Roger Pertwee

Professor

    • 26771 Citations
    1970 …2020

    Research output per year

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    1999

    Agonist inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630

    Ross, R. A., Brockie, H. C., Stevenson, L. A., Murphy, V. L., Templeton, F., Makriyannis, A. & Pertwee, R. G., Feb 1999, In : British Journal of Pharmacology. 126, 3, p. 665-672 8 p.

    Research output: Contribution to journalArticle

    323 Citations (Scopus)

    Cannabis and cannabinoids: Pharmacology and rationale for clinical use

    Pertwee, R. G., 1999, In : Forschende Komplementärmedizin. 6, p. 12-15 4 p.

    Research output: Contribution to journalArticle

    62 Citations (Scopus)

    Design and synthesis of the CB1 selective cannabinoid antagonist AM281

    Lan, R. X., Lu, Q., Fan, P. S., Gatley, J., Volkow, N. D., Fernando, S. R., Pertwee, R. G. & Makriyannis, A., Jun 1999, In : AAPS PharmSci. 1, 2, p. 39-45 7 p.

    Research output: Contribution to journalArticle

    Development of agonists, partial agonists and antagonists in the Delta(8)-tetrahydrocannabinol series

    Crocker, P. J., Saha, B., Ryan, W. J., Wiley, J. L., Martin, B. R., Ross, R. A., Pertwee, R. G. & Razdan, R. K., 3 Dec 1999, In : Tetrahedron. 55, 49, p. 13907-13926 20 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor

    Hanus, L., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R. & Fride, E., 7 Dec 1999, In : PNAS. 96, 25, p. 14228-14233 6 p.

    Research output: Contribution to journalArticle

    437 Citations (Scopus)

    Prescribing cannabinoids for multiple sclerosis - Current issues

    Pertwee, R. G., 1999, In : CNS Drugs. 11, p. 327-334 8 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-¿8-tetrahydrocannabinol at cannabinoid receptors

    Ross, R. A., Gibson, T. M., Stevenson, L. A., Saha, B., Crocker, P., Razdan, R. K. & Pertwee, R. G., Oct 1999, In : British Journal of Pharmacology. 128, 3, p. 735-743 9 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

    Lan, R. X., Liu, Q., Fan, P. S., Lin, S. Y., Fernando, S. R., McCallion, D., Pertwee, R. & Makriyannis, A., 1999, In : Journal of Medicinal Chemistry. 42, p. 769-776 8 p.

    Research output: Contribution to journalArticle

    391 Citations (Scopus)

    Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)

    Hillard, C. J., Manna, S., Greenberg, M. J., Dicamelli, R., Ross, R. A., Stevenson, L. A., Murphy, V., Pertwee, R. G. & Campbell, W. B., 1 Jun 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, 3, p. 1427-1433 7 p.

    Research output: Contribution to journalArticle

    281 Citations (Scopus)
    2000

    Cannabinoids control spasticity and tremor in a multiple sclerosis model

    Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Huffman, J. W. & Layward, L., 2000, In : Nature. 404, p. 84-87 4 p.

    Research output: Contribution to journalArticle

    451 Citations (Scopus)

    Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine

    Coutts, A. A., Brewster, N., Ingram, T., Razdan, R. K. & Pertwee, R. G., 2000, In : British Journal of Pharmacology. 129, p. 645-652 8 p.

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons

    Irving, A. J., Coutts, A. A., Harvey, J., Rae, M. G., Mackie, K., Bewick, G. S. & Pertwee, R. G., Jun 2000, In : Neuroscience. 98, 2, p. 253-262 10 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Functional expression of cell surface cannabinoid CB1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons

    Irving, A. J., Coutts, A. A., Harvey, J., Rae, M. G., Mackie, K., Bewick, G. S. & Pertwee, R. G., 2000, In : Neuroscience. 98, p. 253-262 10 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide

    Ross, R. A., Brockie, H. C. & Pertwee, R. G., 4 Aug 2000, In : European Journal of Pharmacology. 401, 2, p. 121-130 10 p.

    Research output: Contribution to journalArticle

    92 Citations (Scopus)

    O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties

    Pertwee, R. G., Gibson, T. M., Stevenson, L. A., Ross, R. A., Banner, W. K., Saha, B., Razdan, R. K. & Martin, B. R., Apr 2000, In : British Journal of Pharmacology. 129, 8, p. 1577-1584 8 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity

    De Petrocellis, L., Bisogno, T., Davis, J. B., Pertwee, R. G. & Di Marzo, V., 2000, In : FEBS Letters. 483, p. 52-56 5 p.

    Research output: Contribution to journalArticle

    312 Citations (Scopus)
    2001

    Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception

    Ross, R. A., Coutts, A. A., McFarlane, S. M., Anavi-Goffer, S., Irving, A. J., Pertwee, R. G., MacEwan, D. J. & Scott, R. H., Jan 2001, In : Neuropharmacology. 40, 2, p. 221-232 11 p.

    Research output: Contribution to journalArticle

    148 Citations (Scopus)

    Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion

    Krylatov, A. V., Ugdyshekova, D. S., Bernatskaya, N. A., Maslov, L. N., Mekhoulam, R., Pertwee, R. G. & Stephano, G. B., 2001, In : Bulletin of Experimental Biology and Medicine. 131, p. 523-525 3 p.

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons

    Coutts, A. A., Anavi-Goffer, S., Ross, R. A., MacEwan, D. J., Mackie, K., Pertwee, R. G. & Irving, A. J., Apr 2001, In : Journal of Neuroscience. 21, 7, p. 2425-2433 9 p.

    Research output: Contribution to journalArticle

    130 Citations (Scopus)

    Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints

    Gauldie, S. D., McQueen, D. S., Pertwee, R. & Chessell, I. P., 2001, In : British Journal of Pharmacology. 132, p. 617-621 5 p.

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus

    Craib, S., Ellington, H. C., Pertwee, R. G. & Ross, R. A., Sep 2001, In : British Journal of Pharmacology. 134, 1, p. 30-37 7 p.

    Research output: Contribution to journalArticle

    89 Citations (Scopus)

    Cannabinoid receptors and pain

    Pertwee, R. G., Apr 2001, In : Progress in Neurobiology. 63, 5, p. 569-611 42 p.

    Research output: Contribution to journalArticle

    580 Citations (Scopus)

    Cannabinoids and the gastrointestinal tract

    Pertwee, R. G., Jun 2001, In : Gut. 48, 6, p. 859-867 8 p.

    Research output: Contribution to journalArticle

    238 Citations (Scopus)

    Endocannabinoids control spasticity in a multiple sclerosis model.

    Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Makriyannis, A., Khanolkar, A., Fezza, F., Bisogno, T. & Di Marzo, V., Feb 2001, In : The FASEB Journal. 15, 2, p. 300-302 2 p.

    Research output: Contribution to journalArticle

    342 Citations (Scopus)

    Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens

    Ross, R. A., Gibson, T. M., Brockie, H. C., Leslie, M., Pashmi, G., Craib, S., Di Marzo, V. & Pertwee, R. G., Feb 2001, In : British Journal of Pharmacology. 132, 3, p. 631-640 9 p.

    Research output: Contribution to journalArticle

    205 Citations (Scopus)

    The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice

    Al-Hayani, A., Wease, K., Ross, R. A., Pertwee, R. G. & Davies, S. N., Dec 2001, In : Neuropharmacology. 41, 8, p. 1000-1005 5 p.

    Research output: Contribution to journalArticle

    109 Citations (Scopus)
    2002

    Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

    Ugdyzhekova, D. S., Krylatov, A. V., Bernatskaya, N. A., Maslov, L. N., Mechoulam, R. & Pertwee, R. G., 2002, In : Bulletin of Experimental Biology and Medicine. 133, p. 125-126 2 p.

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Cannabinoid receptors and their ligands

    Pertwee, R. G. & Ross, R., Feb 2002, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 66, 2-3, p. 101-121 20 p.

    Research output: Contribution to journalArticle

    396 Citations (Scopus)

    Cannabinoids and multiple sclerosis

    Pertwee, R. G., Aug 2002, In : Pharmacology & Therapeutics. 95, 2, p. 165-174 10 p.

    Research output: Contribution to journalArticle

    152 Citations (Scopus)

    Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism

    Krylatov, A. V., Uzhachenko, R. V., Maslov, L. N., Bernatskaya, N. A., Makriyannis, A., Mechoulam, R., Pertwee, R. G., Sal'nikova, O. M., Stefano, J. B. & Lishmanov, Y. B., 2002, In : Bulletin of Experimental Biology and Medicine. 133, p. 122-124 3 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Functions of cannabinoid receptors in the hippocampus

    Davies, S. N., Pertwee, R. G. & Riedel, G., Jun 2002, In : Neuropharmacology. 42, 8, p. 993-1007 14 p.

    Research output: Contribution to journalArticle

    145 Citations (Scopus)

    Localisation of cannabinoid CB1 receptor-immunoreactivity in the guinea-pig and rat myenteric plexus

    Coutts, A. A., Irving, A. J., Mackie, K., Pertwee, R. G. & Anavi-Goffer, S., Jul 2002, In : Journal of Comparative Neurology. 448, 4, p. 410-422 12 p.

    Research output: Contribution to journalArticle

    123 Citations (Scopus)

    Pharmacological characterization of the anandamide cyclooxygenase metabolite

    Ross, R. A., Craib, S., Stevenson, L. A., Pertwee, R. G., Henderson, A., Toole, J. & Ellington, H. C., 1 Jun 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 900-907 7 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)

    Francisco, M. E. Y., Seltzman, H. H., Gilliam, A. F., Mitchell, R. A., Rider, S. L., Pertwee, R. G., Stevenson, L. A. & Thomas, B. F., 2002, In : Journal of Medicinal Chemistry. 45, p. 2708-2719 12 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)
    2003

    Effects of delta-9-THC and WIN-55,212-2 on place preference in the water maze in rats

    Robinson, L., Hinder, L., Pertwee, R. G. & Riedel, G., Feb 2003, In : Psychopharmacology. 166, 1, p. 40-50 10 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'

    Papahatjis, D. P., Nikas, S. P., Kourouli, T., Chari, R., Xu, W., Pertwee, R. G. & Makriyannis, A., 2003, In : Journal of Medicinal Chemistry. 46, p. 3221-3229 9 p.

    Research output: Contribution to journalArticle

    42 Citations (Scopus)
    2004

    Cannabinoids and glaucoma

    Tomida, I., Pertwee, R. G. & Azuara-Blanco, A., May 2004, In : British Journal of Ophthalmology. 88, 5, p. 708-713 5 p.

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Differential effects of THC or CBD-rich cannabis extracts on working memory in rats

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2004, In : Neuropharmacology. 47, p. 1170-1179 10 p.

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol

    Ghafouri, N., Tiger, G., Razdan, R. K., Mahadevan, A., Pertwee, R. G., Martin, B. R. & Fowler, C. J., 2004, In : British Journal of Pharmacology. 143, p. 774-784 11 p.

    Research output: Contribution to journalArticle

    73 Citations (Scopus)

    Pharmacological and therapeutic targets for Delta(9)-tetrahydrocannabinol and cannabidiol

    Pertwee, R. G., 2004, In : Euphytica. 140, p. 73-82 10 p.

    Research output: Contribution to journalArticle

    Selective cannabinoiod receptor agonist HU-210 decreases pump function of isolated perfused heart: Role of cAMP and cGMP

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Uzhachenko, R. V. & Pertwee, R., 2004, In : Bulletin of Experimental Biology and Medicine. 138, p. 550-553 4 p.

    Research output: Contribution to journalArticle

    2005

    Allosteric modulation of the cannabinoid CB1 receptor

    Price, M. R., Baillie, G. L., Thomas, A., Stevenson, L. A., Easson, M., Goodwin, R., McLean, A., McIntosh, L., Goodwin, G., Walker, G., Westwood, P., Marrs, J., Thomson, F., Cowley, P., Christopoulos, A., Pertwee, R. G. & Ross, R. A., Nov 2005, In : Molecular Pharmacology. 68, 5, p. 1484-1495 12 p.

    Research output: Contribution to journalArticle

    313 Citations (Scopus)

    Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart

    Krylatov, A. V., Maslov, L. N., Lasukova, O. V. & Pertwee, R. G., 2005, In : Bulletin of Experimental Biology and Medicine. 139, p. 558-561 4 p.

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Evidence that (-)-7-hydroxy-4 '-dimethylheptyl-cannabidiol activates a non-CB1, non-CB2, non-TRPV1 target in the mouse vas deferens

    Pertwee, R. G., Thomas, A., Stevenson, L. A., Maor, Y. & Mechoulam, R., 2005, In : Neuropharmacology. 48, p. 1139-1146 8 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Evidence that the plant cannabinoid ¿9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist

    Thomas, A., Stevenson, L. A., Wease, K., Price, M., Baillie, G., Ross, R. A. & Pertwee, R. G., Dec 2005, In : British Journal of Pharmacology. 146, 7, p. 917-926 9 p.

    Research output: Contribution to journalArticle

    110 Citations (Scopus)

    Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase

    Vandevoorde, S., Saha, B., Mahadevan, A., Razdan, R. K., Pertwee, R. G., Martin, B. R. & Fowler, C. J., 2005, In : Biochemical and Biophysical Research Communications. 337, p. 104-109 6 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities

    Thomas, B. F., Francisco, M. E. Y., Seltzman, H. H., Thomas, J. B., Fix, S. E., Schulz, A. K., Gilliam, A. F., Pertwee, R. G. & Stevenson, L. A., 2005, In : Bioorganic & Medicinal Chemistry. 13, p. 5463-5474 12 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)
    2006

    Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells

    Drysdale, A. J., Ryan, D., Pertwee, R. G. & Platt, B., Apr 2006, In : Neuropharmacology. 50, 5, p. 621-631 11 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitis

    Baker, D., Croxford, J. L., Pryce, G., Jackson, S. M., Ledent, C., Marsicano, G., Lutz, B., Giovannoni, G., Pertwee, R. G. & Yamamura, T., Sep 2006, In : Journal of Neuroimmunology. 178, Suppl. 1, p. 90-91 2 p.

    Research output: Contribution to journalArticle