Roger Pertwee

Professor

    • 27006 Citations
    1970 …2020

    Research output per year

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    Research Output

    2011

    Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist

    Wiley, J. L., Breivogel, C. S., Mahadevan, A., Pertwee, R. G., Cascio, M. G., Bolognini, D., Huffman, J. W., Walentiny, D. M., Vann, R. E., Razdan, R. K. & Martin, B. R., 25 Jan 2011, In : European Journal of Pharmacology. 651, 1-3, p. 96-105 10 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    The endocannabinoid 2-AG provides neuroprotection in the MPTP model of Parkinson's disease

    Mounsey, R. B., Mustafa, S., Ross, R., Pertwee, R. G. & Teismann, P., 2011.

    Research output: Contribution to conferencePoster

    2010

    Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

    Thors, L., Burston, J. J., Alter, B. J., McKinney, M. K., Cravatt, B. F., Ross, R. A., Pertwee, R. G., Gereau, R. W., Wiley, J. L. & Fowler, C. J., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 549-560 12 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

    Brown, I., Cascio, M. G., Wahle, K. W. J., Smoum, R., Mechoulam, R., Ross, R. A., Pertwee, R. G. & Heys, S. D., Sep 2010, In : Carcinogenesis. 31, 9, p. 1584-1591 8 p.

    Research output: Contribution to journalArticle

    95 Citations (Scopus)

    Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist

    Cascio, M. G., Gauson, L. A., Stevenson, L. A., Ross, R. A. & Pertwee, R. G., Jan 2010, In : British Journal of Pharmacology. 159, 1, p. 129-141 13 p.

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

    Pertwee, R. G., Howlett, A. C., Abood, M. E., Alexander, S. P. H., Di Marzo, V., Elphick, M. R., Greasley, P. J., Hansen, H. S., Kunos, G., Mackie, K., Mechoulam, R. & Ross, R. A., Dec 2010, In : Pharmacological Reviews. 62, 4, p. 588-631 44 p.

    Research output: Contribution to journalLiterature review

    933 Citations (Scopus)

    Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.

    Pasquini, S., Ligresti, A., Mugnaini, C., Semeraro, T., Cicione, L., De Rosa, M., Guida, F., Luongo, L., De Chiaro, M., Cascio, M. G., Bolognini, D., Marini, P., Pertwee, R. G., Maione, S., Di Marzo, V. & Corelli, F., 26 Aug 2010, In : Journal of Medicinal Chemistry. 53, 16, p. 5915-5928 14 p.

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists

    Cascio, M. G., Bolognini, D., Pertwee, R. G., Palazzo, E., Corelli, F., Pasquini, S., Di Marzo, V. & Maione, S., Apr 2010, In : Pharmacological Research. 61, 4, p. 349-354 6 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Phytocannabinoids beyond the Cannabis plant - do they exist?

    Gertsch, J., Pertwee, R. G. & Di Marzo, V., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 523-529 7 p.

    Research output: Contribution to journalArticle

    86 Citations (Scopus)

    Receptors and Channels Targeted by Synthetic Cannabinoid Receptor Agonists and Antagonists

    Pertwee, R. G., 2010, In : Current Medicinal Chemistry. 17, 14, p. 1360-1381 22 p.

    Research output: Contribution to journalLiterature review

    192 Citations (Scopus)

    The effects of ¿9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

    Jamontt, J. M., Molleman, A., Pertwee, R. G. & Parsons, M. E., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 712-723 12 p.

    Research output: Contribution to journalArticle

    69 Citations (Scopus)

    The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

    Bolognini, D., Costa, B., Maione, S., Comelli, F., Marini, P., Di Marzo, V., Parolaro, D., Ross, R. A., Gauson, L. A., Cascio, M. G. & Pertwee, R. G., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 677-687 11 p.

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R., Platt, B. & Riedel, G., 2 Apr 2010, In : Behavioural Brain Research. 208, 2, p. 584-592 9 p.

    Research output: Contribution to journalArticle

    35 Citations (Scopus)
    2009

    Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels

    Ryan, D., Drysdale, A. J., Lafourcade, C., Pertwee, R. G. & Platt, B., 18 Feb 2009, In : Journal of Neuroscience. 29, 7, p. 2053-2063 11 p.

    Research output: Contribution to journalArticle

    126 Citations (Scopus)

    Conformationally Constrained Fatty Acid Ethanolamides as Cannabinoid and Vanilloid Receptor Probes

    Appendino, G., Ligresti, A., Minassi, A., Cascio, M. G., Allara, M., Taglialatela-Scafati, O., Pertwee, R. G., De Petrocellis, L. & Di Marzo, V., 14 May 2009, In : Journal of Medicinal Chemistry. 52, 9, p. 3001-3009 9 p.

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Emerging strategies for exploiting cannabinoid receptor agonists as medicines

    Pertwee, R. G., Feb 2009, In : British Journal of Pharmacology. 156, 3, p. 397-411 15 p.

    Research output: Contribution to journalLiterature review

    305 Citations (Scopus)

    New pharmaceutical formulation comprising cannabidiol and tetrahydrocannabivarin

    Pertwee, R. G., Guy, G. W. & Whittle, B., 15 Jan 2009, IPC No. A61K31/05; A61K31/352; A61K36/185; A61P19/08;, Patent No. WO2009007697

    Research output: Patent

    Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

    Riedel, G., Fadda, P., McKillop-Smith, S., Pertwee, R. G., Platt, B. & Robinson, L., Apr 2009, In : British Journal of Pharmacology. 156, 7, p. 1154-1166 13 p.

    Research output: Contribution to journalArticle

    74 Citations (Scopus)

    Therapeutic applications for agents that act at CB1 and CB2 receptors

    Pertwee, R. G. & Thomas, A., 27 Feb 2009, The Cannabinoid Receptors. Reggio, P. H. (ed.). New York, NY, USA: Humana Press, p. 361-392

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Use of tetrahydrocannabinol and/or cannabidiol for the treatment of inflammatory bowel disease

    Pertwee, R. G., Guy, G. W., Jamontt, J. & Robson, P., 8 Jan 2009, IPC No. A61K31/05; A61K31/352; A61K36/185; A61P19/08; , Patent No. WO2009004302

    Research output: Patent

    2008

    1,5-diaryl-pyrazoles as cannabinoid receptor neutral antagonists useful as therapeutic agents

    Greig, I. R., Ross, R. A. & Pertwee, R. G., 21 Aug 2008, IPC No. A61K31/415; A61P29/00; C07D231/12; , Patent No. WO2008/099139

    Research output: Patent

    Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis

    Croxford, J. L., Pryce, G., Jackson, S. J., Ledent, C., Giovannoni, G., Pertwee, R. G., Yamamura, T. & Baker, D., Jan 2008, In : Journal of Neuroimmunology. 193, 1-2, p. 120-129 10 p.

    Research output: Contribution to journalArticle

    76 Citations (Scopus)

    CB1 and CB2 receptor pharmacology

    Pertwee, R. G., 21 Apr 2008, Cannabinoids and the Brain. Köfalvi, A. (ed.). New York, NY, USA: Springer Science+Business Media, p. 91-99

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

    Robinson, L., McKillop-Smith, S., Ross, N. L., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Jul 2008, In : Psychopharmacology. 198, 4, p. 551-563 13 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: Evidence for a site distinct from CB1 and CB2

    McHugh, D., Tanner, C., Mechoulam, R., Pertwee, R. G. & Ross, R. A., Feb 2008, In : Molecular Pharmacology. 73, 2, p. 441-450 10 p.

    Research output: Contribution to journalArticle

    90 Citations (Scopus)

    Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

    Pertwee, R. G., Jun 2008, In : Addiction Biology. 13, 2, p. 147-159 13 p.

    Research output: Contribution to journalLiterature review

    211 Citations (Scopus)

    Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

    Alvarez, F. J., Lafuente, H., Rey-Santano, M. C., Mielgo, V. E., Gastiasoro, E., Rueda, M., Pertwee, R. G., Castillo, A. I., Romero, J. & Martinez-Orgado, J., Dec 2008, In : Pediatric Research. 64, 6, p. 653-658 6 p.

    Research output: Contribution to journalArticle

    92 Citations (Scopus)

    New use for cannabinoid

    Pertwee, R. G. & Guy, G. W., 21 Oct 2008, IPC No. A61K31/00; A61K31/33; A61K31/454; , Patent No. BRPI0518011

    Research output: Patent

    Therapeutic uses of cannabigerol

    Pertwee, R. G., 31 Dec 2008, IPC No. A61K31/352; A61K36/185; A61P25/28; (+3), Patent No. WO2009001081

    Research output: Patent

    Use for cannabinoid

    Pertwee, R. G. & Guy, G. W., 22 May 2008, IPC No. A61K31/353; A61K36/185; A61K31/352; , Patent No. US2008119544

    Research output: Patent

    2 Citations (Scopus)
    2007

    Anti-inflammatory property of the cannaboinid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

    Xu, H., Cheng, C. L., Chen, M., Manivannan, A., Cabay, L., Pertwee, R. G., Coutts, A. A. & Forrester, J. V., 1 Sep 2007, In : Journal of Leukocyte Biology. 82, 3, p. 532-541 10 p.

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

    Thomas, A., Baillie, G., Phillips, A. M., Razdan, R. K., Ross, R. A. & Pertwee, R. G., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 613-623 11 p.

    Research output: Contribution to journalArticle

    344 Citations (Scopus)

    Cannabinoids and multiple sclerosis

    Pertwee, R. G., Aug 2007, In : Molecular Neurobiology. 36, 1, p. 45-59 15 p.

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    GPR55: a new member of the cannabinoid receptor clan?

    Pertwee, R. G., Dec 2007, In : British Journal of Pharmacology. 152, 7, p. 984-986 3 p.

    Research output: Contribution to journalEditorial

    133 Citations (Scopus)

    Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences

    McPartland, J. M., Glass, M. & Pertwee, R. G., Nov 2007, In : British Journal of Pharmacology. 152, 5, p. 583-593 11 p.

    Research output: Contribution to journalLiterature review

    135 Citations (Scopus)

    New use for cannabinoid

    Pertwee, R. G. & Guy, G., 6 Dec 2007, IPC No. A61K31/05; A61K31/352; A61P19/08; , Patent No. WO200713822

    Research output: Patent

    Significance of cardiac cannabinoid receptors in regulation of cardiac rhythm, myocardial contractility, and electrophysiologic processes in heart

    Krylatov, A. V., Maslov, L. N., Ermakov, S. Y., Lasukova, O. V., Barzakh, E. I., Crawford, D. & Pertwee, R. G., Jan 2007, In : Bulletin of Experimental Biology and Medicine. 34, 1, p. 28-35 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo

    Pertwee, R. G., Thomas, A., Stevenson, L. A., Ross, R. A., Varvel, S. A., Lichtman, A. H., Martin, B. R. & Razdan, R. K., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 586-594 9 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R. E. & Riedel, G., Jul 2007, In : British Journal of Pharmacology. 151, 5, p. 688-700 13 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)
    2006

    Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells

    Drysdale, A. J., Ryan, D., Pertwee, R. G. & Platt, B., Apr 2006, In : Neuropharmacology. 50, 5, p. 621-631 11 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitis

    Baker, D., Croxford, J. L., Pryce, G., Jackson, S. M., Ledent, C., Marsicano, G., Lutz, B., Giovannoni, G., Pertwee, R. G. & Yamamura, T., Sep 2006, In : Journal of Neuroimmunology. 178, Suppl. 1, p. 90-91 2 p.

    Research output: Contribution to journalArticle

    Cannabinoid pharmacology

    Pertwee, R. G., Jan 2006, In : British Journal of Pharmacology. 147, S1, p. S163-S171 9 p.

    Research output: Contribution to journalArticle

    341 Citations (Scopus)

    Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

    Ryan, D., Drysdale, A. J., Pertwee, R. G. & Platt, B., 20 Nov 2006, In : Neuroscience Letters. 408, 3, p. 236-241 6 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Effect of sublingual application of cannabinoids on intraocular pressure: A pilot study

    Tomida, I., Azuara-Blanco, A., House, H., Flint, M., Pertwee, R. G. & Robson, P. J., Oct 2006, In : Journal of Glaucoma. 15, 5, p. 349-353 5 p.

    Research output: Contribution to journalArticle

    62 Citations (Scopus)

    First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

    Appendino, G., Cascio, M. G., Bacchiega, S., Moriello, A. S., Minassi, A., Thomas, A., Ross, R., Pertwee, R., De Petrocellis, L. & Di Marzo, V., 2006, In : FEBS Letters. 580, p. 568-574 7 p.

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands

    Cascio, M. G., Bisogno, T., Palazzo, E., Thomas, A. D., van der Stelt, M., Brizzi, A., De Novellis, V., Marabese, I., Ross, R. A., van de Doelen, T., Brizzi, V., Pertwee, R. G., Maione, S. & Di Marzo, V., Oct 2006, In : British Journal of Pharmacology. 149, 4, p. 431-440 10 p.

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Novel compounds that interact with both leukotriene B-4 receptors and vanilloid TRPV1 receptors

    McHugh, D., McMaster, R. S., Pertwee, R. G., Roy, S., Mahadevan, A., Razdan, R. K. & Ross, R. A., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, p. 955-965 11 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Hanus, L. O., Pertwee, R. G., Ivanchuk, I. I. & Crowford, D., 2006, In : Bulletin of Experimental Biology and Medicine. 142, 5, p. 557-561 5 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2006, In : Behavioural Brain Research. 168, p. 307-311 5 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)