Roger Pertwee

Professor

    • 26727 Citations
    1970 …2020

    Research output per year

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    Article
    2006

    Cannabinoid pharmacology

    Pertwee, R. G., Jan 2006, In : British Journal of Pharmacology. 147, S1, p. S163-S171 9 p.

    Research output: Contribution to journalArticle

    334 Citations (Scopus)

    Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

    Ryan, D., Drysdale, A. J., Pertwee, R. G. & Platt, B., 20 Nov 2006, In : Neuroscience Letters. 408, 3, p. 236-241 6 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Effect of sublingual application of cannabinoids on intraocular pressure: A pilot study

    Tomida, I., Azuara-Blanco, A., House, H., Flint, M., Pertwee, R. G. & Robson, P. J., Oct 2006, In : Journal of Glaucoma. 15, 5, p. 349-353 5 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

    Appendino, G., Cascio, M. G., Bacchiega, S., Moriello, A. S., Minassi, A., Thomas, A., Ross, R., Pertwee, R., De Petrocellis, L. & Di Marzo, V., 2006, In : FEBS Letters. 580, p. 568-574 7 p.

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands

    Cascio, M. G., Bisogno, T., Palazzo, E., Thomas, A. D., van der Stelt, M., Brizzi, A., De Novellis, V., Marabese, I., Ross, R. A., van de Doelen, T., Brizzi, V., Pertwee, R. G., Maione, S. & Di Marzo, V., Oct 2006, In : British Journal of Pharmacology. 149, 4, p. 431-440 10 p.

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Novel compounds that interact with both leukotriene B-4 receptors and vanilloid TRPV1 receptors

    McHugh, D., McMaster, R. S., Pertwee, R. G., Roy, S., Mahadevan, A., Razdan, R. K. & Ross, R. A., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, p. 955-965 11 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Hanus, L. O., Pertwee, R. G., Ivanchuk, I. I. & Crowford, D., 2006, In : Bulletin of Experimental Biology and Medicine. 142, 5, p. 557-561 5 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2006, In : Behavioural Brain Research. 168, p. 307-311 5 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    The pharmacology of cannabinoid receptors and their ligands: an overview

    Pertwee, R. G., 2006, In : International Journal of Obesity. 30, Supplement 1, p. S13–S18 6 p.

    Research output: Contribution to journalArticle

    320 Citations (Scopus)
    2007

    Anti-inflammatory property of the cannaboinid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

    Xu, H., Cheng, C. L., Chen, M., Manivannan, A., Cabay, L., Pertwee, R. G., Coutts, A. A. & Forrester, J. V., 1 Sep 2007, In : Journal of Leukocyte Biology. 82, 3, p. 532-541 10 p.

    Research output: Contribution to journalArticle

    79 Citations (Scopus)

    Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

    Thomas, A., Baillie, G., Phillips, A. M., Razdan, R. K., Ross, R. A. & Pertwee, R. G., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 613-623 11 p.

    Research output: Contribution to journalArticle

    334 Citations (Scopus)

    Cannabinoids and multiple sclerosis

    Pertwee, R. G., Aug 2007, In : Molecular Neurobiology. 36, 1, p. 45-59 15 p.

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Significance of cardiac cannabinoid receptors in regulation of cardiac rhythm, myocardial contractility, and electrophysiologic processes in heart

    Krylatov, A. V., Maslov, L. N., Ermakov, S. Y., Lasukova, O. V., Barzakh, E. I., Crawford, D. & Pertwee, R. G., Jan 2007, In : Bulletin of Experimental Biology and Medicine. 34, 1, p. 28-35 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo

    Pertwee, R. G., Thomas, A., Stevenson, L. A., Ross, R. A., Varvel, S. A., Lichtman, A. H., Martin, B. R. & Razdan, R. K., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 586-594 9 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R. E. & Riedel, G., Jul 2007, In : British Journal of Pharmacology. 151, 5, p. 688-700 13 p.

    Research output: Contribution to journalArticle

    39 Citations (Scopus)
    2008

    Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis

    Croxford, J. L., Pryce, G., Jackson, S. J., Ledent, C., Giovannoni, G., Pertwee, R. G., Yamamura, T. & Baker, D., Jan 2008, In : Journal of Neuroimmunology. 193, 1-2, p. 120-129 10 p.

    Research output: Contribution to journalArticle

    76 Citations (Scopus)

    Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

    Robinson, L., McKillop-Smith, S., Ross, N. L., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Jul 2008, In : Psychopharmacology. 198, 4, p. 551-563 13 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: Evidence for a site distinct from CB1 and CB2

    McHugh, D., Tanner, C., Mechoulam, R., Pertwee, R. G. & Ross, R. A., Feb 2008, In : Molecular Pharmacology. 73, 2, p. 441-450 10 p.

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

    Alvarez, F. J., Lafuente, H., Rey-Santano, M. C., Mielgo, V. E., Gastiasoro, E., Rueda, M., Pertwee, R. G., Castillo, A. I., Romero, J. & Martinez-Orgado, J., Dec 2008, In : Pediatric Research. 64, 6, p. 653-658 6 p.

    Research output: Contribution to journalArticle

    91 Citations (Scopus)
    2009

    Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels

    Ryan, D., Drysdale, A. J., Lafourcade, C., Pertwee, R. G. & Platt, B., 18 Feb 2009, In : Journal of Neuroscience. 29, 7, p. 2053-2063 11 p.

    Research output: Contribution to journalArticle

    126 Citations (Scopus)

    Conformationally Constrained Fatty Acid Ethanolamides as Cannabinoid and Vanilloid Receptor Probes

    Appendino, G., Ligresti, A., Minassi, A., Cascio, M. G., Allara, M., Taglialatela-Scafati, O., Pertwee, R. G., De Petrocellis, L. & Di Marzo, V., 14 May 2009, In : Journal of Medicinal Chemistry. 52, 9, p. 3001-3009 9 p.

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

    Riedel, G., Fadda, P., McKillop-Smith, S., Pertwee, R. G., Platt, B. & Robinson, L., Apr 2009, In : British Journal of Pharmacology. 156, 7, p. 1154-1166 13 p.

    Research output: Contribution to journalArticle

    71 Citations (Scopus)
    2010

    Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

    Thors, L., Burston, J. J., Alter, B. J., McKinney, M. K., Cravatt, B. F., Ross, R. A., Pertwee, R. G., Gereau, R. W., Wiley, J. L. & Fowler, C. J., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 549-560 12 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

    Brown, I., Cascio, M. G., Wahle, K. W. J., Smoum, R., Mechoulam, R., Ross, R. A., Pertwee, R. G. & Heys, S. D., Sep 2010, In : Carcinogenesis. 31, 9, p. 1584-1591 8 p.

    Research output: Contribution to journalArticle

    95 Citations (Scopus)

    Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist

    Cascio, M. G., Gauson, L. A., Stevenson, L. A., Ross, R. A. & Pertwee, R. G., Jan 2010, In : British Journal of Pharmacology. 159, 1, p. 129-141 13 p.

    Research output: Contribution to journalArticle

    76 Citations (Scopus)

    Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.

    Pasquini, S., Ligresti, A., Mugnaini, C., Semeraro, T., Cicione, L., De Rosa, M., Guida, F., Luongo, L., De Chiaro, M., Cascio, M. G., Bolognini, D., Marini, P., Pertwee, R. G., Maione, S., Di Marzo, V. & Corelli, F., 26 Aug 2010, In : Journal of Medicinal Chemistry. 53, 16, p. 5915-5928 14 p.

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists

    Cascio, M. G., Bolognini, D., Pertwee, R. G., Palazzo, E., Corelli, F., Pasquini, S., Di Marzo, V. & Maione, S., Apr 2010, In : Pharmacological Research. 61, 4, p. 349-354 6 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Phytocannabinoids beyond the Cannabis plant - do they exist?

    Gertsch, J., Pertwee, R. G. & Di Marzo, V., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 523-529 7 p.

    Research output: Contribution to journalArticle

    85 Citations (Scopus)

    The effects of ¿9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

    Jamontt, J. M., Molleman, A., Pertwee, R. G. & Parsons, M. E., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 712-723 12 p.

    Research output: Contribution to journalArticle

    68 Citations (Scopus)

    The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

    Bolognini, D., Costa, B., Maione, S., Comelli, F., Marini, P., Di Marzo, V., Parolaro, D., Ross, R. A., Gauson, L. A., Cascio, M. G. & Pertwee, R. G., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 677-687 11 p.

    Research output: Contribution to journalArticle

    62 Citations (Scopus)

    WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R., Platt, B. & Riedel, G., 2 Apr 2010, In : Behavioural Brain Research. 208, 2, p. 584-592 9 p.

    Research output: Contribution to journalArticle

    34 Citations (Scopus)
    2011

    Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

    Brown, I., Wahle, K. W., Cascio, M. G., Smoum, R., Mechoulam, R., Pertwee, R. G. & Heys, S. D., Dec 2011, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, 6, p. 305-310 6 p.

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist

    Wiley, J. L., Breivogel, C. S., Mahadevan, A., Pertwee, R. G., Cascio, M. G., Bolognini, D., Huffman, J. W., Walentiny, D. M., Vann, R. E., Razdan, R. K. & Martin, B. R., 25 Jan 2011, In : European Journal of Pharmacology. 651, 1-3, p. 96-105 10 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)
    2012

    AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor

    Bolognini, D., Cascio, M. G., Parolaro, D. & Pertwee, R. G., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2561-2574 14 p.

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus

    Rock, E. M., Bolognini, D., Limebeer, C. L., Cascio, M. G., Anavi-Goffer, S., Fletcher, P. J., Mechoulam, R., Pertwee, R. G. & Parker, L. A., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2620-2634 15 p.

    Research output: Contribution to journalArticle

    99 Citations (Scopus)

    Delta(8)-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

    Batkai, S., Mukhopadhyay, P., Horvath, B., Rajesh, M., Gao, R. Y., Mahadevan, A., Amere, M., Battista, N., Lichtman, A. H., Gauson, L. A., Maccarrone, M., Pertwee, R. G. & Pacher, P., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2450-2461 12 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

    Pasquini, S., De Rosa, M., Ligresti, A., Mugnaini, C., Brizzi, A., Caradonna, N. P., Cascio, M. G., Bolognini, D., Pertwee, R. G., Di Marzo, V. & Corelli, F., Dec 2012, In : European Journal of Medicinal Chemistry. 58, p. 30-43 14 p.

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach

    Mugnaini, C., Nocerino, S., Pedani, V., Pasquini, S., Tafi, A., De Chiaro, M., Bellucci, L., Valoti, M., Guida, F., Luongo, L., Dragoni, S., Ligresti, A., Rosenberg, A., Bolognini, D., Cascio, M. G., Pertwee, R. G., Moaddel, R., Maione, S., Di Marzo, V. & Corelli, F., May 2012, In : ChemMedChem. 7, 5, p. 920-934 15 p.

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

    Anavi-Goffer, S., Baillie, G., Irving, A., Gertsch, J., Greig, I. R., Pertwee, R. G. & Ross, R. A., 2 Jan 2012, In : The Journal of Biological Chemistry. 287, 1, p. 91-104 15 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB1 and CB2 Receptors

    Valdeolivas, S., Satta, V., Pertwee, R. G., Fernandez-Ruiz, J. & Sagredo, O., 9 Feb 2012, In : ACS Chemical Neuroscience. 3, 5, p. 400-406 7 p.

    Research output: Contribution to journalArticle

    63 Citations (Scopus)
    2013

    Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

    Fernandez-Ruiz, J., Sagredo, O., Ruth Pazos, M., Garcia, C., Pertwee, R., Mechoulam, R. & Martinez-Orgado, J., Feb 2013, In : British Journal of Clinical Pharmacology. 75, 2, p. 323-333 11 p.

    Research output: Contribution to journalArticle

    137 Citations (Scopus)

    Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation

    Bolognini, D., Rock, EM., Cluny, NL., Cascio, MG., Limebeer, CL., Duncan, M., Stott, CG., Javid, FA., Parker, LA. & Pertwee, RG., Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1456-1470 15 p.

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

    Hill, T. D. M., Cascio, M-G., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., Whalley, B. J. & Hill, A. J., Oct 2013, In : British Journal of Pharmacology. 170, 3, p. 679-692 14 p.

    Research output: Contribution to journalArticle

    91 Citations (Scopus)

    Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

    Brown, I., Cascio, M. G., Rotondo, D., Pertwee, R. G., Heys, S. D. & Wahle, K. W. J., Jan 2013, In : Progress in Lipid Research. 52, 1, p. 80-109 30 p.

    Research output: Contribution to journalArticle

    61 Citations (Scopus)

    CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

    Baillie, G. L., Horswill, J. G., Anavi-Goffer, S., Reggio, P. H., Bolognini, D., Abood, M. E., McAllister, S., Strange, P. G., Stephens, G. J., Pertwee, R. G. & Ross, R. A., Feb 2013, In : Molecular Pharmacology. 83, 2, p. 322-338 17 p.

    Research output: Contribution to journalArticle

    76 Citations (Scopus)

    Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors

    Marini, P., Cascio, M. G., King, A., Pertwee, R. G. & Ross, R. A., Jun 2013, In : British Journal of Pharmacology. 169, 4, p. 887-899 13 p.

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors

    Espejo-Porras, F., Fernandez-Ruiz, J., Pertwee, R. G., Mechoulam, R. & Garcia, C., Dec 2013, In : Neuropharmacology. 75, p. 155-163 9 p.

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

    Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M. G., Pertwee, R. G., Coppola, D., Vassallo, L., Orlando, P., Di Marzo, V. & Izzo, A. A., May 2013, In : British Journal of Pharmacology. 169, 1, p. 213-229 16 p.

    Research output: Contribution to journalArticle

    72 Citations (Scopus)
    2014

    Early phytocannabinoid chemistry to endocannabinoids and beyond

    Mechoulam, R., Hanus, L. O., Pertwee, R. & Howlett, A. C., Nov 2014, In : Nature reviews neuroscience. 15, 11, p. 757-764 8 p.

    Research output: Contribution to journalArticle

    122 Citations (Scopus)
    46 Citations (Scopus)