Roger Pertwee

Professor

    • 26449 Citations
    1970 …2020

    Research output per year

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    Research Output

    2000

    Cannabinoids and pain modulation in animals and humans.

    Holdcroft, A., Hargreaves, K. M., Rice, A. S. C. & Pertwee, R. G., 2000, Proceedings of the 9th World Congress on Pain, . Devor, M., Rowbotham, M. C. & Wiesenfeld-Hallin, Z. (eds.). Seattle: IASP Press, Vol. 16. p. 915-926 (Progress in Pain Research and Management).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Cannabinoids control spasticity and tremor in a multiple sclerosis model

    Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Huffman, J. W. & Layward, L., 2000, In : Nature. 404, p. 84-87 4 p.

    Research output: Contribution to journalArticle

    449 Citations (Scopus)

    Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine

    Coutts, A. A., Brewster, N., Ingram, T., Razdan, R. K. & Pertwee, R. G., 2000, In : British Journal of Pharmacology. 129, p. 645-652 8 p.

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons

    Irving, A. J., Coutts, A. A., Harvey, J., Rae, M. G., Mackie, K., Bewick, G. S. & Pertwee, R. G., Jun 2000, In : Neuroscience. 98, 2, p. 253-262 10 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Functional expression of cell surface cannabinoid CB1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons

    Irving, A. J., Coutts, A. A., Harvey, J., Rae, M. G., Mackie, K., Bewick, G. S. & Pertwee, R. G., 2000, In : Neuroscience. 98, p. 253-262 10 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide

    Ross, R. A., Brockie, H. C. & Pertwee, R. G., 4 Aug 2000, In : European Journal of Pharmacology. 401, 2, p. 121-130 10 p.

    Research output: Contribution to journalArticle

    92 Citations (Scopus)

    Neuropharmacology and therapeutic potential of cannabinoids

    Pertwee, R. G., 2000, In : Addiction Biology. 5, p. 37-46 10 p.

    Research output: Contribution to journalLiterature review

    64 Citations (Scopus)

    O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties

    Pertwee, R. G., Gibson, T. M., Stevenson, L. A., Ross, R. A., Banner, W. K., Saha, B., Razdan, R. K. & Martin, B. R., Apr 2000, In : British Journal of Pharmacology. 129, 8, p. 1577-1584 8 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity

    De Petrocellis, L., Bisogno, T., Davis, J. B., Pertwee, R. G. & Di Marzo, V., 2000, In : FEBS Letters. 483, p. 52-56 5 p.

    Research output: Contribution to journalArticle

    312 Citations (Scopus)
    1999

    Agonist inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630

    Ross, R. A., Brockie, H. C., Stevenson, L. A., Murphy, V. L., Templeton, F., Makriyannis, A. & Pertwee, R. G., Feb 1999, In : British Journal of Pharmacology. 126, 3, p. 665-672 8 p.

    Research output: Contribution to journalArticle

    320 Citations (Scopus)

    Cannabinoid receptors and their ligands in brain and other tissues

    Pertwee, R. G., 5 Apr 1999, Marihuana and Medicine. Nahas, G. G., Sutin, K. M., Harvey, D. J. & Agurell, S. (eds.). Totowa, NJ, USA: Humana Press, p. 177-185

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Cannabis and cannabinoids: Pharmacology and rationale for clinical use

    Pertwee, R. G., 1999, In : Forschende Komplementärmedizin. 6, p. 12-15 4 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Design and synthesis of the CB1 selective cannabinoid antagonist AM281

    Lan, R. X., Lu, Q., Fan, P. S., Gatley, J., Volkow, N. D., Fernando, S. R., Pertwee, R. G. & Makriyannis, A., Jun 1999, In : AAPS PharmSci. 1, 2, p. 39-45 7 p.

    Research output: Contribution to journalArticle

    Development of agonists, partial agonists and antagonists in the Delta(8)-tetrahydrocannabinol series

    Crocker, P. J., Saha, B., Ryan, W. J., Wiley, J. L., Martin, B. R., Ross, R. A., Pertwee, R. G. & Razdan, R. K., 3 Dec 1999, In : Tetrahedron. 55, 49, p. 13907-13926 20 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor

    Hanus, L., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R. & Fride, E., 7 Dec 1999, In : PNAS. 96, 25, p. 14228-14233 6 p.

    Research output: Contribution to journalArticle

    436 Citations (Scopus)

    Medical uses of cannabinoids: the way forward

    Pertwee, R. G., 1999, In : Addiction. 94, p. 317-320 4 p.

    Research output: Contribution to journalEditorial

    11 Citations (Scopus)

    Pharmacology of cannabinoid receptor ligands

    Pertwee, R. G., 1999, In : Current Medicinal Chemistry. 6, p. 635-664 30 p.

    Research output: Contribution to journalLiterature review

    423 Citations (Scopus)

    Prescribing cannabinoids for multiple sclerosis - Current issues

    Pertwee, R. G., 1999, In : CNS Drugs. 11, p. 327-334 8 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-¿8-tetrahydrocannabinol at cannabinoid receptors

    Ross, R. A., Gibson, T. M., Stevenson, L. A., Saha, B., Crocker, P., Razdan, R. K. & Pertwee, R. G., Oct 1999, In : British Journal of Pharmacology. 128, 3, p. 735-743 9 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

    Lan, R. X., Liu, Q., Fan, P. S., Lin, S. Y., Fernando, S. R., McCallion, D., Pertwee, R. & Makriyannis, A., 1999, In : Journal of Medicinal Chemistry. 42, p. 769-776 8 p.

    Research output: Contribution to journalArticle

    391 Citations (Scopus)

    Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)

    Hillard, C. J., Manna, S., Greenberg, M. J., Dicamelli, R., Ross, R. A., Stevenson, L. A., Murphy, V., Pertwee, R. G. & Campbell, W. B., 1 Jun 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, 3, p. 1427-1433 7 p.

    Research output: Contribution to journalArticle

    277 Citations (Scopus)
    1998

    Advances in cannabinoid receptor pharmacology

    Pertwee, R. G., 19 Nov 1998, Cannabis. The Genus Cannabis. Brown, D. T. (ed.). Amsterdam, Netherlands: Harwood Academic Publishers, p. 133-185 (Medicinal and Aromatic Plants: Industrial Profiles).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Cannabinoid Receptors

    Howlett, A. C., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Martin, B. R., Mechoulam, R. & Pertwee, R. G., 1998, The IUPHAR Compendium of Receptor Characterization and Classification: International Union of Pharmacology Committee on Receptor Characterization and Classification. Girdlestone, D. (ed.). London, United Kingdom: IUPHAR Media, p. 97-104

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Characterization of cannabinoid receptors in the spleen and in mast cells

    Ross, R. A., Murphy, V. L., McKay, N. G., Ashford, M. L. J. & Pertwee, R. G., 1998, Essential Fatty Acids and Eicosanoids: Invited Papers from the Fourth International Congress. Riemersma, R. A., Armstrong, R., Kelly, R. W. & Wilson, R. (eds.). Champaign, Illinois: AOCS Press, p. 376-379 4 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Characterization of Cannabinoid Receptors in the Spleen and in Mast Cells

    Ross, R. A., Murphy, V. L., McKay, N. G., Ashford, M. L. J. & Pertwee, R. G., Dec 1998, Essential Fatty Acids and Eicosanoids: Proceedings of the 4th Int. Congress on Fatty Acids and Eicosanoids, Edinburgh. Riemersma, R., Armstrong, R., Kelly, R. & Wilson, R. (eds.). Champaign: AOCS Press, p. 376-379

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine

    Ross, R. A., Brockie, H. C., Fernando, S. R., Saha, B., Razdan, R. K. & Pertwee, R. G., Nov 1998, In : British Journal of Pharmacology. 125, 6, p. 1345-1351 7 p.

    Research output: Contribution to journalArticle

    41 Citations (Scopus)
    50 Citations (Scopus)

    Interactions between synthetic vanilloids and the endogenous cannabinoid system

    Di Marzo, V., Bisogno, T., Melck, D., Ross, R. A., Brockie, H., Stevenson, L. A., Pertwee, R. G. & De Petrocellis, L., 9 Oct 1998, In : FEBS Letters. 436, 3, p. 449-454 6 p.

    Research output: Contribution to journalArticle

    132 Citations (Scopus)

    The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: Insights gained from (E)- and (Z)-naphthylidene indenes

    Reggio, P. H., Basu-Dutt, S., Barnett-Norris, J., Castro, M. T., Hurst, D. P., Seltzman, H. H., Roche, M. J., Gilliam, A. F., Thomas, B. F., Stevenson, L. A., Pertwee, R. G. & Abood, M. E., 1998, In : Journal of Medicinal Chemistry. 41, p. 5177-5187 11 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum

    LopezRedondo, F., Lees, G. M. & Pertwee, R. G., Sep 1997, In : British Journal of Pharmacology. 122, 2, p. 330-334 5 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals

    Griffin, G., Fernando, S. R., Ross, R. A., McKay, G., Ashford, M. L. J., Shire, D., Huffman, J. W., Yu, S., Lainton, J. A. H. & Pertwee, R. G., 19 Nov 1997, In : European Journal of Pharmacology. 339, 1, p. 53-61 9 p.

    Research output: Contribution to journalArticle

    152 Citations (Scopus)

    Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist

    Fernando, S. R. & Pertwee, R. G., Aug 1997, In : British Journal of Pharmacology. 121, 8, p. 1716-1720 5 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: Synthesis and characterization of a series of O,2-propano-Delta(8)-tetrahydrocannabinol analogs

    Reggio, P. H., Wang, T., Brown, A. E., Fleming, D. N., Seltzman, H. H., Griffin, G., Pertwee, R. G., Compton, D. R., Abood, M. E. & Martin, R., 26 Sep 1997, In : Journal of Medicinal Chemistry. 40, 20, p. 3312-3318 7 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus

    Coutts, A. A. & Pertwee, R. G., Aug 1997, In : British Journal of Pharmacology. 121, 8, p. 1557-1566 10 p.

    Research output: Contribution to journalArticle

    132 Citations (Scopus)

    Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide

    Seltzman, H. H., Fleming, D. N., Thomas, B. F., Gilliam, A. F., McCallion, D. S., Pertwee, R. G., Compton, D. R. & Martin, B. R., 24 Oct 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3626-3634 9 p.

    Research output: Contribution to journalArticle

    58 Citations (Scopus)

    The perceived effects of smoked cannabis on patients with multiple sclerosis

    Consroe, P., Musty, R., Rein, J., Tillery, W. & Pertwee, R. G., 1997, In : European Journal of Neurology. 38, 1, p. 44-48 5 p.

    Research output: Contribution to journalArticle

    251 Citations (Scopus)

    Therapeutic Uses of Cannabis

    Ashton, C. H., Holdcroft, A., Mars, S., Moffat, A. C., Pertwee, R. G. & Wall, P., 18 Nov 1997, Amsterdam, Netherlands: Harwood Academic Publishers. 142 p. (British Medical Association )

    Research output: Book/ReportBook

    1996

    Agonist-antagonist characterization of 6'-cyanohex-2'-yne-Delta(8)-tetrahydrocannabinol in two isolated tissue preparations

    Pertwee, R. G., Fernando, S. R., Griffin, G., Ryan, W., Razdan, R. K., Compton, D. R. & Billy R., M., 14 Nov 1996, In : European Journal of Pharmacology. 315, 2, p. 195-201 7 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder

    Pertwee, R. G. & Fernando, S. R., Aug 1996, In : British Journal of Pharmacology. 118, 8, p. 2053-2058 6 p.

    Research output: Contribution to journalArticle

    117 Citations (Scopus)

    Further evidence for the presence of cannabinoid CB1, receptors in mouse vas deferens

    Pertwee, R. G., JoeAdigwe, G. & Hawksworth, G. M., 25 Jan 1996, In : European Journal of Pharmacology. 296, 2, p. 169-172 4 p.

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine

    Pertwee, R. G., Fernando, S. R., Nash, J. E. & Coutts, A. A., Aug 1996, In : British Journal of Pharmacology. 118, 8, p. 2199-2205 7 p.

    Research output: Contribution to journalArticle

    156 Citations (Scopus)
    1995

    AM630, a competitive cannabinoid receptor antagonist

    Pertwee, R. G., Griffin, G., Fernando, S., Li, X., Hill, A. & Makriyannis, A., 5 May 1995, In : Life Sciences. 56, 23-24, p. 1949-1955 7 p.

    Research output: Contribution to journalArticle

    117 Citations (Scopus)

    A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens

    Pertwee, R. G. & Griffin, G., 5 Jan 1995, In : European Journal of Pharmacology. 272, 1, p. 67-72 6 p.

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Cannabinoid Receptors

    Pertwee, R. G., Mar 1995, London, United Kingdom: Academic Press. 264 p. (Neuroscience Perspectives)

    Research output: Book/ReportBook

    EFFECT OF DELTA(9)-TETRAHYDROCANNABINOL ON CIRCLING IN RATS INDUCED BY INTRANIGRAL MUSCIMOL ADMINISTRATION

    WICKENS, A. P. & Pertwee, R. G., 25 Aug 1995, In : European Journal of Pharmacology. 282, 1-3, p. 251-254 4 p.

    Research output: Contribution to journalComment/debate

    14 Citations (Scopus)

    Effect of phenylmethylsulfonyl fluoride on the potency of anandamide as an inhibitor of electrically-evoked contractions in 2 isolated tissue preparations

    Pertwee, R. G., Fernando, S. R., Griffin, G., Abadji, V. & Makriyannis, A., 5 Jan 1995, In : European Journal of Pharmacology. 272, 1, p. 73-78 6 p.

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    IDENTIFICATION OF AN ENDOGENOUS 2-MONOGLYCERIDE, PRESENT IN CANINE GUT, THAT BINDS TO CANNABINOID RECEPTORS

    MECHOULAM, R., BENSHABAT, S., HANUS, L., LIGUMSKY, M., KAMINSKI, N. E., SCHATZ, A. R., GOPHER, A., ALMOG, S., COMPTON, D. R., Pertwee, R. G., GRIFFIN, G., BAYEWITCH, M., BARG, J., VOGEL, Z. & Martin, B. R., 29 Jun 1995, In : Biochemical Pharmacology. 50, 1, p. 83-90 8 p.

    Research output: Contribution to journalArticle

    2050 Citations (Scopus)