptor CB2 100%
  • Cannabinoid Receptors 89%
  • Neuralgia 72%
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 55%
  • Allosteric Site 50%
  49 Citations (Scopus)
• 2018

  Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

  Slivicki, R. A., Xu, Z., Kulkarni, P. M., Pertwee, R. G., Mackie, K., Thakur, G. A. & Hohmann, A. G., 15 Nov 2018, In: Biological Psychiatry. 84, 10, p. 722-733 12 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole 100%
  • Cannabinoid Receptors 55%
  • Cannabinoid Receptor CB1 28%
  • Pain 25%
  • JZL 184 19%
  84 Citations (Scopus)
• 2017

  Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor

  Laprairie, R. B., Kulkarni, P. M., Deschamps, J. R., Kelly, M. E. M., Janero, D. R., Cascio, M. G., Stevenson, L. A., Pertwee, R. G., Kenakin, T. P., Denovan-Wright, E. M. & Thakur, G. A., 21 Jun 2017, In: ACS Chemical Neuroscience. 8, 6, p. 1188-1203 16 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole 100%
  • Cannabinoid 61%
  • Cannabinoid Receptors 61%
  • Agonist 15%
  • Pharmacology 11%
  75 Citations (Scopus)

• Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

  Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E. & Zanda, M., 2017, In: Organic & Biomolecular Chemistry. 15, 9, p. 2086-2096 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • HU 211 100%
  • Cannabinoid 75%
  • Radio 60%
  • tracers 57%
  • aspartates 45%
  5 Citations (Scopus)

  11 Downloads (Pure)

• The pharmacology and therapeutic potential of plant cannabinoids

  Cascio, M. G., Pertwee, R. G. & Marini, P., 2017, Cannabis sativa L. - Botany and Biotechnology. Chandra, S., Lata, H. & ElSohly, M. A. (eds.). Springer, Biomedicine & Life Sciences, p. 207-225 19 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Phytocannabinoid 100%
  • Cannabinoid 66%
  • Recreational Drug 22%
  • Pharmacological Effect 16%
  • Fiber 8%
  23 Citations (Scopus)
• 2016

  Exploring the Benzimidazole Ring as a Substitution for Indole in Cannabinoid Allosteric Modulators

  Hernandez-Folgado, L., Stevenson, L. A., Morales, P., Gómez-Cañas, M., Pazos, M. R., Cascio, M. G., Jagerovic, N., Elguero, J., Pertwee, R. & Goya, P., Dec 2016, In: Cannabis and Cannabinoid Research. 1, 1, p. 196-201 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 5-chloro-3-ethyl-1H-indole-2-carboxylic acid (2-(4-piperidin-1-yl-phenyl)ethyl)amide 100%
  • benzimidazole 66%
  • indole 60%
  • Cannabinoids 53%
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 48%
  2 Citations (Scopus)

• Pure Δ⁹-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ⁹-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages

  Romano, B., Pagano, E., Orlando, P., Capasso, R., Cascio, M. G., Pertwee, R., Marzo, V. D., Izzo, A. A. & Borrelli, F., 1 Nov 2016, In: Pharmacological Research. 113, A, p. 199-208 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Peritoneal Macrophages 100%
  • Nitrites 99%
  • Cannabis 96%
  • Lipopolysaccharides 77%
  • Transient Receptor Potential Channels 58%
  32 Citations (Scopus)

• Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

  Laprairie, R. B., Kulkarni, A. R., Kulkarni, P. M., Hurst, D. P., Lynch, D., Reggio, P. H., Janero, D. R., Pertwee, R. G., Stevenson, L. A., Kelly, M. E. M., Denovan-Wright, E. M. & Thakur, G. A., 15 Jun 2016, In: ACS Chemical Neuroscience. 7, 6, p. 776-798 23 p.

  Research output: Contribution to journal › Article › peer-review

  • GAT100 100%
  • Allosteric Site 56%
  • Cannabinoid 50%
  • Cannabinoid Receptors 50%
  • 5-chloro-3-ethyl-1H-indole-2-carboxylic acid (2-(4-piperidin-1-yl-phenyl)ethyl)amide 31%
  31 Citations (Scopus)

• The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

  Cascio, M. G., Marini, P. & Pertwee, R. G., 1 Jun 2016, Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). Springer Science+Business Media, Vol. 1412. p. 57-63 7 p. (Methods in Molecular Biology; vol. 1412).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Cannabinoid Receptor CB2 100%
  • Phytochemicals 76%
  • Cricetulus 75%
  3 Citations (Scopus)

• Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

  Colizzi, M., McGuire, P., Pertwee, R. G. & Bhattacharyya, S., May 2016, In: Neuroscience & Biobehavioral Reviews. 64, p. 359-381 23 p.

  Research output: Contribution to journal › Literature review › peer-review

  • Cannabis 100%
  • Dronabinol 96%
  • Glutamic Acid 82%
  • Systematic Reviews 69%
  • Animals 47%
  111 Citations (Scopus)

• Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

  Kulkarni, P. M., Kulkarni, A. R., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan-Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., Cascio, M. G., Pertwee, R. G. & Thakur, G. A., 14 Jan 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 44-60 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Allosteric Site 100%
  • Photoaffinity 90%
  • Cannabinoid 89%
  • Cannabinoid Receptors 88%
  • Probe 42%
  47 Citations (Scopus)

  12 Downloads (Pure)

• The Cyclic AMP Assay Using Human Cannabinoid CB₂ Receptor-Transfected Cells

  Marini, P., Cascio, M. G. & Pertwee, R. G., 2016, Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). New York: Springer Science+Business Media, p. 85-93 9 p. (Methods in Molecular Biology; vol. 1412).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Cannabinoid Receptor CB2 100%
  • Cyclic AMP 69%
  • Cricetulus 37%
  • G-Protein-Coupled Receptors 35%
  • Ligands 24%
  4 Citations (Scopus)
• 2015

  Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

  Mounsey, R. B., Mustafa, S., Robinson, L., Ross, R. A., Riedel, G., Pertwee, R. G. & Teismann, P., Nov 2015, In: Experimental Neurology. 273, p. 36-44 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • glyceryl 2-arachidonate 100%
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 87%
  • Endocannabinoids 84%
  • Parkinson Disease 58%
  • Cell Death 35%
  54 Citations (Scopus)

  9 Downloads (Pure)

• CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

  Smoum, R., Baraghithy, S., Chourasia, M., Breuer, A., Mussai, N., Attar-Namdar, M., Kogan, N. M., Raphael, B., Bolognini, D., Cascio, M. G., Marini, P., Pertwee, R. G., Shurki, A., Mechoulam, R. & Bab, I., 14 Jul 2015, In: PNAS. 112, 28, p. 8774-8779 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabinoid 2 Receptor Agonist 100%
  • Cannabinoid 72%
  • Enantiomer 44%
  • Kd 43%
  • Radioligand 21%
  53 Citations (Scopus)

• Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

  Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Apr 2015, In: Behavioural Pharmacology. 26, 3, p. 289-303 15 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazol-3-yl) 4-methoxyphenyl methanone 100%
  • Sleep 30%
  • Food 27%
  • AM 251 19%
  • Psychological Power 18%
  18 Citations (Scopus)

• The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects

  Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D. & Pertwee, R. G., Mar 2015, In: British Journal of Pharmacology. 172, 5, p. 1305-1318 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Serotonin 5-HT1 Receptors 100%
  • Receptor, Serotonin, 5-HT1A 81%
  • 8-Hydroxy-2-(di-n-propylamino)tetralin 76%
  • Antipsychotic Agents 60%
  • hydroxide ion 56%
  39 Citations (Scopus)

  8 Downloads (Pure)

• Tricyclic fused pyrazoles with a 'Click' 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands

  Zanato, C., Cascio, M. G., Lazzari, P., Pertwee, R., Testa, A. & Zanda, M., Mar 2015, In: Synthesis. 47, 6, p. 817-826 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ligands 100%
  • Chlorine 91%
  • 1,2,3-triazole 89%
  • Pyrazoles 88%
  • Pyrazole 78%
  14 Citations (Scopus)

  29 Downloads (Pure)

• Are cannabidiol and Delta(9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

  McPartland, J. M., Duncan, M., Di Marzo, V. & Pertwee, R. G., Feb 2015, In: British Journal of Pharmacology. 172, 3, p. 737-753 17 p.

  Research output: Contribution to journal › Literature review › peer-review

  • tetrahydrocannabivarin 9 100%
  • Cannabidiol 57%
  • Cannabinoid Receptor CB1 51%
  • Endocannabinoids 49%
  • Systematic Reviews 29%
  388 Citations (Scopus)

• Endocannabinoids

  Pertwee, R. G., 2015, 1 ed. Springer . 30 p. (Handbook of Experimental Pharmacology; vol. 231)

  Research output: Book/Report › Book
• 2014

  Early phytocannabinoid chemistry to endocannabinoids and beyond

  Mechoulam, R., Hanus, L. O., Pertwee, R. & Howlett, A. C., Nov 2014, In: Nature reviews neuroscience. 15, 11, p. 757-764 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocannabinoids 100%
  • Cannabinoid Receptors 51%
  • Dronabinol 50%
  • Cannabinoids 47%
  • Cannabis 43%
  259 Citations (Scopus)

• Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands

  Distinto, R., Zanato, C., Montanari, S., Cascio, M. G., Lazzari, P., Pertwee, R. & Zanda, M., Nov 2014, In: Journal of Fluorine Chemistry. 167, p. 184-191 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 1,2,3-triazolyl Group 100%
  • Pyrazoles 87%
  • Rimonabant 66%
  • Triazoles 64%
  • Cannabinoid Receptor CB1 61%
  5 Citations (Scopus)

• Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

  Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., De Petrocellis, L., Ligresti, A., Luongo, L., Lamponi, S., Maione, S., Pertwee, R. G. & Di Marzo, V., 1 Sept 2014, In: Behavioral and Brain Sciences. 22, 17, p. 4770-4783 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Monoacylglycerol Lipases 100%
  • resorcinol 98%
  • fatty-acid amide hydrolase 93%
  • Ankyrins 89%
  • Cannabinoid Receptors 79%
  13 Citations (Scopus)

  1 Downloads (Pure)

• The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act trough 5HT1A receptors to produce anti-psychotic effects

  Cascio, M. G., Zamberletti, E., Marini, P., Pertwee, R. G. & Parolaro, D., 29 Jun 2014.

  Research output: Contribution to conference › Poster › peer-review

• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

  Romano, B., Borrelli, F., Pagano, E., Cascio, M. G., Pertwee, R. G. & Izzo, A. A., 15 Apr 2014, In: Phytomedicine. 21, 5, p. 631-639 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabidiol 100%
  • Cannabis 68%
  • Colon 51%
  • Carcinogenesis 49%
  • Cannabinoid Receptor CB2 26%
  90 Citations (Scopus)

• In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

  Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In: Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-chloro-3-ethyl-1H-indole-2-carboxylic acid (2-(4-piperidin-1-yl-phenyl)ethyl)amide 100%
  • Cannabinoid Receptor CB1 59%
  • Pharmacology 30%
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 29%
  • anandamide 24%
  55 Citations (Scopus)

• Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications

  Pertwee, R. G., Feb 2014, In: Proceedings of the Nutrition Society. 73, 1, p. 96-105 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocannabinoids 100%
  • Monoacylglycerol Lipases 57%
  • Pharmacology 54%
  • fatty-acid amide hydrolase 54%
  • glyceryl 2-arachidonate 26%
  76 Citations (Scopus)

• Handbook of Cannabis

  Pertwee, R. G. (ed.), 2014, 1 ed. Oxford: OXFORD UNIV PRESS.

  Research output: Book/Report › Book

  • Cannabis 100%
  • Cannabinoids 62%
  • Illicit Drugs 29%
  • Pharmacology 26%
  • Designer Drugs 20%
• 2013

  Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors

  Espejo-Porras, F., Fernandez-Ruiz, J., Pertwee, R. G., Mechoulam, R. & Garcia, C., Dec 2013, In: Neuropharmacology. 75, p. 155-163 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabidiol 100%
  • Receptor, Serotonin, 5-HT1A 87%
  • 8-Hydroxy-2-(di-n-propylamino)tetralin 50%
  • hydroxide ion 36%
  • Cannabinoid Receptor CB1 27%
  57 Citations (Scopus)

• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

  Hill, T. D. M., Cascio, M-G., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., Whalley, B. J. & Hill, A. J., Oct 2013, In: British Journal of Pharmacology. 170, 3, p. 679-692 14 p.

  Research output: Contribution to journal › Article › peer-review

  • cannabidivarin 100%
  • Cannabinoid Receptor CB1 62%
  • Cannabis 52%
  • Anticonvulsants 46%
  • Seizures 19%
  164 Citations (Scopus)

• Effects of Δ9-tetrahydrocannabivarin at serotoninergic 5-HT1A receptors, and of its 11-Hydroxy-metabolite at cannabinoid CB1 and CB2 receptors

  Cascio, M. G., Marini, P. & Pertwee, R. G., 27 Sept 2013.

  Research output: Contribution to conference › Poster › peer-review

• Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors

  Marini, P., Cascio, M. G., King, A., Pertwee, R. G. & Ross, R. A., Jun 2013, In: British Journal of Pharmacology. 169, 4, p. 887-899 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cannabinoid Receptor CB2 100%
  • Cannabinoid Receptors 89%
  • CHO Cells 59%
  • Ligands 49%
  • Spleen 27%
  21 Citations (Scopus)

• The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

  Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M. G., Pertwee, R. G., Coppola, D., Vassallo, L., Orlando, P., Di Marzo, V. & Izzo, A. A., May 2013, In: British Journal of Pharmacology. 169, 1, p. 213-229 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cannabichromene 100%
  • Ankyrins 70%
  • Cannabinoid Receptors 62%
  • Colitis 51%
  • anandamide 50%
  132 Citations (Scopus)

• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation

  Bolognini, D., Rock, EM., Cluny, NL., Cascio, MG., Limebeer, CL., Duncan, M., Stott, CG., Javid, FA., Parker, LA. & Pertwee, RG., Mar 2013, In: British Journal of Pharmacology. 168, 6, p. 1456-1470 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cannabidiolic acid 100%
  • Receptor, Serotonin, 5-HT1A 61%
  • Nausea 43%
  • Vomiting 42%
  • Lithium Chloride 34%
  128 Citations (Scopus)

• Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

  Fernandez-Ruiz, J., Sagredo, O., Ruth Pazos, M., Garcia, C., Pertwee, R., Mechoulam, R. & Martinez-Orgado, J., Feb 2013, In: British Journal of Clinical Pharmacology. 75, 2, p. 323-333 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabidiol 100%
  • Neurodegenerative Diseases 60%
  • Endocannabinoids 42%
  • Cannabinoid Receptor CB2 24%
  • Cannabinoid Receptors 22%
  255 Citations (Scopus)

• CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

  Baillie, G. L., Horswill, J. G., Anavi-Goffer, S., Reggio, P. H., Bolognini, D., Abood, M. E., McAllister, S., Strange, P. G., Stephens, G. J., Pertwee, R. G. & Ross, R. A., Feb 2013, In: Molecular Pharmacology. 83, 2, p. 322-338 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Cannabinoid Receptor CB1 100%
  • 1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea 69%
  • Extracellular Signal-Regulated MAP Kinases 67%
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 49%
  • beta-Arrestins 45%
  103 Citations (Scopus)

• Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

  Brown, I., Cascio, M. G., Rotondo, D., Pertwee, R. G., Heys, S. D. & Wahle, K. W. J., Jan 2013, In: Progress in Lipid Research. 52, 1, p. 80-109 30 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocannabinoid 100%
  • Cannabinoid 84%
  • Endocannabinoids 81%
  • Cannabinoids 77%
  • Antiinvasive 77%
  79 Citations (Scopus)
• 2012

  Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

  Pertwee, R. G., 5 Dec 2012, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 367, 1607, p. 3353-3363 11 p.

  Research output: Contribution to journal › Literature review › peer-review

  • Cannabinoid Receptor Agonist 100%
  • cannabinoid receptors 86%
  • Endocannabinoid 84%
  • Cannabinoid Receptor Agonists 77%
  • cannabinoids 75%
  278 Citations (Scopus)

• Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

  Pasquini, S., De Rosa, M., Ligresti, A., Mugnaini, C., Brizzi, A., Caradonna, N. P., Cascio, M. G., Bolognini, D., Pertwee, R. G., Di Marzo, V. & Corelli, F., Dec 2012, In: European Journal of Medicinal Chemistry. 58, p. 30-43 14 p.

  Research output: Contribution to journal › Article › peer-review

  • 4-quinolone-3-carboxylic acid 100%
  • Cannabinoid 55%
  • Cannabinoid Receptors 55%
  • Cannabinoids 50%
  • Quinolones 50%
  21 Citations (Scopus)